GREMLIN Database
YCLK - Sensor histidine kinase YclK
UniProt: P94414 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 473 (438)
Sequences: 50988 (44628)
Seq/√Len: 2132.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
399_E461_K3.9771.00
400_D404_G3.8851.00
322_V358_A3.7101.00
393_E465_R3.6351.00
440_R444_E3.5961.00
451_E463_I3.5391.00
397_E461_K3.3221.00
270_V290_I3.2941.00
386_R397_E2.9941.00
347_M384_W2.9501.00
397_E463_I2.9221.00
410_I454_S2.8631.00
395_I465_R2.8481.00
395_I463_I2.8201.00
274_N291_S2.7241.00
347_M382_D2.7001.00
382_D401_T2.6901.00
388_M395_I2.6861.00
358_A446_H2.6551.00
321_D357_H2.6351.00
384_W399_E2.6291.00
452_I462_F2.5751.00
349_Q386_R2.5551.00
406_P409_D2.5411.00
453_K463_I2.5231.00
267_N295_K2.5011.00
439_V450_V2.4641.00
388_M397_E2.4191.00
321_D355_I2.4171.00
455_E458_K2.4101.00
453_K461_K2.4081.00
274_N288_S2.3661.00
366_I443_V2.3641.00
378_T401_T2.3601.00
386_R399_E2.3501.00
405_I413_I2.3311.00
323_P326_E2.2721.00
410_I452_I2.2611.00
414_W450_V2.2231.00
443_V448_G2.2091.00
409_D412_H2.2091.00
267_N294_T2.1951.00
449_T465_R2.1881.00
330_I364_I2.1661.00
349_Q384_W2.1601.00
227_F231_A2.0981.00
335_L368_V2.0961.00
345_K382_D2.0301.00
298_L302_K2.0221.00
454_S460_T2.0141.00
320_L360_Y2.0001.00
443_V464_I1.9921.00
267_N298_L1.9801.00
407_K410_I1.9551.00
451_E465_R1.9251.00
319_K357_H1.9131.00
412_H415_E1.8921.00
412_H418_Y1.8471.00
245_E248_R1.8421.00
366_I439_V1.8281.00
390_G395_I1.8131.00
366_I442_L1.8111.00
372_K376_Q1.8091.00
228_N231_A1.8091.00
381_G401_T1.8071.00
218_D221_G1.8041.00
409_D418_Y1.8031.00
358_A363_F1.8001.00
339_A375_I1.7701.00
250_Q254_D1.7551.00
280_E283_K1.7481.00
442_L446_H1.7341.00
405_I409_D1.7141.00
271_E291_S1.7011.00
27_S31_H1.6831.00
367_L396_I1.6761.00
269_L286_C1.6751.00
409_D420_A1.6591.00
202_K207_D1.6401.00
359_D362_R1.6291.00
227_F230_M1.6141.00
444_E449_T1.6001.00
378_T381_G1.5961.00
405_I460_T1.5891.00
274_N284_D1.5821.00
291_S295_K1.5731.00
217_G221_G1.5651.00
270_V291_S1.5481.00
244_L248_R1.5411.00
325_I329_E1.5361.00
243_R247_R1.5341.00
384_W401_T1.5281.00
246_K250_Q1.5251.00
266_I294_T1.5001.00
362_R365_Q1.4991.00
369_N439_V1.4961.00
273_L287_F1.4841.00
216_Y221_G1.4641.00
414_W452_I1.4481.00
396_I464_I1.4441.00
360_Y364_I1.4421.00
400_D459_G1.4381.00
415_E418_Y1.4201.00
334_H364_I1.4171.00
406_P456_E1.4161.00
267_N291_S1.4111.00
443_V450_V1.4071.00
265_T293_E1.4041.00
410_I414_W1.3941.00
332_K348_I1.3871.00
197_R201_D1.3821.00
197_R222_V1.3791.00
454_S457_G1.3731.00
258_E365_Q1.3651.00
366_I464_I1.3631.00
279_P282_K1.3511.00
330_I360_Y1.3501.00
265_T269_L1.3401.00
203_V231_A1.3391.00
454_S458_K1.3381.00
323_P355_I1.3381.00
336_Q340_E1.3341.00
325_I387_G1.3341.00
84_N88_Q1.3181.00
329_E348_I1.2941.00
441_Q444_E1.2871.00
248_R252_I1.2721.00
207_D210_I1.2561.00
338_Q341_E1.2541.00
362_R445_M1.2541.00
362_R442_L1.2531.00
194_Q197_R1.2431.00
413_I452_I1.2401.00
245_E249_R1.2361.00
327_V331_V1.2311.00
254_D416_R1.2281.00
269_L289_L1.2221.00
266_I290_I1.2171.00
200_T203_V1.2071.00
226_D229_I1.2061.00
270_V294_T1.1951.00
288_S292_E1.1901.00
299_R361_D1.1851.00
211_H232_K1.1801.00
224_A228_N1.1761.00
419_K429_Y1.1741.00
452_I460_T1.1731.00
369_N372_K1.1711.00
302_K306_D1.1671.00
377_F419_K1.1621.00
165_L169_Y1.1611.00
325_I350_V1.1561.00
350_V387_G1.1511.00
448_G466_L1.1511.00
230_M234_L1.1411.00
363_F446_H1.1401.00
251_F255_V1.1391.00
328_F387_G1.1291.00
34_K38_Y1.1261.00
414_W440_R1.1251.00
273_L283_K1.1221.00
260_K302_K1.1211.00
331_V368_V1.1201.00
246_K249_R1.1151.00
220_I223_L1.1151.00
182_S186_S1.1151.00
28_L32_F1.1141.00
202_K210_I1.1131.00
331_V335_L1.1061.00
265_T268_G1.1061.00
393_E449_T1.0981.00
270_V274_N1.0941.00
407_K454_S1.0921.00
317_L359_D1.0911.00
351_E388_M1.0861.00
285_K289_L1.0731.00
289_L293_E1.0671.00
197_R200_T1.0641.00
322_V327_V1.0631.00
414_W462_F1.0631.00
374_S383_I1.0591.00
305_L308_E1.0571.00
319_K446_H1.0511.00
399_E455_E1.0501.00
200_T204_A1.0481.00
370_I462_F1.0461.00
210_I213_E1.0441.00
268_G272_G1.0431.00
229_I233_K1.0421.00
230_M233_K1.0401.00
81_I148_L1.0401.00
279_P283_K1.0381.00
364_I368_V1.0311.00
416_R441_Q1.0281.00
405_I410_I1.0251.00
153_I157_E1.0251.00
332_K336_Q1.0251.00
293_E296_R1.0231.00
250_Q416_R1.0231.00
400_D460_T1.0191.00
280_E284_D1.0141.00
224_A227_F1.0071.00
331_V364_I1.0041.00
104_L109_W1.0011.00
334_H368_V0.9971.00
196_L200_T0.9971.00
405_I452_I0.9961.00
390_G393_E0.9931.00
200_T226_D0.9911.00
244_L247_R0.9911.00
371_T385_L0.9901.00
294_T298_L0.9901.00
70_Q74_S0.9891.00
258_E369_N0.9811.00
45_L49_A0.9801.00
270_V287_F0.9801.00
370_I450_V0.9801.00
327_V358_A0.9781.00
42_V46_T0.9771.00
186_S190_V0.9741.00
200_T227_F0.9721.00
83_F89_P0.9721.00
26_I30_S0.9701.00
223_L227_F0.9701.00
48_Y51_Q0.9691.00
81_I89_P0.9681.00
276_H283_K0.9631.00
9_Q218_D0.9611.00
199_A212_L0.9611.00
367_L398_I0.9601.00
303_E362_R0.9591.00
299_R303_E0.9551.00
284_D288_S0.9541.00
267_N271_E0.9521.00
335_L371_T0.9471.00
109_W112_L0.9471.00
180_L184_L0.9471.00
326_E330_I0.9451.00
220_I224_A0.9441.00
367_L371_T0.9431.00
377_F403_I0.9421.00
189_H192_R0.9421.00
65_R68_P0.9421.00
370_I439_V0.9301.00
324_L396_I0.9291.00
368_V372_K0.9281.00
216_Y224_A0.9221.00
260_K298_L0.9171.00
31_H35_E0.9171.00
404_G460_T0.9151.00
361_D364_I0.9151.00
46_T50_V0.9131.00
197_R226_D0.9081.00
41_K44_E0.9071.00
31_H34_K0.9061.00
49_A53_A0.9041.00
338_Q372_K0.9011.00
441_Q445_M0.9011.00
210_I214_N0.8981.00
413_I462_F0.8971.00
288_S291_S0.8961.00
378_T383_I0.8961.00
345_K348_I0.8961.00
317_L362_R0.8951.00
214_N225_S0.8941.00
105_K108_E0.8921.00
261_T265_T0.8821.00
179_I183_W0.8811.00
204_A229_I0.8801.00
439_V443_V0.8791.00
405_I411_E0.8761.00
257_H369_N0.8751.00
38_Y42_V0.8721.00
434_L438_I0.8701.00
290_I294_T0.8671.00
66_L69_Y0.8641.00
161_N165_L0.8631.00
390_G465_R0.8621.00
252_I255_V0.8601.00
264_T268_G0.8601.00
344_N348_I0.8581.00
295_K298_L0.8531.00
66_L72_I0.8501.00
201_D222_V0.8491.00
231_A235_K0.8481.00
30_S164_N0.8471.00
319_K447_Q0.8451.00
258_E262_P0.8451.00
443_V466_L0.8441.00
202_K206_G0.8431.00
440_R449_T0.8411.00
365_Q442_L0.8371.00
211_H228_N0.8361.00
89_P92_L0.8351.00
221_G225_S0.8341.00
221_G224_A0.8321.00
370_I464_I0.8311.00
38_Y41_K0.8311.00
134_A146_A0.8301.00
201_D205_S0.8301.00
335_L372_K0.8301.00
285_K288_S0.8271.00
136_P146_A0.8261.00
184_L188_F0.8261.00
306_D365_Q0.8241.00
331_V371_T0.8241.00
49_A52_I0.8241.00
448_G464_I0.8221.00
62_D66_L0.8161.00
269_L290_I0.8161.00
79_Q92_L0.8101.00
213_E228_N0.8091.00
329_E333_E0.8071.00
337_Q341_E0.8021.00
319_K358_A0.8011.00
328_F385_L0.7991.00
69_Y73_L0.7971.00
66_L70_Q0.7971.00
292_E330_I0.7951.00
165_L168_F0.7951.00
257_H261_T0.7931.00
329_E332_K0.7921.00
344_N378_T0.7921.00
317_L445_M0.7901.00
145_G149_L0.7891.00
44_E47_S0.7881.00
78_T81_I0.7871.00
138_F143_F0.7851.00
371_T383_I0.7851.00
63_M66_L0.7831.00
183_W187_K0.7821.00
40_N44_E0.7801.00
192_R196_L0.7801.00
272_G276_H0.7781.00
243_R246_K0.7771.00
343_Q380_N0.7751.00
303_E365_Q0.7741.00
39_Q42_V0.7741.00
289_L292_E0.7711.00
194_Q198_E0.7701.00
328_F367_L0.7681.00
156_V160_V0.7681.00
43_E46_T0.7681.00
231_A234_L0.7671.00
331_V334_H0.7661.00
130_V134_A0.7651.00
223_L226_D0.7641.00
160_V164_N0.7611.00
71_D74_S0.7611.00
79_Q150_I0.7601.00
259_L297_M0.7591.00
83_F148_L0.7571.00
62_D65_R0.7551.00
199_A210_I0.7541.00
222_V225_S0.7531.00
30_S34_K0.7511.00
44_E48_Y0.7511.00
337_Q340_E0.7501.00
269_L293_E0.7501.00
198_E202_K0.7501.00
41_K45_L0.7491.00
201_D226_D0.7491.00
413_I437_S0.7491.00
385_L398_I0.7481.00
17_I21_A0.7481.00
315_I362_R0.7461.00
333_E336_Q0.7451.00
278_I283_K0.7421.00
161_N164_N0.7421.00
330_I334_H0.7411.00
40_N43_E0.7391.00
187_K191_K0.7381.00
274_N287_F0.7381.00
36_F40_N0.7361.00
286_C290_I0.7341.00
146_A150_I0.7331.00
322_V360_Y0.7331.00
307_Y437_S0.7331.00
400_D403_I0.7321.00
264_T267_N0.7301.00
203_V230_M0.7291.00
438_I442_L0.7291.00
37_A40_N0.7281.00
45_L48_Y0.7281.00
362_R366_I0.7251.00
212_L228_N0.7241.00
339_A383_I0.7231.00
324_L356_V0.7211.00
338_Q342_K0.7191.00
344_N375_I0.7191.00
397_E453_K0.7181.00
228_N232_K0.7171.00
366_I446_H0.7161.00
249_R311_R0.7151.00
403_I429_Y0.7141.00
211_H231_A0.7131.00
107_S111_K0.7111.00
405_I454_S0.7081.00
419_K431_E0.7081.00
339_A342_K0.7051.00
296_R364_I0.7021.00
142_E145_G0.7021.00
265_T289_L0.7001.00
393_E467_P0.7001.00
370_I443_V0.6991.00
410_I462_F0.6971.00
276_H282_K0.6971.00
141_N144_K0.6961.00
374_S398_I0.6961.00
306_D362_R0.6941.00
130_V150_I0.6941.00
211_H214_N0.6911.00
318_N359_D0.6911.00
362_R446_H0.6891.00
287_F291_S0.6881.00
305_L309_K0.6881.00
322_V357_H0.6881.00
387_G394_T0.6871.00
209_D235_K0.6871.00
407_K411_E0.6851.00
132_L135_Q0.6851.00
106_K110_N0.6841.00
332_K346_L0.6841.00
164_N168_F0.6831.00
334_H338_Q0.6821.00
23_V27_S0.6821.00
218_D222_V0.6791.00
52_I55_E0.6771.00
166_Y169_Y0.6771.00
214_N217_G0.6771.00
47_S50_V0.6771.00
258_E438_I0.6771.00
252_I256_S0.6751.00
448_G467_P0.6751.00
212_L224_A0.6751.00
298_L301_V0.6731.00
42_V45_L0.6721.00
84_N90_Y0.6711.00
43_E47_S0.6681.00
255_V304_N0.6681.00
188_F191_K0.6681.00
168_F172_I0.6671.00
324_L394_T0.6651.00
130_V133_V0.6651.00
226_D230_M0.6641.00
156_V159_M0.6641.00
329_E350_V0.6631.00
409_D422_I0.6631.00
107_S110_N0.6611.00
190_V194_Q0.6611.00
50_V53_A0.6601.00
67_Y70_Q0.6601.00
339_A346_L0.6591.00
395_I451_E0.6591.00
193_I197_R0.6581.00
92_L96_F0.6561.00
202_K205_S0.6561.00
108_E113_K0.6561.00
63_M67_Y0.6551.00
410_I453_K0.6521.00
199_A202_K0.6521.00
407_K455_E0.6521.00
354_V387_G0.6511.00
102_E106_K0.6481.00
51_Q55_E0.6481.00
351_E387_G0.6471.00
283_K286_C0.6471.00
376_Q429_Y0.6471.00
335_L375_I0.6461.00
39_Q43_E0.6451.00
291_S294_T0.6431.00
214_N224_A0.6431.00
365_Q368_V0.6421.00
383_I398_I0.6411.00
253_A256_S0.6411.00
223_L230_M0.6401.00
157_E161_N0.6401.00
192_R197_R0.6401.00
376_Q431_E0.6371.00
333_E337_Q0.6361.00
340_E343_Q0.6341.00
297_M301_V0.6331.00
259_L262_P0.6331.00
451_E464_I0.6321.00
327_V364_I0.6321.00
216_Y220_I0.6321.00
332_K385_L0.6311.00
277_T283_K0.6311.00
258_E300_L0.6301.00
387_G396_I0.6281.00
157_E160_V0.6271.00
405_I462_F0.6271.00
193_I196_L0.6261.00
278_I282_K0.6261.00
439_V442_L0.6261.00
42_V131_S0.6251.00
113_K116_Q0.6241.00
172_I176_V0.6231.00
191_K195_K0.6231.00
166_Y170_A0.6231.00
201_D204_A0.6221.00
263_L301_V0.6181.00
195_K199_A0.6181.00
35_E38_Y0.6171.00
186_S189_H0.6161.00
327_V363_F0.6161.00
450_V462_F0.6161.00
196_L224_A0.6161.00
273_L286_C0.6161.00
339_A344_N0.6161.00
406_P420_A0.6151.00
115_G118_V0.6141.00
295_K299_R0.6131.00
325_I352_D0.6131.00
133_V136_P0.6131.00
437_S441_Q0.6121.00
162_Q166_Y0.6101.00
24_I28_L0.6091.00
419_K430_G0.6091.00
178_T182_S0.6091.00
50_V54_N0.6071.00
32_F36_F0.6071.00
216_Y223_L0.6051.00
195_K198_E0.6051.00
281_D284_D0.6041.00
293_E334_H0.6021.00
384_W387_G0.6021.00
16_S19_I0.6021.00
118_V122_A0.6021.00
110_N113_K0.6011.00
204_A233_K0.5991.00
32_F35_E0.5961.00
110_N114_K0.5961.00
272_G286_C0.5921.00
351_E386_R0.5921.00
269_L294_T0.5901.00
134_A137_I0.5871.00
399_E457_G0.5861.00
276_H279_P0.5851.00
204_A207_D0.5851.00
84_N87_Q0.5841.00
34_K37_A0.5841.00
276_H286_C0.5831.00
104_L108_E0.5831.00
36_F39_Q0.5831.00
35_E39_Q0.5811.00
69_Y72_I0.5781.00
200_T223_L0.5781.00
351_E354_V0.5771.00
325_I353_H0.5771.00
204_A208_Y0.5761.00
64_R67_Y0.5761.00
326_E360_Y0.5761.00
254_D258_E0.5751.00
158_Q162_Q0.5731.00
349_Q388_M0.5731.00
27_S30_S0.5721.00
410_I460_T0.5721.00
167_M171_V0.5711.00
188_F192_R0.5711.00
144_K148_L0.5701.00
64_R68_P0.5681.00
406_P410_I0.5681.00
423_S429_Y0.5671.00
339_A343_Q0.5671.00
307_Y441_Q0.5661.00
191_K194_Q0.5661.00
14_H182_S0.5651.00
33_V36_F0.5651.00
132_L150_I0.5651.00
153_I156_V0.5641.00
266_I270_V0.5631.00
108_E111_K0.5631.00
219_E223_L0.5621.00
19_I23_V0.5611.00
251_F258_E0.5611.00
124_G128_D0.5611.00
119_T122_A0.5601.00
306_D309_K0.5591.00
266_I293_E0.5581.00
102_E105_K0.5581.00
211_H235_K0.5551.00
323_P353_H0.5541.00
131_S134_A0.5531.00
297_M305_L0.5521.00
109_W113_K0.5521.00
15_I18_L0.5521.00
160_V163_V0.5501.00
219_E224_A0.5491.00
286_C289_L0.5491.00
335_L338_Q0.5461.00
65_R73_L0.5461.00
67_Y71_D0.5441.00
134_A148_L0.5431.00
303_E361_D0.5431.00
13_S17_I0.5421.00
417_F437_S0.5421.00
192_R200_T0.5401.00
415_E440_R0.5401.00
14_H17_I0.5401.00
192_R195_K0.5391.00
47_S51_Q0.5391.00
261_T268_G0.5391.00
423_S430_G0.5381.00
120_I123_D0.5381.00
94_E97_H0.5381.00
103_Q108_E0.5381.00
271_E274_N0.5371.00
282_K286_C0.5361.00
247_R250_Q0.5361.00
256_S262_P0.5351.00
258_E261_T0.5341.00
327_V330_I0.5341.00
264_T269_L0.5321.00
414_W417_F0.5321.00
79_Q82_I0.5321.00
413_I418_Y0.5321.00
155_G158_Q0.5311.00
311_R441_Q0.5311.00
403_I460_T0.5291.00
222_V226_D0.5271.00
169_Y173_S0.5271.00
443_V449_T0.5261.00
332_K335_L0.5261.00
200_T206_G0.5231.00
411_E415_E0.5221.00
111_K115_G0.5221.00
296_R300_L0.5211.00
167_M170_A0.5211.00
262_P297_M0.5201.00
363_F367_L0.5191.00
269_L273_L0.5191.00
293_E297_M0.5181.00
224_A231_A0.5181.00
81_I92_L0.5171.00
304_N417_F0.5161.00
119_T123_D0.5161.00
93_P96_F0.5141.00
259_L301_V0.5141.00
251_F256_S0.5111.00
129_E132_L0.5111.00
48_Y52_I0.5091.00
376_Q419_K0.5091.00
325_I348_I0.5081.00
271_E275_S0.5071.00
28_L31_H0.5071.00
269_L272_G0.5071.00
135_Q138_F0.5051.00
68_P71_D0.5051.00
195_K213_E0.5031.00
317_L446_H0.5031.00
294_T297_M0.5031.00
103_Q107_S0.5021.00
261_T264_T0.5021.00
225_S229_I0.5021.00
203_V206_G0.5021.00
16_S23_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.5899 100 0.332 Contact Map
4bixA 2 0.482 100 0.387 Contact Map
4ctiA 2 0.482 100 0.425 Contact Map
4q20A 2 0.4841 100 0.462 Contact Map
3a0rA 2 0.6956 100 0.463 Contact Map
4mpcA 2 0.6427 100 0.47 Contact Map
3jz3A 2 0.3383 100 0.473 Contact Map
4e01A 3 0.6216 100 0.477 Contact Map
2c2aA 2 0.4905 100 0.479 Contact Map
4gczA 2 0.7505 100 0.48 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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