GREMLIN Database
YCLJ - Uncharacterized transcriptional regulatory protein YclJ
UniProt: P94413 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (207)
Sequences: 78776 (56560)
Seq/√Len: 3931.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_C29_F3.7701.00
13_C31_H3.3951.00
17_E29_F3.3201.00
6_I36_G2.8301.00
37_Y65_K2.7851.00
34_L56_S2.5861.00
28_E45_W2.4721.00
33_G57_M2.4541.00
41_T69_T2.4011.00
57_M65_K2.4001.00
32_D56_S2.3321.00
30_V39_R2.1131.00
19_F104_P2.0451.00
17_E21_F2.0381.00
2_K26_E1.9931.00
53_M80_K1.9341.00
86_Q106_T1.9221.00
23_E108_V1.9031.00
63_C74_I1.8931.00
50_L62_I1.8821.00
31_H35_E1.8661.00
193_R196_D1.8611.00
76_M89_G1.8291.00
158_K161_D1.7941.00
28_E39_R1.7701.00
2_K28_E1.7571.00
39_R43_E1.7461.00
32_D35_E1.7271.00
65_K69_T1.7251.00
76_M94_A1.7251.00
4_L30_V1.7231.00
28_E43_E1.7041.00
67_R95_D1.6671.00
83_E103_S1.6481.00
33_G62_I1.5951.00
58_D61_T1.5911.00
64_R92_M1.5701.00
96_D110_R1.5621.00
57_M61_T1.5611.00
135_C148_N1.5471.00
39_R42_E1.5331.00
164_Y168_Q1.5201.00
40_F66_I1.5191.00
65_K68_E1.4901.00
20_F111_I1.4701.00
165_Y182_Q1.4681.00
174_F182_Q1.4511.00
80_K85_D1.4501.00
48_I72_V1.4471.00
198_H201_R1.4451.00
95_D117_R1.4351.00
63_C76_M1.4331.00
34_L57_M1.4131.00
37_Y62_I1.3931.00
61_T64_R1.3711.00
176_R196_D1.3651.00
165_Y169_N1.3641.00
39_R45_W1.3481.00
175_S178_Q1.3211.00
47_L111_I1.3191.00
75_I114_V1.3161.00
95_D114_V1.3131.00
52_I60_V1.3071.00
10_V31_H1.2721.00
7_E13_C1.2571.00
6_I54_L1.2501.00
37_Y57_M1.2361.00
38_Q42_E1.2291.00
8_D51_D1.2251.00
159_E205_K1.2241.00
52_I76_M1.2181.00
25_F112_K1.2151.00
50_L63_C1.1981.00
35_E39_R1.1831.00
35_E38_Q1.1811.00
108_V112_K1.1781.00
30_V36_G1.1761.00
34_L38_Q1.1741.00
4_L45_W1.1701.00
201_R204_K1.1661.00
82_T85_D1.1581.00
137_T146_L1.1501.00
60_V89_G1.1501.00
60_V88_I1.1441.00
139_N142_T1.1391.00
88_I92_M1.1371.00
4_L36_G1.1241.00
130_M137_T1.1141.00
83_E87_V1.1071.00
132_E137_T1.0861.00
144_E151_P1.0791.00
2_K43_E1.0721.00
3_I25_F1.0721.00
36_G62_I1.0721.00
4_L39_R1.0701.00
37_Y41_T1.0691.00
64_R88_I1.0571.00
87_V91_E1.0541.00
24_G112_K1.0491.00
109_A113_A1.0491.00
106_T109_A1.0441.00
161_D164_Y1.0391.00
165_Y174_F1.0361.00
178_Q182_Q1.0341.00
14_T29_F1.0321.00
140_K164_Y1.0211.00
47_L115_I1.0171.00
91_E112_K1.0121.00
30_V35_E1.0121.00
197_V200_K1.0081.00
5_M16_T0.9971.00
84_S88_I0.9871.00
36_G40_F0.9821.00
160_F164_Y0.9731.00
146_L151_P0.9651.00
138_I167_V0.9631.00
48_I66_I0.9621.00
23_E112_K0.9581.00
4_L40_F0.9571.00
48_I74_I0.9511.00
199_I203_R0.9501.00
208_S216_T0.9481.00
60_V92_M0.9481.00
86_Q99_T0.9481.00
193_R197_V0.9471.00
10_V14_T0.9461.00
174_F178_Q0.9451.00
143_R220_V0.9421.00
83_E86_Q0.9391.00
6_I48_I0.9381.00
17_E27_A0.9341.00
11_S15_M0.9321.00
52_I58_D0.9281.00
61_T65_K0.9271.00
88_I91_E0.9251.00
6_I30_V0.9241.00
73_P95_D0.9241.00
50_L74_I0.9111.00
38_Q41_T0.9091.00
177_E192_E0.9081.00
194_T198_H0.9031.00
50_L76_M0.9031.00
63_C92_M0.8981.00
75_I110_R0.8981.00
63_C94_A0.8961.00
16_T77_L0.8941.00
14_T17_E0.8871.00
114_V117_R0.8821.00
151_P154_N0.8731.00
190_G194_T0.8721.00
49_I107_L0.8711.00
5_M27_A0.8591.00
157_P161_D0.8471.00
52_I85_D0.8441.00
18_M22_K0.8421.00
10_V13_C0.8411.00
193_R200_K0.8411.00
81_D99_T0.8381.00
25_F108_V0.8371.00
64_R68_E0.8341.00
208_S212_P0.8311.00
40_F70_S0.8291.00
54_L62_I0.8221.00
129_D141_K0.8181.00
62_I66_I0.8161.00
162_L166_L0.8121.00
138_I160_F0.8051.00
104_P108_V0.8041.00
73_P121_T0.8011.00
106_T110_R0.8001.00
87_V105_L0.7901.00
40_F45_W0.7881.00
85_D88_I0.7851.00
57_M62_I0.7831.00
209_E212_P0.7761.00
44_N70_S0.7731.00
146_L149_G0.7731.00
40_F72_V0.7731.00
177_E181_E0.7701.00
14_T18_M0.7701.00
49_I111_I0.7691.00
73_P117_R0.7681.00
132_E135_C0.7631.00
102_F107_L0.7611.00
16_T107_L0.7531.00
52_I80_K0.7531.00
113_A116_R0.7521.00
103_S106_T0.7481.00
165_Y179_L0.7471.00
49_I77_L0.7471.00
156_T205_K0.7451.00
96_D113_A0.7441.00
216_T220_V0.7441.00
12_V102_F0.7431.00
33_G37_Y0.7371.00
77_L102_F0.7361.00
6_I62_I0.7321.00
197_V201_R0.7201.00
71_T121_T0.7191.00
33_G56_S0.7191.00
53_M79_A0.7151.00
66_I74_I0.7131.00
200_K204_K0.7121.00
115_I118_Y0.7111.00
90_F110_R0.7111.00
147_L150_E0.7101.00
130_M139_N0.7101.00
207_A210_D0.7061.00
113_A118_Y0.7061.00
178_Q181_E0.7051.00
84_S105_L0.7041.00
136_F147_L0.6981.00
41_T65_K0.6961.00
67_R73_P0.6941.00
91_E109_A0.6861.00
89_G94_A0.6851.00
5_M17_E0.6851.00
37_Y40_F0.6841.00
143_R161_D0.6821.00
40_F48_I0.6781.00
15_M19_F0.6761.00
143_R160_F0.6731.00
105_L109_A0.6711.00
2_K46_D0.6631.00
165_Y168_Q0.6621.00
118_Y122_G0.6611.00
13_C17_E0.6591.00
33_G54_L0.6531.00
75_I96_D0.6521.00
37_Y69_T0.6501.00
110_R114_V0.6421.00
19_F108_V0.6401.00
49_I75_I0.6401.00
190_G195_V0.6351.00
5_M29_F0.6351.00
83_E105_L0.6281.00
168_Q182_Q0.6281.00
7_E54_L0.6251.00
168_Q174_F0.6231.00
192_E196_D0.6231.00
67_R72_V0.6181.00
203_R208_S0.6181.00
112_K116_R0.6171.00
73_P115_I0.6131.00
86_Q103_S0.6111.00
176_R180_L0.6101.00
60_V85_D0.6071.00
78_T86_Q0.6061.00
73_P118_Y0.6051.00
212_P215_Y0.6021.00
63_C67_R0.5971.00
21_F27_A0.5971.00
166_L199_I0.5971.00
84_S87_V0.5971.00
9_N79_A0.5961.00
50_L54_L0.5961.00
176_R192_E0.5961.00
102_F106_T0.5961.00
12_V15_M0.5931.00
158_K198_H0.5861.00
9_N12_V0.5851.00
161_D165_Y0.5811.00
41_T70_S0.5811.00
175_S180_L0.5801.00
66_I72_V0.5781.00
109_A112_K0.5721.00
71_T120_A0.5711.00
211_K219_G0.5681.00
40_F62_I0.5641.00
52_I89_G0.5641.00
135_C147_L0.5601.00
79_A101_P0.5551.00
198_H202_L0.5531.00
87_V90_F0.5521.00
156_T159_E0.5511.00
20_F25_F0.5481.00
191_D194_T0.5471.00
5_M13_C0.5451.00
147_L209_E0.5441.00
145_V152_V0.5441.00
35_E56_S0.5431.00
131_I140_K0.5431.00
113_A117_R0.5401.00
207_A212_P0.5361.00
3_I47_L0.5351.00
25_F115_I0.5341.00
3_I20_F0.5321.00
50_L66_I0.5301.00
165_Y178_Q0.5291.00
81_D101_P0.5281.00
19_F23_E0.5251.00
162_L167_V0.5241.00
145_V149_G0.5181.00
138_I164_Y0.5171.00
8_D78_T0.5171.00
199_I202_L0.5161.00
2_K45_W0.5141.00
130_M135_C0.5131.00
91_E96_D0.5081.00
51_D100_K0.5081.00
6_I33_G0.5071.00
21_F26_E0.5051.00
67_R70_S0.5041.00
180_L183_V0.5041.00
32_D54_L0.5031.00
111_I115_I0.5021.00
117_R121_T0.5021.00
189_Y194_T0.5021.00
159_E162_L0.5011.00
18_M21_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r0jA 2 0.9604 100 0.19 Contact Map
2gwrA 1 0.9648 100 0.2 Contact Map
4b09A 2 0.9119 100 0.204 Contact Map
1ys7A 2 0.9824 100 0.205 Contact Map
2oqrA 2 0.9824 100 0.208 Contact Map
4kfcA 2 0.9736 100 0.222 Contact Map
1kgsA 1 0.9515 100 0.224 Contact Map
2hqrA 2 0.9427 100 0.252 Contact Map
1p2fA 1 0.9339 100 0.254 Contact Map
3q9sA 1 0.9163 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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