GREMLIN Database
YCLI - Uncharacterized ABC transporter permease YclI
UniProt: P94412 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 486 (378)
Sequences: 25521 (21703)
Seq/√Len: 1116.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_E228_K3.6691.00
206_S222_K3.5911.00
206_S220_K3.5451.00
351_M368_F3.5171.00
193_E197_E3.2811.00
208_T220_K3.1991.00
189_T249_L2.9461.00
477_H480_T2.8881.00
188_V224_V2.8291.00
172_K228_K2.8111.00
188_V222_K2.7941.00
347_R371_E2.7141.00
285_V289_K2.6891.00
190_V225_G2.5781.00
12_K15_K2.5591.00
85_K88_D2.5321.00
355_M361_R2.5021.00
372_I466_T2.5001.00
280_N283_T2.4611.00
360_K363_K2.4341.00
467_L471_I2.3931.00
26_T382_L2.3381.00
97_H276_D2.3281.00
196_A226_I2.3101.00
199_N202_S2.2451.00
189_T221_L2.2281.00
99_K276_D2.2261.00
177_R224_V2.2011.00
97_H287_A2.1651.00
89_A93_A2.1611.00
471_I475_R2.1461.00
57_V61_V2.1281.00
376_A462_A2.0861.00
90_N93_A2.0811.00
190_V227_Y2.0621.00
365_I471_I2.0341.00
221_L255_A2.0271.00
380_I455_G2.0121.00
251_T256_T1.9741.00
99_K274_Y1.9611.00
191_I196_A1.9561.00
189_T251_T1.9301.00
173_I178_A1.9111.00
22_L26_T1.9011.00
189_T207_I1.8771.00
283_T287_A1.8751.00
192_N227_Y1.8551.00
447_S450_D1.8411.00
254_T257_A1.8261.00
86_V90_N1.8161.00
191_I195_L1.7971.00
187_K255_A1.7911.00
191_I249_L1.7821.00
383_A387_G1.7781.00
30_V386_T1.7741.00
347_R350_E1.7541.00
202_S205_D1.7391.00
282_D285_V1.7321.00
252_P255_A1.7271.00
26_T386_T1.7101.00
56_S60_Q1.7021.00
91_K94_A1.6951.00
191_I223_I1.6841.00
190_V224_V1.6041.00
194_T229_T1.5951.00
44_K48_L1.5891.00
33_L387_G1.5721.00
201_L205_D1.5681.00
379_A383_A1.5641.00
22_L379_A1.5451.00
194_T197_E1.5411.00
88_D91_K1.5351.00
389_L393_Q1.5341.00
287_A291_T1.5281.00
286_K290_K1.5271.00
174_T193_E1.5251.00
275_M284_F1.5251.00
282_D286_K1.5091.00
178_A190_V1.5081.00
9_W12_K1.4821.00
281_M285_V1.4811.00
286_K289_K1.4771.00
84_I88_D1.4771.00
287_A290_K1.4631.00
25_F379_A1.4531.00
448_M452_L1.4381.00
253_Y257_A1.4351.00
179_I183_D1.4291.00
362_W366_G1.4201.00
30_V387_G1.4191.00
174_T228_K1.4161.00
203_V226_I1.4131.00
11_M18_T1.4081.00
175_D201_L1.4061.00
87_S91_K1.4011.00
376_A380_I1.3981.00
354_L367_Q1.3941.00
90_N94_A1.3941.00
470_S474_L1.3921.00
29_C383_A1.3921.00
352_G481_I1.3911.00
40_S447_S1.3831.00
208_T218_T1.3661.00
177_R188_V1.3651.00
173_I225_G1.3491.00
348_K481_I1.3491.00
100_S274_Y1.3391.00
351_M364_L1.3351.00
157_V161_A1.3331.00
192_N195_L1.3291.00
277_D280_N1.3221.00
381_G385_V1.3181.00
177_R183_D1.3151.00
201_L223_I1.3141.00
452_L456_G1.3081.00
49_A52_E1.2961.00
350_E354_L1.2911.00
10_N371_E1.2901.00
363_K366_G1.2901.00
385_V389_L1.2891.00
54_G58_T1.2871.00
449_N453_I1.2871.00
104_T270_S1.2851.00
95_L287_A1.2831.00
191_I226_I1.2781.00
16_G19_L1.2761.00
348_K476_L1.2721.00
44_K445_A1.2721.00
179_I224_V1.2701.00
200_D205_D1.2701.00
361_R474_L1.2691.00
319_S323_N1.2671.00
465_A469_P1.2561.00
7_A370_T1.2531.00
322_K326_Y1.2521.00
251_T255_A1.2431.00
471_I474_L1.2391.00
179_I188_V1.2321.00
17_K346_E1.2321.00
472_S475_R1.2241.00
193_E229_T1.2171.00
445_A448_M1.2151.00
263_D266_N1.2141.00
389_L392_N1.2081.00
87_S90_N1.2051.00
276_D280_N1.2041.00
33_L454_L1.1981.00
299_T302_T1.1971.00
380_I458_G1.1901.00
95_L284_F1.1861.00
26_T30_V1.1851.00
30_V390_V1.1831.00
43_Q47_E1.1801.00
192_N247_N1.1791.00
158_I161_A1.1771.00
308_Q312_G1.1571.00
30_V383_A1.1561.00
86_V89_A1.1561.00
359_E363_K1.1521.00
175_D203_V1.1481.00
352_G356_A1.1431.00
365_I467_L1.1421.00
333_A465_A1.1361.00
285_V302_T1.1301.00
185_G188_V1.1291.00
284_F288_A1.1281.00
40_S43_Q1.1261.00
458_G462_A1.1191.00
393_Q396_N1.1171.00
183_D188_V1.1091.00
177_R180_T1.1091.00
354_L359_E1.1081.00
8_F12_K1.1071.00
387_G391_A1.1071.00
154_I157_V1.1001.00
48_L51_Q1.0991.00
18_T375_V1.0981.00
203_V224_V1.0981.00
40_S44_K1.0911.00
97_H284_F1.0881.00
179_I190_V1.0861.00
175_D202_S1.0821.00
98_V101_Y1.0811.00
19_L23_F1.0761.00
195_L199_N1.0671.00
361_R475_R1.0651.00
382_L385_V1.0591.00
376_A458_G1.0581.00
328_V335_I1.0561.00
446_V451_M1.0561.00
311_V315_E1.0481.00
43_Q318_A1.0451.00
283_T286_K1.0431.00
194_T198_E1.0411.00
48_L52_E1.0331.00
348_K484_K1.0321.00
297_T300_L1.0271.00
22_L378_I1.0261.00
14_K346_E1.0201.00
373_L463_I1.0141.00
315_E319_S1.0121.00
91_K95_L1.0111.00
275_M281_M1.0081.00
37_A391_A0.9941.00
366_G370_T0.9881.00
347_R368_F0.9741.00
472_S476_L0.9711.00
89_A101_Y0.9671.00
271_A275_M0.9631.00
392_N396_N0.9621.00
47_E51_Q0.9601.00
154_I251_T0.9601.00
469_P473_V0.9551.00
340_V372_I0.9511.00
91_K291_T0.9501.00
34_S390_V0.9501.00
22_L382_L0.9491.00
449_N452_L0.9421.00
391_A444_V0.9411.00
255_A258_A0.9371.00
388_N446_V0.9361.00
24_V335_I0.9361.00
156_G256_T0.9321.00
89_A103_Y0.9321.00
54_G57_V0.9311.00
470_S473_V0.9271.00
37_A41_A0.9221.00
173_I227_Y0.9221.00
44_K47_E0.9201.00
180_T183_D0.9171.00
333_A461_I0.9151.00
45_S49_A0.9071.00
50_R53_L0.9041.00
58_T61_V0.9001.00
100_S167_S0.8961.00
192_N246_Y0.8941.00
95_L291_T0.8881.00
14_K17_K0.8881.00
288_A291_T0.8881.00
93_A101_Y0.8851.00
337_G465_A0.8851.00
456_G460_L0.8831.00
210_E218_T0.8771.00
193_E196_A0.8741.00
305_Q308_Q0.8741.00
227_Y250_Y0.8701.00
284_F291_T0.8681.00
88_D92_L0.8661.00
284_F287_A0.8661.00
55_G61_V0.8651.00
175_D226_I0.8641.00
478_P481_I0.8621.00
171_S227_Y0.8611.00
26_T379_A0.8601.00
55_G59_L0.8601.00
326_Y330_V0.8591.00
309_Q312_G0.8581.00
152_L249_L0.8581.00
361_R365_I0.8561.00
348_K352_G0.8551.00
58_T62_D0.8541.00
453_I456_G0.8531.00
384_S451_M0.8501.00
476_L481_I0.8491.00
211_S216_D0.8441.00
209_I221_L0.8361.00
28_I325_V0.8351.00
359_E364_L0.8291.00
373_L462_A0.8271.00
204_G222_K0.8231.00
179_I182_S0.8231.00
55_G60_Q0.8221.00
302_T305_Q0.8221.00
211_S217_T0.8211.00
16_G20_L0.8191.00
26_T29_C0.8131.00
192_N248_K0.8101.00
384_S455_G0.8101.00
355_M478_P0.8091.00
105_T256_T0.8081.00
85_K89_A0.8061.00
192_N229_T0.8061.00
337_G341_M0.8031.00
460_L464_I0.8021.00
28_I335_I0.7961.00
97_H280_N0.7951.00
21_Q338_L0.7941.00
448_M451_M0.7921.00
168_D274_Y0.7901.00
380_I459_I0.7831.00
189_T223_I0.7791.00
312_G315_E0.7791.00
247_N250_Y0.7761.00
450_D453_I0.7751.00
380_I462_A0.7751.00
152_L155_E0.7721.00
349_Y353_V0.7711.00
278_A281_M0.7711.00
307_Y311_V0.7701.00
156_G159_S0.7681.00
191_I207_I0.7621.00
372_I376_A0.7601.00
107_A256_T0.7591.00
166_F178_A0.7581.00
174_T227_Y0.7581.00
479_K482_L0.7571.00
158_I253_Y0.7561.00
93_A100_S0.7551.00
10_N350_E0.7531.00
6_R354_L0.7521.00
279_K284_F0.7511.00
28_I329_S0.7501.00
6_R367_Q0.7491.00
479_K483_T0.7441.00
103_Y158_I0.7431.00
92_L288_A0.7391.00
21_Q24_V0.7371.00
98_V273_Y0.7351.00
46_S50_R0.7351.00
173_I190_V0.7301.00
454_L458_G0.7271.00
39_Q318_A0.7251.00
476_L480_T0.7231.00
186_K222_K0.7221.00
39_Q321_S0.7211.00
221_L251_T0.7211.00
369_L463_I0.7201.00
370_T373_L0.7191.00
468_L471_I0.7191.00
32_V36_L0.7191.00
466_T470_S0.7181.00
290_K294_D0.7181.00
350_E371_E0.7151.00
15_K19_L0.7141.00
343_S371_E0.7111.00
190_V250_Y0.7081.00
391_A395_G0.7081.00
36_L40_S0.7071.00
469_P474_L0.7051.00
176_G179_I0.7051.00
34_S387_G0.7051.00
101_Y273_Y0.7031.00
61_V64_Q0.7011.00
297_T302_T0.6971.00
21_Q339_I0.6971.00
102_N158_I0.6961.00
259_L262_D0.6941.00
343_S347_R0.6931.00
385_V388_N0.6921.00
372_I462_A0.6901.00
118_E208_T0.6891.00
55_G58_T0.6891.00
92_L95_L0.6881.00
352_G482_L0.6871.00
388_N392_N0.6861.00
183_D186_K0.6851.00
372_I469_P0.6841.00
89_A271_A0.6841.00
40_S450_D0.6821.00
24_V338_L0.6811.00
153_S156_G0.6811.00
340_V343_S0.6811.00
335_I338_L0.6811.00
29_C458_G0.6801.00
154_I249_L0.6781.00
279_K283_T0.6781.00
253_Y256_T0.6771.00
150_A198_E0.6771.00
104_T107_A0.6741.00
461_I465_A0.6741.00
100_S168_D0.6741.00
325_V329_S0.6741.00
10_N347_R0.6721.00
256_T260_K0.6711.00
84_I87_S0.6691.00
231_S246_Y0.6691.00
45_S48_L0.6681.00
193_E226_I0.6681.00
57_V60_Q0.6681.00
355_M364_L0.6681.00
223_I226_I0.6671.00
388_N451_M0.6631.00
316_N320_F0.6621.00
109_A154_I0.6601.00
25_F29_C0.6591.00
8_F374_I0.6571.00
187_K219_V0.6561.00
166_F171_S0.6551.00
468_L472_S0.6521.00
338_L342_M0.6521.00
336_L376_A0.6491.00
40_S449_N0.6471.00
370_T374_I0.6451.00
56_S274_Y0.6441.00
60_Q63_R0.6431.00
49_A53_L0.6421.00
314_I318_A0.6421.00
393_Q398_L0.6371.00
187_K222_K0.6361.00
386_T389_L0.6361.00
52_E274_Y0.6341.00
107_A110_N0.6341.00
378_I381_G0.6331.00
151_D154_I0.6331.00
457_I460_L0.6331.00
176_G225_G0.6321.00
6_R10_N0.6301.00
221_L259_L0.6301.00
457_I461_I0.6291.00
365_I474_L0.6281.00
25_F336_L0.6281.00
300_L303_N0.6261.00
161_A166_F0.6251.00
350_E353_V0.6241.00
24_V28_I0.6241.00
281_M284_F0.6231.00
169_G172_K0.6231.00
55_G62_D0.6221.00
160_T167_S0.6221.00
100_S103_Y0.6221.00
392_N444_V0.6211.00
102_N168_D0.6211.00
47_E50_R0.6211.00
352_G478_P0.6201.00
31_F368_F0.6181.00
174_T226_I0.6171.00
33_L383_A0.6161.00
271_A274_Y0.6151.00
308_Q311_V0.6141.00
296_D299_T0.6141.00
57_V63_R0.6131.00
24_V332_G0.6131.00
453_I457_I0.6111.00
357_I478_P0.6101.00
352_G368_F0.6091.00
64_Q67_M0.6061.00
399_L403_I0.6031.00
327_L331_A0.6021.00
392_N395_G0.6011.00
99_K102_N0.6001.00
96_D99_K0.6001.00
451_M455_G0.6001.00
102_N105_T0.6001.00
99_K275_M0.5991.00
212_A216_D0.5991.00
298_Y302_T0.5991.00
480_T484_K0.5971.00
62_D65_K0.5921.00
400_S404_S0.5881.00
178_A182_S0.5881.00
188_V252_P0.5871.00
157_V250_Y0.5871.00
57_V62_D0.5871.00
365_I470_S0.5861.00
196_A199_N0.5851.00
203_V223_I0.5841.00
172_K176_G0.5841.00
372_I465_A0.5841.00
104_T272_V0.5831.00
328_V332_G0.5831.00
56_S62_D0.5831.00
28_I31_F0.5831.00
173_I177_R0.5821.00
230_T233_G0.5801.00
212_A217_T0.5781.00
345_R348_K0.5751.00
377_V459_I0.5731.00
372_I470_S0.5721.00
455_G459_I0.5721.00
155_E158_I0.5721.00
445_A449_N0.5681.00
89_A92_L0.5681.00
268_I271_A0.5681.00
191_I201_L0.5671.00
36_L450_D0.5661.00
39_Q322_K0.5661.00
196_A223_I0.5661.00
205_D223_I0.5661.00
285_V291_T0.5651.00
7_A367_Q0.5651.00
103_Y268_I0.5641.00
365_I369_L0.5641.00
187_K221_L0.5631.00
60_Q301_N0.5631.00
175_D196_A0.5621.00
446_V450_D0.5601.00
195_L247_N0.5601.00
173_I179_I0.5601.00
353_V356_A0.5591.00
344_I351_M0.5561.00
275_M279_K0.5551.00
293_I298_Y0.5541.00
46_S49_A0.5531.00
177_R225_G0.5531.00
278_A282_D0.5521.00
345_R472_S0.5511.00
344_I473_V0.5511.00
197_E229_T0.5511.00
24_V342_M0.5491.00
333_A337_G0.5481.00
256_T259_L0.5481.00
320_F324_V0.5471.00
18_T22_L0.5471.00
340_V466_T0.5461.00
173_I228_K0.5461.00
196_A203_V0.5421.00
17_K21_Q0.5411.00
368_F372_I0.5401.00
5_K9_W0.5391.00
100_S160_T0.5371.00
350_E367_Q0.5341.00
101_Y271_A0.5341.00
332_G335_I0.5331.00
102_N157_V0.5321.00
462_A465_A0.5311.00
154_I158_I0.5301.00
203_V225_G0.5271.00
38_I394_L0.5271.00
207_I221_L0.5261.00
474_L478_P0.5261.00
384_S388_N0.5251.00
168_D171_S0.5251.00
348_K472_S0.5251.00
177_R182_S0.5251.00
107_A260_K0.5231.00
450_D454_L0.5231.00
103_Y271_A0.5231.00
167_S170_D0.5221.00
355_M481_I0.5221.00
289_K294_D0.5221.00
92_L271_A0.5211.00
275_M278_A0.5211.00
300_L304_D0.5211.00
17_K343_S0.5201.00
270_S273_Y0.5181.00
36_L39_Q0.5171.00
253_Y268_I0.5161.00
156_G253_Y0.5161.00
272_V275_M0.5151.00
148_V151_D0.5151.00
105_T108_S0.5151.00
336_L469_P0.5151.00
353_V357_I0.5151.00
289_K300_L0.5131.00
59_L273_Y0.5131.00
248_K251_T0.5131.00
58_T270_S0.5111.00
368_F371_E0.5111.00
180_T224_V0.5101.00
155_E250_Y0.5101.00
37_A444_V0.5091.00
276_D279_K0.5081.00
95_L288_A0.5081.00
294_D298_Y0.5071.00
111_A152_L0.5071.00
269_D273_Y0.5071.00
314_I317_V0.5051.00
29_C380_I0.5041.00
177_R181_K0.5041.00
106_S153_S0.5041.00
323_N330_V0.5031.00
42_A45_S0.5021.00
54_G60_Q0.5021.00
101_Y104_T0.5021.00
298_Y301_N0.5011.00
297_T301_N0.5011.00
248_K252_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ftjA 1 0.4177 99.3 0.783 Contact Map
3is6A 2 0.4568 98.9 0.819 Contact Map
3w9iA 3 0.8292 29.8 0.949 Contact Map
2m8rA 1 0.0844 17 0.955 Contact Map
1yfbA 2 0.107 16.9 0.955 Contact Map
2l66A 2 0.1091 15.1 0.956 Contact Map
3ne5A 3 0.7757 14.2 0.956 Contact Map
3bmbA 1 0.2551 11.2 0.959 Contact Map
4av3A 2 0.2243 10.1 0.959 Contact Map
2kncA 1 0.1029 8.1 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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