GREMLIN Database
YCLF - Uncharacterized transporter YclF
UniProt: P94408 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 492 (464)
Sequences: 4642 (2919)
Seq/√Len: 135.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_L191_A4.3231.00
382_V464_G3.8041.00
380_I404_L3.6751.00
334_F395_P3.6101.00
301_F408_G3.4281.00
92_F97_T3.3651.00
87_L92_F3.2881.00
369_I411_C3.1551.00
322_L328_E3.0381.00
107_F127_L2.9891.00
468_L472_V2.9811.00
180_G332_S2.8441.00
87_L91_V2.7891.00
111_A124_S2.7801.00
341_F403_L2.7421.00
48_Y313_A2.7251.00
106_M197_L2.6781.00
111_A127_L2.6631.00
416_G436_W2.6591.00
316_A398_L2.6321.00
38_S109_H2.6211.00
92_F100_Y2.5681.00
278_K282_K2.5351.00
372_I474_G2.4921.00
101_G134_L2.4841.00
32_E36_R2.4751.00
103_I107_F2.4591.00
323_S328_E2.4391.00
399_V403_L2.4041.00
373_L407_L2.3451.00
379_I467_G2.2361.00
181_Q331_S2.2301.00
302_W413_S2.2111.00
32_E35_E2.2001.00
70_M309_A2.1591.00
70_M310_T2.1521.00
380_I400_L2.1431.00
35_E136_K2.1381.00
278_K283_T2.1351.00
362_S365_V2.0991.00
337_L399_V2.0971.00
348_I352_L2.0651.00
256_I259_V2.0441.00
226_S230_T2.0391.00
475_G479_L2.0301.00
99_F204_A2.0231.00
158_F421_T2.0211.00
375_G471_I2.0161.00
112_L124_S1.9981.00
63_K314_V1.9881.00
47_L51_Y1.9851.00
39_Y74_G1.9791.00
113_A193_A1.9701.00
95_A207_R1.9641.00
345_F407_L1.9501.00
81_T88_A1.9411.00
224_K227_A1.9301.00
471_I475_G1.9121.00
252_I260_S1.8961.00
338_N406_V1.8631.00
32_E136_K1.8611.00
279_K283_T1.8591.00
344_I348_I1.8351.00
80_S83_I1.8261.00
80_S129_I1.8181.00
108_G128_I1.8131.00
353_W357_G1.7921.00
458_P461_M1.7891.00
229_G233_G1.7751.00
47_L314_V1.7661.00
119_I123_I1.7571.00
163_M343_V1.7551.00
170_L343_V1.7461.00
105_I135_L1.7241.00
230_T233_G1.7171.00
143_V157_G1.7141.00
214_A219_P1.7091.00
476_I480_L1.6931.00
275_F288_L1.6551.00
330_Q333_W1.6521.00
61_F69_I1.6321.00
207_R212_G1.6131.00
372_I376_L1.6011.00
482_P485_K1.5951.00
110_I193_A1.5871.00
48_Y331_S1.5701.00
474_G478_L1.5411.00
118_S122_Y1.5311.00
108_G131_G1.5231.00
52_T185_Y1.5201.00
140_S437_F1.5131.00
479_L483_V1.5101.00
161_F165_I1.5081.00
50_L70_M1.4991.00
341_F406_V1.4971.00
338_N342_V1.4851.00
377_S405_V1.4781.00
300_M473_L1.4751.00
184_N187_L1.4731.00
258_L262_L1.4621.00
298_A439_T1.4591.00
62_D65_T1.4571.00
194_V198_L1.4431.00
386_M460_T1.4381.00
385_A388_G1.4341.00
277_S283_T1.4271.00
323_S326_G1.4011.00
322_L331_S1.3851.00
51_Y314_V1.3811.00
145_D421_T1.3741.00
375_G474_G1.3541.00
162_Y409_E1.3531.00
166_N338_N1.3501.00
368_S474_G1.3491.00
27_T206_T1.3431.00
465_T469_I1.3431.00
464_G468_L1.3411.00
33_F164_G1.3401.00
41_G176_V1.3381.00
373_L408_G1.3371.00
394_S397_W1.3371.00
124_S128_I1.3351.00
179_L183_Y1.3351.00
100_Y103_I1.3311.00
305_Q308_G1.3261.00
106_M110_I1.3241.00
177_G332_S1.3231.00
303_A443_A1.3221.00
231_G234_V1.3201.00
383_F387_Q1.3191.00
229_G232_I1.3151.00
316_A395_P1.3131.00
342_V409_E1.3121.00
393_V397_W1.3091.00
282_K286_S1.3071.00
279_K282_K1.3071.00
381_M401_S1.3041.00
230_T234_V1.3031.00
187_L190_G1.3011.00
32_E161_F1.2971.00
94_T145_D1.2921.00
47_L66_A1.2831.00
87_L97_T1.2781.00
364_P481_S1.2701.00
365_V481_S1.2661.00
84_G133_G1.2661.00
368_S478_L1.2621.00
465_T468_L1.2621.00
361_P369_I1.2611.00
176_V179_L1.2601.00
68_A452_G1.2571.00
319_R391_A1.2561.00
50_L121_F1.2551.00
352_L356_L1.2531.00
319_R392_L1.2451.00
227_A230_T1.2421.00
375_G379_I1.2361.00
163_M346_A1.2331.00
132_T135_L1.2321.00
214_A217_N1.2281.00
376_L404_L1.2281.00
162_Y342_V1.2281.00
49_Y115_P1.2221.00
155_D418_S1.2141.00
175_I191_A1.2131.00
233_G236_I1.2111.00
36_R39_Y1.2101.00
257_D260_S1.2061.00
222_L225_K1.2051.00
132_T136_K1.1951.00
327_F333_W1.1941.00
106_M200_L1.1911.00
283_T286_S1.1840.99
257_D261_I1.1840.99
413_S417_L1.1800.99
430_A434_S1.1740.99
136_K437_F1.1690.99
218_V221_P1.1650.99
355_K358_K1.1650.99
367_F412_L1.1570.99
169_G339_P1.1520.99
36_R136_K1.1500.99
35_E40_Y1.1410.99
115_P120_A1.1400.99
177_G333_W1.1350.99
49_Y121_F1.1330.99
140_S161_F1.1300.99
34_W195_G1.1230.99
105_I132_T1.1230.99
275_F282_K1.1210.99
85_G430_A1.1200.99
277_S282_K1.1200.99
463_F466_I1.1190.99
77_V129_I1.1190.99
225_K229_G1.1170.99
215_G218_V1.1160.99
419_V484_I1.1110.99
92_F96_N1.1110.99
322_L330_Q1.1080.99
33_F167_L1.1030.99
280_A283_T1.1020.99
223_S226_S1.0990.99
43_R306_E1.0980.99
482_P486_R1.0840.99
61_F118_S1.0840.99
260_S263_G1.0740.99
255_F259_V1.0740.99
147_Y157_G1.0710.99
221_P225_K1.0680.99
162_Y166_N1.0650.99
36_R40_Y1.0630.99
32_E135_L1.0560.99
227_A231_G1.0510.99
165_I437_F1.0490.99
232_I238_A1.0490.99
224_K228_I1.0440.99
233_G237_V1.0380.99
480_L483_V1.0380.99
275_F279_K1.0360.99
312_L401_S1.0360.99
403_L407_L1.0340.99
80_S133_G1.0340.99
320_I398_L1.0340.99
225_K282_K1.0310.99
205_L208_K1.0250.99
48_Y52_T1.0240.98
249_V252_I1.0240.98
303_A446_I1.0220.98
335_Q339_P1.0220.98
274_M277_S1.0220.98
85_G434_S1.0160.98
384_P397_W1.0140.98
78_Y136_K1.0120.98
226_S233_G1.0110.98
461_M464_G1.0090.98
256_I261_I1.0070.98
201_I205_L0.9990.98
376_L380_I0.9970.98
346_A350_A0.9940.98
77_V80_S0.9900.98
144_G421_T0.9880.98
280_A284_E0.9860.98
165_I417_L0.9840.98
143_V146_L0.9830.98
277_S280_A0.9830.98
346_A414_P0.9780.98
223_S227_A0.9770.98
140_S433_M0.9740.98
226_S229_G0.9740.98
52_T181_Q0.9740.98
342_V347_P0.9720.98
370_G412_L0.9700.98
310_T451_A0.9670.98
237_V240_A0.9650.98
178_T183_Y0.9630.98
225_K228_I0.9610.98
329_L333_W0.9550.98
258_L261_I0.9510.98
190_G194_V0.9490.98
472_V479_L0.9490.98
308_G405_V0.9480.98
281_D284_E0.9470.97
43_R70_M0.9460.97
65_T68_A0.9440.97
312_L402_F0.9440.97
413_S416_G0.9420.97
241_V244_S0.9420.97
319_R459_E0.9400.97
301_F342_V0.9380.97
409_E413_S0.9370.97
239_I242_I0.9370.97
316_A320_I0.9330.97
298_A436_W0.9300.97
462_Y466_I0.9290.97
61_F65_T0.9290.97
29_F164_G0.9290.97
106_M193_A0.9270.97
190_G193_A0.9270.97
48_Y317_D0.9190.97
108_G112_L0.9180.97
78_Y437_F0.9110.97
76_L445_A0.9100.97
483_V487_A0.9080.97
249_V253_K0.9070.97
156_S350_A0.9020.97
34_W139_V0.9010.97
255_F290_A0.9010.97
277_S281_D0.9000.97
21_H25_L0.8990.97
456_K459_E0.8990.97
178_T182_K0.8970.97
226_S239_I0.8960.96
174_L333_W0.8890.96
177_G180_G0.8890.96
345_F348_I0.8880.96
51_Y63_K0.8840.96
248_G251_T0.8840.96
36_R165_I0.8830.96
235_I239_I0.8820.96
214_A218_V0.8790.96
315_Y398_L0.8790.96
459_E462_Y0.8780.96
228_I232_I0.8720.96
99_F102_G0.8690.96
171_L174_L0.8690.96
418_S422_K0.8660.96
345_F403_L0.8660.96
232_I237_V0.8640.96
413_S436_W0.8600.96
306_E440_N0.8590.96
32_E165_I0.8580.96
321_R392_L0.8530.95
348_I353_W0.8500.95
308_G409_E0.8490.95
373_L404_L0.8490.95
306_E444_Q0.8480.95
257_D262_L0.8470.95
107_F111_A0.8470.95
52_T58_G0.8460.95
294_L367_F0.8460.95
68_A448_A0.8420.95
159_S353_W0.8420.95
382_V386_M0.8410.95
69_I122_Y0.8410.95
305_Q406_V0.8410.95
140_S417_L0.8400.95
203_F207_R0.8390.95
221_P230_T0.8390.95
67_V310_T0.8360.95
252_I263_G0.8320.95
368_S481_S0.8320.95
71_S447_N0.8320.95
45_I50_L0.8280.95
380_I401_S0.8280.95
305_Q413_S0.8260.94
230_T237_V0.8220.94
34_W37_F0.8210.94
317_D331_S0.8200.94
232_I239_I0.8190.94
135_L139_V0.8160.94
161_F409_E0.8160.94
341_F399_V0.8150.94
345_F410_L0.8150.94
166_N409_E0.8130.94
173_P336_S0.8100.94
82_I434_S0.8090.94
476_I479_L0.8080.94
158_F294_L0.8070.94
251_T254_R0.8050.94
52_T317_D0.8040.94
349_F407_L0.8040.94
367_F416_G0.8030.94
170_L340_L0.8020.94
231_G235_I0.8020.94
19_F22_P0.8010.94
160_I163_M0.7980.93
237_V244_S0.7980.93
254_R259_V0.7970.93
113_A190_G0.7960.93
89_D93_G0.7960.93
483_V486_R0.7950.93
230_T240_A0.7930.93
33_F165_I0.7920.93
62_D66_A0.7910.93
443_A446_I0.7900.93
233_G239_I0.7890.93
253_K256_I0.7890.93
161_F417_L0.7880.93
370_G408_G0.7860.93
349_F352_L0.7840.93
449_Q453_L0.7830.93
329_L395_P0.7830.93
220_N223_S0.7810.93
21_H24_G0.7800.93
145_D429_S0.7800.93
216_S219_P0.7770.93
338_N409_E0.7770.93
268_V271_F0.7770.93
236_I241_V0.7770.93
218_V226_S0.7750.92
235_I238_A0.7710.92
233_G242_I0.7690.92
259_V263_G0.7650.92
295_F420_T0.7610.92
252_I255_F0.7600.92
384_P393_V0.7580.92
35_E39_Y0.7560.91
90_R220_N0.7550.91
454_F465_T0.7520.91
84_G147_Y0.7500.91
381_M384_P0.7500.91
77_V138_N0.7470.91
161_F424_A0.7460.91
446_I449_Q0.7440.91
246_Q249_V0.7440.91
51_Y317_D0.7430.91
137_P141_S0.7430.91
22_P25_L0.7410.91
236_I240_A0.7390.91
67_V314_V0.7370.90
256_I260_S0.7360.90
183_Y330_Q0.7360.90
139_V165_I0.7340.90
319_R390_E0.7320.90
230_T239_I0.7320.90
35_E196_M0.7320.90
382_V460_T0.7320.90
467_G471_I0.7280.90
228_I231_G0.7270.90
186_H190_G0.7270.90
45_I188_G0.7260.90
472_V476_I0.7250.90
349_F353_W0.7240.90
297_G477_L0.7240.90
239_I244_S0.7230.90
181_Q332_S0.7200.89
461_M468_L0.7190.89
255_F260_S0.7190.89
254_R257_D0.7180.89
38_S132_T0.7180.89
304_I374_A0.7170.89
304_I470_S0.7170.89
277_S284_E0.7170.89
236_I243_I0.7150.89
232_I236_I0.7120.89
75_S445_A0.7100.89
76_L129_I0.7090.89
148_T211_L0.7080.89
102_G196_M0.7070.88
35_E307_Q0.7050.88
365_V368_S0.7050.88
305_Q338_N0.7030.88
36_R132_T0.7010.88
315_Y320_I0.7000.88
353_W361_P0.7000.88
113_A200_L0.6990.88
98_V203_F0.6980.88
110_I114_Y0.6980.88
233_G240_A0.6970.88
175_I179_L0.6970.88
166_N339_P0.6970.88
232_I235_I0.6960.88
294_L419_V0.6960.88
301_F412_L0.6930.87
47_L67_V0.6910.87
226_S232_I0.6910.87
175_I178_T0.6910.87
144_G158_F0.6890.87
230_T235_I0.6890.87
97_T134_L0.6880.87
27_T209_K0.6880.87
252_I257_D0.6880.87
278_K281_D0.6860.87
237_V241_V0.6840.87
256_I262_L0.6830.87
225_K233_G0.6810.87
322_L395_P0.6800.87
140_S165_I0.6790.86
39_Y136_K0.6780.86
275_F278_K0.6780.86
470_S474_G0.6770.86
225_K230_T0.6750.86
229_G235_I0.6740.86
391_A394_S0.6730.86
166_N169_G0.6720.86
109_H196_M0.6700.86
311_I463_F0.6680.86
78_Y166_N0.6670.85
376_L379_I0.6650.85
36_R41_G0.6640.85
194_V224_K0.6640.85
368_S477_L0.6640.85
47_L313_A0.6620.85
99_F200_L0.6610.85
96_N100_Y0.6600.85
138_N430_A0.6590.85
259_V262_L0.6580.85
308_G402_F0.6560.84
300_M408_G0.6550.84
355_K359_R0.6550.84
291_Y420_T0.6530.84
181_Q317_D0.6520.84
273_I276_T0.6520.84
29_F33_F0.6510.84
140_S413_S0.6480.84
229_G453_L0.6480.84
304_I405_V0.6470.84
383_F386_M0.6470.84
224_K232_I0.6460.84
426_A429_S0.6460.84
79_M444_Q0.6450.83
299_V443_A0.6450.83
86_W91_V0.6430.83
255_F258_L0.6430.83
382_V385_A0.6400.83
254_R260_S0.6390.83
82_I86_W0.6390.83
216_S220_N0.6370.83
388_G393_V0.6360.83
382_V466_I0.6360.83
337_L341_F0.6350.83
213_L343_V0.6340.82
180_G184_N0.6330.82
268_V272_I0.6330.82
49_Y350_A0.6320.82
67_V454_F0.6310.82
50_L59_L0.6300.82
320_I395_P0.6300.82
232_I241_V0.6280.82
226_S262_L0.6280.82
104_F130_V0.6260.82
248_G426_A0.6260.82
412_L436_W0.6250.82
229_G239_I0.6240.81
105_I128_I0.6200.81
70_M444_Q0.6200.81
275_F280_A0.6190.81
68_A72_I0.6190.81
166_N413_S0.6190.81
329_L403_L0.6170.81
185_Y189_F0.6170.81
373_L411_C0.6160.81
35_E41_G0.6160.81
109_H193_A0.6160.81
173_P177_G0.6120.80
74_G77_V0.6120.80
135_L161_F0.6110.80
141_S433_M0.6110.80
224_K231_G0.6100.80
88_A93_G0.6100.80
138_N192_A0.6090.80
170_L339_P0.6090.80
135_L140_S0.6090.80
238_A252_I0.6080.80
312_L316_A0.6080.80
224_K230_T0.6040.79
26_F30_F0.6020.79
158_F424_A0.6010.79
461_M465_T0.6010.79
364_P486_R0.5990.79
301_F338_N0.5970.79
139_V142_V0.5960.78
17_G23_R0.5940.78
372_I475_G0.5940.78
32_E41_G0.5930.78
206_T209_K0.5920.78
269_I272_I0.5920.78
99_F103_I0.5890.78
218_V223_S0.5890.78
385_A460_T0.5870.77
157_G421_T0.5870.77
368_S372_I0.5870.77
220_N226_S0.5870.77
250_L254_R0.5860.77
349_F410_L0.5860.77
206_T210_N0.5860.77
135_L138_N0.5850.77
78_Y338_N0.5840.77
202_V210_N0.5840.77
218_V222_L0.5840.77
354_M357_G0.5830.77
226_S258_L0.5820.77
307_Q311_I0.5820.77
236_I264_I0.5820.77
225_K232_I0.5810.77
16_K23_R0.5800.77
180_G185_Y0.5800.77
162_Y338_N0.5780.76
37_F195_G0.5740.76
308_G338_N0.5730.76
44_A173_P0.5720.76
35_E135_L0.5700.75
159_S350_A0.5700.75
384_P401_S0.5690.75
387_Q393_V0.5690.75
45_I63_K0.5690.75
187_L192_A0.5690.75
198_L202_V0.5680.75
162_Y165_I0.5660.75
427_A434_S0.5660.75
105_I131_G0.5660.75
358_K472_V0.5660.75
40_Y140_S0.5650.75
379_I383_F0.5630.74
307_Q378_F0.5630.74
100_Y204_A0.5620.74
274_M278_K0.5620.74
423_L484_I0.5610.74
108_G124_S0.5610.74
71_S448_A0.5600.74
32_E39_Y0.5600.74
407_L468_L0.5580.74
38_S42_M0.5580.74
111_A120_A0.5570.74
465_T472_V0.5570.74
48_Y51_Y0.5570.74
44_A172_A0.5570.74
309_A313_A0.5550.73
231_G244_S0.5540.73
315_Y393_V0.5540.73
293_P484_I0.5520.73
291_Y298_A0.5520.73
357_G360_Q0.5510.73
389_K392_L0.5510.73
109_H113_A0.5510.73
275_F289_A0.5490.73
32_E40_Y0.5490.73
149_K154_R0.5490.73
417_L433_M0.5490.73
31_T135_L0.5480.72
79_M443_A0.5470.72
304_I466_I0.5450.72
254_R258_L0.5440.72
229_G241_V0.5440.72
290_A487_A0.5440.72
224_K234_V0.5440.72
181_Q322_L0.5430.72
38_S186_H0.5420.72
174_L336_S0.5410.71
50_L159_S0.5410.71
302_W409_E0.5400.71
273_I277_S0.5380.71
464_G470_S0.5370.71
223_S285_K0.5360.71
102_G138_N0.5350.71
15_Q19_F0.5350.71
163_M167_L0.5350.71
36_R161_F0.5350.71
253_K260_S0.5340.71
477_L481_S0.5340.71
224_K235_I0.5320.70
354_M360_Q0.5320.70
73_Y77_V0.5310.70
286_S289_A0.5300.70
162_Y408_G0.5300.70
24_G27_T0.5300.70
34_W38_S0.5280.70
254_R262_L0.5260.69
216_S222_L0.5260.69
155_D366_K0.5260.69
338_N405_V0.5250.69
225_K241_V0.5250.69
217_N221_P0.5250.69
27_T202_V0.5240.69
220_N224_K0.5240.69
303_A450_V0.5230.69
309_A405_V0.5230.69
66_A317_D0.5210.69
315_Y381_M0.5200.69
61_F122_Y0.5200.69
91_V112_L0.5200.69
165_I413_S0.5200.69
204_A207_R0.5190.68
305_Q309_A0.5180.68
413_S433_M0.5180.68
256_I263_G0.5180.68
322_L334_F0.5180.68
374_A377_S0.5170.68
342_V346_A0.5160.68
373_L376_L0.5150.68
172_A334_F0.5140.68
78_Y165_I0.5140.68
420_T432_T0.5130.67
253_K262_L0.5120.67
258_L480_L0.5120.67
374_A470_S0.5110.67
180_G187_L0.5110.67
136_K161_F0.5100.67
364_P423_L0.5100.67
302_W305_Q0.5090.67
68_A71_S0.5090.67
417_L437_F0.5080.67
106_M163_M0.5080.67
238_A264_I0.5080.67
74_G379_I0.5070.67
208_K211_L0.5070.67
365_V485_K0.5070.67
156_S159_S0.5070.67
40_Y166_N0.5060.66
162_Y335_Q0.5060.66
237_V242_I0.5050.66
143_V158_F0.5040.66
216_S223_S0.5040.66
409_E416_G0.5040.66
23_R209_K0.5030.66
370_G374_A0.5030.66
429_S432_T0.5030.66
136_K165_I0.5030.66
136_K196_M0.5020.66
252_I262_L0.5020.66
31_T164_G0.5010.66
69_I126_V0.5010.66
300_M303_A0.5010.66
372_I478_L0.5010.66
108_G158_F0.5000.66
225_K234_V0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oh3A 2 0.9329 100 0.5 Contact Map
4uvmA 1 0.9411 100 0.537 Contact Map
4ikvA 1 0.9797 100 0.567 Contact Map
4q65A 1 0.8659 100 0.571 Contact Map
4tphA 2 0.8659 100 0.596 Contact Map
4xnjA 1 0.937 100 0.599 Contact Map
4w6vA 1 0.937 100 0.697 Contact Map
1pw4A 1 0.8476 100 0.731 Contact Map
3wdoA 1 0.8069 100 0.736 Contact Map
2cfqA 1 0.8232 100 0.74 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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