GREMLIN Database
YCLE - AB hydrolase superfamily protein YclE
UniProt: P94407 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (254)
Sequences: 55708 (46509)
Seq/√Len: 2918.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_I47_Q4.9761.00
54_R76_D4.6781.00
90_T114_K4.6571.00
38_F272_D3.4171.00
230_R257_E2.9851.00
78_E104_Y2.9391.00
119_N232_D2.8151.00
267_E270_A2.7931.00
90_T113_R2.7491.00
254_V274_S2.5501.00
88_D113_R2.5381.00
118_F271_F2.5321.00
98_A120_T2.4521.00
81_R89_V2.3951.00
82_T111_Q2.2941.00
13_D60_K2.2031.00
104_Y108_Y2.1891.00
256_F274_S2.1131.00
245_D251_V2.1061.00
78_E108_Y2.0731.00
91_I101_A2.0661.00
45_K276_R2.0611.00
75_A107_T2.0461.00
230_R255_I2.0401.00
17_R32_V2.0361.00
16_Y80_M2.0241.00
15_A58_K2.0181.00
90_T116_A1.9791.00
78_E111_Q1.9751.00
259_S267_E1.9471.00
78_E82_T1.8961.00
101_A115_V1.8731.00
225_Y278_W1.7711.00
18_I49_V1.7671.00
103_E107_T1.7581.00
46_Y90_T1.7541.00
51_V77_I1.7421.00
24_P49_V1.7321.00
23_A90_T1.7191.00
41_D272_D1.6761.00
105_A115_V1.6671.00
116_A275_F1.6631.00
225_Y254_V1.6581.00
19_E50_F1.6341.00
77_I104_Y1.6281.00
224_V248_Y1.5801.00
23_A113_R1.5791.00
15_A32_V1.5791.00
71_D107_T1.5711.00
24_P86_L1.5671.00
238_V255_I1.5641.00
243_A247_L1.5611.00
104_Y112_V1.5371.00
69_R72_A1.5251.00
108_Y111_Q1.5251.00
53_H100_M1.5241.00
274_S277_K1.5061.00
273_Q277_K1.5021.00
24_P47_Q1.4981.00
216_R219_D1.4881.00
10_D79_R1.4771.00
28_I53_H1.4321.00
49_V80_M1.4231.00
90_T279_L1.4131.00
117_L120_T1.3981.00
74_L103_E1.3691.00
52_D57_A1.3641.00
28_I101_A1.3631.00
51_V80_M1.3551.00
39_S50_F1.3531.00
104_Y111_Q1.3491.00
27_V92_L1.3281.00
27_V48_W1.3181.00
41_D44_Q1.3151.00
86_L89_V1.3101.00
15_A52_D1.3091.00
248_Y251_V1.3071.00
41_D276_R1.3041.00
238_V242_D1.3001.00
256_F259_S1.2991.00
14_L59_P1.2971.00
81_R86_L1.2831.00
270_A274_S1.2701.00
82_T108_Y1.2541.00
12_F54_R1.2481.00
26_L81_R1.2461.00
94_H264_M1.2371.00
230_R258_K1.2371.00
20_G47_Q1.2281.00
81_R104_Y1.2251.00
242_D246_G1.2211.00
228_L241_W1.2111.00
80_M84_L1.2031.00
14_L76_D1.1991.00
19_E39_S1.1941.00
28_I77_I1.1821.00
116_A225_Y1.1801.00
218_A247_L1.1801.00
106_R216_R1.1751.00
22_G47_Q1.1491.00
102_L117_L1.1451.00
271_F275_F1.1421.00
270_A273_Q1.1321.00
95_S261_H1.1081.00
103_E106_R1.1001.00
23_A46_Y1.0931.00
175_E178_S1.0871.00
243_A246_G1.0801.00
259_S263_P1.0641.00
89_V112_V1.0591.00
34_Y264_M1.0521.00
94_H262_Q1.0451.00
115_V224_V1.0381.00
206_N209_A1.0361.00
41_D269_E1.0301.00
92_L118_F1.0271.00
32_V58_K1.0241.00
269_E273_Q1.0191.00
89_V111_Q1.0161.00
16_Y84_L1.0121.00
227_G256_F1.0101.00
256_F270_A1.0041.00
53_H96_G0.9941.00
49_V84_L0.9931.00
227_G274_S0.9841.00
259_S266_E0.9821.00
78_E81_R0.9791.00
53_H56_F0.9781.00
256_F267_E0.9671.00
26_L77_I0.9671.00
74_L100_M0.9661.00
26_L89_V0.9591.00
92_L275_F0.9581.00
31_A56_F0.9501.00
43_K48_W0.9461.00
78_E107_T0.9421.00
118_F264_M0.9401.00
242_D255_I0.9391.00
228_L253_K0.9391.00
245_D253_K0.9361.00
37_L40_S0.9311.00
36_R50_F0.9221.00
180_Y183_R0.9221.00
23_A88_D0.9191.00
71_D103_E0.9141.00
242_D253_K0.9111.00
252_D274_S0.9091.00
228_L255_I0.9081.00
67_D72_A0.8991.00
260_G266_E0.8941.00
226_I251_V0.8931.00
242_D245_D0.8931.00
24_P46_Y0.8921.00
93_G101_A0.8911.00
32_V52_D0.8901.00
25_I46_Y0.8851.00
181_Q184_P0.8841.00
85_Q88_D0.8781.00
241_W253_K0.8741.00
74_L107_T0.8711.00
28_I51_V0.8691.00
105_A112_V0.8681.00
33_Y36_R0.8651.00
103_E216_R0.8651.00
196_N199_I0.8611.00
25_I92_L0.8571.00
19_E43_K0.8541.00
91_I104_Y0.8481.00
25_I48_W0.8461.00
167_F171_C0.8421.00
23_A114_K0.8311.00
118_F263_P0.8271.00
225_Y252_D0.8241.00
30_S34_Y0.8211.00
75_A79_R0.8191.00
93_G98_A0.8171.00
79_R83_F0.8101.00
116_A279_L0.8081.00
175_E179_F0.8061.00
187_A190_W0.8051.00
53_H73_V0.7991.00
14_L54_R0.7971.00
190_W194_F0.7961.00
227_G271_F0.7911.00
30_S95_S0.7891.00
112_V222_M0.7831.00
254_V270_A0.7821.00
133_E137_M0.7791.00
40_S44_Q0.7781.00
72_A75_A0.7771.00
39_S48_W0.7741.00
176_A179_F0.7731.00
79_R82_T0.7721.00
28_I91_I0.7721.00
12_F60_K0.7701.00
114_K223_P0.7691.00
165_R168_V0.7671.00
254_V277_K0.7671.00
73_V96_G0.7641.00
199_I202_E0.7581.00
119_N228_L0.7521.00
52_D58_K0.7511.00
150_K153_E0.7471.00
179_F182_E0.7461.00
32_V50_F0.7441.00
239_S242_D0.7401.00
182_E185_H0.7321.00
268_P272_D0.7281.00
49_V86_L0.7271.00
35_P38_F0.7231.00
200_I203_L0.7201.00
93_G97_H0.7191.00
54_R73_V0.7171.00
206_N210_R0.7171.00
92_L116_A0.7131.00
179_F183_R0.7131.00
168_V172_I0.7121.00
17_R36_R0.7111.00
258_K267_E0.7101.00
75_A78_E0.7101.00
198_P202_E0.7101.00
40_S43_K0.7101.00
74_L104_Y0.7091.00
94_H119_N0.7081.00
95_S262_Q0.7031.00
134_S137_M0.7011.00
177_K180_Y0.7001.00
189_L192_G0.6991.00
146_K150_K0.6951.00
149_E153_E0.6921.00
228_L238_V0.6921.00
119_N263_P0.6921.00
152_I155_L0.6921.00
24_P89_V0.6921.00
46_Y279_L0.6911.00
53_H77_I0.6911.00
207_T211_I0.6891.00
114_K278_W0.6851.00
186_A190_W0.6841.00
231_Y258_K0.6791.00
198_P201_D0.6781.00
102_L120_T0.6771.00
75_A108_Y0.6771.00
39_S43_K0.6761.00
191_D195_T0.6751.00
10_D72_A0.6751.00
87_E111_Q0.6751.00
44_Q276_R0.6721.00
81_R111_Q0.6711.00
80_M83_F0.6691.00
165_R169_H0.6671.00
147_R150_K0.6671.00
272_D276_R0.6661.00
226_I245_D0.6651.00
105_A222_M0.6631.00
89_V104_Y0.6621.00
178_S182_E0.6601.00
46_Y276_R0.6591.00
213_L216_R0.6571.00
70_L103_E0.6561.00
215_Q218_A0.6561.00
38_F41_D0.6551.00
21_E47_Q0.6531.00
221_R249_P0.6491.00
32_V35_P0.6461.00
25_I42_I0.6451.00
173_R176_A0.6441.00
91_I112_V0.6431.00
164_E167_F0.6421.00
229_G263_P0.6421.00
26_L91_I0.6401.00
199_I204_W0.6391.00
94_H118_F0.6381.00
163_P166_R0.6361.00
220_V248_Y0.6351.00
188_A191_D0.6341.00
226_I253_K0.6311.00
98_A117_L0.6311.00
164_E168_V0.6311.00
19_E40_S0.6301.00
15_A59_P0.6281.00
47_Q86_L0.6281.00
187_A191_D0.6281.00
106_R219_D0.6271.00
186_A189_L0.6271.00
227_G254_V0.6261.00
190_W193_V0.6231.00
117_L226_I0.6231.00
105_A220_V0.6211.00
197_M201_D0.6201.00
71_D75_A0.6181.00
189_L193_V0.6171.00
151_D155_L0.6171.00
34_Y94_H0.6131.00
102_L122_P0.6101.00
27_V35_P0.6101.00
89_V113_R0.6081.00
32_V51_V0.6071.00
73_V100_M0.6071.00
199_I203_L0.6071.00
146_K149_E0.6041.00
181_Q185_H0.6041.00
150_K154_N0.6031.00
166_R170_M0.6031.00
88_D111_Q0.6021.00
172_I175_E0.6021.00
166_R169_H0.6021.00
153_E156_P0.5991.00
191_D194_F0.5981.00
228_L235_V0.5971.00
230_R238_V0.5941.00
207_T210_R0.5901.00
96_G100_M0.5901.00
29_G95_S0.5881.00
195_T199_I0.5831.00
188_A192_G0.5821.00
119_N229_G0.5811.00
148_F152_I0.5801.00
169_H172_I0.5801.00
17_R50_F0.5791.00
193_V196_N0.5761.00
133_E136_F0.5761.00
99_F121_A0.5761.00
45_K48_W0.5751.00
226_I241_W0.5741.00
240_L243_A0.5741.00
187_A193_V0.5731.00
17_R33_Y0.5721.00
257_E270_A0.5711.00
25_I90_T0.5711.00
34_Y265_L0.5691.00
231_Y259_S0.5691.00
27_V50_F0.5681.00
263_P271_F0.5671.00
209_A212_D0.5621.00
192_G195_T0.5621.00
159_I163_P0.5621.00
38_F271_F0.5621.00
226_I248_Y0.5601.00
196_N200_I0.5581.00
116_A227_G0.5571.00
200_I204_W0.5571.00
179_F184_P0.5531.00
214_L243_A0.5501.00
107_T216_R0.5481.00
70_L100_M0.5481.00
180_Y184_P0.5451.00
273_Q276_R0.5441.00
77_I100_M0.5441.00
147_R151_D0.5441.00
220_V224_V0.5431.00
201_D204_W0.5391.00
52_D59_P0.5381.00
214_L247_L0.5371.00
208_F211_I0.5371.00
153_E157_Q0.5341.00
252_D277_K0.5321.00
190_W196_N0.5311.00
18_I84_L0.5311.00
221_R250_H0.5291.00
241_W245_D0.5271.00
156_P159_I0.5251.00
62_E68_S0.5251.00
54_R61_R0.5251.00
135_F138_E0.5251.00
151_D156_P0.5241.00
74_L78_E0.5241.00
27_V42_I0.5211.00
154_N158_D0.5201.00
172_I176_A0.5181.00
191_D196_N0.5141.00
152_I156_P0.5121.00
94_H263_P0.5121.00
175_E183_R0.5121.00
167_F170_M0.5111.00
168_V171_C0.5111.00
197_M200_I0.5031.00
36_R40_S0.5031.00
196_N201_D0.5011.00
151_D158_D0.5011.00
178_S181_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oosA 1 0.968 100 0.188 Contact Map
1ehyA 1 0.9395 100 0.198 Contact Map
4inzA 1 0.968 100 0.204 Contact Map
2pujA 4 0.9324 100 0.205 Contact Map
1iupA 2 0.9324 100 0.216 Contact Map
3om8A 4 0.9181 100 0.218 Contact Map
4psuA 1 0.9466 100 0.227 Contact Map
2wueA 4 0.9466 100 0.236 Contact Map
3bwxA 1 0.9466 100 0.237 Contact Map
2xuaA 2 0.9039 100 0.239 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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