GREMLIN Database
BSDC - Phenolic acid decarboxylase subunit C
UniProt: P94405 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 473 (438)
Sequences: 1803 (939)
Seq/√Len: 44.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_A198_L4.8691.00
21_T52_N4.8641.00
23_N52_N4.7261.00
112_H242_K4.5611.00
14_E21_T4.5571.00
25_E55_Y4.0791.00
114_N296_N3.9621.00
259_E290_K3.9491.00
392_N395_Q3.9031.00
354_K386_E3.6621.00
109_A239_V3.3001.00
10_L63_A3.2111.00
29_E130_R3.2051.00
170_G173_R3.2021.00
149_D190_Q3.1851.00
130_R138_Y3.1731.00
207_E232_Q3.1121.00
122_L125_I3.1111.00
122_L171_K3.0191.00
32_L62_I2.9621.00
18_Q71_P2.9291.00
365_G435_I2.9261.00
201_T241_S2.8551.00
36_A64_M2.8061.00
192_E265_R2.7971.00
404_M436_L2.7601.00
5_D251_G2.7411.00
197_N262_A2.7141.00
27_K55_Y2.6171.00
104_K237_R2.6011.00
237_R251_G2.4371.00
267_Y283_S2.4241.00
25_E53_N2.4231.00
28_P56_G2.4161.00
243_L291_R2.3081.00
256_L289_I2.2581.00
113_E296_N2.2491.00
14_E52_N2.2431.00
114_N294_H2.1961.00
197_N261_I2.1961.00
240_K245_D2.1711.00
60_A254_V2.1411.00
11_A14_E2.1401.00
241_S248_V2.1331.00
160_N224_E2.0820.99
111_F293_Y2.0350.99
197_N259_E2.0260.99
159_Q247_D2.0260.99
173_R266_E2.0220.99
112_H293_Y1.9900.99
404_M410_A1.9620.99
267_Y281_G1.9550.99
240_K247_D1.9450.99
166_M174_L1.9120.99
115_E242_K1.9040.99
18_Q72_N1.8980.99
410_A434_M1.8940.99
204_L301_E1.8840.99
154_D190_Q1.8820.99
39_A49_L1.8670.99
173_R288_K1.8590.99
366_M413_I1.8520.99
60_A298_P1.8420.99
118_E121_N1.8020.98
389_D392_N1.7930.98
124_D168_V1.7200.98
63_A66_V1.7110.98
175_G266_E1.7070.98
351_V368_A1.7020.98
259_E288_K1.6910.98
50_L63_A1.6900.98
128_L168_V1.6890.98
332_Y367_R1.6780.98
201_T248_V1.6760.98
241_S244_S1.6480.97
16_E71_P1.6340.97
137_G271_F1.6240.97
7_R299_I1.6230.97
218_L227_M1.6220.97
199_P244_S1.6200.97
183_D224_E1.6110.97
264_E288_K1.6030.97
146_I225_Y1.5950.97
200_V287_I1.5940.97
352_S390_P1.5540.96
117_T291_R1.5460.96
169_K266_E1.5430.96
169_K175_G1.5390.96
9_F76_M1.5130.95
106_E109_A1.5050.95
201_T244_S1.5030.95
379_K422_D1.5030.95
382_I400_L1.4990.95
349_A378_C1.4920.95
202_I287_I1.4880.95
123_F174_L1.4880.95
245_D293_Y1.4560.94
192_E263_G1.4490.94
7_R253_E1.4480.94
103_V229_G1.4420.94
241_S247_D1.4390.94
7_R297_N1.4360.94
50_L299_I1.4240.94
337_V352_S1.4140.94
271_F305_L1.4070.93
121_N172_D1.4040.93
26_V35_S1.3970.93
146_I203_A1.3970.93
112_H115_E1.3910.93
19_L50_L1.3900.93
12_A16_E1.3770.93
123_F289_I1.3760.93
406_P432_H1.3670.92
412_I434_M1.3620.92
191_A199_P1.3590.92
12_A75_M1.3580.92
407_K432_H1.3530.92
348_I401_S1.3530.92
136_G167_Q1.3480.92
105_R247_D1.3420.92
405_H424_G1.3310.91
203_A255_V1.3240.91
266_E286_I1.3200.91
19_L48_A1.3170.91
34_A38_A1.3150.91
7_R295_R1.3090.91
243_L293_Y1.3080.91
174_L287_I1.2950.90
159_Q223_S1.2910.90
140_L204_L1.2630.89
16_E75_M1.2590.89
190_Q193_E1.2560.89
74_A78_G1.2550.89
351_V383_V1.2510.88
398_W402_T1.2410.88
135_D271_F1.2400.88
116_I120_I1.2400.88
384_V438_A1.2210.87
115_E291_R1.2130.87
13_L48_A1.2110.87
369_L435_I1.2010.86
121_N171_K1.1980.86
166_M202_I1.1980.86
362_K411_V1.1920.86
116_I294_H1.1910.86
380_M406_P1.1700.85
241_S293_Y1.1660.85
129_F302_H1.1650.85
289_I292_V1.1630.84
400_L436_L1.1600.84
352_S384_V1.1590.84
124_D171_K1.1590.84
4_Q234_E1.1550.84
407_K414_P1.1540.84
172_D256_L1.1480.84
244_S247_D1.1480.84
179_V279_S1.1480.84
359_G430_I1.1470.84
62_I129_F1.1430.83
374_G377_Y1.1400.83
365_G369_L1.1400.83
203_A206_C1.1400.83
58_H125_I1.1370.83
10_L299_I1.1260.82
124_D138_Y1.1250.82
106_E250_W1.1240.82
37_R41_N1.1170.82
340_N391_F1.1110.82
254_V294_H1.1080.81
169_K173_R1.1050.81
174_L202_I1.1010.81
172_D288_K1.1010.81
149_D153_P1.0940.81
201_T246_L1.0930.81
26_V32_L1.0920.81
261_I264_E1.0880.80
207_E210_I1.0830.80
68_G72_N1.0750.79
35_S38_A1.0690.79
212_T320_T1.0680.79
14_E17_G1.0630.79
307_M395_Q1.0600.78
189_R192_E1.0570.78
162_G184_I1.0540.78
395_Q398_W1.0460.78
199_P259_E1.0460.78
406_P434_M1.0370.77
202_I256_L1.0330.77
176_I287_I1.0280.76
255_V354_K1.0270.76
10_L19_L1.0260.76
147_S184_I1.0220.76
149_D154_D1.0220.76
256_L292_V1.0170.76
264_E286_I1.0110.75
14_E23_N1.0090.75
91_E94_K1.0040.75
399_A402_T1.0020.74
241_S246_L0.9920.74
412_I432_H0.9900.74
243_L290_K0.9810.73
111_F252_A0.9800.73
168_V289_I0.9790.73
49_L64_M0.9760.72
117_T242_K0.9720.72
7_R294_H0.9660.72
350_I396_V0.9610.71
18_Q75_M0.9590.71
201_T255_V0.9580.71
170_G266_E0.9580.71
142_K301_E0.9570.71
336_I351_V0.9510.70
204_L300_F0.9490.70
338_A352_S0.9430.70
336_I339_V0.9410.70
399_A403_K0.9390.69
254_V300_F0.9380.69
337_V354_K0.9370.69
185_A189_R0.9370.69
64_M302_H0.9360.69
353_T383_V0.9340.69
140_L300_F0.9340.69
389_D395_Q0.9310.69
350_I382_I0.9300.69
382_I438_A0.9300.69
147_S187_H0.9220.68
350_I397_M0.9210.68
173_R264_E0.9190.68
192_E261_I0.9170.68
106_E239_V0.9120.67
144_C161_V0.9120.67
148_R245_D0.9110.67
36_A40_S0.9090.67
33_G304_Y0.8940.66
193_E196_I0.8930.66
144_C206_C0.8900.65
140_L143_A0.8890.65
12_A15_K0.8890.65
338_A391_F0.8860.65
32_L302_H0.8820.65
209_V232_Q0.8810.65
341_A349_A0.8800.64
284_M420_P0.8790.64
29_E138_Y0.8770.64
189_R193_E0.8760.64
337_V386_E0.8740.64
384_V396_V0.8720.64
32_L64_M0.8690.63
32_L129_F0.8670.63
28_P54_I0.8660.63
117_T120_I0.8620.63
116_I125_I0.8620.63
105_R238_I0.8610.63
215_S320_T0.8570.62
272_G278_Y0.8550.62
244_S290_K0.8510.62
203_A249_P0.8470.61
413_I435_I0.8420.61
33_G131_I0.8380.61
392_N396_V0.8380.61
32_L54_I0.8360.60
111_F291_R0.8340.60
420_P429_G0.8320.60
174_L260_I0.8240.59
149_D156_F0.8240.59
242_K291_R0.8230.59
273_E322_V0.8230.59
160_N183_D0.8220.59
201_T247_D0.8210.59
261_I288_K0.8210.59
338_A390_P0.8140.58
246_L249_P0.8120.58
154_D157_G0.8110.58
144_C210_I0.8110.58
110_P251_G0.8100.58
351_V364_V0.8090.58
318_I340_N0.8090.58
146_I161_V0.8070.58
48_A63_A0.8070.58
27_K56_G0.8050.58
186_I190_Q0.8040.57
103_V238_I0.8040.57
393_L397_M0.8020.57
148_R247_D0.8020.57
350_I384_V0.8020.57
121_N256_L0.7960.57
7_R10_L0.7950.57
360_F442_V0.7940.56
26_V33_G0.7930.56
11_A15_K0.7930.56
89_F94_K0.7920.56
33_G302_H0.7920.56
161_V225_Y0.7920.56
58_H61_R0.7900.56
253_E295_R0.7890.56
234_E237_R0.7880.56
183_D220_Y0.7860.56
199_P258_G0.7850.56
149_D157_G0.7840.56
225_Y238_I0.7830.55
20_L24_E0.7810.55
397_M400_L0.7790.55
195_G262_A0.7790.55
131_I302_H0.7760.55
164_Y178_P0.7750.55
348_I397_M0.7730.54
54_I62_I0.7730.54
174_L289_I0.7730.54
115_E294_H0.7720.54
204_L256_L0.7630.53
311_E317_G0.7630.53
65_N273_E0.7630.53
195_G263_G0.7620.53
97_D100_P0.7610.53
148_R244_S0.7600.53
145_V166_M0.7590.53
405_H432_H0.7570.53
167_Q270_P0.7560.53
113_E295_R0.7560.53
110_P113_E0.7540.53
413_I416_L0.7520.52
366_M416_L0.7520.52
143_A174_L0.7510.52
166_M256_L0.7500.52
22_V49_L0.7490.52
112_H245_D0.7490.52
387_D403_K0.7480.52
54_I386_E0.7470.52
101_M235_P0.7470.52
143_A163_I0.7460.52
112_H243_L0.7450.52
182_H346_G0.7450.52
362_K365_G0.7440.52
147_S162_G0.7440.52
111_F239_V0.7440.52
200_V262_A0.7430.52
165_R268_E0.7420.51
91_E95_R0.7420.51
248_V293_Y0.7400.51
351_V381_V0.7370.51
241_S257_E0.7370.51
108_T112_H0.7370.51
148_R199_P0.7350.51
154_D194_R0.7350.51
388_V399_A0.7350.51
111_F250_W0.7340.51
312_C345_H0.7340.51
298_P301_E0.7340.51
121_N125_I0.7340.51
101_M230_A0.7310.50
147_S164_Y0.7300.50
279_S371_T0.7280.50
362_K435_I0.7280.50
78_G315_M0.7260.50
359_G363_A0.7260.50
109_A238_I0.7250.50
272_G277_H0.7230.50
213_A228_A0.7220.50
113_E294_H0.7210.49
197_N290_K0.7210.49
217_P311_E0.7210.49
192_E264_E0.7200.49
116_I299_I0.7200.49
164_Y184_I0.7190.49
199_P245_D0.7190.49
115_E293_Y0.7170.49
368_A381_V0.7150.49
17_G24_E0.7090.48
366_M411_V0.7090.48
317_G421_L0.7050.48
192_E262_A0.7050.48
421_L433_K0.7030.48
44_D47_P0.7030.48
395_Q399_A0.7000.47
203_A248_V0.7000.47
325_Y329_K0.6990.47
317_G345_H0.6990.47
197_N263_G0.6990.47
297_N392_N0.6990.47
269_G272_G0.6970.47
48_A72_N0.6950.47
206_C256_L0.6940.47
77_L209_V0.6920.47
14_E19_L0.6900.46
166_M187_H0.6890.46
27_K31_D0.6870.46
11_A20_L0.6870.46
244_S291_R0.6850.46
365_G411_V0.6840.46
257_E293_Y0.6840.46
241_S245_D0.6820.46
206_C301_E0.6800.45
176_I260_I0.6790.45
82_D104_K0.6770.45
139_Y413_I0.6760.45
143_A166_M0.6750.45
106_E237_R0.6750.45
202_I289_I0.6750.45
348_I380_M0.6720.45
120_I171_K0.6700.44
10_L126_L0.6700.44
206_C252_A0.6700.44
181_Q371_T0.6690.44
121_N124_D0.6660.44
5_D8_E0.6640.44
168_V174_L0.6640.44
82_D326_Q0.6630.44
22_V35_S0.6630.44
8_E11_A0.6590.43
154_D198_L0.6590.43
319_N323_P0.6590.43
48_A75_M0.6590.43
387_D399_A0.6590.43
134_G278_Y0.6570.43
73_H315_M0.6560.43
335_E360_F0.6550.43
198_L260_I0.6550.43
160_N271_F0.6540.43
238_I244_S0.6530.43
104_K433_K0.6530.43
34_A39_A0.6500.43
28_P57_Y0.6500.43
22_V294_H0.6500.43
10_L66_V0.6500.43
242_K293_Y0.6500.43
63_A299_I0.6500.43
10_L354_K0.6480.42
109_A113_E0.6480.42
28_P55_Y0.6480.42
167_Q269_G0.6480.42
332_Y364_V0.6470.42
362_K413_I0.6470.42
111_F241_S0.6450.42
239_V248_V0.6450.42
35_S51_F0.6420.42
277_H421_L0.6390.42
132_N177_Q0.6390.42
364_V368_A0.6360.41
23_N53_N0.6350.41
62_I302_H0.6330.41
86_K90_F0.6330.41
89_F168_V0.6330.41
90_F104_K0.6330.41
101_M229_G0.6320.41
7_R11_A0.6310.41
102_P226_E0.6310.41
143_A318_I0.6310.41
58_H122_L0.6300.41
5_D10_L0.6290.41
233_G237_R0.6290.41
145_V176_I0.6290.41
126_L254_V0.6270.40
179_V375_L0.6260.40
365_G381_V0.6260.40
148_R159_Q0.6260.40
382_I436_L0.6240.40
250_W295_R0.6240.40
321_C343_Y0.6230.40
65_N214_A0.6230.40
14_E25_E0.6220.40
136_G271_F0.6220.40
187_H198_L0.6220.40
321_C325_Y0.6220.40
114_N293_Y0.6200.40
125_I288_K0.6190.40
350_I390_P0.6180.40
201_T258_G0.6180.40
395_Q402_T0.6180.40
24_E34_A0.6180.40
181_Q185_A0.6160.39
187_H220_Y0.6160.39
164_Y272_G0.6150.39
69_S161_V0.6140.39
183_D187_H0.6130.39
17_G386_E0.6130.39
113_E297_N0.6120.39
138_Y168_V0.6120.39
146_I241_S0.6120.39
60_A297_N0.6110.39
411_V435_I0.6110.39
137_G306_G0.6100.39
83_T88_Q0.6100.39
179_V282_R0.6090.39
141_D271_F0.6080.39
415_D430_I0.6080.39
368_A375_L0.6060.38
156_F190_Q0.6060.38
92_F95_R0.6060.38
4_Q8_E0.6060.38
109_A294_H0.6050.38
380_M434_M0.6050.38
179_V346_G0.6040.38
255_V389_D0.6030.38
299_I362_K0.6030.38
129_F300_F0.6010.38
364_V381_V0.6010.38
109_A250_W0.6010.38
398_W446_T0.5980.38
192_E296_N0.5980.38
113_E382_I0.5950.37
168_V292_V0.5950.37
89_F92_F0.5950.37
23_N107_E0.5930.37
142_K305_L0.5910.37
28_P262_A0.5890.37
158_K221_D0.5890.37
177_Q279_S0.5880.37
275_T347_L0.5880.37
107_E128_L0.5860.37
203_A252_A0.5860.37
273_E433_K0.5860.37
20_L49_L0.5850.37
115_E118_E0.5850.37
154_D158_K0.5840.36
105_R394_P0.5820.36
9_F275_T0.5820.36
159_Q244_S0.5820.36
116_I121_N0.5810.36
26_V51_F0.5810.36
355_T442_V0.5810.36
109_A130_R0.5810.36
32_L51_F0.5810.36
113_E250_W0.5780.36
317_G387_D0.5780.36
177_Q273_E0.5770.36
182_H314_Y0.5770.36
204_L254_V0.5750.36
15_K24_E0.5750.36
418_V423_P0.5740.36
54_I57_Y0.5730.35
83_T90_F0.5730.35
30_P285_P0.5730.35
312_C319_N0.5730.35
350_I393_L0.5720.35
180_P377_Y0.5710.35
111_F248_V0.5690.35
36_A39_A0.5680.35
88_Q336_I0.5680.35
71_P200_V0.5680.35
121_N292_V0.5680.35
178_P184_I0.5670.35
239_V249_P0.5670.35
63_A442_V0.5660.35
371_T374_G0.5660.35
79_M83_T0.5660.35
242_K245_D0.5650.35
352_S395_Q0.5650.35
52_N61_R0.5620.34
177_Q346_G0.5610.34
136_G281_G0.5610.34
21_T50_L0.5610.34
132_N305_L0.5590.34
395_Q434_M0.5580.34
191_A292_V0.5580.34
11_A23_N0.5580.34
17_G195_G0.5580.34
62_I367_R0.5580.34
348_I406_P0.5570.34
384_V436_L0.5570.34
435_I439_T0.5550.34
40_S314_Y0.5550.34
377_Y433_K0.5550.34
412_I443_A0.5540.34
25_E54_I0.5540.34
65_N132_N0.5540.34
111_F243_L0.5530.34
440_T449_H0.5520.34
320_T346_G0.5520.34
257_E290_K0.5510.34
39_A46_S0.5510.34
379_K424_G0.5510.34
132_N272_G0.5480.33
80_P104_K0.5470.33
33_G129_F0.5470.33
10_L35_S0.5470.33
133_Q166_M0.5450.33
111_F245_D0.5450.33
168_V256_L0.5440.33
122_L172_D0.5430.33
27_K214_A0.5430.33
20_L172_D0.5420.33
71_P81_K0.5420.33
45_K315_M0.5410.33
339_V360_F0.5400.33
171_K256_L0.5400.33
160_N164_Y0.5390.33
153_P157_G0.5380.32
17_G35_S0.5380.32
128_L174_L0.5380.32
188_L198_L0.5360.32
105_R195_G0.5360.32
126_L298_P0.5350.32
22_V25_E0.5350.32
177_Q377_Y0.5350.32
292_V437_D0.5340.32
135_D270_P0.5340.32
20_L47_P0.5340.32
342_M350_I0.5330.32
353_T360_F0.5320.32
386_E390_P0.5310.32
256_L287_I0.5310.32
355_T360_F0.5300.32
145_V200_V0.5300.32
245_D381_V0.5300.32
95_R100_P0.5290.32
420_P423_P0.5270.31
233_G295_R0.5260.31
74_A88_Q0.5250.31
305_L373_H0.5250.31
181_Q419_L0.5230.31
118_E291_R0.5220.31
206_C336_I0.5210.31
141_D204_L0.5200.31
17_G296_N0.5200.31
8_E14_E0.5200.31
440_T446_T0.5200.31
36_A41_N0.5180.31
15_K23_N0.5180.31
23_N154_D0.5180.31
388_V395_Q0.5170.31
106_E110_P0.5160.31
199_P241_S0.5150.30
385_D437_D0.5150.30
382_I396_V0.5150.30
216_T320_T0.5150.30
180_P429_G0.5140.30
265_R283_S0.5130.30
119_D125_I0.5130.30
78_G255_V0.5120.30
295_R298_P0.5120.30
182_H345_H0.5120.30
262_A265_R0.5120.30
273_E374_G0.5110.30
193_E354_K0.5100.30
153_P156_F0.5100.30
58_H298_P0.5100.30
11_A102_P0.5090.30
33_G351_V0.5090.30
367_R372_P0.5080.30
70_W122_L0.5080.30
232_Q237_R0.5080.30
110_P250_W0.5070.30
60_A294_H0.5070.30
279_S346_G0.5070.30
180_P381_V0.5070.30
359_G434_M0.5060.30
167_Q272_G0.5060.30
396_V399_A0.5050.30
69_S72_N0.5050.30
87_E91_E0.5050.30
139_Y305_L0.5050.30
10_L15_K0.5040.30
224_E306_G0.5040.30
362_K414_P0.5020.29
16_E20_L0.5020.29
110_P239_V0.5010.29
248_V255_V0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2idbA 3 0.9514 100 0.073 Contact Map
4ip2A 2 0.9831 100 0.093 Contact Map
4zadA 2 0.9831 100 0.112 Contact Map
4za9A 2 0.9789 100 0.119 Contact Map
4zacA 2 0.9831 100 0.122 Contact Map
4kunA 2 0.1522 57.9 0.975 Contact Map
2cyyA 2 0.2431 44.5 0.977 Contact Map
2e1cA 1 0.2431 40.8 0.977 Contact Map
3i4pA 5 0.2516 39.3 0.977 Contact Map
2p5vA 5 0.2537 37.2 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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