GREMLIN Database
YCIC - Putative metal chaperone YciC
UniProt: P94400 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (326)
Sequences: 2366 (1290)
Seq/√Len: 71.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_E211_R7.7711.00
181_I212_S5.9381.00
138_A188_V4.8761.00
208_R221_E4.5011.00
189_S192_E4.4471.00
24_I96_V4.3051.00
186_D213_V4.1671.00
289_A305_M3.5991.00
271_H274_R3.2691.00
3_K128_Q3.0671.00
208_R227_L2.9211.00
31_L224_H2.7511.00
180_L200_L2.7201.00
214_K313_T2.7201.00
242_E250_H2.6821.00
206_R232_E2.6581.00
131_T179_V2.6411.00
183_N212_S2.6341.00
197_E201_R2.5481.00
70_C73_C2.4701.00
24_I219_P2.4331.00
270_F275_F2.4201.00
24_I33_I2.3721.00
192_E195_Q2.3491.00
138_A182_L2.3001.00
33_I96_V2.2761.00
190_E194_E2.2731.00
185_C193_L2.2381.00
99_S108_V2.2301.00
264_Y270_F2.2241.00
144_D154_R2.1581.00
4_I95_I2.1431.00
273_T277_R2.1221.00
177_C180_L2.1191.00
149_E154_R2.0201.00
177_C204_Q2.0181.00
31_L220_Q1.9291.00
40_M103_S1.9101.00
269_P294_W1.8771.00
185_C211_R1.8711.00
144_D147_S1.8691.00
193_L211_R1.8661.00
24_I222_I1.8421.00
84_E88_K1.8261.00
141_F174_I1.7851.00
194_E198_N1.7791.00
196_L200_L1.7391.00
68_N72_C1.7301.00
272_S296_A1.7211.00
206_R241_Q1.7171.00
240_I244_T1.7091.00
23_S27_N1.7041.00
193_L197_E1.6941.00
23_S216_N1.6791.00
294_W320_W1.6701.00
212_S215_G1.6460.99
41_S58_R1.6440.99
94_Y224_H1.6360.99
239_W243_L1.6340.99
298_H303_L1.6250.99
138_A193_L1.6170.99
20_L215_G1.6010.99
103_S108_V1.5960.99
181_I211_R1.5840.99
174_I180_L1.5830.99
229_N232_E1.5820.99
110_Q240_I1.5820.99
82_E85_K1.5780.99
293_V303_L1.5540.99
31_L94_Y1.5470.99
188_V196_L1.5390.99
304_L315_E1.5150.99
95_I127_C1.4530.99
53_E56_L1.4380.99
237_A241_Q1.4360.99
329_Q332_V1.4280.99
12_Y287_V1.4130.98
135_V183_N1.4100.98
180_L207_A1.3860.98
20_L212_S1.3460.98
301_L316_P1.3450.98
40_M102_I1.3440.98
276_Y280_D1.3380.98
326_K329_Q1.3230.98
99_S103_S1.3230.98
131_T225_T1.3170.98
100_T103_S1.3130.97
77_E81_I1.3080.97
237_A243_L1.3060.97
157_A160_E1.2950.97
178_D206_R1.2880.97
22_N26_Q1.2800.97
9_L21_L1.2730.97
213_V216_N1.2600.97
204_Q207_A1.2460.97
237_A240_I1.2430.96
174_I200_L1.1870.95
85_K89_D1.1870.95
201_R209_F1.1860.95
325_P329_Q1.1680.95
44_N47_A1.1670.95
139_N187_L1.1640.95
321_V329_Q1.1560.95
235_G243_L1.1540.95
283_P307_Q1.1530.95
87_A126_F1.1360.94
239_W242_E1.1350.94
103_S307_Q1.1340.94
277_R281_Q1.1320.94
98_E101_G1.1320.94
84_E125_K1.1310.94
283_P286_V1.1160.94
146_Q199_V1.1130.94
43_V263_V1.1120.93
10_S132_M1.1110.93
13_L38_N1.1050.93
13_L16_G1.1040.93
272_S297_S1.1040.93
236_S240_I1.1000.93
237_A244_T1.0980.93
137_D184_K1.0920.93
148_G310_P1.0880.93
275_F312_V1.0860.93
13_L17_K1.0720.92
14_G17_K1.0710.92
253_E257_Y1.0700.92
272_S295_C1.0690.92
269_P274_R1.0680.92
295_C303_L1.0680.92
14_G18_T1.0530.91
238_G243_L1.0460.91
150_S153_D1.0400.91
210_I217_V1.0390.91
228_F233_A1.0330.91
22_N41_S1.0320.91
13_L19_T1.0240.90
228_F231_E1.0140.90
48_G292_I1.0140.90
89_D92_F1.0120.90
103_S172_D1.0110.90
45_I292_I1.0100.90
253_E256_E1.0100.90
135_V212_S1.0090.90
272_S298_H1.0000.89
46_D49_L0.9990.89
305_M312_V0.9970.89
179_V222_I0.9940.89
29_E219_P0.9930.89
180_L204_Q0.9880.89
130_D226_G0.9850.89
66_M114_Y0.9770.88
275_F279_L0.9730.88
181_I217_V0.9720.88
84_E126_F0.9710.88
293_V305_M0.9590.87
194_E201_R0.9580.87
39_D44_N0.9570.87
151_L158_L0.9500.87
101_G290_K0.9450.86
80_L111_T0.9410.86
154_R157_A0.9410.86
271_H296_A0.9400.86
13_L18_T0.9360.86
148_G151_L0.9310.86
177_C205_P0.9280.85
147_S167_A0.9280.85
321_V330_E0.9220.85
244_T248_A0.9200.85
44_N102_I0.9180.85
175_E288_R0.9150.85
240_I243_L0.9130.84
247_H250_H0.9080.84
98_E105_P0.9030.84
222_I227_L0.9030.84
37_V46_D0.9030.84
185_C213_V0.9010.84
268_L294_W0.9010.84
230_F234_S0.8980.83
133_V179_V0.8950.83
279_L312_V0.8930.83
182_L211_R0.8850.83
8_V132_M0.8800.82
16_G19_T0.8770.82
217_V222_I0.8760.82
48_G52_Q0.8720.82
44_N49_L0.8650.81
238_G241_Q0.8650.81
13_L101_G0.8640.81
292_I303_L0.8620.81
302_A317_V0.8600.81
98_E288_R0.8560.80
275_F293_V0.8550.80
188_V193_L0.8490.80
138_A200_L0.8470.80
64_V74_T0.8440.79
177_C230_F0.8440.79
7_T133_V0.8420.79
54_G60_D0.8410.79
98_E290_K0.8410.79
289_A307_Q0.8400.79
45_I259_I0.8380.79
94_Y225_T0.8340.79
158_L161_K0.8310.78
23_S185_C0.8270.78
70_C74_T0.8240.78
326_K330_E0.8230.78
37_V44_N0.8220.78
37_V47_A0.8210.78
54_G57_S0.8190.77
11_G17_K0.8160.77
23_S26_Q0.8160.77
35_V96_V0.8150.77
78_D111_T0.8120.77
200_L274_R0.8120.77
236_S239_W0.8120.77
149_E152_L0.8110.77
108_V177_C0.8090.76
182_L197_E0.8060.76
176_F233_A0.8030.76
194_E211_R0.8030.76
139_N143_H0.7980.76
75_L256_E0.7940.75
83_V127_C0.7900.75
101_G184_K0.7900.75
136_V259_I0.7890.75
269_P296_A0.7850.74
151_L155_K0.7790.74
10_S99_S0.7770.74
267_R270_F0.7760.73
27_N30_G0.7750.73
105_P288_R0.7730.73
194_E277_R0.7690.73
210_I227_L0.7690.73
237_A242_E0.7680.73
86_L279_L0.7680.73
264_Y267_R0.7660.72
213_V277_R0.7660.72
210_I221_E0.7660.72
133_V222_I0.7630.72
26_Q29_E0.7630.72
105_P173_Q0.7620.72
110_Q113_S0.7610.72
183_N214_K0.7600.72
141_F196_L0.7590.72
43_V46_D0.7580.72
256_E259_I0.7570.72
254_T257_Y0.7540.71
25_L35_V0.7540.71
165_E312_V0.7530.71
227_L230_F0.7520.71
147_S154_R0.7510.71
108_V111_T0.7500.71
274_R278_W0.7460.70
324_L328_E0.7450.70
189_S194_E0.7410.70
302_A319_Y0.7410.70
129_L136_V0.7390.70
107_P132_M0.7380.70
215_G311_S0.7380.70
154_R166_I0.7350.69
107_P110_Q0.7350.69
301_L319_Y0.7340.69
153_D157_A0.7340.69
7_T130_D0.7310.69
163_E169_L0.7310.69
33_I134_T0.7300.69
13_L21_L0.7290.69
321_V324_L0.7290.69
181_I210_I0.7280.69
74_T97_I0.7270.69
106_I110_Q0.7250.68
329_Q333_K0.7240.68
145_Y199_V0.7220.68
295_C298_H0.7200.68
66_M70_C0.7200.68
11_G14_G0.7150.67
115_I125_K0.7140.67
14_G19_T0.7120.67
97_I130_D0.7110.67
272_S276_Y0.7100.67
83_V112_F0.7100.67
4_I87_A0.7070.66
88_K126_F0.7060.66
152_L157_A0.7060.66
251_T254_T0.7030.66
324_L329_Q0.7020.66
90_G96_V0.7010.66
104_E172_D0.6990.65
327_L331_Q0.6950.65
11_G16_G0.6930.65
37_V309_G0.6910.65
107_P242_E0.6900.64
222_I237_A0.6890.64
21_L61_E0.6890.64
38_N101_G0.6870.64
190_E211_R0.6860.64
276_Y281_Q0.6850.64
316_P319_Y0.6840.64
49_L52_Q0.6840.64
98_E184_K0.6830.64
144_D149_E0.6810.63
77_E110_Q0.6790.63
157_A161_K0.6780.63
12_Y95_I0.6780.63
66_M87_A0.6770.63
44_N75_L0.6750.63
29_E220_Q0.6740.63
330_E333_K0.6720.62
169_L257_Y0.6710.62
129_L225_T0.6690.62
151_L160_E0.6670.62
40_M261_S0.6650.62
286_V292_I0.6590.61
238_G242_E0.6570.61
94_Y130_D0.6560.61
113_S240_I0.6550.60
242_E252_P0.6540.60
29_E218_K0.6540.60
244_T299_N0.6510.60
14_G101_G0.6500.60
187_L213_V0.6480.60
48_G51_K0.6480.60
32_K314_I0.6480.60
46_D76_R0.6480.60
75_L109_A0.6470.60
191_Q273_T0.6450.59
307_Q312_V0.6440.59
188_V192_E0.6400.59
22_N35_V0.6390.59
244_T292_I0.6380.58
18_T38_N0.6350.58
10_S108_V0.6340.58
183_N217_V0.6330.58
269_P320_W0.6310.58
76_R108_V0.6290.57
148_G152_L0.6290.57
135_V267_R0.6280.57
283_P312_V0.6250.57
330_E334_Q0.6240.57
12_Y177_C0.6240.57
69_G73_C0.6220.57
161_K191_Q0.6220.57
53_E57_S0.6210.56
15_A95_I0.6210.56
145_Y166_I0.6210.56
20_L181_I0.6170.56
243_L247_H0.6160.56
46_D50_V0.6160.56
28_R31_L0.6150.56
143_H231_E0.6150.56
184_K290_K0.6140.56
75_L308_A0.6120.55
93_D98_E0.6120.55
177_C206_R0.6120.55
29_E33_I0.6120.55
54_G310_P0.6090.55
44_N170_L0.6080.55
78_D104_E0.6080.55
6_V35_V0.6060.55
83_V95_I0.6050.54
110_Q244_T0.6050.54
242_E251_T0.6000.54
23_S219_P0.6000.54
15_A36_I0.6000.54
66_M81_I0.5990.54
178_D227_L0.5990.54
241_Q244_T0.5960.53
300_N323_A0.5950.53
275_F314_I0.5930.53
219_P222_I0.5930.53
104_E253_E0.5930.53
202_K205_P0.5900.53
242_E254_T0.5900.53
235_G241_Q0.5890.53
138_A184_K0.5890.53
33_I94_Y0.5880.52
40_M178_D0.5880.52
319_Y324_L0.5860.52
109_A129_L0.5860.52
56_L63_L0.5850.52
110_Q237_A0.5840.52
16_G101_G0.5840.52
87_A127_C0.5830.52
252_P255_E0.5830.52
32_K334_Q0.5820.52
267_R329_Q0.5780.51
179_V221_E0.5780.51
127_C278_W0.5760.51
275_F303_L0.5750.51
12_Y17_K0.5730.51
282_M286_V0.5720.50
138_A196_L0.5690.50
45_I49_L0.5690.50
132_M178_D0.5690.50
137_D140_R0.5680.50
303_L316_P0.5680.50
191_Q194_E0.5670.50
20_L24_I0.5660.50
12_Y285_N0.5640.49
18_T46_D0.5640.49
171_I307_Q0.5630.49
62_K77_E0.5630.49
9_L204_Q0.5610.49
61_E91_R0.5590.49
169_L175_E0.5590.49
18_T101_G0.5560.48
322_A329_Q0.5550.48
140_R143_H0.5550.48
241_Q249_E0.5540.48
31_L50_V0.5540.48
195_Q277_R0.5540.48
75_L102_I0.5540.48
92_F133_V0.5530.48
203_L207_A0.5530.48
236_S241_Q0.5510.48
179_V208_R0.5500.48
192_E199_V0.5500.48
83_V90_G0.5500.48
156_E159_G0.5500.48
88_K200_L0.5490.48
159_G195_Q0.5490.48
74_T253_E0.5480.48
93_D130_D0.5480.48
325_P328_E0.5470.47
88_K216_N0.5460.47
141_F186_D0.5450.47
131_T227_L0.5440.47
73_C78_D0.5410.47
14_G98_E0.5410.47
282_M312_V0.5400.47
8_V31_L0.5390.46
15_A266_R0.5380.46
51_K67_S0.5370.46
318_S321_V0.5370.46
110_Q114_Y0.5370.46
189_S193_L0.5360.46
169_L172_D0.5350.46
210_I281_Q0.5340.46
76_R111_T0.5330.46
74_T111_T0.5320.46
303_L314_I0.5310.45
51_K293_V0.5310.45
196_L202_K0.5310.45
34_A38_N0.5310.45
145_Y150_S0.5310.45
190_E221_E0.5310.45
35_V38_N0.5300.45
204_Q310_P0.5300.45
324_L330_E0.5290.45
293_V298_H0.5290.45
292_I295_C0.5270.45
146_Q149_E0.5270.45
218_K221_E0.5260.45
61_E78_D0.5260.45
88_K155_K0.5250.45
83_V117_E0.5240.45
34_A65_E0.5240.45
96_V142_W0.5240.45
79_L97_I0.5220.44
24_I215_G0.5210.44
293_V310_P0.5200.44
128_Q226_G0.5200.44
38_N46_D0.5200.44
71_I109_A0.5180.44
29_E216_N0.5180.44
272_S318_S0.5180.44
177_C312_V0.5170.44
108_V161_K0.5170.44
123_L239_W0.5170.44
102_I107_P0.5170.44
134_T265_K0.5140.43
172_D256_E0.5140.43
78_D309_G0.5120.43
75_L258_G0.5110.43
198_N238_G0.5110.43
152_L161_K0.5100.43
152_L160_E0.5100.43
38_N290_K0.5100.43
7_T178_D0.5100.43
100_T140_R0.5100.43
180_L230_F0.5100.43
188_V273_T0.5070.43
49_L304_L0.5050.42
248_A305_M0.5040.42
62_K265_K0.5030.42
244_T249_E0.5020.42
161_K213_V0.5010.42
72_C98_E0.5010.42
31_L83_V0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nijA 1 0.7733 100 0.505 Contact Map
4ehxA 1 0.6625 99.9 0.791 Contact Map
2wsmA 2 0.4584 99.9 0.808 Contact Map
1xjcA 2 0.3526 99.9 0.817 Contact Map
2hf9A 2 0.471 99.9 0.821 Contact Map
4hi0E 2 0.4736 99.9 0.824 Contact Map
1yrbA 2 0.6071 99.9 0.824 Contact Map
4lpsA 1 0.4861 99.8 0.834 Contact Map
2wwwA 2 0.5642 99.7 0.856 Contact Map
2qm8A 2 0.6398 99.7 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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