YCIC - BACSU - GREMLIN Contacts

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YCIC - Putative metal chaperone YciC

UniProt:	P94400	Sequences: MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVNIDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGISEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGEKDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVKPQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFYRWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQQEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFKWKLNQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	397 (326)
Sequences:	2366 (1290)
Seq/√Len:	71.4

ECOLI - YJIA YEIR
BACSU - YCIC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
197_E	211_R	7.771	1.00
181_I	212_S	5.938	1.00
138_A	188_V	4.876	1.00
208_R	221_E	4.501	1.00
189_S	192_E	4.447	1.00
24_I	96_V	4.305	1.00
186_D	213_V	4.167	1.00
289_A	305_M	3.599	1.00
271_H	274_R	3.269	1.00
3_K	128_Q	3.067	1.00
208_R	227_L	2.921	1.00
31_L	224_H	2.751	1.00
180_L	200_L	2.720	1.00
214_K	313_T	2.720	1.00
242_E	250_H	2.682	1.00
206_R	232_E	2.658	1.00
131_T	179_V	2.641	1.00
183_N	212_S	2.634	1.00
197_E	201_R	2.548	1.00
70_C	73_C	2.470	1.00
24_I	219_P	2.433	1.00
270_F	275_F	2.420	1.00
24_I	33_I	2.372	1.00
192_E	195_Q	2.349	1.00
138_A	182_L	2.300	1.00
33_I	96_V	2.276	1.00
190_E	194_E	2.273	1.00
185_C	193_L	2.238	1.00
99_S	108_V	2.230	1.00
264_Y	270_F	2.224	1.00
144_D	154_R	2.158	1.00
4_I	95_I	2.143	1.00
273_T	277_R	2.122	1.00
177_C	180_L	2.119	1.00
149_E	154_R	2.020	1.00
177_C	204_Q	2.018	1.00
31_L	220_Q	1.929	1.00
40_M	103_S	1.910	1.00
269_P	294_W	1.877	1.00
185_C	211_R	1.871	1.00
144_D	147_S	1.869	1.00
193_L	211_R	1.866	1.00
24_I	222_I	1.842	1.00
84_E	88_K	1.826	1.00
141_F	174_I	1.785	1.00
194_E	198_N	1.779	1.00
196_L	200_L	1.739	1.00
68_N	72_C	1.730	1.00
272_S	296_A	1.721	1.00
206_R	241_Q	1.717	1.00
240_I	244_T	1.709	1.00
23_S	27_N	1.704	1.00
193_L	197_E	1.694	1.00
23_S	216_N	1.679	1.00
294_W	320_W	1.670	1.00
212_S	215_G	1.646	0.99
41_S	58_R	1.644	0.99
94_Y	224_H	1.636	0.99
239_W	243_L	1.634	0.99
298_H	303_L	1.625	0.99
138_A	193_L	1.617	0.99
20_L	215_G	1.601	0.99
103_S	108_V	1.596	0.99
181_I	211_R	1.584	0.99
174_I	180_L	1.583	0.99
229_N	232_E	1.582	0.99
110_Q	240_I	1.582	0.99
82_E	85_K	1.578	0.99
293_V	303_L	1.554	0.99
31_L	94_Y	1.547	0.99
188_V	196_L	1.539	0.99
304_L	315_E	1.515	0.99
95_I	127_C	1.453	0.99
53_E	56_L	1.438	0.99
237_A	241_Q	1.436	0.99
329_Q	332_V	1.428	0.99
12_Y	287_V	1.413	0.98
135_V	183_N	1.410	0.98
180_L	207_A	1.386	0.98
20_L	212_S	1.346	0.98
301_L	316_P	1.345	0.98
40_M	102_I	1.344	0.98
276_Y	280_D	1.338	0.98
326_K	329_Q	1.323	0.98
99_S	103_S	1.323	0.98
131_T	225_T	1.317	0.98
100_T	103_S	1.313	0.97
77_E	81_I	1.308	0.97
237_A	243_L	1.306	0.97
157_A	160_E	1.295	0.97
178_D	206_R	1.288	0.97
22_N	26_Q	1.280	0.97
9_L	21_L	1.273	0.97
213_V	216_N	1.260	0.97
204_Q	207_A	1.246	0.97
237_A	240_I	1.243	0.96
174_I	200_L	1.187	0.95
85_K	89_D	1.187	0.95
201_R	209_F	1.186	0.95
325_P	329_Q	1.168	0.95
44_N	47_A	1.167	0.95
139_N	187_L	1.164	0.95
321_V	329_Q	1.156	0.95
235_G	243_L	1.154	0.95
283_P	307_Q	1.153	0.95
87_A	126_F	1.136	0.94
239_W	242_E	1.135	0.94
103_S	307_Q	1.134	0.94
277_R	281_Q	1.132	0.94
98_E	101_G	1.132	0.94
84_E	125_K	1.131	0.94
283_P	286_V	1.116	0.94
146_Q	199_V	1.113	0.94
43_V	263_V	1.112	0.93
10_S	132_M	1.111	0.93
13_L	38_N	1.105	0.93
13_L	16_G	1.104	0.93
272_S	297_S	1.104	0.93
236_S	240_I	1.100	0.93
237_A	244_T	1.098	0.93
137_D	184_K	1.092	0.93
148_G	310_P	1.088	0.93
275_F	312_V	1.086	0.93
13_L	17_K	1.072	0.92
14_G	17_K	1.071	0.92
253_E	257_Y	1.070	0.92
272_S	295_C	1.069	0.92
269_P	274_R	1.068	0.92
295_C	303_L	1.068	0.92
14_G	18_T	1.053	0.91
238_G	243_L	1.046	0.91
150_S	153_D	1.040	0.91
210_I	217_V	1.039	0.91
228_F	233_A	1.033	0.91
22_N	41_S	1.032	0.91
13_L	19_T	1.024	0.90
228_F	231_E	1.014	0.90
48_G	292_I	1.014	0.90
89_D	92_F	1.012	0.90
103_S	172_D	1.011	0.90
45_I	292_I	1.010	0.90
253_E	256_E	1.010	0.90
135_V	212_S	1.009	0.90
272_S	298_H	1.000	0.89
46_D	49_L	0.999	0.89
305_M	312_V	0.997	0.89
179_V	222_I	0.994	0.89
29_E	219_P	0.993	0.89
180_L	204_Q	0.988	0.89
130_D	226_G	0.985	0.89
66_M	114_Y	0.977	0.88
275_F	279_L	0.973	0.88
181_I	217_V	0.972	0.88
84_E	126_F	0.971	0.88
293_V	305_M	0.959	0.87
194_E	201_R	0.958	0.87
39_D	44_N	0.957	0.87
151_L	158_L	0.950	0.87
101_G	290_K	0.945	0.86
80_L	111_T	0.941	0.86
154_R	157_A	0.941	0.86
271_H	296_A	0.940	0.86
13_L	18_T	0.936	0.86
148_G	151_L	0.931	0.86
177_C	205_P	0.928	0.85
147_S	167_A	0.928	0.85
321_V	330_E	0.922	0.85
244_T	248_A	0.920	0.85
44_N	102_I	0.918	0.85
175_E	288_R	0.915	0.85
240_I	243_L	0.913	0.84
247_H	250_H	0.908	0.84
98_E	105_P	0.903	0.84
222_I	227_L	0.903	0.84
37_V	46_D	0.903	0.84
185_C	213_V	0.901	0.84
268_L	294_W	0.901	0.84
230_F	234_S	0.898	0.83
133_V	179_V	0.895	0.83
279_L	312_V	0.893	0.83
182_L	211_R	0.885	0.83
8_V	132_M	0.880	0.82
16_G	19_T	0.877	0.82
217_V	222_I	0.876	0.82
48_G	52_Q	0.872	0.82
44_N	49_L	0.865	0.81
238_G	241_Q	0.865	0.81
13_L	101_G	0.864	0.81
292_I	303_L	0.862	0.81
302_A	317_V	0.860	0.81
98_E	288_R	0.856	0.80
275_F	293_V	0.855	0.80
188_V	193_L	0.849	0.80
138_A	200_L	0.847	0.80
64_V	74_T	0.844	0.79
177_C	230_F	0.844	0.79
7_T	133_V	0.842	0.79
54_G	60_D	0.841	0.79
98_E	290_K	0.841	0.79
289_A	307_Q	0.840	0.79
45_I	259_I	0.838	0.79
94_Y	225_T	0.834	0.79
158_L	161_K	0.831	0.78
23_S	185_C	0.827	0.78
70_C	74_T	0.824	0.78
326_K	330_E	0.823	0.78
37_V	44_N	0.822	0.78
37_V	47_A	0.821	0.78
54_G	57_S	0.819	0.77
11_G	17_K	0.816	0.77
23_S	26_Q	0.816	0.77
35_V	96_V	0.815	0.77
78_D	111_T	0.812	0.77
200_L	274_R	0.812	0.77
236_S	239_W	0.812	0.77
149_E	152_L	0.811	0.77
108_V	177_C	0.809	0.76
182_L	197_E	0.806	0.76
176_F	233_A	0.803	0.76
194_E	211_R	0.803	0.76
139_N	143_H	0.798	0.76
75_L	256_E	0.794	0.75
83_V	127_C	0.790	0.75
101_G	184_K	0.790	0.75
136_V	259_I	0.789	0.75
269_P	296_A	0.785	0.74
151_L	155_K	0.779	0.74
10_S	99_S	0.777	0.74
267_R	270_F	0.776	0.73
27_N	30_G	0.775	0.73
105_P	288_R	0.773	0.73
194_E	277_R	0.769	0.73
210_I	227_L	0.769	0.73
237_A	242_E	0.768	0.73
86_L	279_L	0.768	0.73
264_Y	267_R	0.766	0.72
213_V	277_R	0.766	0.72
210_I	221_E	0.766	0.72
133_V	222_I	0.763	0.72
26_Q	29_E	0.763	0.72
105_P	173_Q	0.762	0.72
110_Q	113_S	0.761	0.72
183_N	214_K	0.760	0.72
141_F	196_L	0.759	0.72
43_V	46_D	0.758	0.72
256_E	259_I	0.757	0.72
254_T	257_Y	0.754	0.71
25_L	35_V	0.754	0.71
165_E	312_V	0.753	0.71
227_L	230_F	0.752	0.71
147_S	154_R	0.751	0.71
108_V	111_T	0.750	0.71
274_R	278_W	0.746	0.70
324_L	328_E	0.745	0.70
189_S	194_E	0.741	0.70
302_A	319_Y	0.741	0.70
129_L	136_V	0.739	0.70
107_P	132_M	0.738	0.70
215_G	311_S	0.738	0.70
154_R	166_I	0.735	0.69
107_P	110_Q	0.735	0.69
301_L	319_Y	0.734	0.69
153_D	157_A	0.734	0.69
7_T	130_D	0.731	0.69
163_E	169_L	0.731	0.69
33_I	134_T	0.730	0.69
13_L	21_L	0.729	0.69
321_V	324_L	0.729	0.69
181_I	210_I	0.728	0.69
74_T	97_I	0.727	0.69
106_I	110_Q	0.725	0.68
329_Q	333_K	0.724	0.68
145_Y	199_V	0.722	0.68
295_C	298_H	0.720	0.68
66_M	70_C	0.720	0.68
11_G	14_G	0.715	0.67
115_I	125_K	0.714	0.67
14_G	19_T	0.712	0.67
97_I	130_D	0.711	0.67
272_S	276_Y	0.710	0.67
83_V	112_F	0.710	0.67
4_I	87_A	0.707	0.66
88_K	126_F	0.706	0.66
152_L	157_A	0.706	0.66
251_T	254_T	0.703	0.66
324_L	329_Q	0.702	0.66
90_G	96_V	0.701	0.66
104_E	172_D	0.699	0.65
327_L	331_Q	0.695	0.65
11_G	16_G	0.693	0.65
37_V	309_G	0.691	0.65
107_P	242_E	0.690	0.64
222_I	237_A	0.689	0.64
21_L	61_E	0.689	0.64
38_N	101_G	0.687	0.64
190_E	211_R	0.686	0.64
276_Y	281_Q	0.685	0.64
316_P	319_Y	0.684	0.64
49_L	52_Q	0.684	0.64
98_E	184_K	0.683	0.64
144_D	149_E	0.681	0.63
77_E	110_Q	0.679	0.63
157_A	161_K	0.678	0.63
12_Y	95_I	0.678	0.63
66_M	87_A	0.677	0.63
44_N	75_L	0.675	0.63
29_E	220_Q	0.674	0.63
330_E	333_K	0.672	0.62
169_L	257_Y	0.671	0.62
129_L	225_T	0.669	0.62
151_L	160_E	0.667	0.62
40_M	261_S	0.665	0.62
286_V	292_I	0.659	0.61
238_G	242_E	0.657	0.61
94_Y	130_D	0.656	0.61
113_S	240_I	0.655	0.60
242_E	252_P	0.654	0.60
29_E	218_K	0.654	0.60
244_T	299_N	0.651	0.60
14_G	101_G	0.650	0.60
187_L	213_V	0.648	0.60
48_G	51_K	0.648	0.60
32_K	314_I	0.648	0.60
46_D	76_R	0.648	0.60
75_L	109_A	0.647	0.60
191_Q	273_T	0.645	0.59
307_Q	312_V	0.644	0.59
188_V	192_E	0.640	0.59
22_N	35_V	0.639	0.59
244_T	292_I	0.638	0.58
18_T	38_N	0.635	0.58
10_S	108_V	0.634	0.58
183_N	217_V	0.633	0.58
269_P	320_W	0.631	0.58
76_R	108_V	0.629	0.57
148_G	152_L	0.629	0.57
135_V	267_R	0.628	0.57
283_P	312_V	0.625	0.57
330_E	334_Q	0.624	0.57
12_Y	177_C	0.624	0.57
69_G	73_C	0.622	0.57
161_K	191_Q	0.622	0.57
53_E	57_S	0.621	0.56
15_A	95_I	0.621	0.56
145_Y	166_I	0.621	0.56
20_L	181_I	0.617	0.56
243_L	247_H	0.616	0.56
46_D	50_V	0.616	0.56
28_R	31_L	0.615	0.56
143_H	231_E	0.615	0.56
184_K	290_K	0.614	0.56
75_L	308_A	0.612	0.55
93_D	98_E	0.612	0.55
177_C	206_R	0.612	0.55
29_E	33_I	0.612	0.55
54_G	310_P	0.609	0.55
44_N	170_L	0.608	0.55
78_D	104_E	0.608	0.55
6_V	35_V	0.606	0.55
83_V	95_I	0.605	0.54
110_Q	244_T	0.605	0.54
242_E	251_T	0.600	0.54
23_S	219_P	0.600	0.54
15_A	36_I	0.600	0.54
66_M	81_I	0.599	0.54
178_D	227_L	0.599	0.54
241_Q	244_T	0.596	0.53
300_N	323_A	0.595	0.53
275_F	314_I	0.593	0.53
219_P	222_I	0.593	0.53
104_E	253_E	0.593	0.53
202_K	205_P	0.590	0.53
242_E	254_T	0.590	0.53
235_G	241_Q	0.589	0.53
138_A	184_K	0.589	0.53
33_I	94_Y	0.588	0.52
40_M	178_D	0.588	0.52
319_Y	324_L	0.586	0.52
109_A	129_L	0.586	0.52
56_L	63_L	0.585	0.52
110_Q	237_A	0.584	0.52
16_G	101_G	0.584	0.52
87_A	127_C	0.583	0.52
252_P	255_E	0.583	0.52
32_K	334_Q	0.582	0.52
267_R	329_Q	0.578	0.51
179_V	221_E	0.578	0.51
127_C	278_W	0.576	0.51
275_F	303_L	0.575	0.51
12_Y	17_K	0.573	0.51
282_M	286_V	0.572	0.50
138_A	196_L	0.569	0.50
45_I	49_L	0.569	0.50
132_M	178_D	0.569	0.50
137_D	140_R	0.568	0.50
303_L	316_P	0.568	0.50
191_Q	194_E	0.567	0.50
20_L	24_I	0.566	0.50
12_Y	285_N	0.564	0.49
18_T	46_D	0.564	0.49
171_I	307_Q	0.563	0.49
62_K	77_E	0.563	0.49
9_L	204_Q	0.561	0.49
61_E	91_R	0.559	0.49
169_L	175_E	0.559	0.49
18_T	101_G	0.556	0.48
322_A	329_Q	0.555	0.48
140_R	143_H	0.555	0.48
241_Q	249_E	0.554	0.48
31_L	50_V	0.554	0.48
195_Q	277_R	0.554	0.48
75_L	102_I	0.554	0.48
92_F	133_V	0.553	0.48
203_L	207_A	0.553	0.48
236_S	241_Q	0.551	0.48
179_V	208_R	0.550	0.48
192_E	199_V	0.550	0.48
83_V	90_G	0.550	0.48
156_E	159_G	0.550	0.48
88_K	200_L	0.549	0.48
159_G	195_Q	0.549	0.48
74_T	253_E	0.548	0.48
93_D	130_D	0.548	0.48
325_P	328_E	0.547	0.47
88_K	216_N	0.546	0.47
141_F	186_D	0.545	0.47
131_T	227_L	0.544	0.47
73_C	78_D	0.541	0.47
14_G	98_E	0.541	0.47
282_M	312_V	0.540	0.47
8_V	31_L	0.539	0.46
15_A	266_R	0.538	0.46
51_K	67_S	0.537	0.46
318_S	321_V	0.537	0.46
110_Q	114_Y	0.537	0.46
189_S	193_L	0.536	0.46
169_L	172_D	0.535	0.46
210_I	281_Q	0.534	0.46
76_R	111_T	0.533	0.46
74_T	111_T	0.532	0.46
303_L	314_I	0.531	0.45
51_K	293_V	0.531	0.45
196_L	202_K	0.531	0.45
34_A	38_N	0.531	0.45
145_Y	150_S	0.531	0.45
190_E	221_E	0.531	0.45
35_V	38_N	0.530	0.45
204_Q	310_P	0.530	0.45
324_L	330_E	0.529	0.45
293_V	298_H	0.529	0.45
292_I	295_C	0.527	0.45
146_Q	149_E	0.527	0.45
218_K	221_E	0.526	0.45
61_E	78_D	0.526	0.45
88_K	155_K	0.525	0.45
83_V	117_E	0.524	0.45
34_A	65_E	0.524	0.45
96_V	142_W	0.524	0.45
79_L	97_I	0.522	0.44
24_I	215_G	0.521	0.44
293_V	310_P	0.520	0.44
128_Q	226_G	0.520	0.44
38_N	46_D	0.520	0.44
71_I	109_A	0.518	0.44
29_E	216_N	0.518	0.44
272_S	318_S	0.518	0.44
177_C	312_V	0.517	0.44
108_V	161_K	0.517	0.44
123_L	239_W	0.517	0.44
102_I	107_P	0.517	0.44
134_T	265_K	0.514	0.43
172_D	256_E	0.514	0.43
78_D	309_G	0.512	0.43
75_L	258_G	0.511	0.43
198_N	238_G	0.511	0.43
152_L	161_K	0.510	0.43
152_L	160_E	0.510	0.43
38_N	290_K	0.510	0.43
7_T	178_D	0.510	0.43
100_T	140_R	0.510	0.43
180_L	230_F	0.510	0.43
188_V	273_T	0.507	0.43
49_L	304_L	0.505	0.42
248_A	305_M	0.504	0.42
62_K	265_K	0.503	0.42
244_T	249_E	0.502	0.42
161_K	213_V	0.501	0.42
72_C	98_E	0.501	0.42
31_L	83_V	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nijA	1	0.7733	100	0.505	Contact Map
4ehxA	1	0.6625	99.9	0.791	Contact Map
2wsmA	2	0.4584	99.9	0.808	Contact Map
1xjcA	2	0.3526	99.9	0.817	Contact Map
2hf9A	2	0.471	99.9	0.821	Contact Map
4hi0E	2	0.4736	99.9	0.824	Contact Map
1yrbA	2	0.6071	99.9	0.824	Contact Map
4lpsA	1	0.4861	99.8	0.834	Contact Map
2wwwA	2	0.5642	99.7	0.856	Contact Map
2qm8A	2	0.6398	99.7	0.856	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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