GREMLIN Database
GCH4 - GTP cyclohydrolase FolE2
UniProt: P94398 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (255)
Sequences: 1042 (659)
Seq/√Len: 41.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_I225_A6.1671.00
254_R262_L4.1481.00
199_G282_N3.9581.00
78_T133_E3.4691.00
228_N266_D3.3241.00
170_K206_D3.2211.00
77_F134_V3.0051.00
141_E150_A2.9521.00
268_F276_F2.8971.00
90_I95_L2.8921.00
205_A221_L2.5651.00
281_R290_D2.5351.00
100_Q141_E2.5231.00
192_Y251_E2.4521.00
176_S200_T2.4451.00
158_F174_G2.4241.00
180_T249_A2.4111.00
151_G236_V2.3941.00
133_E160_S2.3531.00
181_T259_L2.3461.00
164_R168_P2.3341.00
268_F297_F2.3041.00
208_H274_S2.2781.00
143_K150_A2.2351.00
136_F157_I2.1680.99
48_I295_L2.1590.99
142_R226_E2.1320.99
174_G204_W2.1120.99
79_M121_L2.0650.99
55_N76_N2.0560.99
182_L194_A1.9810.99
191_E251_E1.9550.99
90_I125_M1.9290.99
65_A220_D1.9210.99
176_S202_S1.8980.99
82_N128_S1.8670.98
277_E296_C1.8570.98
232_R248_T1.8480.98
155_A222_L1.8410.98
231_A248_T1.8290.98
227_S266_D1.7990.98
267_L278_I1.7800.98
243_K247_E1.7780.98
135_R158_F1.7700.98
172_R206_D1.7290.97
143_K148_E1.7230.97
260_A280_C1.7180.97
201_V225_A1.6980.97
56_V96_T1.6920.97
135_R156_D1.6850.97
147_L240_P1.6660.97
48_I260_A1.6530.97
115_Q169_F1.6520.97
95_L125_M1.6260.96
172_R204_W1.6170.96
202_S281_R1.5850.96
179_V201_V1.5820.96
223_H227_S1.5800.95
182_L250_Y1.5600.95
50_H131_T1.5520.95
49_Q296_C1.5000.94
181_T199_G1.4950.94
84_P256_V1.4540.93
182_L249_A1.4150.92
75_A134_V1.3940.91
35_K40_I1.3920.91
265_A269_E1.3440.90
277_E294_K1.3430.90
65_A223_H1.3170.89
61_T70_E1.3040.88
182_L192_Y1.3010.88
122_A130_A1.3000.88
118_T161_V1.2900.88
231_A245_V1.2900.88
201_V263_I1.2810.87
129_S164_R1.2670.87
57_S76_N1.2670.87
53_V56_V1.2650.87
101_V120_E1.2520.86
194_A246_T1.2280.85
89_G93_S1.2220.85
177_A225_A1.2140.84
202_S279_E1.2090.84
186_S246_T1.2080.84
200_T283_E1.2030.84
65_A219_A1.2010.84
259_L282_N1.1990.84
178_K233_L1.1950.83
179_V259_L1.1910.83
186_S194_A1.1750.82
82_N129_S1.1640.82
79_M148_E1.1600.82
199_G280_C1.1470.81
220_D272_W1.1430.81
142_R223_H1.1240.80
113_S117_F1.1240.80
234_H244_A1.1230.79
189_I243_K1.1220.79
223_H232_R1.1210.79
119_K163_Y1.1100.79
95_L288_L1.1080.79
60_V75_A1.1050.78
57_S154_H1.1020.78
204_W277_E1.1010.78
140_F155_A1.0770.77
128_S165_K1.0740.76
131_T162_T1.0660.76
96_T191_E1.0540.75
130_A275_A1.0490.75
88_K282_N1.0470.74
246_T250_Y1.0460.74
279_E294_K1.0440.74
117_F132_V1.0380.74
173_A207_I1.0270.73
182_L193_S1.0190.72
221_L225_A1.0110.72
190_S246_T1.0110.72
180_T282_N1.0070.72
163_Y169_F0.9960.71
248_T252_N0.9950.71
140_F222_L0.9930.70
84_P128_S0.9880.70
263_I278_I0.9830.70
154_H288_L0.9740.69
86_N165_K0.9720.69
146_K244_A0.9720.69
80_T131_T0.9650.68
140_F223_H0.9610.68
185_C196_N0.9550.67
80_T133_E0.9510.67
114_L290_D0.9490.67
115_Q119_K0.9480.67
283_E290_D0.9410.66
231_A234_H0.9390.66
89_G94_R0.9370.66
91_N193_S0.9300.65
182_L246_T0.9300.65
136_F178_K0.9290.65
180_T231_A0.9230.65
165_K168_P0.9230.65
114_L161_V0.9220.65
189_I194_A0.9080.63
49_Q64_S0.9070.63
35_K282_N0.9010.63
185_C239_R0.9000.63
192_Y250_Y0.8940.62
276_F297_F0.8840.61
155_A226_E0.8840.61
98_L121_L0.8780.61
237_L245_V0.8710.60
54_A281_R0.8670.60
194_A243_K0.8660.60
243_K246_T0.8650.60
42_K46_F0.8630.59
90_I189_I0.8610.59
159_M171_Q0.8520.58
62_I137_P0.8520.58
40_I86_N0.8500.58
188_E196_N0.8500.58
189_I193_S0.8490.58
131_T160_S0.8460.58
186_S190_S0.8460.58
174_G202_S0.8400.57
80_T292_Y0.8370.57
228_N262_L0.8240.56
99_L221_L0.8230.56
55_N143_K0.8180.55
151_G235_P0.8170.55
56_V100_Q0.8150.55
154_H290_D0.8130.55
90_I288_L0.8120.55
46_F264_A0.8110.55
145_P246_T0.8100.55
206_D275_A0.8080.54
238_K255_F0.8080.54
173_A222_L0.8050.54
203_I221_L0.8000.54
71_Q137_P0.7940.53
128_S164_R0.7930.53
187_K192_Y0.7910.53
87_Q91_N0.7880.53
130_A141_E0.7800.52
91_N262_L0.7780.52
92_M291_A0.7780.52
55_N170_K0.7780.52
149_K290_D0.7730.51
264_A276_F0.7720.51
164_R167_Q0.7720.51
61_T72_T0.7710.51
145_P230_S0.7710.51
244_A248_T0.7660.51
196_N250_Y0.7660.51
187_K250_Y0.7640.50
177_A222_L0.7590.50
55_N290_D0.7570.50
187_K193_S0.7550.50
78_T135_R0.7470.49
151_G199_G0.7450.49
56_V199_G0.7440.48
188_E270_L0.7390.48
264_A295_L0.7350.48
187_K246_T0.7340.48
42_K45_F0.7330.47
101_V110_S0.7280.47
198_R291_A0.7270.47
223_H278_I0.7240.47
225_A263_I0.7190.46
237_L286_I0.7190.46
179_V229_A0.7170.46
38_Q247_E0.7120.46
40_I167_Q0.7100.45
116_Q119_K0.7100.45
246_T286_I0.7080.45
111_F134_V0.7080.45
145_P245_V0.7060.45
48_I159_M0.7050.45
189_I246_T0.7040.45
40_I88_K0.7030.45
193_S246_T0.7000.44
88_K256_V0.7000.44
34_M290_D0.6980.44
162_T172_R0.6970.44
142_R290_D0.6960.44
120_E124_N0.6870.43
142_R247_E0.6860.43
244_A247_E0.6850.43
89_G92_M0.6850.43
54_A296_C0.6770.42
101_V164_R0.6770.42
60_V77_F0.6720.42
54_A78_T0.6710.42
139_F154_H0.6710.42
199_G259_L0.6690.42
183_C255_F0.6680.42
183_C195_H0.6640.41
75_A233_L0.6600.41
144_S236_V0.6570.41
45_F188_E0.6570.41
186_S291_A0.6510.40
249_A286_I0.6500.40
187_K194_A0.6490.40
182_L196_N0.6460.40
259_L280_C0.6450.39
105_N109_L0.6420.39
101_V148_E0.6420.39
138_W222_L0.6400.39
73_T137_P0.6390.39
181_T254_R0.6380.39
183_C261_R0.6370.39
37_L81_C0.6350.39
184_P197_Q0.6320.38
279_E292_Y0.6310.38
206_D274_S0.6280.38
67_M165_K0.6270.38
79_M181_T0.6250.38
190_S194_A0.6250.38
78_T292_Y0.6220.37
229_A246_T0.6200.37
145_P234_H0.6200.37
211_A270_L0.6200.37
53_V96_T0.6200.37
81_C95_L0.6200.37
38_Q236_V0.6190.37
35_K199_G0.6190.37
44_Y196_N0.6180.37
145_P286_I0.6160.37
162_T209_P0.6140.37
91_N232_R0.6100.36
60_V170_K0.6090.36
181_T282_N0.6080.36
40_I55_N0.6080.36
34_M134_V0.6080.36
81_C144_S0.6060.36
37_L244_A0.6050.36
237_L243_K0.6050.36
143_K209_P0.6040.36
84_P125_M0.6020.36
63_T110_S0.6000.36
189_I199_G0.5990.35
146_K178_K0.5970.35
142_R281_R0.5960.35
57_S74_A0.5960.35
54_A279_E0.5960.35
73_T295_L0.5950.35
225_A228_N0.5930.35
47_D181_T0.5900.35
97_E124_N0.5890.35
97_E236_V0.5890.35
67_M123_E0.5890.35
66_M69_A0.5880.34
115_Q209_P0.5870.34
43_D104_Q0.5860.34
63_T219_A0.5840.34
179_V199_G0.5830.34
78_T165_K0.5810.34
186_S241_D0.5810.34
61_T221_L0.5760.33
34_M228_N0.5720.33
278_I295_L0.5720.33
181_T266_D0.5700.33
137_P156_D0.5680.33
161_V171_Q0.5680.33
178_K281_R0.5680.33
88_K103_H0.5680.33
64_S69_A0.5660.33
60_V133_E0.5660.33
220_D270_L0.5660.33
144_S292_Y0.5650.33
151_G244_A0.5620.32
262_L290_D0.5610.32
60_V165_K0.5600.32
81_C267_L0.5600.32
144_S293_A0.5590.32
194_A250_Y0.5590.32
63_T209_P0.5580.32
209_P274_S0.5580.32
182_L233_L0.5570.32
86_N164_R0.5560.32
212_S219_A0.5550.32
118_T163_Y0.5540.32
145_P282_N0.5540.32
113_S116_Q0.5520.32
74_A137_P0.5520.32
266_D269_E0.5490.31
114_L159_M0.5460.31
195_H257_E0.5460.31
61_T105_N0.5450.31
186_S243_K0.5450.31
62_I71_Q0.5450.31
43_D269_E0.5450.31
124_N203_I0.5430.31
62_I173_A0.5430.31
76_N208_H0.5410.31
100_Q117_F0.5390.30
182_L243_K0.5380.30
197_Q287_H0.5360.30
184_P287_H0.5360.30
145_P189_I0.5350.30
44_Y146_K0.5340.30
53_V253_P0.5320.30
64_S71_Q0.5320.30
189_I229_A0.5320.30
257_E261_R0.5310.30
64_S98_L0.5310.30
127_T140_F0.5280.30
183_C284_E0.5280.30
70_E132_V0.5270.30
203_I263_I0.5270.30
250_Y286_I0.5270.30
59_P190_S0.5260.29
147_L241_D0.5260.29
59_P179_V0.5240.29
47_D100_Q0.5240.29
173_A211_A0.5240.29
126_D161_V0.5230.29
183_C198_R0.5220.29
165_K274_S0.5220.29
258_D284_E0.5160.29
49_Q56_V0.5150.29
179_V194_A0.5150.29
83_L144_S0.5140.29
190_S250_Y0.5140.29
64_S80_T0.5130.28
86_N134_V0.5130.28
86_N119_K0.5120.28
147_L199_G0.5110.28
63_T66_M0.5100.28
183_C258_D0.5090.28
285_S289_H0.5080.28
119_K164_R0.5060.28
195_H255_F0.5060.28
179_V246_T0.5050.28
81_C181_T0.5050.28
48_I232_R0.5050.28
237_L246_T0.5040.28
270_L273_V0.5030.28
97_E256_V0.5020.28
65_A212_S0.5010.28
117_F265_A0.5010.28
39_N248_T0.5010.28
242_E261_R0.5000.28
60_V208_H0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r5rA 4 0.8092 100 0.129 Contact Map
3d2oA 4 0.8026 100 0.137 Contact Map
3v9oA 3 0.375 32.9 0.968 Contact Map
1sqlA 5 0.375 22.2 0.97 Contact Map
2o90A 4 0.352 17.7 0.972 Contact Map
1b9lA 4 0.3651 14 0.973 Contact Map
1sczA 4 0.3059 13.9 0.973 Contact Map
3o1kA 4 0.3651 12.6 0.973 Contact Map
1dhnA 4 0.3684 10.4 0.974 Contact Map
1nbuA 4 0.3586 10.1 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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