GREMLIN Database
YCGS - Uncharacterized hydrolase YcgS
UniProt: P94396 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 284 (258)
Sequences: 59611 (49641)
Seq/√Len: 3090.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_V51_S4.9111.00
91_H115_T4.3191.00
58_P77_F3.7991.00
42_Y275_G3.0461.00
79_V105_F2.9791.00
233_V259_H2.8731.00
91_H114_N2.7741.00
269_K273_E2.7481.00
256_C277_I2.6711.00
89_S114_N2.6481.00
120_S235_D2.4811.00
119_Q274_T2.3611.00
258_L277_I2.3391.00
14_T64_S2.3141.00
18_S36_C2.2511.00
82_L90_V2.1871.00
79_V112_R2.1621.00
105_F109_Y2.1391.00
79_V109_Y2.1271.00
92_V102_G2.1081.00
233_V257_L2.0631.00
79_V83_D2.0631.00
83_D112_R2.0601.00
99_G121_A2.0011.00
247_K253_A1.9561.00
16_E62_R1.9461.00
17_Y81_L1.9341.00
76_R108_H1.9021.00
104_C108_H1.9011.00
49_G279_L1.8911.00
25_P53_I1.8551.00
25_P87_I1.8471.00
19_V53_I1.8151.00
45_L275_G1.8131.00
240_L257_L1.8021.00
261_W269_K1.8011.00
106_A116_L1.7591.00
20_T54_T1.7241.00
24_T91_H1.7211.00
91_H117_T1.7181.00
102_G116_L1.7081.00
228_L256_C1.6961.00
16_E36_C1.6881.00
25_P51_S1.6631.00
24_T114_N1.6521.00
72_A108_H1.6301.00
30_H57_R1.6291.00
227_V250_I1.6041.00
30_H60_Y1.5931.00
50_Y91_H1.5811.00
70_S73_N1.5791.00
245_H249_H1.5781.00
277_I280_G1.5571.00
11_D80_K1.5521.00
91_H282_L1.5501.00
57_R101_S1.5391.00
55_P78_Y1.5331.00
228_L281_F1.5211.00
34_S38_E1.5201.00
105_F113_V1.4931.00
109_Y112_R1.4821.00
276_S280_G1.4771.00
75_C104_C1.4671.00
78_Y105_F1.4341.00
29_M57_R1.4201.00
16_E56_S1.3981.00
219_D222_A1.3951.00
117_T278_L1.3731.00
29_M78_Y1.3651.00
231_Q243_A1.3501.00
29_M102_G1.3441.00
53_I81_L1.3391.00
45_L279_L1.3221.00
273_E277_I1.2881.00
45_L48_Q1.2851.00
36_C56_S1.2841.00
83_D109_Y1.2821.00
105_F112_R1.2761.00
28_V93_I1.2721.00
15_L77_F1.2651.00
118_L121_A1.2571.00
104_C107_S1.2441.00
95_I266_W1.2421.00
33_H60_Y1.2301.00
28_V52_I1.2271.00
103_I118_L1.2261.00
240_L244_H1.2171.00
209_L212_T1.2171.00
13_G58_P1.2151.00
244_H248_E1.2141.00
21_G51_S1.2051.00
273_E276_S1.2021.00
36_C62_R1.1921.00
87_I90_V1.1871.00
81_L85_L1.1871.00
117_T228_L1.1851.00
20_T43_T1.1801.00
258_L261_W1.1771.00
96_S263_H1.1681.00
250_I253_A1.1581.00
43_T54_T1.1551.00
56_S61_G1.1381.00
93_I119_Q1.1231.00
221_Q249_H1.1131.00
23_G51_S1.1121.00
27_L82_L1.1101.00
45_L272_A1.0991.00
26_I50_Y1.0951.00
55_P81_L1.0881.00
24_T50_Y1.0801.00
31_G96_S1.0771.00
22_K51_S1.0751.00
33_H96_S1.0731.00
107_S219_D1.0731.00
230_M258_L1.0711.00
247_K255_L1.0601.00
48_Q279_L1.0541.00
36_C54_T1.0501.00
245_H248_E1.0501.00
90_V113_V1.0471.00
231_Q255_L1.0421.00
274_T278_L1.0401.00
272_A276_S1.0261.00
17_Y85_L1.0251.00
29_M92_V1.0241.00
231_Q257_L1.0241.00
72_A104_C1.0101.00
231_Q240_L1.0081.00
82_L87_I1.0041.00
93_I278_L0.9951.00
38_E266_W0.9911.00
27_L90_V0.9871.00
258_L273_E0.9861.00
24_T89_S0.9861.00
254_V277_I0.9851.00
75_C101_S0.9791.00
205_F208_D0.9741.00
79_V108_H0.9731.00
15_L63_T0.9691.00
202_G205_F0.9621.00
261_W268_G0.9611.00
233_V260_S0.9601.00
228_L254_V0.9601.00
95_I264_L0.9531.00
79_V82_L0.9521.00
41_G44_A0.9521.00
82_L105_F0.9501.00
148_W152_L0.9491.00
115_T226_P0.9401.00
262_G268_G0.9291.00
244_H257_L0.9221.00
53_I85_L0.9221.00
244_H255_L0.9201.00
137_G141_F0.9151.00
164_M168_M0.9121.00
210_S213_A0.9111.00
119_Q266_W0.9071.00
203_E207_I0.9011.00
244_H247_K0.8981.00
256_C280_G0.8941.00
68_G73_N0.8901.00
13_G64_S0.8891.00
116_L227_V0.8841.00
90_V112_R0.8841.00
80_K84_H0.8691.00
94_A102_G0.8691.00
104_C219_D0.8691.00
26_I52_I0.8681.00
57_R97_A0.8671.00
185_N188_D0.8551.00
40_F54_T0.8521.00
80_K83_D0.8511.00
29_M55_P0.8461.00
230_M277_I0.8441.00
26_I93_I0.8381.00
209_L213_A0.8371.00
27_L78_Y0.8321.00
106_A113_V0.8311.00
192_F195_M0.8261.00
25_P50_Y0.8251.00
256_C273_E0.8251.00
216_S219_D0.8251.00
73_N76_R0.8221.00
75_C108_H0.8201.00
205_F209_L0.8151.00
19_V22_K0.8141.00
258_L269_K0.8111.00
148_W151_K0.8061.00
117_T282_L0.8001.00
191_A194_K0.7971.00
207_I210_S0.7961.00
261_W265_I0.7941.00
208_D211_Q0.7921.00
119_Q265_I0.7891.00
243_A255_L0.7841.00
136_L140_L0.7841.00
190_E193_R0.7791.00
24_T115_T0.7771.00
92_V105_F0.7741.00
94_A99_G0.7701.00
204_G207_I0.7681.00
136_L139_I0.7651.00
43_T52_I0.7651.00
36_C55_P0.7631.00
178_Q181_K0.7611.00
229_I253_A0.7601.00
18_S40_F0.7581.00
186_E190_E0.7561.00
76_R80_K0.7531.00
191_A195_M0.7531.00
163_L167_A0.7531.00
242_H245_H0.7511.00
208_D212_T0.7491.00
195_M198_R0.7491.00
241_S244_H0.7491.00
86_Q89_S0.7481.00
138_E142_R0.7461.00
180_I183_L0.7421.00
165_F168_M0.7401.00
206_L209_L0.7391.00
190_E194_K0.7371.00
230_M274_T0.7341.00
42_Y45_L0.7341.00
157_N160_F0.7331.00
50_Y282_L0.7321.00
25_P90_V0.7301.00
28_V39_E0.7291.00
194_K198_R0.7291.00
76_R79_V0.7291.00
57_R74_A0.7291.00
20_T47_E0.7291.00
224_I251_R0.7271.00
120_S265_I0.7201.00
269_K272_A0.7181.00
192_F196_N0.7141.00
157_N161_P0.7121.00
275_G279_L0.7121.00
75_C105_F0.7101.00
271_A275_G0.7101.00
74_A97_A0.7071.00
32_G97_A0.7051.00
160_F163_L0.7051.00
188_D191_A0.7021.00
188_D192_F0.6971.00
168_M172_F0.6951.00
161_P164_M0.6941.00
161_P165_F0.6931.00
162_R166_R0.6931.00
33_H97_A0.6911.00
193_R197_S0.6901.00
56_S62_R0.6891.00
106_A225_C0.6891.00
260_S269_K0.6831.00
204_G208_D0.6821.00
136_L141_F0.6811.00
50_Y279_L0.6801.00
163_L166_R0.6801.00
44_A47_E0.6781.00
194_K197_S0.6771.00
232_S265_I0.6761.00
15_L58_P0.6751.00
181_K185_N0.6741.00
201_S204_G0.6731.00
203_E208_D0.6681.00
72_A76_R0.6671.00
138_E141_F0.6641.00
233_V240_L0.6641.00
120_S231_Q0.6631.00
92_V113_V0.6631.00
180_I184_M0.6621.00
95_I120_S0.6611.00
135_K138_E0.6581.00
113_V225_C0.6581.00
40_F44_A0.6541.00
23_G49_G0.6511.00
30_H55_P0.6511.00
20_T44_A0.6501.00
164_M167_A0.6491.00
16_E63_T0.6431.00
218_K221_Q0.6421.00
37_Y40_F0.6401.00
88_E112_R0.6361.00
177_F181_K0.6341.00
135_K139_I0.6331.00
51_S87_I0.6331.00
115_T281_F0.6331.00
160_F164_M0.6331.00
183_L186_E0.6321.00
71_L104_C0.6311.00
165_F169_S0.6291.00
53_I87_I0.6291.00
26_I91_H0.6261.00
276_S279_L0.6241.00
137_G140_L0.6241.00
182_S185_N0.6201.00
90_V114_N0.6201.00
23_G50_Y0.6171.00
107_S222_A0.6151.00
99_G118_L0.6141.00
42_Y274_T0.6141.00
200_R203_E0.6131.00
58_P74_A0.6131.00
57_R60_Y0.6121.00
169_S173_S0.6111.00
169_S172_F0.6101.00
100_P122_V0.6101.00
39_E43_T0.6061.00
187_K190_E0.6051.00
207_I211_Q0.6051.00
167_A170_P0.6051.00
90_V105_F0.6041.00
28_V54_T0.6021.00
166_R170_P0.6021.00
27_L92_V0.6011.00
189_I193_R0.5991.00
76_R109_Y0.5991.00
95_I119_Q0.5991.00
93_I117_T0.5981.00
193_R196_N0.5961.00
103_I123_T0.5961.00
178_Q182_S0.5961.00
168_M171_Q0.5951.00
11_D73_N0.5881.00
39_E42_Y0.5861.00
74_A101_S0.5841.00
42_Y46_I0.5781.00
19_V85_L0.5771.00
120_S232_S0.5771.00
94_A98_G0.5761.00
117_T230_M0.5711.00
229_I243_A0.5711.00
215_V219_D0.5711.00
156_L159_A0.5701.00
202_G208_D0.5691.00
44_A48_Q0.5681.00
43_T47_E0.5681.00
161_P168_M0.5671.00
229_I250_I0.5651.00
18_S54_T0.5641.00
201_S205_F0.5631.00
215_V218_K0.5621.00
189_I192_F0.5571.00
215_V220_L0.5551.00
199_Q202_G0.5551.00
234_Y260_S0.5531.00
38_E95_I0.5531.00
118_L229_I0.5521.00
156_L160_F0.5501.00
75_C79_V0.5501.00
203_E206_L0.5501.00
57_R78_Y0.5491.00
164_M169_S0.5471.00
49_G52_I0.5461.00
229_I247_K0.5431.00
103_I121_A0.5421.00
230_M256_C0.5411.00
231_Q238_V0.5411.00
202_G206_L0.5401.00
18_S37_Y0.5391.00
187_K191_A0.5371.00
108_H219_D0.5371.00
47_E52_I0.5371.00
96_S264_L0.5351.00
11_D76_R0.5351.00
81_L84_H0.5331.00
229_I255_L0.5331.00
246_A250_I0.5311.00
217_L249_H0.5301.00
165_F170_P0.5291.00
29_M101_S0.5291.00
235_D263_H0.5291.00
259_H273_E0.5261.00
162_R165_F0.5251.00
173_S177_F0.5211.00
27_L55_P0.5181.00
206_L210_S0.5181.00
214_A217_L0.5171.00
182_S186_E0.5161.00
82_L112_R0.5101.00
234_Y261_W0.5091.00
205_F212_T0.5061.00
265_I274_T0.5061.00
217_L245_H0.5061.00
155_S158_N0.5061.00
204_G212_T0.5041.00
254_V280_G0.5021.00
35_N60_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4inzA 1 0.9366 100 0.139 Contact Map
1ehyA 1 0.9331 100 0.149 Contact Map
3oosA 1 0.9437 100 0.178 Contact Map
2pujA 4 0.9331 100 0.184 Contact Map
1iupA 2 0.912 100 0.189 Contact Map
4psuA 1 0.9437 100 0.191 Contact Map
2wueA 4 0.9296 100 0.197 Contact Map
3r40A 2 0.9613 100 0.2 Contact Map
3om8A 4 0.912 100 0.208 Contact Map
1q0rA 1 0.9648 100 0.209 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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