YCGS - BACSU - GREMLIN Contacts

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YCGS - Uncharacterized hydrolase YcgS

UniProt:	P94396	Sequences: MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTALIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSGICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAFPRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLKDLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGSILLGFLES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	284 (258)
Sequences:	59611 (49641)
Seq/√Len:	3090.5

ECOLI - MHPC YBFF RUTD PLDB BIOH MENH YCJY YFHR
BACSU - YCGS YFHM YUGF YISY YRAK NAP YBFK YDJP YBAC RSBQ YBDG MENH YCLE YVAM YQJL PLBAC EST YQKD CAH
HALSA - Q9HPT9 Q9HHP4 Q9HRJ0
SULSO - PIP Q7LXY9 Q97WG0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_V	51_S	4.911	1.00
91_H	115_T	4.319	1.00
58_P	77_F	3.799	1.00
42_Y	275_G	3.046	1.00
79_V	105_F	2.979	1.00
233_V	259_H	2.873	1.00
91_H	114_N	2.774	1.00
269_K	273_E	2.748	1.00
256_C	277_I	2.671	1.00
89_S	114_N	2.648	1.00
120_S	235_D	2.481	1.00
119_Q	274_T	2.361	1.00
258_L	277_I	2.339	1.00
14_T	64_S	2.314	1.00
18_S	36_C	2.251	1.00
82_L	90_V	2.187	1.00
79_V	112_R	2.162	1.00
105_F	109_Y	2.139	1.00
79_V	109_Y	2.127	1.00
92_V	102_G	2.108	1.00
233_V	257_L	2.063	1.00
79_V	83_D	2.063	1.00
83_D	112_R	2.060	1.00
99_G	121_A	2.001	1.00
247_K	253_A	1.956	1.00
16_E	62_R	1.946	1.00
17_Y	81_L	1.934	1.00
76_R	108_H	1.902	1.00
104_C	108_H	1.901	1.00
49_G	279_L	1.891	1.00
25_P	53_I	1.855	1.00
25_P	87_I	1.847	1.00
19_V	53_I	1.815	1.00
45_L	275_G	1.813	1.00
240_L	257_L	1.802	1.00
261_W	269_K	1.801	1.00
106_A	116_L	1.759	1.00
20_T	54_T	1.724	1.00
24_T	91_H	1.721	1.00
91_H	117_T	1.718	1.00
102_G	116_L	1.708	1.00
228_L	256_C	1.696	1.00
16_E	36_C	1.688	1.00
25_P	51_S	1.663	1.00
24_T	114_N	1.652	1.00
72_A	108_H	1.630	1.00
30_H	57_R	1.629	1.00
227_V	250_I	1.604	1.00
30_H	60_Y	1.593	1.00
50_Y	91_H	1.581	1.00
70_S	73_N	1.579	1.00
245_H	249_H	1.578	1.00
277_I	280_G	1.557	1.00
11_D	80_K	1.552	1.00
91_H	282_L	1.550	1.00
57_R	101_S	1.539	1.00
55_P	78_Y	1.533	1.00
228_L	281_F	1.521	1.00
34_S	38_E	1.520	1.00
105_F	113_V	1.493	1.00
109_Y	112_R	1.482	1.00
276_S	280_G	1.477	1.00
75_C	104_C	1.467	1.00
78_Y	105_F	1.434	1.00
29_M	57_R	1.420	1.00
16_E	56_S	1.398	1.00
219_D	222_A	1.395	1.00
117_T	278_L	1.373	1.00
29_M	78_Y	1.365	1.00
231_Q	243_A	1.350	1.00
29_M	102_G	1.344	1.00
53_I	81_L	1.339	1.00
45_L	279_L	1.322	1.00
273_E	277_I	1.288	1.00
45_L	48_Q	1.285	1.00
36_C	56_S	1.284	1.00
83_D	109_Y	1.282	1.00
105_F	112_R	1.276	1.00
28_V	93_I	1.272	1.00
15_L	77_F	1.265	1.00
118_L	121_A	1.257	1.00
104_C	107_S	1.244	1.00
95_I	266_W	1.242	1.00
33_H	60_Y	1.230	1.00
28_V	52_I	1.227	1.00
103_I	118_L	1.226	1.00
240_L	244_H	1.217	1.00
209_L	212_T	1.217	1.00
13_G	58_P	1.215	1.00
244_H	248_E	1.214	1.00
21_G	51_S	1.205	1.00
273_E	276_S	1.202	1.00
36_C	62_R	1.192	1.00
87_I	90_V	1.187	1.00
81_L	85_L	1.187	1.00
117_T	228_L	1.185	1.00
20_T	43_T	1.180	1.00
258_L	261_W	1.177	1.00
96_S	263_H	1.168	1.00
250_I	253_A	1.158	1.00
43_T	54_T	1.155	1.00
56_S	61_G	1.138	1.00
93_I	119_Q	1.123	1.00
221_Q	249_H	1.113	1.00
23_G	51_S	1.112	1.00
27_L	82_L	1.110	1.00
45_L	272_A	1.099	1.00
26_I	50_Y	1.095	1.00
55_P	81_L	1.088	1.00
24_T	50_Y	1.080	1.00
31_G	96_S	1.077	1.00
22_K	51_S	1.075	1.00
33_H	96_S	1.073	1.00
107_S	219_D	1.073	1.00
230_M	258_L	1.071	1.00
247_K	255_L	1.060	1.00
48_Q	279_L	1.054	1.00
36_C	54_T	1.050	1.00
245_H	248_E	1.050	1.00
90_V	113_V	1.047	1.00
231_Q	255_L	1.042	1.00
274_T	278_L	1.040	1.00
272_A	276_S	1.026	1.00
17_Y	85_L	1.025	1.00
29_M	92_V	1.024	1.00
231_Q	257_L	1.024	1.00
72_A	104_C	1.010	1.00
231_Q	240_L	1.008	1.00
82_L	87_I	1.004	1.00
93_I	278_L	0.995	1.00
38_E	266_W	0.991	1.00
27_L	90_V	0.987	1.00
258_L	273_E	0.986	1.00
24_T	89_S	0.986	1.00
254_V	277_I	0.985	1.00
75_C	101_S	0.979	1.00
205_F	208_D	0.974	1.00
79_V	108_H	0.973	1.00
15_L	63_T	0.969	1.00
202_G	205_F	0.962	1.00
261_W	268_G	0.961	1.00
233_V	260_S	0.960	1.00
228_L	254_V	0.960	1.00
95_I	264_L	0.953	1.00
79_V	82_L	0.952	1.00
41_G	44_A	0.952	1.00
82_L	105_F	0.950	1.00
148_W	152_L	0.949	1.00
115_T	226_P	0.940	1.00
262_G	268_G	0.929	1.00
244_H	257_L	0.922	1.00
53_I	85_L	0.922	1.00
244_H	255_L	0.920	1.00
137_G	141_F	0.915	1.00
164_M	168_M	0.912	1.00
210_S	213_A	0.911	1.00
119_Q	266_W	0.907	1.00
203_E	207_I	0.901	1.00
244_H	247_K	0.898	1.00
256_C	280_G	0.894	1.00
68_G	73_N	0.890	1.00
13_G	64_S	0.889	1.00
116_L	227_V	0.884	1.00
90_V	112_R	0.884	1.00
80_K	84_H	0.869	1.00
94_A	102_G	0.869	1.00
104_C	219_D	0.869	1.00
26_I	52_I	0.868	1.00
57_R	97_A	0.867	1.00
185_N	188_D	0.855	1.00
40_F	54_T	0.852	1.00
80_K	83_D	0.851	1.00
29_M	55_P	0.846	1.00
230_M	277_I	0.844	1.00
26_I	93_I	0.838	1.00
209_L	213_A	0.837	1.00
27_L	78_Y	0.832	1.00
106_A	113_V	0.831	1.00
192_F	195_M	0.826	1.00
25_P	50_Y	0.825	1.00
256_C	273_E	0.825	1.00
216_S	219_D	0.825	1.00
73_N	76_R	0.822	1.00
75_C	108_H	0.820	1.00
205_F	209_L	0.815	1.00
19_V	22_K	0.814	1.00
258_L	269_K	0.811	1.00
148_W	151_K	0.806	1.00
117_T	282_L	0.800	1.00
191_A	194_K	0.797	1.00
207_I	210_S	0.796	1.00
261_W	265_I	0.794	1.00
208_D	211_Q	0.792	1.00
119_Q	265_I	0.789	1.00
243_A	255_L	0.784	1.00
136_L	140_L	0.784	1.00
190_E	193_R	0.779	1.00
24_T	115_T	0.777	1.00
92_V	105_F	0.774	1.00
94_A	99_G	0.770	1.00
204_G	207_I	0.768	1.00
136_L	139_I	0.765	1.00
43_T	52_I	0.765	1.00
36_C	55_P	0.763	1.00
178_Q	181_K	0.761	1.00
229_I	253_A	0.760	1.00
18_S	40_F	0.758	1.00
186_E	190_E	0.756	1.00
76_R	80_K	0.753	1.00
191_A	195_M	0.753	1.00
163_L	167_A	0.753	1.00
242_H	245_H	0.751	1.00
208_D	212_T	0.749	1.00
195_M	198_R	0.749	1.00
241_S	244_H	0.749	1.00
86_Q	89_S	0.748	1.00
138_E	142_R	0.746	1.00
180_I	183_L	0.742	1.00
165_F	168_M	0.740	1.00
206_L	209_L	0.739	1.00
190_E	194_K	0.737	1.00
230_M	274_T	0.734	1.00
42_Y	45_L	0.734	1.00
157_N	160_F	0.733	1.00
50_Y	282_L	0.732	1.00
25_P	90_V	0.730	1.00
28_V	39_E	0.729	1.00
194_K	198_R	0.729	1.00
76_R	79_V	0.729	1.00
57_R	74_A	0.729	1.00
20_T	47_E	0.729	1.00
224_I	251_R	0.727	1.00
120_S	265_I	0.720	1.00
269_K	272_A	0.718	1.00
192_F	196_N	0.714	1.00
157_N	161_P	0.712	1.00
275_G	279_L	0.712	1.00
75_C	105_F	0.710	1.00
271_A	275_G	0.710	1.00
74_A	97_A	0.707	1.00
32_G	97_A	0.705	1.00
160_F	163_L	0.705	1.00
188_D	191_A	0.702	1.00
188_D	192_F	0.697	1.00
168_M	172_F	0.695	1.00
161_P	164_M	0.694	1.00
161_P	165_F	0.693	1.00
162_R	166_R	0.693	1.00
33_H	97_A	0.691	1.00
193_R	197_S	0.690	1.00
56_S	62_R	0.689	1.00
106_A	225_C	0.689	1.00
260_S	269_K	0.683	1.00
204_G	208_D	0.682	1.00
136_L	141_F	0.681	1.00
50_Y	279_L	0.680	1.00
163_L	166_R	0.680	1.00
44_A	47_E	0.678	1.00
194_K	197_S	0.677	1.00
232_S	265_I	0.676	1.00
15_L	58_P	0.675	1.00
181_K	185_N	0.674	1.00
201_S	204_G	0.673	1.00
203_E	208_D	0.668	1.00
72_A	76_R	0.667	1.00
138_E	141_F	0.664	1.00
233_V	240_L	0.664	1.00
120_S	231_Q	0.663	1.00
92_V	113_V	0.663	1.00
180_I	184_M	0.662	1.00
95_I	120_S	0.661	1.00
135_K	138_E	0.658	1.00
113_V	225_C	0.658	1.00
40_F	44_A	0.654	1.00
23_G	49_G	0.651	1.00
30_H	55_P	0.651	1.00
20_T	44_A	0.650	1.00
164_M	167_A	0.649	1.00
16_E	63_T	0.643	1.00
218_K	221_Q	0.642	1.00
37_Y	40_F	0.640	1.00
88_E	112_R	0.636	1.00
177_F	181_K	0.634	1.00
135_K	139_I	0.633	1.00
51_S	87_I	0.633	1.00
115_T	281_F	0.633	1.00
160_F	164_M	0.633	1.00
183_L	186_E	0.632	1.00
71_L	104_C	0.631	1.00
165_F	169_S	0.629	1.00
53_I	87_I	0.629	1.00
26_I	91_H	0.626	1.00
276_S	279_L	0.624	1.00
137_G	140_L	0.624	1.00
182_S	185_N	0.620	1.00
90_V	114_N	0.620	1.00
23_G	50_Y	0.617	1.00
107_S	222_A	0.615	1.00
99_G	118_L	0.614	1.00
42_Y	274_T	0.614	1.00
200_R	203_E	0.613	1.00
58_P	74_A	0.613	1.00
57_R	60_Y	0.612	1.00
169_S	173_S	0.611	1.00
169_S	172_F	0.610	1.00
100_P	122_V	0.610	1.00
39_E	43_T	0.606	1.00
187_K	190_E	0.605	1.00
207_I	211_Q	0.605	1.00
167_A	170_P	0.605	1.00
90_V	105_F	0.604	1.00
28_V	54_T	0.602	1.00
166_R	170_P	0.602	1.00
27_L	92_V	0.601	1.00
189_I	193_R	0.599	1.00
76_R	109_Y	0.599	1.00
95_I	119_Q	0.599	1.00
93_I	117_T	0.598	1.00
193_R	196_N	0.596	1.00
103_I	123_T	0.596	1.00
178_Q	182_S	0.596	1.00
168_M	171_Q	0.595	1.00
11_D	73_N	0.588	1.00
39_E	42_Y	0.586	1.00
74_A	101_S	0.584	1.00
42_Y	46_I	0.578	1.00
19_V	85_L	0.577	1.00
120_S	232_S	0.577	1.00
94_A	98_G	0.576	1.00
117_T	230_M	0.571	1.00
229_I	243_A	0.571	1.00
215_V	219_D	0.571	1.00
156_L	159_A	0.570	1.00
202_G	208_D	0.569	1.00
44_A	48_Q	0.568	1.00
43_T	47_E	0.568	1.00
161_P	168_M	0.567	1.00
229_I	250_I	0.565	1.00
18_S	54_T	0.564	1.00
201_S	205_F	0.563	1.00
215_V	218_K	0.562	1.00
189_I	192_F	0.557	1.00
215_V	220_L	0.555	1.00
199_Q	202_G	0.555	1.00
234_Y	260_S	0.553	1.00
38_E	95_I	0.553	1.00
118_L	229_I	0.552	1.00
156_L	160_F	0.550	1.00
75_C	79_V	0.550	1.00
203_E	206_L	0.550	1.00
57_R	78_Y	0.549	1.00
164_M	169_S	0.547	1.00
49_G	52_I	0.546	1.00
229_I	247_K	0.543	1.00
103_I	121_A	0.542	1.00
230_M	256_C	0.541	1.00
231_Q	238_V	0.541	1.00
202_G	206_L	0.540	1.00
18_S	37_Y	0.539	1.00
187_K	191_A	0.537	1.00
108_H	219_D	0.537	1.00
47_E	52_I	0.537	1.00
96_S	264_L	0.535	1.00
11_D	76_R	0.535	1.00
81_L	84_H	0.533	1.00
229_I	255_L	0.533	1.00
246_A	250_I	0.531	1.00
217_L	249_H	0.530	1.00
165_F	170_P	0.529	1.00
29_M	101_S	0.529	1.00
235_D	263_H	0.529	1.00
259_H	273_E	0.526	1.00
162_R	165_F	0.525	1.00
173_S	177_F	0.521	1.00
27_L	55_P	0.518	1.00
206_L	210_S	0.518	1.00
214_A	217_L	0.517	1.00
182_S	186_E	0.516	1.00
82_L	112_R	0.510	1.00
234_Y	261_W	0.509	1.00
205_F	212_T	0.506	1.00
265_I	274_T	0.506	1.00
217_L	245_H	0.506	1.00
155_S	158_N	0.506	1.00
204_G	212_T	0.504	1.00
254_V	280_G	0.502	1.00
35_N	60_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4inzA	1	0.9366	100	0.139	Contact Map
1ehyA	1	0.9331	100	0.149	Contact Map
3oosA	1	0.9437	100	0.178	Contact Map
2pujA	4	0.9331	100	0.184	Contact Map
1iupA	2	0.912	100	0.189	Contact Map
4psuA	1	0.9437	100	0.191	Contact Map
2wueA	4	0.9296	100	0.197	Contact Map
3r40A	2	0.9613	100	0.2	Contact Map
3om8A	4	0.912	100	0.208	Contact Map
1q0rA	1	0.9648	100	0.209	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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