GREMLIN Database
YCGR - UPF0718 protein YcgR
UniProt: P94395 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 294 (283)
Sequences: 2177 (1415)
Seq/√Len: 84.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_L123_G5.0191.00
262_L278_I4.2911.00
266_L271_K4.1481.00
222_F282_V3.7611.00
275_F279_T3.6141.00
60_A131_L3.4171.00
239_S247_L3.3121.00
120_F124_G3.2761.00
34_I169_T3.0981.00
88_H138_S2.7331.00
14_F192_A2.7251.00
129_V288_G2.5481.00
92_A134_G2.4951.00
96_T130_S2.4731.00
101_N104_V2.2651.00
55_A89_A2.2651.00
142_K276_L2.2361.00
56_V92_A2.2011.00
271_K275_F2.1631.00
118_V244_L2.1591.00
57_L131_L2.1491.00
60_A130_S2.0971.00
129_V284_I2.0891.00
160_G164_Q2.0771.00
77_T90_G2.0641.00
201_S204_L2.0441.00
262_L274_V1.9881.00
214_S249_A1.9731.00
235_A247_L1.9591.00
145_Q272_R1.9491.00
202_T205_A1.9491.00
259_I263_L1.9471.00
161_T164_Q1.9421.00
28_G32_S1.9181.00
212_S215_L1.8971.00
59_G92_A1.8521.00
56_V88_H1.8421.00
253_F282_V1.8171.00
112_F239_S1.7901.00
122_R255_A1.7801.00
163_L167_G1.7631.00
10_L189_F1.7541.00
38_F162_L1.7511.00
106_F110_I1.7421.00
167_G171_R1.7411.00
50_K54_L1.7061.00
125_L288_G1.7031.00
144_N272_R1.6991.00
245_G289_S1.6971.00
253_F285_V1.6801.00
192_A196_T1.6681.00
43_M47_I1.6391.00
193_A197_Y1.6341.00
60_A127_L1.6301.00
108_T122_R1.6121.00
212_S216_V1.6101.00
203_L242_F1.5971.00
272_R276_L1.5871.00
47_I58_F1.5731.00
29_V33_G1.5271.00
222_F262_L1.5150.99
213_S246_S1.5080.99
73_I229_E1.5020.99
108_T112_F1.5010.99
43_M46_R1.5000.99
95_L133_I1.4950.99
129_V133_I1.4780.99
266_L274_V1.4760.99
249_A253_F1.4170.99
33_G37_M1.4110.99
200_T234_I1.4060.99
10_L193_A1.4030.99
249_A289_S1.3970.99
169_T173_A1.3940.99
147_L266_L1.3930.99
162_L166_L1.3670.99
248_I292_V1.3670.99
279_T283_V1.3460.99
81_L87_L1.3390.99
101_N228_S1.3280.99
262_L266_L1.3270.99
85_V90_G1.3070.98
242_F246_S1.2960.98
33_G169_T1.2870.98
167_G170_L1.2870.98
51_N54_L1.2800.98
211_V286_L1.2700.98
63_G96_T1.2680.98
229_E281_I1.2670.98
187_G191_A1.2570.98
30_I173_A1.2560.98
211_V290_L1.2560.98
22_I26_L1.2380.98
194_M224_L1.2270.98
184_L188_A1.2260.98
218_M286_L1.2200.98
248_I259_I1.1900.97
182_K186_I1.1880.97
228_S231_D1.1840.97
228_S232_A1.1780.97
194_M237_S1.1700.97
55_A59_G1.1700.97
53_F135_V1.1670.97
136_I140_Q1.1620.97
37_M168_G1.1620.97
113_G116_W1.1620.97
243_S246_S1.1420.96
154_H157_H1.1400.96
68_A99_I1.1250.96
53_F57_L1.1200.96
154_H161_T1.0920.95
130_S134_G1.0880.95
109_Y119_V1.0850.95
257_V278_I1.0790.95
86_P89_A1.0720.95
66_F217_M1.0680.95
142_K272_R1.0640.95
156_H159_H1.0580.95
70_E233_F1.0470.94
186_I189_F1.0400.94
287_A290_L1.0380.94
269_F273_F1.0380.94
285_V289_S1.0350.94
79_R83_K1.0340.94
166_L170_L1.0330.94
133_I280_Y1.0270.94
155_H159_H1.0240.94
227_C255_A1.0220.93
90_G269_F1.0150.93
111_A228_S1.0050.93
208_Q212_S0.9970.93
201_S205_A0.9930.92
153_G156_H0.9920.92
276_L280_Y0.9900.92
85_V89_A0.9880.92
233_F258_D0.9760.92
245_G265_M0.9730.92
209_N212_S0.9720.92
128_A167_G0.9700.92
132_I292_V0.9660.91
124_G171_R0.9640.91
80_L95_L0.9630.91
10_L197_Y0.9620.91
60_A134_G0.9570.91
234_I237_S0.9550.91
225_S241_T0.9540.91
13_I196_T0.9510.91
190_I224_L0.9460.91
112_F183_Y0.9460.91
183_Y232_A0.9460.91
284_I288_G0.9450.91
67_P225_S0.9420.90
70_E260_K0.9390.90
36_Q172_H0.9340.90
163_L186_I0.9290.90
261_N265_M0.9290.90
170_L174_I0.9250.90
38_F183_Y0.9240.89
95_L252_V0.9140.89
13_I17_I0.9090.89
207_G245_G0.9030.88
24_F72_G0.9030.88
150_D153_G0.8970.88
124_G128_A0.8960.88
68_A72_G0.8960.88
130_S255_A0.8950.88
49_P112_F0.8940.88
94_M277_L0.8930.88
227_C254_G0.8900.88
31_L76_I0.8840.87
59_G126_A0.8820.87
91_V137_L0.8820.87
56_V59_G0.8800.87
143_D287_A0.8760.87
7_F10_L0.8740.87
137_L276_L0.8730.87
35_I76_I0.8720.87
70_E258_D0.8680.86
196_T200_T0.8650.86
140_Q276_L0.8650.86
214_S289_S0.8610.86
99_I252_V0.8590.86
215_L219_G0.8570.86
92_A96_T0.8560.86
9_Q12_S0.8540.85
111_A232_A0.8460.85
152_P156_H0.8430.85
210_D213_S0.8430.85
155_H160_G0.8390.84
202_T276_L0.8350.84
136_I280_Y0.8340.84
104_V229_E0.8320.84
231_D258_D0.8260.83
233_F238_F0.8220.83
218_M253_F0.8210.83
227_C235_A0.8200.83
57_L245_G0.8190.83
31_L287_A0.8180.83
200_T204_L0.8170.83
80_L85_V0.8160.83
24_F108_T0.8140.83
187_G192_A0.8100.82
16_S20_E0.8080.82
287_A291_L0.8080.82
91_V112_F0.8080.82
225_S233_F0.8070.82
122_R261_N0.8020.82
155_H158_H0.7980.81
75_P101_N0.7960.81
64_V100_I0.7930.81
275_F287_A0.7910.81
42_E185_I0.7880.81
33_G173_A0.7870.80
205_A208_Q0.7870.80
125_L129_V0.7840.80
120_F190_I0.7830.80
162_L165_K0.7800.80
136_I154_H0.7760.80
87_L180_V0.7740.79
232_A252_V0.7710.79
78_R221_A0.7700.79
17_I20_E0.7680.79
63_G192_A0.7670.79
25_I73_I0.7650.79
94_M259_I0.7640.78
128_A215_L0.7520.77
78_R268_A0.7520.77
34_I272_R0.7510.77
102_P254_G0.7510.77
92_A131_L0.7490.77
35_I119_V0.7470.77
39_V44_I0.7470.77
101_N232_A0.7440.77
176_E181_G0.7430.76
154_H160_G0.7410.76
28_G255_A0.7400.76
103_I111_A0.7400.76
93_F97_A0.7400.76
113_G239_S0.7400.76
97_A199_K0.7370.76
71_C122_R0.7360.76
211_V215_L0.7360.76
152_P157_H0.7350.76
132_I284_I0.7270.75
164_Q167_G0.7270.75
120_F123_G0.7250.75
206_I242_F0.7250.75
62_A237_S0.7210.74
129_V256_M0.7190.74
190_I234_I0.7170.74
53_F131_L0.7160.74
21_A172_H0.7140.74
30_I33_G0.7120.73
105_L120_F0.7120.73
14_F189_F0.7110.73
62_A77_T0.7080.73
153_G161_T0.7070.73
218_M221_A0.7060.73
46_R49_P0.7030.72
70_E225_S0.7020.72
156_H287_A0.7020.72
35_I39_V0.7000.72
70_E236_S0.7000.72
124_G283_V0.6990.72
152_P155_H0.6990.72
251_L257_V0.6980.72
10_L192_A0.6970.72
128_A132_I0.6880.71
203_L240_S0.6860.71
136_I185_I0.6840.70
124_G160_G0.6840.70
116_W120_F0.6820.70
157_H209_N0.6810.70
22_I181_G0.6800.70
131_L159_H0.6780.70
34_I46_R0.6770.70
25_I32_S0.6770.70
77_T94_M0.6760.69
99_I129_V0.6750.69
81_L86_P0.6720.69
118_V130_S0.6700.69
23_P28_G0.6700.69
227_C231_D0.6690.69
225_S256_M0.6680.69
21_A24_F0.6680.69
167_G279_T0.6570.67
94_M187_G0.6550.67
228_S255_A0.6530.67
107_S232_A0.6500.66
164_Q168_G0.6500.66
225_S232_A0.6480.66
212_S290_L0.6470.66
71_C75_P0.6460.66
167_G205_A0.6460.66
50_K83_K0.6450.66
144_N201_S0.6440.66
59_G166_L0.6440.66
54_L57_L0.6440.66
198_V220_L0.6440.66
10_L14_F0.6420.66
47_I50_K0.6410.65
15_I19_I0.6370.65
113_G117_S0.6360.65
91_V277_L0.6360.65
82_L170_L0.6350.65
109_Y116_W0.6320.64
35_I267_A0.6310.64
227_C250_F0.6310.64
266_L272_R0.6270.64
45_A120_F0.6260.64
173_A176_E0.6260.64
28_G227_C0.6260.64
73_I230_V0.6230.63
153_G160_G0.6220.63
191_A227_C0.6210.63
53_F171_R0.6200.63
206_I209_N0.6190.63
148_K270_K0.6160.62
28_G122_R0.6110.62
107_S221_A0.6090.61
61_L283_V0.6080.61
73_I97_A0.6070.61
112_F232_A0.6050.61
206_I213_S0.6040.61
128_A158_H0.6020.61
99_I281_I0.6020.61
36_Q169_T0.6000.60
52_R138_S0.5990.60
226_L250_F0.5990.60
169_T181_G0.5980.60
144_N150_D0.5980.60
277_L281_I0.5980.60
35_I72_G0.5950.60
61_L156_H0.5950.60
121_Y292_V0.5940.60
231_D260_K0.5940.60
23_P27_I0.5910.59
181_G185_I0.5900.59
57_L61_L0.5900.59
46_R54_L0.5890.59
99_I256_M0.5870.59
32_S122_R0.5860.59
116_W129_V0.5850.58
152_P161_T0.5840.58
41_E44_I0.5830.58
41_E62_A0.5830.58
160_G163_L0.5830.58
70_E94_M0.5820.58
36_Q82_L0.5800.58
54_L139_Y0.5770.57
163_L291_L0.5770.57
140_Q144_N0.5770.57
88_H134_G0.5760.57
217_M249_A0.5750.57
142_K283_V0.5750.57
124_G219_G0.5750.57
61_L65_L0.5730.57
128_A159_H0.5730.57
89_A92_A0.5730.57
198_V203_L0.5730.57
153_G279_T0.5710.57
94_M191_A0.5710.57
74_I264_M0.5710.57
168_G171_R0.5710.57
77_T87_L0.5690.56
171_R278_I0.5660.56
154_H159_H0.5650.56
52_R100_I0.5620.55
250_F254_G0.5620.55
41_E76_I0.5620.55
139_Y143_D0.5600.55
61_L265_M0.5590.55
14_F187_G0.5570.55
97_A191_A0.5550.54
150_D219_G0.5540.54
119_V248_I0.5540.54
24_F28_G0.5540.54
42_E55_A0.5510.54
28_G72_G0.5500.54
128_A139_Y0.5480.54
104_V255_A0.5480.54
62_A198_V0.5460.53
143_D150_D0.5430.53
156_H167_G0.5430.53
82_L146_L0.5420.53
194_M238_F0.5410.53
33_G280_Y0.5390.52
91_V192_A0.5380.52
136_I276_L0.5370.52
32_S35_I0.5330.52
46_R51_N0.5330.52
126_A129_V0.5320.51
135_V150_D0.5320.51
106_F125_L0.5310.51
43_M199_K0.5310.51
30_I170_L0.5300.51
47_I61_L0.5300.51
160_G186_I0.5280.51
31_L262_L0.5270.51
24_F67_P0.5270.51
29_V207_G0.5250.51
153_G158_H0.5250.51
174_I178_F0.5240.50
223_V241_T0.5210.50
198_V202_T0.5190.50
48_M288_G0.5170.49
194_M198_V0.5160.49
17_I191_A0.5140.49
86_P95_L0.5140.49
60_A63_G0.5110.49
17_I224_L0.5110.49
17_I260_K0.5110.49
190_I193_A0.5100.49
257_V289_S0.5090.48
232_A258_D0.5080.48
84_G134_G0.5070.48
24_F122_R0.5070.48
44_I78_R0.5070.48
61_L139_Y0.5040.48
130_S133_I0.5040.48
68_A94_M0.5030.48
262_L267_A0.5020.47
214_S286_L0.5000.47
67_P254_G0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.4728 46 0.948 Contact Map
3llqA 3 0.3673 40.7 0.95 Contact Map
4n7wA 2 0.4864 15.4 0.959 Contact Map
3c02A 3 0.3435 10.7 0.962 Contact Map
4pd6A 3 0.9048 9.4 0.963 Contact Map
1j4nA 4 0.3912 8.1 0.964 Contact Map
4oj2X 3 0.3401 7.8 0.964 Contact Map
3tx3A 2 0.2925 7.5 0.965 Contact Map
2b6oA 6 0.3469 7.5 0.965 Contact Map
3gd8A 4 0.3537 6.8 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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