GREMLIN Database
YCGQ - UPF0703 protein YcgQ
UniProt: P94394 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (229)
Sequences: 788 (609)
Seq/√Len: 40.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_E245_H6.2291.00
195_H245_H5.8991.00
193_E247_K4.8751.00
245_H271_N4.3761.00
192_I265_V4.2541.00
211_V244_I4.1991.00
191_T247_K4.1381.00
195_H273_I3.5571.00
275_K279_P3.3611.00
216_I223_S3.0571.00
111_S241_D2.9071.00
230_V267_V2.8801.00
168_L192_I2.7561.00
211_V246_I2.7371.00
198_A244_I2.6071.00
98_L102_I2.3501.00
209_L232_F2.3161.00
245_H273_I2.2991.00
11_T39_I2.2711.00
8_M46_T2.1870.99
13_F101_G2.1570.99
191_T249_T2.1290.99
189_G249_T2.0470.99
239_K242_E1.9100.99
15_Y39_I1.8440.98
4_L50_A1.8110.98
247_K271_N1.8060.98
169_T172_D1.7940.98
167_S193_E1.7220.97
4_L46_T1.6920.97
247_K269_D1.6810.97
49_Q52_L1.6520.96
191_T268_T1.6340.96
251_A266_K1.6270.96
90_I216_I1.6250.96
192_I274_K1.6220.96
267_V270_W1.6160.96
246_I265_V1.5910.95
168_L278_D1.5880.95
7_L45_L1.5480.95
28_N218_H1.5160.94
208_Q231_E1.5030.94
79_E83_P1.4830.93
155_Q158_N1.4830.93
200_K240_D1.4820.93
211_V230_V1.4810.93
214_F241_D1.4730.93
198_A209_L1.4690.93
253_E264_V1.4470.92
215_G281_V1.4430.92
179_T187_F1.4280.92
249_T268_T1.4070.91
242_E272_T1.3760.90
168_L173_F1.3580.90
103_F247_K1.3500.89
35_S108_T1.3230.88
273_I279_P1.3190.88
185_G252_S1.3120.88
80_Q84_F1.3090.88
80_Q83_P1.2940.87
154_K158_N1.2930.87
25_K35_S1.2900.87
38_A270_W1.2870.87
44_I239_K1.2820.87
82_K85_Y1.2670.86
42_L114_V1.2480.85
6_V277_D1.2290.84
57_P249_T1.2160.84
18_H218_H1.2010.83
238_I244_I1.1950.83
223_S279_P1.1930.83
110_D246_I1.1800.82
166_I199_Y1.1790.82
164_K190_R1.1700.81
5_L12_F1.1580.81
201_G208_Q1.1460.80
230_V238_I1.1460.80
99_V159_K1.1440.80
45_L225_V1.1380.79
179_T183_Y1.1310.79
102_I265_V1.1270.79
177_M228_M1.1250.79
96_F166_I1.1180.78
46_T103_F1.1010.77
34_L54_I1.0980.77
27_I49_Q1.0920.77
111_S181_Y1.0800.76
194_F228_M1.0770.76
157_F161_S1.0760.75
210_F229_L1.0670.75
50_A212_L1.0520.74
100_S278_D1.0510.74
165_E191_T1.0420.73
124_M277_D1.0400.73
11_T93_V1.0400.73
207_N231_E1.0380.73
220_I226_Y1.0240.72
23_L35_S1.0170.71
185_G188_L1.0060.70
14_F226_Y0.9900.69
238_I250_L0.9900.69
27_I173_F0.9820.69
21_G242_E0.9810.68
35_S218_H0.9800.68
14_F35_S0.9780.68
199_Y216_I0.9780.68
31_Y34_L0.9770.68
183_Y187_F0.9680.67
11_T22_N0.9660.67
48_V94_F0.9630.67
48_V103_F0.9600.67
8_M50_A0.9530.66
28_N31_Y0.9470.66
46_T194_F0.9450.66
195_H244_I0.9380.65
244_I261_T0.9380.65
30_K33_Y0.9380.65
98_L215_G0.9360.65
88_Y93_V0.9320.64
219_C222_D0.9310.64
205_N274_K0.9310.64
38_A107_A0.9090.62
13_F98_L0.9040.62
105_P183_Y0.9020.62
236_M246_I0.9010.62
35_S38_A0.8940.61
197_F279_P0.8940.61
232_F235_D0.8890.61
8_M53_F0.8880.61
20_S262_L0.8850.60
4_L54_I0.8850.60
100_S107_A0.8720.59
25_K31_Y0.8670.59
206_K271_N0.8670.59
26_Y262_L0.8660.59
27_I108_T0.8640.59
27_I223_S0.8610.58
180_I189_G0.8530.58
200_K238_I0.8530.58
165_E190_R0.8500.57
46_T94_F0.8500.57
31_Y35_S0.8480.57
21_G277_D0.8460.57
114_V217_I0.8380.56
230_V264_V0.8360.56
36_F96_F0.8350.56
14_F34_L0.8340.56
190_R221_A0.8340.56
100_S104_F0.8320.56
9_G215_G0.8300.55
220_I224_G0.8290.55
17_L27_I0.8250.55
8_M43_A0.8240.55
43_A247_K0.8200.55
215_G226_Y0.8190.54
156_L159_K0.8190.54
169_T274_K0.8030.53
43_A250_L0.7990.53
178_E218_H0.7910.52
31_Y101_G0.7840.51
49_Q118_G0.7830.51
17_L26_Y0.7820.51
199_Y250_L0.7770.51
190_R229_L0.7740.50
209_L230_V0.7650.49
160_Y190_R0.7650.49
44_I237_D0.7640.49
180_I263_P0.7600.49
263_P267_V0.7540.48
215_G265_V0.7520.48
109_L201_G0.7470.48
28_N220_I0.7430.47
5_L164_K0.7420.47
18_H35_S0.7420.47
50_A165_E0.7400.47
15_Y19_A0.7390.47
20_S85_Y0.7340.47
50_A56_S0.7330.47
45_L265_V0.7330.47
36_F39_I0.7310.46
39_I172_D0.7310.46
274_K278_D0.7300.46
7_L190_R0.7280.46
167_S191_T0.7260.46
37_I185_G0.7260.46
244_I249_T0.7240.46
115_K122_K0.7230.46
27_I35_S0.7200.45
206_K274_K0.7200.45
173_F194_F0.7140.45
18_H104_F0.7120.45
166_I191_T0.7080.44
212_L225_V0.7070.44
26_Y109_L0.7060.44
168_L216_I0.7040.44
100_S110_D0.7000.44
111_S214_F0.6980.43
109_L216_I0.6980.43
169_T254_Y0.6940.43
180_I187_F0.6920.43
95_L205_N0.6910.43
203_A246_I0.6900.43
46_T231_E0.6880.42
251_A254_Y0.6850.42
166_I227_G0.6840.42
254_Y257_P0.6810.42
43_A88_Y0.6800.42
91_Y166_I0.6780.42
11_T46_T0.6710.41
41_L58_E0.6710.41
97_P187_F0.6700.41
248_G265_V0.6680.41
164_K247_K0.6670.41
57_P265_V0.6660.41
86_Q158_N0.6650.40
79_E115_K0.6640.40
195_H206_K0.6640.40
221_A276_P0.6630.40
245_H274_K0.6610.40
114_V257_P0.6580.40
173_F277_D0.6530.39
213_R222_D0.6510.39
12_F96_F0.6500.39
168_L177_M0.6460.39
112_S228_M0.6430.38
12_F94_F0.6420.38
97_P221_A0.6410.38
10_F255_Y0.6390.38
17_L248_G0.6390.38
222_D243_W0.6370.38
25_K218_H0.6350.38
30_K227_G0.6350.38
4_L53_F0.6340.38
220_I267_V0.6310.37
31_Y94_F0.6290.37
39_I225_V0.6270.37
83_P98_L0.6250.37
51_Y95_L0.6220.37
23_L27_I0.6210.37
5_L270_W0.6190.36
6_V202_N0.6180.36
22_N25_K0.6140.36
26_Y107_A0.6140.36
25_K40_F0.6130.36
20_S266_K0.6120.36
90_I94_F0.6110.36
217_I240_D0.6080.35
45_L174_L0.6070.35
98_L157_F0.6060.35
55_K206_K0.6050.35
213_R243_W0.6050.35
5_L35_S0.6040.35
4_L16_H0.6030.35
174_L251_A0.6010.35
31_Y272_T0.6000.35
100_S216_I0.5980.35
90_I114_V0.5950.34
99_V225_V0.5950.34
100_S154_K0.5940.34
124_M275_K0.5890.34
16_H22_N0.5880.34
174_L215_G0.5870.34
43_A51_Y0.5860.34
29_M282_Y0.5860.34
166_I190_R0.5850.34
48_V235_D0.5840.33
10_F189_G0.5830.33
25_K225_V0.5810.33
106_I194_F0.5800.33
186_E226_Y0.5800.33
17_L101_G0.5740.33
17_L117_K0.5730.33
238_I242_E0.5720.33
218_H221_A0.5710.32
12_F124_M0.5660.32
198_A233_P0.5640.32
3_R273_I0.5630.32
11_T25_K0.5610.32
3_R190_R0.5610.32
18_H23_L0.5600.32
33_Y218_H0.5590.31
37_I107_A0.5590.31
27_I279_P0.5550.31
194_F269_D0.5530.31
200_K239_K0.5520.31
31_Y87_R0.5510.31
96_F173_F0.5490.31
155_Q272_T0.5490.31
218_H222_D0.5480.31
217_I257_P0.5470.31
189_G244_I0.5460.30
230_V241_D0.5460.30
17_L20_S0.5460.30
168_L265_V0.5440.30
3_R23_L0.5430.30
34_L278_D0.5430.30
31_Y214_F0.5420.30
42_L230_V0.5400.30
34_L225_V0.5360.30
100_S257_P0.5350.30
97_P166_I0.5350.30
6_V19_A0.5330.29
122_K212_L0.5320.29
45_L57_P0.5320.29
91_Y255_Y0.5320.29
174_L212_L0.5310.29
21_G237_D0.5290.29
253_E256_Q0.5270.29
174_L187_F0.5270.29
56_S90_I0.5260.29
216_I279_P0.5260.29
44_I80_Q0.5260.29
163_K166_I0.5250.29
10_F164_K0.5240.29
229_L262_L0.5230.29
23_L225_V0.5220.29
183_Y265_V0.5220.29
106_I220_I0.5210.29
26_Y201_G0.5200.28
31_Y218_H0.5170.28
40_F205_N0.5170.28
4_L216_I0.5160.28
27_I233_P0.5130.28
6_V165_E0.5130.28
28_N32_A0.5120.28
269_D274_K0.5120.28
210_F227_G0.5100.28
44_I57_P0.5090.28
244_I270_W0.5080.28
170_D239_K0.5080.28
154_K264_V0.5060.27
165_E193_E0.5050.27
29_M270_W0.5040.27
99_V266_K0.5040.27
244_I273_I0.5040.27
110_D225_V0.5030.27
16_H19_A0.5030.27
49_Q172_D0.5030.27
202_N237_D0.5030.27
41_L122_K0.5020.27
177_M217_I0.5010.27
37_I218_H0.5010.27
173_F215_G0.5010.27
11_T51_Y0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f2bA 1 0.3509 94.7 0.921 Contact Map
4hspA 3 0.4912 93.8 0.925 Contact Map
1wydA 2 0.3684 91.8 0.93 Contact Map
2xgtA 2 0.3544 90 0.933 Contact Map
4j15A 2 0.4632 89.1 0.934 Contact Map
4pg3A 2 0.4877 88.8 0.934 Contact Map
1n9wA 2 0.3333 88.1 0.935 Contact Map
3k8aA 2 0.3018 87.7 0.935 Contact Map
3nemA 2 0.3789 87.5 0.936 Contact Map
1x54A 2 0.3789 87.3 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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