GREMLIN Database
YCGP - Uncharacterized protein YcgP
UniProt: P94393 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 411 (354)
Sequences: 5787 (4798)
Seq/√Len: 255.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
273_G285_S7.2551.00
359_N369_Q6.1751.00
348_E351_K3.9361.00
385_T391_D3.8911.00
372_I376_T3.5491.00
394_D397_T3.4481.00
359_N366_A2.9601.00
271_G292_V2.9591.00
372_I377_L2.9371.00
341_K345_S2.8831.00
366_A377_L2.8341.00
351_K355_I2.7951.00
358_L369_Q2.7541.00
396_R406_M2.6811.00
274_N288_E2.6701.00
353_L384_I2.6191.00
271_G289_A2.5911.00
355_I359_N2.5791.00
374_Q378_N2.5541.00
18_I31_L2.5411.00
231_I290_L2.5241.00
193_I289_A2.5241.00
354_E358_L2.3311.00
195_H297_E2.3161.00
390_I397_T2.2971.00
385_T392_L2.2861.00
373_H376_T2.2401.00
355_I366_A2.2361.00
365_P368_E2.1971.00
191_V285_S2.1281.00
341_K347_T2.1001.00
15_D19_D2.0871.00
194_L270_I2.0681.00
233_I286_Y2.0541.00
352_T366_A2.0261.00
360_N394_D2.0091.00
278_H281_K2.0061.00
161_K228_E1.9651.00
192_V272_I1.9071.00
296_A307_Y1.8661.00
382_K385_T1.8621.00
382_K386_E1.8391.00
383_Q386_E1.8391.00
131_L135_S1.8311.00
124_T127_E1.8181.00
33_S37_F1.8121.00
352_T377_L1.7751.00
338_L384_I1.7641.00
352_T384_I1.7591.00
363_T378_N1.7411.00
286_Y290_L1.7321.00
390_I400_Q1.7301.00
327_F407_L1.7181.00
364_K378_N1.7141.00
276_Y288_E1.7021.00
399_C402_Y1.6911.00
162_R177_E1.6911.00
159_L178_A1.6681.00
361_C398_R1.6591.00
364_K368_E1.6511.00
356_Y361_C1.6191.00
359_N365_P1.6171.00
283_G287_T1.6161.00
398_R402_Y1.6151.00
385_T393_S1.6141.00
338_L350_L1.5971.00
193_I290_L1.5961.00
384_I388_T1.5751.00
308_E311_K1.5711.00
355_I369_Q1.5691.00
357_L398_R1.5371.00
195_H231_I1.5231.00
22_S42_N1.5231.00
352_T380_R1.5151.00
104_A112_G1.5141.00
271_G293_I1.5011.00
162_R167_Q1.4871.00
276_Y285_S1.4861.00
21_I134_T1.4791.00
349_L384_I1.4581.00
276_Y281_K1.4391.00
285_S289_A1.4311.00
388_T397_T1.4131.00
365_P369_Q1.4101.00
195_H269_Y1.4041.00
274_N310_A1.3681.00
195_H293_I1.3621.00
190_S238_F1.3591.00
101_V113_Y1.3551.00
141_I144_K1.3491.00
334_D337_L1.3481.00
191_V289_A1.3481.00
361_C366_A1.3431.00
383_Q387_M1.3421.00
340_A344_E1.3411.00
86_F90_K1.3411.00
355_I370_L1.3371.00
364_K374_Q1.3301.00
193_I286_Y1.3191.00
362_K377_L1.3051.00
190_S275_E1.2981.00
370_L377_L1.2831.00
191_V235_V1.2761.00
161_K165_Y1.2711.00
272_I308_E1.2691.00
250_E254_K1.2651.00
349_L387_M1.2561.00
13_D141_I1.2531.00
67_F71_L1.2501.00
357_L361_C1.2431.00
375_N378_N1.2381.00
356_Y363_T1.2341.00
350_L354_E1.2331.00
62_C65_Q1.2291.00
211_I214_Y1.2291.00
379_Y383_Q1.2251.00
273_G276_Y1.2211.00
358_L402_Y1.2161.00
31_L114_I1.2091.00
214_Y217_L1.2081.00
292_V296_A1.2031.00
272_I306_P1.1951.00
291_E320_S1.1871.00
313_G316_R1.1801.00
281_K284_K1.1781.00
339_K350_L1.1761.00
150_Q154_E1.1721.00
336_A340_A1.1651.00
191_V273_G1.1641.00
362_K365_P1.1611.00
362_K374_Q1.1551.00
235_V282_L1.1431.00
212_R216_N1.1421.00
150_Q153_E1.1411.00
402_Y406_M1.1341.00
360_N395_F1.1331.00
69_R73_D1.1331.00
363_T381_I1.1281.00
315_Y396_R1.1181.00
349_L352_T1.1071.00
32_E115_W1.1061.00
352_T372_I1.0921.00
26_Q29_V1.0901.00
135_S139_G1.0851.00
271_G288_E1.0831.00
18_I29_V1.0661.00
359_N377_L1.0651.00
251_F259_F1.0631.00
388_T401_L1.0601.00
112_G117_Q1.0421.00
189_F282_L1.0381.00
356_Y381_I1.0311.00
253_N257_T1.0301.00
271_G296_A1.0291.00
85_P88_V1.0281.00
67_F70_F1.0271.00
253_N256_L1.0231.00
130_F134_T1.0221.00
316_R333_K1.0211.00
315_Y406_M1.0161.00
225_L234_V1.0061.00
184_V187_S1.0051.00
64_V68_E1.0041.00
20_F23_Y1.0031.00
66_I69_R0.9991.00
363_T375_N0.9931.00
68_E71_L0.9931.00
317_Y330_Y0.9891.00
191_V286_Y0.9891.00
105_K110_V0.9851.00
193_I233_I0.9841.00
358_L396_R0.9831.00
192_V236_A0.9771.00
312_L316_R0.9741.00
193_I293_I0.9711.00
171_E280_L0.9711.00
292_V309_Y0.9701.00
350_L405_L0.9701.00
29_V116_I0.9691.00
392_L397_T0.9681.00
152_K156_A0.9651.00
379_Y386_E0.9641.00
381_I385_T0.9641.00
341_K349_L0.9641.00
371_F379_Y0.9631.00
70_F73_D0.9581.00
314_I400_Q0.9541.00
250_E253_N0.9541.00
354_E406_M0.9521.00
14_V39_L0.9511.00
334_D400_Q0.9461.00
82_E88_V0.9431.00
353_L357_L0.9391.00
190_S310_A0.9371.00
157_E161_K0.9351.00
104_A107_K0.9341.00
254_K258_H0.9251.00
374_Q382_K0.9241.00
343_E347_T0.9231.00
86_F89_N0.9191.00
332_N340_A0.9191.00
352_T370_L0.9181.00
193_I271_G0.9151.00
69_R72_K0.9151.00
84_E88_V0.9141.00
65_Q68_E0.9141.00
192_V234_V0.9121.00
289_A292_V0.9111.00
13_D16_K0.9101.00
396_R399_C0.9101.00
392_L398_R0.9091.00
104_A138_V0.9081.00
31_L104_A0.9071.00
381_I384_I0.9071.00
314_I403_L0.9071.00
340_A343_E0.9061.00
123_L127_E0.9051.00
324_K328_L0.9001.00
83_P86_F0.8961.00
88_V91_I0.8941.00
18_I22_S0.8901.00
357_L402_Y0.8881.00
63_P66_I0.8851.00
21_I25_L0.8821.00
341_K344_E0.8801.00
269_Y297_E0.8761.00
159_L177_E0.8701.00
144_K148_L0.8631.00
352_T379_Y0.8621.00
83_P87_R0.8600.99
129_D132_Y0.8540.99
313_G330_Y0.8520.99
270_I306_P0.8520.99
101_V115_W0.8460.99
337_L387_M0.8400.99
63_P69_R0.8330.99
129_D135_S0.8310.99
332_N336_A0.8300.99
175_R178_A0.8300.99
276_Y284_K0.8270.99
99_R115_W0.8260.99
385_T389_S0.8240.99
393_S398_R0.8230.99
252_I256_L0.8130.99
28_P42_N0.8120.99
240_Q243_S0.8120.99
31_L40_A0.8120.99
31_L138_V0.8110.99
132_Y135_S0.8110.99
397_T400_Q0.8090.99
66_I70_F0.8080.99
38_L42_N0.8050.99
178_A185_L0.8040.99
22_S28_P0.8040.99
334_D404_D0.8030.99
341_K346_S0.7990.99
276_Y282_L0.7950.99
80_K88_V0.7920.99
395_F402_Y0.7910.99
169_T173_E0.7900.99
288_E329_E0.7870.99
102_V135_S0.7830.99
28_P32_E0.7810.99
385_T388_T0.7810.99
25_L130_F0.7780.99
233_I290_L0.7760.99
29_V114_I0.7750.99
362_K378_N0.7740.99
193_I231_I0.7740.99
20_F24_E0.7680.99
82_E90_K0.7670.99
154_E158_D0.7650.99
355_I358_L0.7650.99
143_Y146_N0.7650.99
131_L134_T0.7640.99
87_R90_K0.7630.99
102_V106_H0.7630.99
265_P268_I0.7600.99
354_E405_L0.7600.99
133_E140_K0.7590.99
395_F398_R0.7580.99
183_T189_F0.7570.99
392_L401_L0.7570.99
208_K214_Y0.7570.99
28_P117_Q0.7550.99
62_C69_R0.7540.99
292_V312_L0.7530.99
172_K176_R0.7520.99
102_V132_Y0.7510.99
356_Y385_T0.7500.99
391_D394_D0.7490.99
18_I40_A0.7480.99
323_Q326_E0.7470.99
25_L28_P0.7470.99
399_C403_L0.7450.99
344_E347_T0.7440.99
185_L279_L0.7440.99
126_E130_F0.7380.98
287_T291_E0.7370.98
16_K20_F0.7360.98
85_P90_K0.7330.98
151_E154_E0.7320.98
17_L28_P0.7320.98
356_Y366_A0.7300.98
360_N398_R0.7280.98
330_Y404_D0.7280.98
84_E87_R0.7280.98
22_S27_K0.7280.98
295_A299_T0.7260.98
33_S39_L0.7260.98
65_Q69_R0.7260.98
330_Y334_D0.7220.98
210_N215_L0.7190.98
166_Q283_G0.7110.98
251_F256_L0.7090.98
63_P73_D0.7070.98
374_Q402_Y0.7010.98
160_I235_V0.7010.98
99_R102_V0.6990.98
132_Y136_F0.6990.98
309_Y316_R0.6960.98
177_E181_I0.6940.98
341_K387_M0.6930.98
159_L163_A0.6920.98
134_T137_H0.6920.98
318_L403_L0.6910.98
292_V307_Y0.6910.98
194_L234_V0.6910.98
82_E86_F0.6890.98
163_A279_L0.6860.98
155_K158_D0.6850.97
27_K127_E0.6850.97
279_L282_L0.6850.97
154_E157_E0.6810.97
30_I36_F0.6790.97
70_F74_G0.6770.97
178_A181_I0.6730.97
97_N104_A0.6720.97
341_K348_E0.6710.97
195_H230_N0.6710.97
126_E129_D0.6710.97
361_C378_N0.6710.97
17_L22_S0.6700.97
134_T138_V0.6650.97
400_Q405_L0.6640.97
331_E336_A0.6630.97
102_V131_L0.6630.97
345_S383_Q0.6590.97
188_M275_E0.6590.97
291_E294_K0.6590.97
284_K288_E0.6590.97
190_S273_G0.6550.97
30_I41_Y0.6550.97
138_V141_I0.6540.97
24_E28_P0.6540.97
32_E99_R0.6530.97
273_G289_A0.6520.97
65_Q72_K0.6510.97
132_Y137_H0.6510.97
348_E383_Q0.6510.97
97_N101_V0.6490.97
385_T390_I0.6490.97
82_E85_P0.6480.97
121_Q127_E0.6480.97
80_K83_P0.6460.96
174_L177_E0.6460.96
399_C406_M0.6430.96
136_F139_G0.6410.96
221_V225_L0.6410.96
32_E41_Y0.6400.96
36_F41_Y0.6400.96
375_N399_C0.6390.96
132_Y139_G0.6390.96
277_N281_K0.6390.96
159_L181_I0.6370.96
132_Y140_K0.6350.96
85_P89_N0.6310.96
330_Y336_A0.6310.96
67_F73_D0.6300.96
133_E136_F0.6290.96
39_L42_N0.6290.96
146_N149_K0.6280.96
396_R400_Q0.6270.96
373_H378_N0.6270.96
313_G333_K0.6260.96
363_T373_H0.6260.96
38_L44_Y0.6250.96
128_L131_L0.6210.96
324_K327_F0.6210.96
296_A301_N0.6190.95
71_L74_G0.6180.95
12_S16_K0.6160.95
213_S217_L0.6160.95
192_V270_I0.6140.95
371_F376_T0.6140.95
332_N404_D0.6120.95
36_F113_Y0.6120.95
191_V233_I0.6100.95
313_G400_Q0.6100.95
209_E212_R0.6100.95
121_Q124_T0.6090.95
65_Q70_F0.6060.95
116_I131_L0.6050.95
130_F140_K0.6050.95
269_Y304_N0.6040.95
83_P89_N0.6030.95
157_E163_A0.6030.95
334_D397_T0.6020.95
68_E72_K0.6020.95
66_I75_I0.6010.95
32_E36_F0.6010.95
81_T87_R0.6000.95
67_F74_G0.5980.95
18_I25_L0.5980.95
14_V138_V0.5980.95
130_F133_E0.5970.95
314_I399_C0.5970.95
192_V252_I0.5960.94
215_L219_D0.5950.94
32_E38_L0.5940.94
209_E213_S0.5930.94
30_I38_L0.5930.94
316_R326_E0.5910.94
310_A333_K0.5890.94
83_P90_K0.5880.94
42_N45_Y0.5880.94
129_D136_F0.5870.94
70_F104_A0.5860.94
333_K337_L0.5850.94
336_A404_D0.5810.94
28_P31_L0.5800.94
197_A269_Y0.5800.94
99_R111_M0.5790.94
243_S250_E0.5780.94
83_P88_V0.5770.93
374_Q379_Y0.5770.93
142_I146_N0.5730.93
269_Y296_A0.5710.93
395_F399_C0.5700.93
316_R320_S0.5690.93
81_T84_E0.5690.93
21_I24_E0.5690.93
288_E309_Y0.5680.93
274_N333_K0.5680.93
255_L259_F0.5650.93
190_S223_H0.5650.93
29_V32_E0.5650.93
31_L36_F0.5650.93
129_D139_G0.5650.93
195_H294_K0.5620.93
28_P40_A0.5590.92
151_E155_K0.5580.92
13_D28_P0.5560.92
357_L381_I0.5550.92
287_T340_A0.5550.92
176_R180_R0.5540.92
137_H140_K0.5540.92
99_R112_G0.5530.92
66_I74_G0.5510.92
363_T377_L0.5500.92
284_K287_T0.5490.92
14_V26_Q0.5480.92
361_C395_F0.5480.92
251_F255_L0.5460.91
318_L407_L0.5450.91
103_S113_Y0.5440.91
29_V99_R0.5430.91
32_E42_N0.5420.91
110_V114_I0.5420.91
161_K226_T0.5410.91
293_I297_E0.5410.91
403_L406_M0.5400.91
174_L184_V0.5400.91
371_F374_Q0.5400.91
38_L41_Y0.5390.91
108_G112_G0.5390.91
311_K314_I0.5380.91
207_L211_I0.5360.91
171_E175_R0.5340.91
97_N105_K0.5330.91
64_V73_D0.5320.90
70_F75_I0.5310.90
62_C67_F0.5300.90
22_S30_I0.5290.90
74_G88_V0.5280.90
210_N213_S0.5280.90
379_Y399_C0.5270.90
390_I401_L0.5270.90
358_L406_M0.5260.90
274_N308_E0.5260.90
82_E89_N0.5250.90
95_G100_V0.5250.90
370_L373_H0.5240.90
227_I230_N0.5240.90
197_A297_E0.5230.90
349_L380_R0.5220.90
12_S21_I0.5220.90
130_F136_F0.5210.90
329_E332_N0.5190.89
196_A208_K0.5190.89
178_A184_V0.5180.89
141_I145_T0.5180.89
334_D390_I0.5170.89
293_I312_L0.5170.89
113_Y117_Q0.5170.89
81_T86_F0.5160.89
115_W118_E0.5160.89
97_N112_G0.5150.89
135_S140_K0.5150.89
295_A316_R0.5140.89
96_L102_V0.5140.89
62_C73_D0.5130.89
218_R254_K0.5130.89
161_K167_Q0.5120.89
153_E212_R0.5120.89
324_K407_L0.5120.89
373_H379_Y0.5120.89
211_I217_L0.5110.89
29_V134_T0.5110.89
36_F40_A0.5100.89
353_L401_L0.5090.88
335_L404_D0.5090.88
320_S326_E0.5080.88
235_V281_K0.5050.88
110_V113_Y0.5040.88
156_A164_I0.5030.88
14_V19_D0.5030.88
292_V362_K0.5020.88
99_R104_A0.5020.88
33_S36_F0.5000.88
134_T140_K0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3onqA 5 0.6156 100 0.439 Contact Map
2gx5A 2 0.3528 98.3 0.86 Contact Map
4eu0A 1 0.6058 97.3 0.888 Contact Map
2w1rA 2 0.2847 96.5 0.899 Contact Map
3e0yA 2 0.3406 95.7 0.906 Contact Map
3ci6A 2 0.3577 95.2 0.91 Contact Map
2qybA 2 0.3358 95.2 0.91 Contact Map
1al3A 1 0 95 0.91 Contact Map
2oolA 2 0.3479 95 0.911 Contact Map
3mz1A 2 0 95 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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