GREMLIN Database
YCGO - Uncharacterized symporter YcgO
UniProt: P94392 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 473 (443)
Sequences: 11434 (7111)
Seq/√Len: 337.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
415_V445_S5.9641.00
346_S349_E4.3081.00
246_S249_E3.9801.00
404_M446_V3.9621.00
342_R349_E3.6101.00
155_V362_S3.3251.00
415_V441_A3.3021.00
186_I190_F3.2091.00
411_A449_V3.1701.00
412_G446_V3.1181.00
197_D200_A3.0901.00
447_F451_I3.0841.00
337_Y345_A3.0511.00
405_T453_T3.0391.00
445_S449_V3.0341.00
82_T247_V3.0321.00
188_T274_G2.9981.00
3_L7_F2.9331.00
419_T441_A2.9241.00
348_K352_F2.8451.00
449_V453_T2.8191.00
407_W453_T2.7591.00
352_F356_L2.7241.00
142_D145_T2.6651.00
408_G450_S2.6441.00
397_L446_V2.5641.00
151_T366_L2.5111.00
356_L360_A2.3881.00
275_G292_I2.3641.00
163_F243_A2.3581.00
98_E109_R2.3551.00
209_M213_F2.3431.00
25_L167_S2.3301.00
16_T23_R2.3191.00
245_T249_E2.2551.00
345_A349_E2.1521.00
411_A445_S2.1361.00
49_G290_E2.1081.00
405_T408_G2.1011.00
407_W411_A2.0901.00
394_V409_A2.0831.00
200_A204_S2.0701.00
401_W404_M2.0521.00
96_F398_S2.0291.00
148_W152_G2.0241.00
17_D22_G2.0231.00
197_D201_E2.0011.00
182_I186_I1.9881.00
107_L410_L1.9661.00
363_I367_V1.9441.00
334_E338_K1.9321.00
408_G449_V1.9271.00
20_L23_R1.9241.00
101_F404_M1.9181.00
248_K252_R1.8991.00
418_A422_I1.8901.00
279_Y299_I1.8871.00
208_D211_N1.8781.00
41_G130_S1.8731.00
90_S99_N1.8641.00
403_R454_Q1.8541.00
444_L448_F1.8421.00
180_A312_A1.8371.00
249_E252_R1.8321.00
405_T450_S1.8111.00
29_V171_F1.7851.00
338_K350_L1.7801.00
397_L443_L1.7791.00
337_Y353_L1.7671.00
342_R345_A1.7651.00
307_G311_S1.7651.00
248_K251_K1.7641.00
161_G165_A1.7351.00
154_V321_I1.7331.00
211_N214_K1.7281.00
295_Q299_I1.7121.00
401_W447_F1.6811.00
27_P249_E1.6771.00
98_E106_K1.6691.00
401_W451_I1.6461.00
352_F355_R1.6391.00
209_M212_I1.6371.00
196_G200_A1.6351.00
408_G412_G1.6221.00
411_A415_V1.5911.00
337_Y342_R1.5781.00
332_L336_L1.5741.00
201_E204_S1.5661.00
32_L171_F1.5601.00
200_A203_R1.5581.00
152_G156_A1.5271.00
325_L362_S1.5211.00
415_V419_T1.5081.00
95_G335_D1.5081.00
403_R451_I1.5061.00
133_V288_D1.4801.00
440_A444_L1.4641.00
203_R206_D1.4561.00
332_L357_A1.4441.00
213_F216_T1.4401.00
30_T244_I1.4361.00
102_G107_L1.4271.00
76_V396_L1.4251.00
102_G406_K1.4201.00
145_T149_I1.4171.00
132_G147_L1.4121.00
14_N17_D1.3981.00
115_V417_A1.3931.00
337_Y349_E1.3901.00
170_D240_R1.3751.00
328_T361_V1.3611.00
349_E352_F1.3491.00
295_Q298_N1.3391.00
154_V318_M1.3321.00
201_E277_A1.3211.00
145_T148_W1.3161.00
95_G334_E1.3141.00
345_A350_L1.3051.00
422_I426_A1.3011.00
106_K339_S1.2961.00
144_H148_W1.2911.00
403_R455_A1.2901.00
21_G25_L1.2781.00
351_V355_R1.2771.00
79_R83_Y1.2701.00
19_M354_G1.2631.00
114_I118_V1.2611.00
100_R398_S1.2581.00
405_T454_Q1.2581.00
147_L366_L1.2491.00
111_F410_L1.2471.00
151_T362_S1.2421.00
98_E339_S1.2391.00
192_T198_T1.2391.00
419_T445_S1.2341.00
332_L337_Y1.2261.00
441_A445_S1.2251.00
96_F100_R1.2111.00
128_M151_T1.2031.00
78_P82_T1.2011.00
169_T322_S1.2001.00
412_G416_G1.1991.00
175_I179_A1.1961.00
4_I172_V1.1941.00
79_R82_T1.1931.00
170_D322_S1.1931.00
131_G150_V1.1931.00
412_G442_S1.1911.00
31_A256_I1.1881.00
92_T330_S1.1791.00
349_E353_L1.1711.00
193_G197_D1.1671.00
106_K110_L1.1661.00
191_H278_Y1.1651.00
37_A323_S1.1571.00
141_M146_G1.1551.00
211_N215_G1.1431.00
187_V191_H1.1341.00
407_W449_V1.1341.00
379_L383_A1.1311.00
108_L410_L1.1261.00
148_W366_L1.1261.00
51_M58_G1.1241.00
112_S413_M1.1241.00
107_L111_F1.1191.00
437_P440_A1.1161.00
443_L447_F1.1131.00
333_V354_G1.1111.00
297_G309_L1.1091.00
195_A199_V1.1091.00
21_G163_F1.1061.00
416_G420_V1.1011.00
33_S323_S1.0981.00
357_A360_A1.0941.00
109_R335_D1.0931.00
173_Q322_S1.0901.00
59_A63_I1.0891.00
136_N143_Y1.0851.00
405_T449_V1.0771.00
179_A183_L1.0711.00
77_A81_R1.0691.00
440_A443_L1.0641.00
124_V365_A1.0631.00
108_L409_A1.0621.00
445_S448_F1.0571.00
333_V353_L1.0571.00
196_G199_V1.0551.00
157_Y322_S1.0521.00
119_F386_G1.0501.00
53_S289_P1.0491.00
157_Y318_M1.0481.00
394_V413_M1.0391.00
407_W452_L1.0351.00
125_S368_L1.0331.00
128_M147_L1.0321.00
406_K410_L1.0311.00
35_G260_W1.0261.00
27_P31_A1.0241.00
183_L187_V1.0211.00
345_A353_L1.0211.00
390_S442_S1.0181.00
203_R207_P1.0121.00
183_L305_I1.0071.00
218_V221_I1.0041.00
404_M450_S1.0031.00
198_T202_I1.0021.00
288_D291_T0.9971.00
274_G278_Y0.9971.00
212_I216_T0.9931.00
341_F345_A0.9901.00
286_L289_P0.9901.00
101_F398_S0.9871.00
294_I297_G0.9841.00
66_C262_I0.9841.00
435_M439_F0.9821.00
353_L357_A0.9821.00
154_V322_S0.9801.00
397_L404_M0.9791.00
209_M214_K0.9761.00
347_D350_L0.9751.00
393_P443_L0.9731.00
19_M330_S0.9711.00
75_Y79_R0.9681.00
114_I336_L0.9671.00
210_F214_K0.9631.00
71_A75_Y0.9621.00
78_P251_K0.9601.00
12_T17_D0.9601.00
354_G358_V0.9591.00
33_S36_A0.9531.00
97_L112_S0.9511.00
332_L361_V0.9501.00
404_M408_G0.9491.00
398_S409_A0.9481.00
414_I418_A0.9421.00
220_G224_L0.9411.00
3_L6_Y0.9391.00
212_I215_G0.9331.00
217_S220_G0.9301.00
199_V203_R0.9281.00
244_I250_I0.9251.00
380_V384_W0.9251.00
107_L406_K0.9191.00
201_E205_V0.9191.00
208_D214_K0.9121.00
416_G442_S0.9121.00
117_L332_L0.9121.00
5_G8_A0.9081.00
170_D323_S0.9071.00
275_G296_L0.9031.00
29_V167_S0.9001.00
111_F413_M0.8981.00
329_S333_V0.8981.00
199_V202_I0.8971.00
208_D212_I0.8961.00
185_P267_G0.8961.00
210_F213_F0.8951.00
360_A364_V0.8941.00
326_L329_S0.8921.00
97_L108_L0.8911.00
407_W454_Q0.8911.00
169_T173_Q0.8891.00
9_Y12_T0.8871.00
448_F451_I0.8861.00
50_A54_T0.8861.00
27_P252_R0.8801.00
7_F10_K0.8781.00
143_Y147_L0.8771.00
37_A170_D0.8701.00
159_L359_L0.8691.00
403_R456_P0.8681.00
194_G197_D0.8671.00
181_L268_A0.8651.00
41_G317_I0.8641.00
198_T274_G0.8641.00
173_Q315_A0.8621.00
397_L447_F0.8611.00
107_L110_L0.8591.00
66_C258_M0.8571.00
64_G68_G0.8561.00
168_W171_F0.8551.00
157_Y173_Q0.8531.00
408_G411_A0.8521.00
297_G306_T0.8511.00
363_I366_L0.8481.00
33_S240_R0.8461.00
115_V413_M0.8451.00
33_S37_A0.8431.00
101_F446_V0.8421.00
33_S167_S0.8421.00
4_I8_A0.8421.00
51_M273_L0.8421.00
157_Y319_S0.8371.00
442_S446_V0.8351.00
102_G457_S0.8331.00
230_G235_P0.8321.00
401_W450_S0.8311.00
141_M149_I0.8311.00
74_L255_R0.8311.00
255_R259_G0.8301.00
405_T455_A0.8291.00
422_I425_N0.8291.00
382_Y424_A0.8271.00
319_S322_S0.8271.00
202_I206_D0.8231.00
32_L174_G0.8231.00
443_L446_V0.8211.00
410_L414_I0.8181.00
337_Y343_R0.8161.00
21_G243_A0.8151.00
166_V169_T0.8131.00
36_A240_R0.8091.00
100_R401_W0.8021.00
208_D213_F0.8021.00
184_V293_F0.8011.00
40_S123_Y0.8011.00
8_A12_T0.8011.00
78_P247_V0.8001.00
337_Y341_F0.8001.00
423_W437_P0.7981.00
210_F215_G0.7971.00
144_H370_W0.7961.00
394_V442_S0.7961.00
441_A444_L0.7951.00
341_F344_S0.7941.00
291_T295_Q0.7941.00
94_P112_S0.7921.00
178_F182_I0.7911.00
184_V188_T0.7911.00
301_F305_I0.7891.00
209_M215_G0.7841.00
25_L30_T0.7831.00
26_G249_E0.7811.00
332_L353_L0.7781.00
448_F452_L0.7761.00
52_F286_L0.7751.00
191_H300_L0.7751.00
192_T277_A0.7741.00
377_L381_S0.7731.00
6_Y9_Y0.7711.00
132_G143_Y0.7701.00
12_T351_V0.7701.00
427_G430_D0.7681.00
356_L359_L0.7671.00
123_Y235_P0.7661.00
304_I308_F0.7641.00
190_F195_A0.7631.00
146_G150_V0.7601.00
106_K109_R0.7571.00
338_K343_R0.7551.00
188_T191_H0.7541.00
374_N378_G0.7541.00
136_N140_G0.7511.00
419_T422_I0.7501.00
244_I249_E0.7491.00
56_L273_L0.7481.00
376_I380_V0.7481.00
358_V362_S0.7461.00
147_L369_A0.7461.00
401_W408_G0.7461.00
173_Q318_M0.7461.00
187_V190_F0.7450.99
110_L340_M0.7420.99
117_L328_T0.7370.99
415_V449_V0.7370.99
27_P256_I0.7350.99
452_L455_A0.7350.99
81_R247_V0.7330.99
6_Y160_F0.7330.99
198_T201_E0.7310.99
61_I65_L0.7310.99
229_L392_G0.7290.99
381_S385_A0.7280.99
439_F442_S0.7270.99
453_T456_P0.7260.99
434_E438_G0.7240.99
192_T197_D0.7220.99
205_V276_I0.7210.99
218_V222_I0.7210.99
83_Y90_S0.7200.99
131_G317_I0.7200.99
157_Y165_A0.7190.99
271_T296_L0.7190.99
5_G9_Y0.7170.99
18_Y358_V0.7170.99
258_M262_I0.7170.99
133_V136_N0.7160.99
95_G99_N0.7160.99
381_S384_W0.7150.99
416_G419_T0.7140.99
92_T335_D0.7140.99
205_V209_M0.7130.99
111_F414_I0.7120.99
75_Y78_P0.7120.99
259_G263_L0.7110.99
206_D209_M0.7110.99
127_G320_T0.7110.99
444_L447_F0.7100.99
419_T423_W0.7090.99
198_T277_A0.7090.99
173_Q319_S0.7090.99
148_W363_I0.7050.99
166_V323_S0.7040.99
52_F281_Q0.7040.99
329_S358_V0.7030.99
454_Q457_S0.7020.99
286_L295_Q0.7010.99
236_H239_V0.6990.99
436_I440_A0.6990.99
420_V438_G0.6980.99
438_G442_S0.6970.99
411_A414_I0.6960.99
7_F11_R0.6960.99
429_S437_P0.6960.99
189_F270_L0.6940.99
447_F450_S0.6930.99
163_F167_S0.6920.99
8_A168_W0.6920.99
271_T293_F0.6920.99
218_V223_S0.6910.99
91_I95_G0.6900.99
110_L114_I0.6870.99
340_M343_R0.6860.99
44_L309_L0.6840.99
133_V290_E0.6840.99
276_I292_I0.6830.99
296_L300_L0.6820.99
127_G321_I0.6820.99
182_I185_P0.6810.99
77_A250_I0.6800.99
276_I280_H0.6800.99
401_W405_T0.6790.99
219_L223_S0.6790.99
202_I205_V0.6760.99
36_A173_Q0.6730.99
13_S17_D0.6710.99
43_L265_A0.6710.99
173_Q320_T0.6710.99
44_L181_L0.6690.99
220_G223_S0.6680.99
417_A421_I0.6670.99
405_T409_A0.6670.99
409_A416_G0.6660.99
94_P116_I0.6650.99
329_S357_A0.6640.99
129_V133_V0.6630.99
158_T322_S0.6620.99
227_W230_G0.6610.99
70_W74_L0.6590.99
320_T324_Q0.6590.99
197_D277_A0.6580.99
52_F292_I0.6580.99
291_T294_I0.6570.99
183_L186_I0.6560.99
50_A58_G0.6550.99
371_E374_N0.6550.99
421_I425_N0.6550.99
26_G29_V0.6540.99
101_F409_A0.6540.99
18_Y355_R0.6510.99
28_A32_L0.6490.99
17_D164_L0.6480.99
108_L112_S0.6480.99
189_F198_T0.6470.99
432_L436_I0.6470.99
155_V359_L0.6470.99
252_R256_I0.6460.99
324_Q327_V0.6460.99
38_D384_W0.6440.99
403_R406_K0.6440.99
221_I224_L0.6420.99
6_Y10_K0.6410.98
191_H195_A0.6390.98
333_V337_Y0.6390.98
397_L401_W0.6370.98
135_F146_G0.6370.98
404_M412_G0.6370.98
62_V69_A0.6370.98
102_G108_L0.6370.98
209_M216_T0.6350.98
110_L113_G0.6340.98
228_G235_P0.6340.98
116_I331_S0.6320.98
195_A198_T0.6300.98
318_M322_S0.6290.98
189_F194_G0.6280.98
188_T300_L0.6280.98
424_A434_E0.6270.98
10_K13_S0.6250.98
128_M165_A0.6240.98
68_G72_N0.6240.98
429_S432_L0.6230.98
350_L354_G0.6220.98
109_R339_S0.6220.98
359_L363_I0.6220.98
164_L168_W0.6220.98
338_K347_D0.6210.98
40_S44_L0.6210.98
227_W234_Q0.6200.98
366_L369_A0.6200.98
80_L238_I0.6200.98
380_V383_A0.6190.98
298_N306_T0.6190.98
245_T248_K0.6180.98
11_R164_L0.6170.98
231_Y235_P0.6160.98
206_D210_F0.6150.98
5_G10_K0.6130.98
68_G228_G0.6120.98
227_W231_Y0.6090.98
15_L19_M0.6090.98
61_I64_G0.6070.98
33_S170_D0.6060.98
419_T438_G0.6060.98
344_S349_E0.6030.98
181_L267_G0.5990.98
418_A421_I0.5970.98
123_Y324_Q0.5950.98
279_Y295_Q0.5940.98
97_L394_V0.5940.98
28_A171_F0.5930.97
269_V273_L0.5920.97
241_F254_R0.5910.97
124_V321_I0.5910.97
170_D319_S0.5910.97
50_A53_S0.5910.97
29_V168_W0.5900.97
202_I273_L0.5890.97
289_P292_I0.5890.97
167_S170_D0.5880.97
25_L243_A0.5870.97
433_Y437_P0.5870.97
31_A35_G0.5870.97
23_R81_R0.5870.97
148_W151_T0.5860.97
155_V159_L0.5810.97
30_T33_S0.5800.97
431_F435_M0.5800.97
14_N22_G0.5800.97
136_N142_D0.5800.97
333_V357_A0.5790.97
404_M409_A0.5790.97
286_L291_T0.5780.97
77_A80_L0.5780.97
364_V367_V0.5770.97
380_V388_G0.5760.97
38_D65_L0.5760.97
393_P446_V0.5760.97
389_A393_P0.5760.97
35_G174_G0.5760.97
61_I68_G0.5750.97
133_V137_S0.5750.97
278_Y296_L0.5740.97
325_L358_V0.5730.97
36_A174_G0.5720.97
333_V350_L0.5720.97
211_N216_T0.5700.97
72_N77_A0.5690.97
355_R358_V0.5690.97
66_C69_A0.5690.97
151_T369_A0.5680.97
185_P270_L0.5670.97
35_G264_S0.5670.97
365_A369_A0.5650.97
65_L68_G0.5650.97
90_S96_F0.5650.97
8_A11_R0.5640.97
141_M145_T0.5640.97
338_K344_S0.5630.97
449_V452_L0.5620.97
179_A182_I0.5610.97
408_G445_S0.5600.96
109_R113_G0.5590.96
392_G396_L0.5590.96
37_A236_H0.5580.96
132_G146_G0.5580.96
189_F195_A0.5570.96
337_Y340_M0.5560.96
137_S291_T0.5560.96
52_F276_I0.5540.96
37_A240_R0.5540.96
57_S60_W0.5530.96
66_C70_W0.5520.96
166_V326_L0.5520.96
207_P210_F0.5520.96
166_V240_R0.5500.96
93_I395_V0.5500.96
184_V309_L0.5480.96
189_F193_G0.5480.96
240_R323_S0.5470.96
101_F397_L0.5470.96
217_S224_L0.5460.96
129_V143_Y0.5460.96
192_T201_E0.5460.96
285_T288_D0.5460.96
47_L51_M0.5450.96
401_W452_L0.5450.96
413_M416_G0.5450.96
422_I427_G0.5440.96
426_A429_S0.5420.96
281_Q285_T0.5420.96
42_W380_V0.5420.96
342_R347_D0.5420.96
451_I454_Q0.5410.96
122_F383_A0.5390.96
26_G30_T0.5390.96
46_G123_Y0.5390.96
202_I276_I0.5380.96
112_S391_F0.5380.96
67_L225_F0.5370.96
403_R407_W0.5370.96
376_I379_L0.5370.96
37_A158_T0.5360.95
115_V390_S0.5350.95
9_Y160_F0.5340.95
204_S207_P0.5330.95
303_P306_T0.5310.95
49_G289_P0.5300.95
255_R258_M0.5290.95
329_S354_G0.5280.95
281_Q286_L0.5280.95
273_L277_A0.5270.95
281_Q287_K0.5270.95
302_H305_I0.5260.95
38_D261_M0.5260.95
127_G130_S0.5240.95
16_T91_I0.5230.95
198_T273_L0.5220.95
64_G69_A0.5210.95
116_I391_F0.5190.95
324_Q391_F0.5190.95
40_S127_G0.5180.95
387_F391_F0.5170.95
247_V251_K0.5170.95
232_F235_P0.5160.94
385_A420_V0.5150.94
15_L18_Y0.5150.94
76_V80_L0.5130.94
91_I334_E0.5120.94
181_L264_S0.5110.94
239_V327_V0.5110.94
207_P211_N0.5100.94
73_W77_A0.5100.94
236_H327_V0.5100.94
311_S315_A0.5100.94
157_Y161_G0.5090.94
30_T253_A0.5090.94
411_A453_T0.5090.94
187_V300_L0.5090.94
35_G39_M0.5090.94
15_L350_L0.5090.94
137_S295_Q0.5080.94
147_L151_T0.5080.94
343_R346_S0.5080.94
261_M265_A0.5070.94
301_F304_I0.5060.94
202_I209_M0.5060.94
110_L336_L0.5050.94
403_R450_S0.5020.94
127_G324_Q0.5020.94
412_G415_V0.5010.94
227_W235_P0.5010.94
21_G24_S0.5000.94
316_A319_S0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9408 100 0.224 Contact Map
3dh4A 3 0.9239 100 0.236 Contact Map
3l1lA 2 0.8541 99.4 0.839 Contact Map
3giaA 1 0.8774 99.2 0.855 Contact Map
4wgvA 2 0.778 99.2 0.855 Contact Map
2jlnA 1 0.8668 99 0.87 Contact Map
4djkA 2 0.8393 98.7 0.884 Contact Map
4c7rA 3 0.871 97.2 0.918 Contact Map
2wswA 3 0.797 96.1 0.928 Contact Map
4us3A 1 0.8245 94.9 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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