ROCA2 - BACSU - GREMLIN Contacts

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ROCA2 - 1-pyrroline-5-carboxylate dehydrogenase 2

UniProt:	P94391	Sequences: MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGERVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLFRAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSREGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFVEVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPGQQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYDQVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDDSKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVITNNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQAKTISEMF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	515 (462)
Sequences:	36068 (21791)
Seq/√Len:	1013.8

ECOLI - PUUC GABD ALDB ABDH FEAB BETB ALDA ASTD PUTA EUTE SAD PAAZ PROA
BACSU - ROCA2 ROCA ALDH4 ALDH1 ALDH5 IOLA BETB ALDY GABD ALDH3 ALDH2 PROA
HALSA - Q9HQZ2 Q9HMJ6 Q9HRB5 Q9HR91
SULSO - Q97YT9 KGSDH GAPN Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
330_E	428_S	5.281	1.00
330_E	426_K	3.293	1.00
268_E	278_Q	3.280	1.00
302_E	339_R	3.190	1.00
407_D	410_A	2.889	1.00
333_Y	426_K	2.883	1.00
297_E	329_H	2.800	1.00
389_T	399_K	2.773	1.00
59_D	62_E	2.743	1.00
83_A	250_K	2.722	1.00
365_Q	369_D	2.686	1.00
53_V	66_R	2.660	1.00
337_L	424_F	2.603	1.00
109_R	142_E	2.566	1.00
306_Q	343_I	2.520	1.00
377_I	411_R	2.501	1.00
375_I	398_I	2.456	1.00
376_E	380_Q	2.422	1.00
216_K	219_E	2.413	1.00
297_E	331_K	2.403	1.00
83_A	252_S	2.394	1.00
111_R	114_E	2.372	1.00
42_N	84_K	2.292	1.00
383_R	405_D	2.214	1.00
71_S	74_H	2.198	1.00
450_T	456_I	2.185	1.00
362_V	371_I	2.177	1.00
39_L	70_A	2.158	1.00
104_A	221_L	2.145	1.00
53_V	63_V	2.143	1.00
372_M	390_G	2.054	1.00
430_F	455_H	2.052	1.00
372_M	376_E	2.044	1.00
377_I	381_E	2.042	1.00
112_K	135_A	2.041	1.00
222_E	228_K	2.027	1.00
170_T	509_K	2.011	1.00
341_I	345_E	1.955	1.00
100_V	226_L	1.942	1.00
209_A	364_D	1.938	1.00
107_K	223_E	1.933	1.00
243_D	247_D	1.916	1.00
327_V	433_A	1.892	1.00
403_F	412_L	1.888	1.00
293_V	308_I	1.878	1.00
372_M	398_I	1.874	1.00
430_F	458_R	1.867	1.00
458_R	462_E	1.862	1.00
441_E	489_M	1.862	1.00
247_D	269_R	1.855	1.00
298_D	455_H	1.822	1.00
335_Q	339_R	1.817	1.00
169_Y	506_M	1.815	1.00
114_E	216_K	1.812	1.00
113_H	131_D	1.811	1.00
40_V	222_E	1.808	1.00
107_K	224_S	1.801	1.00
169_Y	503_A	1.799	1.00
385_V	404_A	1.795	1.00
464_H	488_K	1.781	1.00
327_V	436_V	1.778	1.00
329_H	427_V	1.765	1.00
379_K	384_L	1.765	1.00
80_Q	250_K	1.741	1.00
107_K	220_V	1.730	1.00
46_V	77_Q	1.729	1.00
76_E	244_Y	1.724	1.00
344_T	402_I	1.717	1.00
265_R	268_E	1.701	1.00
408_P	436_V	1.700	1.00
264_T	489_M	1.680	1.00
107_K	110_R	1.676	1.00
308_I	336_V	1.668	1.00
111_R	223_E	1.660	1.00
86_F	90_R	1.655	1.00
411_R	415_E	1.647	1.00
326_A	422_V	1.629	1.00
413_M	425_C	1.628	1.00
218_V	233_F	1.624	1.00
76_E	80_Q	1.617	1.00
341_I	385_V	1.616	1.00
384_L	403_F	1.609	1.00
201_T	230_V	1.603	1.00
301_I	339_R	1.592	1.00
118_L	216_K	1.584	1.00
432_E	435_E	1.582	1.00
102_F	142_E	1.576	1.00
106_A	142_E	1.565	1.00
338_E	342_E	1.562	1.00
313_F	344_T	1.560	1.00
334_D	426_K	1.560	1.00
333_Y	337_L	1.559	1.00
237_S	240_E	1.556	1.00
141_M	193_V	1.553	1.00
431_D	462_E	1.536	1.00
106_A	110_R	1.532	1.00
297_E	455_H	1.525	1.00
76_E	248_H	1.523	1.00
383_R	404_A	1.503	1.00
428_S	432_E	1.478	1.00
373_S	411_R	1.473	1.00
446_G	465_V	1.468	1.00
93_S	96_E	1.460	1.00
109_R	138_I	1.449	1.00
102_F	149_I	1.428	1.00
365_Q	396_Y	1.423	1.00
63_V	66_R	1.417	1.00
155_K	499_P	1.410	1.00
305_A	339_R	1.408	1.00
376_E	379_K	1.406	1.00
339_R	342_E	1.406	1.00
120_V	130_A	1.401	1.00
327_V	427_V	1.398	1.00
96_E	99_A	1.398	1.00
307_S	449_I	1.391	1.00
219_E	223_E	1.391	1.00
308_I	326_A	1.387	1.00
113_H	117_A	1.385	1.00
147_Q	150_E	1.383	1.00
335_Q	338_E	1.382	1.00
62_E	394_K	1.378	1.00
374_Y	417_I	1.376	1.00
44_E	228_K	1.369	1.00
296_D	455_H	1.367	1.00
103_R	106_A	1.365	1.00
296_D	427_V	1.365	1.00
177_V	202_V	1.360	1.00
141_M	189_A	1.358	1.00
328_V	336_V	1.358	1.00
105_A	142_E	1.353	1.00
60_K	394_K	1.349	1.00
74_H	77_Q	1.349	1.00
333_Y	404_A	1.349	1.00
343_I	346_S	1.338	1.00
86_F	201_T	1.337	1.00
381_E	411_R	1.327	1.00
117_A	121_K	1.318	1.00
91_Y	462_E	1.314	1.00
218_V	231_V	1.310	1.00
117_A	353_D	1.308	1.00
51_K	66_R	1.304	1.00
79_I	248_H	1.293	1.00
56_N	59_D	1.288	1.00
267_F	492_T	1.288	1.00
111_R	216_K	1.286	1.00
429_D	432_E	1.283	1.00
434_L	459_A	1.278	1.00
168_V	461_Q	1.275	1.00
368_Y	398_I	1.274	1.00
371_I	419_G	1.271	1.00
342_E	345_E	1.271	1.00
432_E	436_V	1.270	1.00
221_L	231_V	1.266	1.00
345_E	386_S	1.265	1.00
115_F	216_K	1.263	1.00
348_V	356_D	1.259	1.00
253_L	284_I	1.246	1.00
378_G	403_F	1.242	1.00
427_V	436_V	1.238	1.00
369_D	373_S	1.229	1.00
188_M	204_L	1.228	1.00
40_V	45_R	1.226	1.00
296_D	459_A	1.224	1.00
92_T	96_E	1.221	1.00
55_I	63_V	1.204	1.00
105_A	109_R	1.203	1.00
347_K	359_M	1.200	1.00
127_W	131_D	1.197	1.00
208_S	237_S	1.197	1.00
368_Y	372_M	1.196	1.00
368_Y	390_G	1.195	1.00
334_D	338_E	1.189	1.00
337_L	341_I	1.187	1.00
329_H	332_V	1.184	1.00
414_Q	439_N	1.181	1.00
104_A	220_V	1.177	1.00
155_K	500_D	1.171	1.00
329_H	429_D	1.160	1.00
166_Q	457_E	1.158	1.00
192_T	231_V	1.157	1.00
75_A	241_V	1.155	1.00
104_A	226_L	1.149	1.00
104_A	141_M	1.148	1.00
79_I	250_K	1.147	1.00
169_Y	508_A	1.142	1.00
500_D	503_A	1.141	1.00
350_A	357_V	1.140	1.00
365_Q	368_Y	1.138	1.00
340_V	422_V	1.138	1.00
351_K	354_S	1.134	1.00
243_D	269_R	1.131	1.00
336_V	340_V	1.131	1.00
294_V	433_A	1.130	1.00
446_G	468_L	1.129	1.00
103_R	107_K	1.124	1.00
381_E	410_A	1.123	1.00
408_P	439_N	1.123	1.00
208_S	239_A	1.122	1.00
111_R	220_V	1.118	1.00
120_V	352_P	1.118	1.00
342_E	346_S	1.118	1.00
414_Q	441_E	1.113	1.00
176_V	245_L	1.111	1.00
69_K	237_S	1.111	1.00
56_N	351_K	1.111	1.00
177_V	255_T	1.108	1.00
409_K	414_Q	1.105	1.00
348_V	358_Y	1.103	1.00
80_Q	84_K	1.102	1.00
456_I	470_F	1.102	1.00
243_D	265_R	1.101	1.00
117_A	127_W	1.100	1.00
262_V	265_R	1.099	1.00
294_V	459_A	1.097	1.00
499_P	503_A	1.095	1.00
460_K	511_I	1.092	1.00
332_V	335_Q	1.089	1.00
244_Y	248_H	1.088	1.00
337_L	385_V	1.085	1.00
371_I	421_V	1.078	1.00
58_A	352_P	1.077	1.00
92_T	100_V	1.076	1.00
290_K	324_S	1.063	1.00
110_R	223_E	1.063	1.00
115_F	220_V	1.062	1.00
434_L	462_E	1.056	1.00
379_K	403_F	1.046	1.00
65_G	212_V	1.043	1.00
183_F	319_K	1.042	1.00
500_D	508_A	1.042	1.00
341_I	386_S	1.040	1.00
431_D	458_R	1.040	1.00
373_S	377_I	1.038	1.00
391_D	399_K	1.038	1.00
345_E	399_K	1.037	1.00
292_T	446_G	1.037	1.00
430_F	459_A	1.036	1.00
79_I	251_T	1.036	1.00
267_F	283_V	1.031	1.00
293_V	323_G	1.027	1.00
265_R	269_R	1.027	1.00
300_D	451_N	1.023	1.00
215_A	233_F	1.022	1.00
337_L	404_A	1.022	1.00
229_G	232_N	1.021	1.00
387_G	401_T	1.020	1.00
264_T	280_L	1.017	1.00
387_G	399_K	1.015	1.00
85_A	201_T	1.015	1.00
102_F	146_R	1.014	1.00
294_V	437_A	1.009	1.00
87_E	435_E	1.006	1.00
72_Q	244_Y	1.005	1.00
339_R	343_I	1.004	1.00
112_K	131_D	1.001	1.00
52_I	69_K	1.001	1.00
176_V	251_T	0.998	1.00
172_T	253_L	0.998	1.00
60_K	396_Y	0.993	1.00
368_Y	396_Y	0.991	1.00
215_A	235_P	0.990	1.00
87_E	91_Y	0.990	1.00
261_E	265_R	0.990	1.00
192_T	202_V	0.989	1.00
452_N	455_H	0.988	1.00
334_D	337_L	0.984	1.00
137_A	189_A	0.983	1.00
431_D	435_E	0.971	1.00
174_V	251_T	0.959	1.00
87_E	464_H	0.956	1.00
40_V	218_V	0.951	1.00
168_V	511_I	0.951	1.00
42_N	81_A	0.950	1.00
259_S	262_V	0.950	1.00
56_N	121_K	0.949	1.00
252_S	464_H	0.945	1.00
406_L	410_A	0.942	1.00
81_A	232_N	0.938	1.00
44_E	77_Q	0.934	1.00
427_V	433_A	0.932	1.00
374_Y	377_I	0.931	1.00
485_G	494_S	0.929	1.00
267_F	271_A	0.927	1.00
300_D	303_L	0.925	1.00
447_A	473_N	0.925	1.00
388_G	401_T	0.922	1.00
69_K	240_E	0.922	1.00
433_A	436_V	0.921	1.00
305_A	340_V	0.921	1.00
170_T	461_Q	0.917	1.00
494_S	507_Q	0.916	1.00
296_D	430_F	0.914	1.00
377_I	380_Q	0.911	1.00
302_E	335_Q	0.910	1.00
247_D	278_Q	0.910	1.00
111_R	219_E	0.909	1.00
172_T	282_R	0.908	1.00
125_K	133_D	0.906	1.00
148_M	197_V	0.905	1.00
98_A	149_I	0.902	1.00
487_F	507_Q	0.900	1.00
374_Y	411_R	0.899	1.00
311_S	323_G	0.899	1.00
408_P	425_C	0.896	1.00
295_V	336_V	0.893	1.00
448_V	459_A	0.889	1.00
56_N	62_E	0.889	1.00
98_A	145_A	0.889	1.00
312_A	324_S	0.888	1.00
378_G	417_I	0.887	1.00
425_C	436_V	0.887	1.00
90_R	464_H	0.886	1.00
305_A	343_I	0.884	1.00
121_K	353_D	0.883	1.00
108_V	137_A	0.882	1.00
226_L	231_V	0.879	1.00
282_R	507_Q	0.879	1.00
174_V	201_T	0.879	1.00
304_A	308_I	0.877	1.00
333_Y	424_F	0.876	1.00
172_T	200_N	0.875	1.00
427_V	432_E	0.874	1.00
83_A	87_E	0.872	1.00
219_E	222_E	0.867	1.00
254_I	266_I	0.867	1.00
105_A	145_A	0.866	1.00
39_L	235_P	0.866	1.00
305_A	336_V	0.862	1.00
165_N	482_H	0.862	1.00
75_A	176_V	0.859	1.00
72_Q	240_E	0.858	1.00
305_A	309_F	0.854	1.00
50_A	71_S	0.854	1.00
114_E	117_A	0.852	1.00
301_I	305_A	0.850	1.00
85_A	230_V	0.847	1.00
369_D	372_M	0.843	1.00
371_I	417_I	0.843	1.00
435_E	439_N	0.843	1.00
102_F	145_A	0.842	1.00
123_A	210_T	0.841	1.00
175_T	253_L	0.839	1.00
49_E	77_Q	0.838	1.00
94_P	98_A	0.837	1.00
170_T	487_F	0.833	1.00
333_Y	405_D	0.830	1.00
108_V	138_I	0.826	1.00
382_G	410_A	0.826	1.00
309_F	343_I	0.826	1.00
176_V	254_I	0.825	1.00
293_V	449_I	0.825	1.00
204_L	214_A	0.822	1.00
375_I	421_V	0.822	1.00
446_G	463_F	0.821	1.00
296_D	450_T	0.821	1.00
304_A	336_V	0.820	1.00
267_F	280_L	0.819	1.00
303_L	307_S	0.818	1.00
98_A	102_F	0.817	1.00
239_A	243_D	0.817	1.00
172_T	507_Q	0.814	1.00
72_Q	76_E	0.813	1.00
101_L	197_V	0.810	1.00
99_A	103_R	0.810	1.00
254_I	270_A	0.810	1.00
434_L	438_N	0.809	1.00
137_A	185_F	0.808	1.00
291_D	324_S	0.807	1.00
309_F	340_V	0.806	1.00
103_R	224_S	0.804	1.00
209_A	366_G	0.802	1.00
55_I	396_Y	0.802	1.00
48_T	74_H	0.800	1.00
405_D	426_K	0.797	1.00
373_S	376_E	0.796	1.00
39_L	68_S	0.796	1.00
52_I	237_S	0.795	1.00
482_H	510_T	0.795	1.00
107_K	111_R	0.794	1.00
403_F	406_L	0.794	1.00
73_E	76_E	0.793	1.00
49_E	71_S	0.790	1.00
84_K	87_E	0.789	1.00
246_V	266_I	0.788	1.00
91_Y	461_Q	0.786	1.00
267_F	270_A	0.785	1.00
188_M	192_T	0.785	1.00
371_I	398_I	0.781	1.00
453_R	456_I	0.778	1.00
349_T	391_D	0.778	1.00
292_T	437_A	0.773	1.00
263_G	287_M	0.772	1.00
264_T	268_E	0.768	1.00
58_A	397_F	0.766	1.00
296_D	329_H	0.763	1.00
48_T	51_K	0.762	1.00
457_E	461_Q	0.759	1.00
256_F	262_V	0.757	1.00
120_V	127_W	0.755	1.00
42_N	228_K	0.752	1.00
89_W	230_V	0.751	1.00
77_Q	81_A	0.751	1.00
177_V	191_T	0.749	1.00
347_K	358_Y	0.748	1.00
123_A	363_I	0.747	1.00
189_A	217_F	0.747	1.00
116_S	131_D	0.746	1.00
429_D	435_E	0.744	1.00
45_R	222_E	0.744	1.00
73_E	77_Q	0.743	1.00
263_G	285_A	0.741	1.00
116_S	127_W	0.739	1.00
375_I	403_F	0.739	1.00
200_N	506_M	0.739	1.00
116_S	120_V	0.739	1.00
115_F	185_F	0.736	1.00
194_A	501_Y	0.735	1.00
340_V	402_I	0.735	1.00
81_A	229_G	0.734	1.00
246_V	269_R	0.734	1.00
82_A	232_N	0.732	1.00
49_E	73_E	0.731	1.00
128_N	358_Y	0.730	1.00
102_F	106_A	0.729	1.00
368_Y	391_D	0.728	1.00
374_Y	415_E	0.726	1.00
127_W	353_D	0.725	1.00
338_E	341_I	0.721	1.00
198_T	506_M	0.720	1.00
46_V	74_H	0.720	1.00
379_K	389_T	0.720	1.00
119_L	122_E	0.720	1.00
87_E	90_R	0.718	1.00
465_V	468_L	0.718	1.00
95_E	149_I	0.716	1.00
176_V	242_G	0.714	1.00
329_H	430_F	0.713	1.00
125_K	129_E	0.712	1.00
341_I	344_T	0.712	1.00
70_A	74_H	0.711	1.00
203_V	232_N	0.710	1.00
75_A	79_I	0.710	1.00
365_Q	390_G	0.709	1.00
165_N	510_T	0.709	1.00
206_P	235_P	0.708	1.00
351_K	357_V	0.707	1.00
236_G	241_V	0.707	1.00
386_S	402_I	0.707	1.00
236_G	242_G	0.705	1.00
159_S	165_N	0.704	1.00
77_Q	80_Q	0.703	1.00
201_T	232_N	0.702	1.00
188_M	214_A	0.700	1.00
185_F	213_I	0.694	1.00
328_V	332_V	0.694	1.00
195_P	202_V	0.694	1.00
84_K	88_E	0.694	1.00
131_D	135_A	0.692	1.00
191_T	495_K	0.691	1.00
270_A	283_V	0.690	1.00
48_T	68_S	0.688	1.00
88_E	92_T	0.688	1.00
430_F	434_L	0.688	1.00
75_A	244_Y	0.688	1.00
302_E	343_I	0.687	1.00
49_E	74_H	0.687	1.00
264_T	278_Q	0.685	1.00
56_N	353_D	0.685	1.00
64_V	121_K	0.682	1.00
226_L	230_V	0.680	1.00
246_V	254_I	0.680	1.00
301_I	332_V	0.679	1.00
76_E	250_K	0.678	1.00
70_A	234_V	0.678	1.00
239_A	265_R	0.677	1.00
327_V	408_P	0.676	1.00
215_A	219_E	0.676	1.00
344_T	347_K	0.675	1.00
60_K	365_Q	0.674	1.00
354_S	357_V	0.673	1.00
460_K	470_F	0.671	1.00
118_L	212_V	0.671	1.00
55_I	60_K	0.671	1.00
406_L	413_M	0.668	1.00
349_T	359_M	0.668	1.00
70_A	78_A	0.667	1.00
408_P	413_M	0.666	1.00
298_D	450_T	0.666	1.00
344_T	386_S	0.665	1.00
260_R	489_M	0.664	1.00
109_R	135_A	0.663	1.00
89_W	100_V	0.663	1.00
218_V	222_E	0.663	1.00
204_L	231_V	0.662	1.00
268_E	271_A	0.662	1.00
100_V	224_S	0.661	1.00
340_V	424_F	0.659	1.00
282_R	504_L	0.658	1.00
388_G	399_K	0.655	1.00
326_A	336_V	0.655	1.00
372_M	375_I	0.655	1.00
208_S	370_K	0.653	1.00
366_G	369_D	0.650	1.00
240_E	243_D	0.650	1.00
398_I	401_T	0.650	1.00
209_A	363_I	0.649	1.00
341_I	402_I	0.646	1.00
327_V	413_M	0.646	1.00
308_I	340_V	0.645	1.00
94_P	148_M	0.645	1.00
109_R	112_K	0.642	1.00
436_V	439_N	0.642	1.00
42_N	232_N	0.642	1.00
67_V	211_P	0.642	1.00
221_L	226_L	0.640	1.00
381_E	409_K	0.640	1.00
309_F	347_K	0.640	1.00
90_R	170_T	0.639	1.00
451_N	454_K	0.638	1.00
364_D	367_S	0.637	1.00
83_A	86_F	0.637	1.00
90_R	462_E	0.637	1.00
367_S	370_K	0.633	1.00
125_K	183_F	0.633	1.00
450_T	455_H	0.633	1.00
121_K	212_V	0.632	1.00
100_V	225_G	0.632	1.00
316_A	359_M	0.631	1.00
172_T	252_S	0.626	1.00
88_E	91_Y	0.625	1.00
284_I	504_L	0.622	1.00
106_A	109_R	0.620	1.00
68_S	235_P	0.620	1.00
164_K	457_E	0.619	1.00
42_N	77_Q	0.619	1.00
216_K	220_V	0.618	1.00
366_G	370_K	0.618	1.00
107_K	225_G	0.617	1.00
372_M	379_K	0.616	1.00
417_I	421_V	0.616	1.00
384_L	401_T	0.615	1.00
80_Q	83_A	0.615	1.00
453_R	457_E	0.614	1.00
242_G	246_V	0.610	1.00
295_V	304_A	0.609	1.00
246_V	279_H	0.609	1.00
166_Q	511_I	0.608	1.00
188_M	217_F	0.607	1.00
108_V	217_F	0.606	1.00
456_I	460_K	0.606	1.00
113_H	127_W	0.606	1.00
267_F	285_A	0.604	1.00
94_P	197_V	0.604	1.00
362_V	367_S	0.604	1.00
131_D	355_A	0.603	1.00
134_T	138_I	0.603	1.00
120_V	353_D	0.602	1.00
503_A	506_M	0.601	1.00
192_T	204_L	0.601	1.00
293_V	326_A	0.600	1.00
464_H	487_F	0.599	1.00
406_L	412_L	0.598	1.00
175_T	200_N	0.597	1.00
448_V	456_I	0.597	1.00
390_G	399_K	0.596	1.00
185_F	217_F	0.595	1.00
208_S	265_R	0.591	1.00
100_V	104_A	0.591	1.00
119_L	133_D	0.591	1.00
82_A	201_T	0.590	1.00
105_A	138_I	0.590	1.00
271_A	278_Q	0.590	1.00
165_N	512_S	0.589	1.00
87_E	462_E	0.589	1.00
90_R	171_P	0.589	1.00
179_P	188_M	0.588	1.00
108_V	115_F	0.587	1.00
151_L	506_M	0.587	1.00
503_A	508_A	0.586	1.00
134_T	185_F	0.586	1.00
89_W	196_I	0.586	1.00
330_E	333_Y	0.586	1.00
349_T	358_Y	0.585	1.00
108_V	185_F	0.585	1.00
114_E	219_E	0.584	1.00
292_T	465_V	0.584	1.00
104_A	107_K	0.583	1.00
434_L	458_R	0.583	1.00
41_I	78_A	0.581	1.00
176_V	203_V	0.579	1.00
286_E	444_L	0.578	1.00
434_L	463_F	0.578	1.00
191_T	255_T	0.576	1.00
328_V	424_F	0.576	1.00
133_D	183_F	0.576	1.00
119_L	213_I	0.576	1.00
299_A	304_A	0.575	1.00
301_I	335_Q	0.573	1.00
468_L	509_K	0.572	1.00
253_L	504_L	0.571	1.00
54_S	65_G	0.571	1.00
117_A	120_V	0.570	1.00
54_S	211_P	0.570	1.00
362_V	398_I	0.568	1.00
297_E	427_V	0.568	1.00
54_S	122_E	0.567	1.00
370_K	373_S	0.566	1.00
43_G	222_E	0.564	1.00
105_A	141_M	0.564	1.00
115_F	134_T	0.564	1.00
151_L	502_L	0.564	1.00
375_I	401_T	0.564	1.00
146_R	149_I	0.563	1.00
119_L	130_A	0.561	1.00
85_A	88_E	0.561	1.00
168_V	509_K	0.559	1.00
332_V	427_V	0.559	1.00
413_M	436_V	0.559	1.00
298_D	451_N	0.557	1.00
381_E	407_D	0.557	1.00
108_V	141_M	0.556	1.00
319_K	322_A	0.554	1.00
404_A	426_K	0.553	1.00
177_V	192_T	0.553	1.00
78_A	234_V	0.553	1.00
45_R	219_E	0.553	1.00
298_D	452_N	0.552	1.00
72_Q	247_D	0.551	1.00
454_K	458_R	0.549	1.00
303_L	451_N	0.549	1.00
384_L	387_G	0.548	1.00
96_E	100_V	0.548	1.00
293_V	447_A	0.545	1.00
198_T	502_L	0.541	1.00
463_F	468_L	0.541	1.00
303_L	306_Q	0.539	1.00
244_Y	247_D	0.538	1.00
237_S	241_V	0.537	1.00
40_V	43_G	0.535	1.00
39_L	48_T	0.534	1.00
125_K	130_A	0.534	1.00
261_E	366_G	0.533	1.00
64_V	212_V	0.533	1.00
136_E	186_A	0.532	1.00
112_K	116_S	0.531	1.00
326_A	424_F	0.531	1.00
186_A	190_G	0.531	1.00
51_K	68_S	0.530	1.00
81_A	85_A	0.529	1.00
464_H	507_Q	0.529	1.00
323_G	447_A	0.528	1.00
144_Y	194_A	0.528	1.00
208_S	261_E	0.528	1.00
175_T	202_V	0.527	1.00
313_F	347_K	0.527	1.00
217_F	221_L	0.527	1.00
321_S	477_A	0.526	1.00
83_A	174_V	0.525	1.00
454_K	457_E	0.525	1.00
291_D	445_T	0.524	1.00
311_S	473_N	0.523	1.00
103_R	225_G	0.523	1.00
337_L	402_I	0.522	1.00
154_G	168_V	0.522	1.00
174_V	252_S	0.522	1.00
305_A	332_V	0.522	1.00
67_V	212_V	0.522	1.00
143_Y	147_Q	0.522	1.00
82_A	203_V	0.521	1.00
445_T	469_Y	0.520	1.00
222_E	225_G	0.520	1.00
175_T	255_T	0.519	1.00
384_L	388_G	0.517	1.00
312_A	422_V	0.517	1.00
203_V	234_V	0.513	1.00
412_L	417_I	0.513	1.00
350_A	354_S	0.512	1.00
135_A	138_I	0.511	1.00
469_Y	472_R	0.509	1.00
379_K	382_G	0.508	1.00
123_A	315_F	0.508	1.00
79_I	244_Y	0.508	1.00
116_S	130_A	0.506	1.00
112_K	138_I	0.506	1.00
41_I	46_V	0.505	1.00
260_R	264_T	0.505	1.00
487_F	494_S	0.504	1.00
86_F	230_V	0.504	1.00
448_V	470_F	0.504	1.00
374_Y	412_L	0.503	1.00
430_F	462_E	0.503	1.00
81_A	228_K	0.501	1.00
338_E	345_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4nm9A	2	0.9981	100	0.067	Contact Map
1uzbA	5	0.9981	100	0.073	Contact Map
3qanA	2	0.9845	100	0.073	Contact Map
4jdcA	5	0.9786	100	0.093	Contact Map
4pz2A	4	0.9165	100	0.093	Contact Map
4oe6A	5	0.9029	100	0.096	Contact Map
4o5hA	4	0.967	100	0.097	Contact Map
4yweA	5	0.9068	100	0.097	Contact Map
4pxlA	4	0.9184	100	0.099	Contact Map
4lihA	5	0.9398	100	0.099	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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