GREMLIN Database
PROD2 - Proline dehydrogenase 2
UniProt: P94390 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (277)
Sequences: 2793 (1735)
Seq/√Len: 104.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_T150_K6.1331.00
82_A119_T5.2871.00
170_D210_K4.4191.00
197_K201_D3.9081.00
110_Y146_D3.5551.00
205_K230_F3.4471.00
220_I231_T3.2401.00
74_T115_K3.2341.00
208_I220_I3.2311.00
158_L165_T2.9661.00
75_E79_Q2.9351.00
145_K171_D2.7801.00
37_D40_S2.6791.00
209_R234_L2.6161.00
78_I119_T2.5951.00
119_T122_K2.5641.00
129_I144_F2.5201.00
36_N40_S2.5061.00
71_R112_N2.4591.00
118_Q122_K2.4561.00
169_I207_I2.3741.00
117_L127_V2.3261.00
51_Q259_L2.3001.00
194_F203_N2.2281.00
138_Q142_D2.1911.00
208_I231_T2.1861.00
160_A207_I2.1441.00
128_T157_V2.0881.00
114_T118_Q2.0701.00
85_A123_H2.0621.00
205_K226_K2.0501.00
198_S202_E2.0491.00
78_I115_K2.0461.00
71_R75_E2.0161.00
100_L116_I2.0131.00
213_L238_H1.9851.00
82_A123_H1.9731.00
166_E206_K1.9551.00
67_A112_N1.8851.00
76_E274_Y1.8351.00
245_F266_Y1.7781.00
173_D210_K1.7781.00
81_I125_I1.7721.00
67_A71_R1.7691.00
235_A245_F1.7431.00
110_Y143_I1.7371.00
119_T123_H1.7301.00
67_A108_L1.6931.00
166_E170_D1.6821.00
76_E79_Q1.6261.00
158_L172_L1.5961.00
271_Y281_Y1.5831.00
209_R230_F1.5691.00
261_L268_M1.5111.00
110_Y147_F1.5001.00
209_R213_L1.4541.00
196_E199_D1.4521.00
116_I127_V1.4271.00
118_Q151_Y1.4121.00
158_L169_I1.4091.00
83_T87_Q1.4021.00
166_E203_N1.3931.00
144_F156_T1.3821.00
131_M140_T1.3811.00
145_K175_L1.3641.00
199_D202_E1.3310.99
236_K242_N1.3220.99
39_N79_Q1.3200.99
195_P199_D1.3190.99
53_L259_L1.3170.99
164_R168_D1.3130.99
247_F266_Y1.3070.99
225_D257_T1.3070.99
167_K170_D1.3040.99
66_S69_V1.2860.99
46_R87_Q1.2820.99
166_E210_K1.2820.99
98_T136_R1.2660.99
205_K227_M1.2660.99
167_K171_D1.2650.99
110_Y150_K1.2630.99
26_R30_G1.2560.99
96_K99_S1.2530.99
233_Q237_E1.2520.99
81_I123_H1.2420.99
78_I82_A1.2400.99
92_H128_T1.2330.99
45_I57_V1.2190.99
234_L238_H1.2010.99
222_T227_M1.1940.99
172_L177_P1.1880.99
39_N83_T1.1840.99
173_D216_H1.1810.99
35_G40_S1.1760.99
258_Q268_M1.1610.98
222_T228_I1.1450.98
194_F199_D1.1420.98
182_V185_A1.1410.98
75_E78_I1.1360.98
68_E72_E1.1340.98
96_K186_Y1.1270.98
203_N207_I1.1270.98
44_T47_Q1.1190.98
74_T112_N1.1080.98
113_M129_I1.0970.98
58_D271_Y1.0860.98
209_R237_E1.0850.98
230_F234_L1.0830.97
234_L237_E1.0800.97
74_T78_I1.0630.97
92_H178_F1.0580.97
94_S271_Y1.0520.97
79_Q82_A1.0380.97
92_H126_M1.0360.97
45_I55_V1.0330.97
213_L234_L1.0330.97
259_L263_K1.0290.97
54_S267_N1.0250.96
113_M147_F1.0220.96
212_L238_H1.0220.96
179_L211_Q1.0160.96
110_Y114_T1.0140.96
106_M142_D1.0090.96
137_C182_V1.0070.96
257_T260_S1.0060.96
78_I116_I1.0020.96
38_F83_T0.9990.96
53_L262_V0.9980.96
148_R177_P0.9960.96
292_N295_F0.9960.96
187_K195_P0.9960.96
49_N55_V0.9920.96
77_C93_V0.9850.96
163_Y195_P0.9800.95
47_Q50_S0.9740.95
72_E76_E0.9730.95
146_D149_K0.9690.95
101_G108_L0.9680.95
219_A248_Q0.9640.95
81_I93_V0.9610.95
32_I185_A0.9570.95
232_K247_F0.9570.95
133_D136_R0.9560.95
42_I89_L0.9340.94
27_V36_N0.9280.94
82_A122_K0.9230.94
67_A102_L0.9190.94
114_T151_Y0.9190.94
58_D130_D0.9180.94
128_T178_F0.9170.94
260_S264_E0.9140.93
156_T179_L0.9120.93
217_Y245_F0.9110.93
137_C164_R0.9100.93
145_K149_K0.9070.93
46_R50_S0.8920.93
200_V291_S0.8920.93
232_K266_Y0.8880.92
92_H96_K0.8810.92
200_V289_R0.8810.92
173_D215_G0.8790.92
38_F79_Q0.8740.92
212_L235_A0.8670.92
67_A111_E0.8660.91
279_Y290_P0.8610.91
165_T207_I0.8600.91
130_D284_R0.8540.91
169_I210_K0.8500.91
246_E269_R0.8500.91
165_T168_D0.8470.91
49_N91_S0.8460.91
114_T147_F0.8460.91
62_E185_A0.8450.90
117_L154_V0.8450.90
208_I234_L0.8420.90
58_D96_K0.8410.90
161_Y203_N0.8370.90
104_I107_D0.8310.90
181_L207_I0.8260.89
59_H274_Y0.8220.89
42_I83_T0.8200.89
128_T219_A0.8180.89
82_A86_D0.8150.89
125_I154_V0.8130.89
88_E125_I0.8110.89
74_T116_I0.8050.88
134_E162_L0.8040.88
60_L94_S0.8040.88
166_E207_I0.8030.88
31_K253_M0.8030.88
62_E96_K0.8030.88
133_D189_S0.7990.88
232_K264_E0.7940.88
181_L211_Q0.7930.87
82_A85_A0.7900.87
97_M143_I0.7860.87
149_K175_L0.7810.87
187_K193_A0.7790.87
144_F154_V0.7780.86
181_L208_I0.7760.86
84_I93_V0.7750.86
163_Y194_F0.7700.86
284_R288_E0.7680.86
224_D227_M0.7650.86
204_Y227_M0.7630.85
63_F133_D0.7630.85
49_N89_L0.7610.85
24_G27_V0.7600.85
291_S295_F0.7590.85
202_E205_K0.7590.85
259_L262_V0.7580.85
40_S43_P0.7580.85
226_K230_F0.7550.85
147_F154_V0.7540.85
102_L139_K0.7540.85
273_P281_Y0.7530.85
72_E75_E0.7520.85
96_K130_D0.7510.84
55_V272_L0.7480.84
226_K229_D0.7410.84
22_N26_R0.7360.83
279_Y287_A0.7330.83
30_G237_E0.7300.83
53_L268_M0.7280.83
43_P87_Q0.7270.83
282_F289_R0.7240.82
273_P284_R0.7230.82
52_G57_V0.7230.82
112_N115_K0.7220.82
97_M113_M0.7210.82
162_L193_A0.7110.81
180_R183_K0.7090.81
211_Q218_T0.7090.81
38_F76_E0.7060.81
139_K143_I0.7060.81
80_T274_Y0.7040.80
212_L234_L0.7010.80
178_F219_A0.7010.80
197_K227_M0.7000.80
134_E189_S0.6970.80
141_L168_D0.6970.80
281_Y285_R0.6960.80
284_R289_R0.6940.80
203_N206_K0.6930.79
158_L179_L0.6920.79
49_N87_Q0.6880.79
144_F177_P0.6870.79
250_L271_Y0.6870.79
145_K172_L0.6820.78
53_L270_V0.6800.78
96_K248_Q0.6800.78
240_I243_D0.6780.78
121_E152_E0.6770.78
228_I247_F0.6760.78
231_T235_A0.6750.78
58_D62_E0.6720.77
148_R154_V0.6710.77
83_T86_D0.6690.77
186_Y248_Q0.6680.77
222_T231_T0.6670.77
142_D146_D0.6630.76
230_F233_Q0.6610.76
93_V117_L0.6600.76
43_P46_R0.6590.76
42_I46_R0.6580.76
228_I261_L0.6560.76
71_R115_K0.6550.75
130_D159_Q0.6510.75
134_E192_V0.6500.75
118_Q150_K0.6490.75
71_R108_L0.6490.75
108_L111_E0.6480.75
172_L179_L0.6480.75
75_E115_K0.6460.74
24_G28_A0.6450.74
54_S90_N0.6450.74
78_I146_D0.6450.74
171_D174_S0.6420.74
202_E206_K0.6420.74
157_V162_L0.6420.74
169_I182_V0.6410.74
62_E271_Y0.6410.74
253_M282_F0.6400.74
224_D278_W0.6380.74
49_N52_G0.6380.74
71_R111_E0.6380.74
114_T146_D0.6350.73
77_C99_S0.6350.73
157_V182_V0.6330.73
32_I282_F0.6310.73
43_P239_G0.6310.73
233_Q236_K0.6290.73
93_V125_I0.6270.72
80_T93_V0.6270.72
188_E287_A0.6260.72
212_L231_T0.6250.72
182_V253_M0.6240.72
156_T172_L0.6210.72
72_E263_K0.6210.72
62_E288_E0.6210.72
45_I49_N0.6210.72
285_R288_E0.6190.71
196_E202_E0.6180.71
215_G236_K0.6180.71
105_D108_L0.6170.71
118_Q121_E0.6160.71
130_D161_Y0.6130.71
131_M249_M0.6090.70
60_L278_W0.6090.70
169_I173_D0.6090.70
262_V268_M0.6070.70
67_A105_D0.6070.70
29_A278_W0.6060.70
98_T102_L0.6050.70
148_R152_E0.6050.70
96_K157_V0.6050.70
41_S57_V0.6030.69
243_D267_N0.6020.69
102_L106_M0.6010.69
82_A231_T0.6010.69
155_S180_R0.6000.69
75_E82_A0.5990.69
134_E280_G0.5970.69
115_K119_T0.5950.68
92_H125_I0.5940.68
47_Q68_E0.5940.68
58_D94_S0.5910.68
95_L127_V0.5900.68
182_V201_D0.5890.68
181_L220_I0.5870.67
194_F200_V0.5870.67
207_I211_Q0.5820.67
41_S45_I0.5820.67
42_I57_V0.5820.67
70_A77_C0.5820.67
137_C200_V0.5820.67
137_C140_T0.5820.67
138_Q171_D0.5810.67
194_F206_K0.5800.66
224_D253_M0.5800.66
96_K250_L0.5790.66
20_A24_G0.5790.66
247_F261_L0.5790.66
73_R253_M0.5770.66
62_E250_L0.5760.66
23_W28_A0.5760.66
126_M178_F0.5760.66
236_K239_G0.5750.66
182_V277_D0.5740.66
126_M155_S0.5720.65
134_E164_R0.5720.65
128_T280_G0.5700.65
200_V224_D0.5700.65
204_Y231_T0.5680.65
182_V200_V0.5660.65
65_N121_E0.5640.64
161_Y284_R0.5640.64
118_Q149_K0.5630.64
225_D229_D0.5620.64
58_D273_P0.5620.64
168_D172_L0.5600.64
253_M289_R0.5600.64
149_K198_S0.5580.63
232_K245_F0.5570.63
56_T269_R0.5540.63
71_R74_T0.5540.63
251_Y287_A0.5520.63
94_S248_Q0.5520.63
126_M157_V0.5500.62
101_G107_D0.5490.62
136_R140_T0.5490.62
23_W27_V0.5470.62
185_A288_E0.5470.62
115_K264_E0.5450.62
35_G52_G0.5450.62
145_K158_L0.5440.61
122_K152_E0.5410.61
201_D253_M0.5410.61
74_T127_V0.5400.61
240_I247_F0.5390.61
208_I230_F0.5380.61
159_Q250_L0.5370.60
111_E115_K0.5340.60
253_M291_S0.5340.60
117_L147_F0.5330.60
126_M140_T0.5310.60
258_Q289_R0.5310.60
64_V69_V0.5310.60
273_P280_G0.5300.59
42_I45_I0.5250.59
201_D226_K0.5240.59
120_A127_V0.5230.58
56_T94_S0.5220.58
113_M150_K0.5220.58
161_Y200_V0.5200.58
62_E130_D0.5180.58
188_E290_P0.5160.57
188_E193_A0.5160.57
107_D111_E0.5160.57
261_L266_Y0.5150.57
185_A223_H0.5150.57
229_D232_K0.5140.57
258_Q270_V0.5130.57
197_K200_V0.5110.57
173_D214_N0.5100.57
50_S68_E0.5070.56
262_V266_Y0.5050.56
137_C277_D0.5050.56
187_K287_A0.5040.56
100_L273_P0.5040.56
61_G155_S0.5030.56
287_A290_P0.5030.56
125_I128_T0.5030.56
101_G104_I0.5020.55
249_M258_Q0.5010.55
158_L168_D0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ekgA 2 0.9472 100 0.095 Contact Map
4h6qA 1 0.9109 100 0.102 Contact Map
4nm9A 2 0.9538 100 0.169 Contact Map
3hazA 3 0.9736 100 0.173 Contact Map
3e2qA 2 0.9571 100 0.181 Contact Map
4o8aA 2 0.9472 100 0.184 Contact Map
3obeA 1 0.7558 49.6 0.96 Contact Map
1i60A 1 0.7789 43.5 0.961 Contact Map
3canA 2 0.3894 40.7 0.962 Contact Map
3ngfA 1 0.7723 40.2 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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