PROD2 - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

PROD2 - Proline dehydrogenase 2

UniProt:	P94390	Sequences: MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPTIRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGLDIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQAYLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYTAIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGEDWYGYFMRRLAERPSNIAFAFKGMTKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	303 (277)
Sequences:	2793 (1735)
Seq/√Len:	104.3

ECOLI - PUTA
BACSU - PROD2 PROD1
HALSA - Q9HNG0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_T	150_K	6.133	1.00
82_A	119_T	5.287	1.00
170_D	210_K	4.419	1.00
197_K	201_D	3.908	1.00
110_Y	146_D	3.555	1.00
205_K	230_F	3.447	1.00
220_I	231_T	3.240	1.00
74_T	115_K	3.234	1.00
208_I	220_I	3.231	1.00
158_L	165_T	2.966	1.00
75_E	79_Q	2.935	1.00
145_K	171_D	2.780	1.00
37_D	40_S	2.679	1.00
209_R	234_L	2.616	1.00
78_I	119_T	2.595	1.00
119_T	122_K	2.564	1.00
129_I	144_F	2.520	1.00
36_N	40_S	2.506	1.00
71_R	112_N	2.459	1.00
118_Q	122_K	2.456	1.00
169_I	207_I	2.374	1.00
117_L	127_V	2.326	1.00
51_Q	259_L	2.300	1.00
194_F	203_N	2.228	1.00
138_Q	142_D	2.191	1.00
208_I	231_T	2.186	1.00
160_A	207_I	2.144	1.00
128_T	157_V	2.088	1.00
114_T	118_Q	2.070	1.00
85_A	123_H	2.062	1.00
205_K	226_K	2.050	1.00
198_S	202_E	2.049	1.00
78_I	115_K	2.046	1.00
71_R	75_E	2.016	1.00
100_L	116_I	2.013	1.00
213_L	238_H	1.985	1.00
82_A	123_H	1.973	1.00
166_E	206_K	1.955	1.00
67_A	112_N	1.885	1.00
76_E	274_Y	1.835	1.00
245_F	266_Y	1.778	1.00
173_D	210_K	1.778	1.00
81_I	125_I	1.772	1.00
67_A	71_R	1.769	1.00
235_A	245_F	1.743	1.00
110_Y	143_I	1.737	1.00
119_T	123_H	1.730	1.00
67_A	108_L	1.693	1.00
166_E	170_D	1.682	1.00
76_E	79_Q	1.626	1.00
158_L	172_L	1.596	1.00
271_Y	281_Y	1.583	1.00
209_R	230_F	1.569	1.00
261_L	268_M	1.511	1.00
110_Y	147_F	1.500	1.00
209_R	213_L	1.454	1.00
196_E	199_D	1.452	1.00
116_I	127_V	1.427	1.00
118_Q	151_Y	1.412	1.00
158_L	169_I	1.409	1.00
83_T	87_Q	1.402	1.00
166_E	203_N	1.393	1.00
144_F	156_T	1.382	1.00
131_M	140_T	1.381	1.00
145_K	175_L	1.364	1.00
199_D	202_E	1.331	0.99
236_K	242_N	1.322	0.99
39_N	79_Q	1.320	0.99
195_P	199_D	1.319	0.99
53_L	259_L	1.317	0.99
164_R	168_D	1.313	0.99
247_F	266_Y	1.307	0.99
225_D	257_T	1.307	0.99
167_K	170_D	1.304	0.99
66_S	69_V	1.286	0.99
46_R	87_Q	1.282	0.99
166_E	210_K	1.282	0.99
98_T	136_R	1.266	0.99
205_K	227_M	1.266	0.99
167_K	171_D	1.265	0.99
110_Y	150_K	1.263	0.99
26_R	30_G	1.256	0.99
96_K	99_S	1.253	0.99
233_Q	237_E	1.252	0.99
81_I	123_H	1.242	0.99
78_I	82_A	1.240	0.99
92_H	128_T	1.233	0.99
45_I	57_V	1.219	0.99
234_L	238_H	1.201	0.99
222_T	227_M	1.194	0.99
172_L	177_P	1.188	0.99
39_N	83_T	1.184	0.99
173_D	216_H	1.181	0.99
35_G	40_S	1.176	0.99
258_Q	268_M	1.161	0.98
222_T	228_I	1.145	0.98
194_F	199_D	1.142	0.98
182_V	185_A	1.141	0.98
75_E	78_I	1.136	0.98
68_E	72_E	1.134	0.98
96_K	186_Y	1.127	0.98
203_N	207_I	1.127	0.98
44_T	47_Q	1.119	0.98
74_T	112_N	1.108	0.98
113_M	129_I	1.097	0.98
58_D	271_Y	1.086	0.98
209_R	237_E	1.085	0.98
230_F	234_L	1.083	0.97
234_L	237_E	1.080	0.97
74_T	78_I	1.063	0.97
92_H	178_F	1.058	0.97
94_S	271_Y	1.052	0.97
79_Q	82_A	1.038	0.97
92_H	126_M	1.036	0.97
45_I	55_V	1.033	0.97
213_L	234_L	1.033	0.97
259_L	263_K	1.029	0.97
54_S	267_N	1.025	0.96
113_M	147_F	1.022	0.96
212_L	238_H	1.022	0.96
179_L	211_Q	1.016	0.96
110_Y	114_T	1.014	0.96
106_M	142_D	1.009	0.96
137_C	182_V	1.007	0.96
257_T	260_S	1.006	0.96
78_I	116_I	1.002	0.96
38_F	83_T	0.999	0.96
53_L	262_V	0.998	0.96
148_R	177_P	0.996	0.96
292_N	295_F	0.996	0.96
187_K	195_P	0.996	0.96
49_N	55_V	0.992	0.96
77_C	93_V	0.985	0.96
163_Y	195_P	0.980	0.95
47_Q	50_S	0.974	0.95
72_E	76_E	0.973	0.95
146_D	149_K	0.969	0.95
101_G	108_L	0.968	0.95
219_A	248_Q	0.964	0.95
81_I	93_V	0.961	0.95
32_I	185_A	0.957	0.95
232_K	247_F	0.957	0.95
133_D	136_R	0.956	0.95
42_I	89_L	0.934	0.94
27_V	36_N	0.928	0.94
82_A	122_K	0.923	0.94
67_A	102_L	0.919	0.94
114_T	151_Y	0.919	0.94
58_D	130_D	0.918	0.94
128_T	178_F	0.917	0.94
260_S	264_E	0.914	0.93
156_T	179_L	0.912	0.93
217_Y	245_F	0.911	0.93
137_C	164_R	0.910	0.93
145_K	149_K	0.907	0.93
46_R	50_S	0.892	0.93
200_V	291_S	0.892	0.93
232_K	266_Y	0.888	0.92
92_H	96_K	0.881	0.92
200_V	289_R	0.881	0.92
173_D	215_G	0.879	0.92
38_F	79_Q	0.874	0.92
212_L	235_A	0.867	0.92
67_A	111_E	0.866	0.91
279_Y	290_P	0.861	0.91
165_T	207_I	0.860	0.91
130_D	284_R	0.854	0.91
169_I	210_K	0.850	0.91
246_E	269_R	0.850	0.91
165_T	168_D	0.847	0.91
49_N	91_S	0.846	0.91
114_T	147_F	0.846	0.91
62_E	185_A	0.845	0.90
117_L	154_V	0.845	0.90
208_I	234_L	0.842	0.90
58_D	96_K	0.841	0.90
161_Y	203_N	0.837	0.90
104_I	107_D	0.831	0.90
181_L	207_I	0.826	0.89
59_H	274_Y	0.822	0.89
42_I	83_T	0.820	0.89
128_T	219_A	0.818	0.89
82_A	86_D	0.815	0.89
125_I	154_V	0.813	0.89
88_E	125_I	0.811	0.89
74_T	116_I	0.805	0.88
134_E	162_L	0.804	0.88
60_L	94_S	0.804	0.88
166_E	207_I	0.803	0.88
31_K	253_M	0.803	0.88
62_E	96_K	0.803	0.88
133_D	189_S	0.799	0.88
232_K	264_E	0.794	0.88
181_L	211_Q	0.793	0.87
82_A	85_A	0.790	0.87
97_M	143_I	0.786	0.87
149_K	175_L	0.781	0.87
187_K	193_A	0.779	0.87
144_F	154_V	0.778	0.86
181_L	208_I	0.776	0.86
84_I	93_V	0.775	0.86
163_Y	194_F	0.770	0.86
284_R	288_E	0.768	0.86
224_D	227_M	0.765	0.86
204_Y	227_M	0.763	0.85
63_F	133_D	0.763	0.85
49_N	89_L	0.761	0.85
24_G	27_V	0.760	0.85
291_S	295_F	0.759	0.85
202_E	205_K	0.759	0.85
259_L	262_V	0.758	0.85
40_S	43_P	0.758	0.85
226_K	230_F	0.755	0.85
147_F	154_V	0.754	0.85
102_L	139_K	0.754	0.85
273_P	281_Y	0.753	0.85
72_E	75_E	0.752	0.85
96_K	130_D	0.751	0.84
55_V	272_L	0.748	0.84
226_K	229_D	0.741	0.84
22_N	26_R	0.736	0.83
279_Y	287_A	0.733	0.83
30_G	237_E	0.730	0.83
53_L	268_M	0.728	0.83
43_P	87_Q	0.727	0.83
282_F	289_R	0.724	0.82
273_P	284_R	0.723	0.82
52_G	57_V	0.723	0.82
112_N	115_K	0.722	0.82
97_M	113_M	0.721	0.82
162_L	193_A	0.711	0.81
180_R	183_K	0.709	0.81
211_Q	218_T	0.709	0.81
38_F	76_E	0.706	0.81
139_K	143_I	0.706	0.81
80_T	274_Y	0.704	0.80
212_L	234_L	0.701	0.80
178_F	219_A	0.701	0.80
197_K	227_M	0.700	0.80
134_E	189_S	0.697	0.80
141_L	168_D	0.697	0.80
281_Y	285_R	0.696	0.80
284_R	289_R	0.694	0.80
203_N	206_K	0.693	0.79
158_L	179_L	0.692	0.79
49_N	87_Q	0.688	0.79
144_F	177_P	0.687	0.79
250_L	271_Y	0.687	0.79
145_K	172_L	0.682	0.78
53_L	270_V	0.680	0.78
96_K	248_Q	0.680	0.78
240_I	243_D	0.678	0.78
121_E	152_E	0.677	0.78
228_I	247_F	0.676	0.78
231_T	235_A	0.675	0.78
58_D	62_E	0.672	0.77
148_R	154_V	0.671	0.77
83_T	86_D	0.669	0.77
186_Y	248_Q	0.668	0.77
222_T	231_T	0.667	0.77
142_D	146_D	0.663	0.76
230_F	233_Q	0.661	0.76
93_V	117_L	0.660	0.76
43_P	46_R	0.659	0.76
42_I	46_R	0.658	0.76
228_I	261_L	0.656	0.76
71_R	115_K	0.655	0.75
130_D	159_Q	0.651	0.75
134_E	192_V	0.650	0.75
118_Q	150_K	0.649	0.75
71_R	108_L	0.649	0.75
108_L	111_E	0.648	0.75
172_L	179_L	0.648	0.75
75_E	115_K	0.646	0.74
24_G	28_A	0.645	0.74
54_S	90_N	0.645	0.74
78_I	146_D	0.645	0.74
171_D	174_S	0.642	0.74
202_E	206_K	0.642	0.74
157_V	162_L	0.642	0.74
169_I	182_V	0.641	0.74
62_E	271_Y	0.641	0.74
253_M	282_F	0.640	0.74
224_D	278_W	0.638	0.74
49_N	52_G	0.638	0.74
71_R	111_E	0.638	0.74
114_T	146_D	0.635	0.73
77_C	99_S	0.635	0.73
157_V	182_V	0.633	0.73
32_I	282_F	0.631	0.73
43_P	239_G	0.631	0.73
233_Q	236_K	0.629	0.73
93_V	125_I	0.627	0.72
80_T	93_V	0.627	0.72
188_E	287_A	0.626	0.72
212_L	231_T	0.625	0.72
182_V	253_M	0.624	0.72
156_T	172_L	0.621	0.72
72_E	263_K	0.621	0.72
62_E	288_E	0.621	0.72
45_I	49_N	0.621	0.72
285_R	288_E	0.619	0.71
196_E	202_E	0.618	0.71
215_G	236_K	0.618	0.71
105_D	108_L	0.617	0.71
118_Q	121_E	0.616	0.71
130_D	161_Y	0.613	0.71
131_M	249_M	0.609	0.70
60_L	278_W	0.609	0.70
169_I	173_D	0.609	0.70
262_V	268_M	0.607	0.70
67_A	105_D	0.607	0.70
29_A	278_W	0.606	0.70
98_T	102_L	0.605	0.70
148_R	152_E	0.605	0.70
96_K	157_V	0.605	0.70
41_S	57_V	0.603	0.69
243_D	267_N	0.602	0.69
102_L	106_M	0.601	0.69
82_A	231_T	0.601	0.69
155_S	180_R	0.600	0.69
75_E	82_A	0.599	0.69
134_E	280_G	0.597	0.69
115_K	119_T	0.595	0.68
92_H	125_I	0.594	0.68
47_Q	68_E	0.594	0.68
58_D	94_S	0.591	0.68
95_L	127_V	0.590	0.68
182_V	201_D	0.589	0.68
181_L	220_I	0.587	0.67
194_F	200_V	0.587	0.67
207_I	211_Q	0.582	0.67
41_S	45_I	0.582	0.67
42_I	57_V	0.582	0.67
70_A	77_C	0.582	0.67
137_C	200_V	0.582	0.67
137_C	140_T	0.582	0.67
138_Q	171_D	0.581	0.67
194_F	206_K	0.580	0.66
224_D	253_M	0.580	0.66
96_K	250_L	0.579	0.66
20_A	24_G	0.579	0.66
247_F	261_L	0.579	0.66
73_R	253_M	0.577	0.66
62_E	250_L	0.576	0.66
23_W	28_A	0.576	0.66
126_M	178_F	0.576	0.66
236_K	239_G	0.575	0.66
182_V	277_D	0.574	0.66
126_M	155_S	0.572	0.65
134_E	164_R	0.572	0.65
128_T	280_G	0.570	0.65
200_V	224_D	0.570	0.65
204_Y	231_T	0.568	0.65
182_V	200_V	0.566	0.65
65_N	121_E	0.564	0.64
161_Y	284_R	0.564	0.64
118_Q	149_K	0.563	0.64
225_D	229_D	0.562	0.64
58_D	273_P	0.562	0.64
168_D	172_L	0.560	0.64
253_M	289_R	0.560	0.64
149_K	198_S	0.558	0.63
232_K	245_F	0.557	0.63
56_T	269_R	0.554	0.63
71_R	74_T	0.554	0.63
251_Y	287_A	0.552	0.63
94_S	248_Q	0.552	0.63
126_M	157_V	0.550	0.62
101_G	107_D	0.549	0.62
136_R	140_T	0.549	0.62
23_W	27_V	0.547	0.62
185_A	288_E	0.547	0.62
115_K	264_E	0.545	0.62
35_G	52_G	0.545	0.62
145_K	158_L	0.544	0.61
122_K	152_E	0.541	0.61
201_D	253_M	0.541	0.61
74_T	127_V	0.540	0.61
240_I	247_F	0.539	0.61
208_I	230_F	0.538	0.61
159_Q	250_L	0.537	0.60
111_E	115_K	0.534	0.60
253_M	291_S	0.534	0.60
117_L	147_F	0.533	0.60
126_M	140_T	0.531	0.60
258_Q	289_R	0.531	0.60
64_V	69_V	0.531	0.60
273_P	280_G	0.530	0.59
42_I	45_I	0.525	0.59
201_D	226_K	0.524	0.59
120_A	127_V	0.523	0.58
56_T	94_S	0.522	0.58
113_M	150_K	0.522	0.58
161_Y	200_V	0.520	0.58
62_E	130_D	0.518	0.58
188_E	290_P	0.516	0.57
188_E	193_A	0.516	0.57
107_D	111_E	0.516	0.57
261_L	266_Y	0.515	0.57
185_A	223_H	0.515	0.57
229_D	232_K	0.514	0.57
258_Q	270_V	0.513	0.57
197_K	200_V	0.511	0.57
173_D	214_N	0.510	0.57
50_S	68_E	0.507	0.56
262_V	266_Y	0.505	0.56
137_C	277_D	0.505	0.56
187_K	287_A	0.504	0.56
100_L	273_P	0.504	0.56
61_G	155_S	0.503	0.56
287_A	290_P	0.503	0.56
125_I	128_T	0.503	0.56
101_G	104_I	0.502	0.55
249_M	258_Q	0.501	0.55
158_L	168_D	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ekgA	2	0.9472	100	0.095	Contact Map
4h6qA	1	0.9109	100	0.102	Contact Map
4nm9A	2	0.9538	100	0.169	Contact Map
3hazA	3	0.9736	100	0.173	Contact Map
3e2qA	2	0.9571	100	0.181	Contact Map
4o8aA	2	0.9472	100	0.184	Contact Map
3obeA	1	0.7558	49.6	0.96	Contact Map
1i60A	1	0.7789	43.5	0.961	Contact Map
3canA	2	0.3894	40.7	0.962	Contact Map
3ngfA	1	0.7723	40.2	0.962	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.