GREMLIN Database
YCGL - Uncharacterized protein YcgL
UniProt: P94389 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (211)
Sequences: 1039 (687)
Seq/√Len: 47.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_D177_V3.7491.00
16_Y48_P3.1811.00
221_E224_R2.9551.00
162_Q166_K2.9491.00
162_Q221_E2.6861.00
120_F164_I2.5581.00
48_P77_E2.4911.00
213_V216_Q2.4711.00
181_E184_A2.4411.00
218_I222_I2.3051.00
133_A158_I2.3021.00
136_N154_V2.2531.00
172_P175_F2.2391.00
176_T180_N2.2061.00
213_V218_I2.1671.00
22_Y45_I2.1391.00
194_T197_E2.1361.00
158_I218_I2.0871.00
140_Y151_Y2.0761.00
205_L208_E2.0411.00
33_F153_Y1.9580.99
60_R64_E1.9550.99
60_R63_I1.9370.99
176_T200_R1.9370.99
46_Y75_G1.9150.99
29_R40_Y1.9010.99
21_V108_T1.8950.99
17_G49_K1.8560.99
191_E213_V1.7480.98
154_V158_I1.6920.98
104_E109_A1.6760.98
62_V66_P1.6750.98
84_L89_N1.6450.98
109_A113_R1.6200.97
214_I217_F1.6130.97
217_F221_E1.5940.97
163_W172_P1.5870.97
202_G205_L1.5750.97
133_A154_V1.5750.97
150_K154_V1.5530.97
203_E206_D1.5330.96
139_D142_Q1.5280.96
137_V215_H1.5240.96
212_D218_I1.5220.96
33_F152_F1.5120.96
44_F75_G1.5070.96
56_I86_K1.4800.96
190_A193_E1.4740.96
29_R53_Y1.4720.95
80_K83_R1.4330.95
221_E225_I1.4310.95
110_E114_K1.4260.95
214_I218_I1.4180.94
37_D204_E1.4020.94
25_E29_R1.3870.94
48_P52_W1.3820.94
29_R43_R1.3760.93
148_I208_E1.3750.93
211_I215_H1.3650.93
202_G208_E1.3530.93
104_E113_R1.3470.93
132_M136_N1.3460.93
26_S153_Y1.3460.93
23_A75_G1.3410.93
24_V98_S1.3340.92
28_S41_D1.3250.92
212_D216_Q1.3190.92
47_V78_L1.3150.92
57_E86_K1.3140.92
134_R226_M1.3010.91
58_Q79_R1.2840.91
218_I221_E1.2810.91
25_E102_Y1.2530.90
42_V161_C1.2530.90
43_R76_W1.2500.90
165_E224_R1.2370.89
18_V63_I1.2360.89
38_S43_R1.2350.89
96_L116_R1.2350.89
179_M183_V1.2280.89
98_S195_L1.2280.89
43_R94_E1.2280.89
180_N183_V1.2260.89
191_E194_T1.2150.88
220_T224_R1.1990.88
109_A112_L1.1990.88
215_H219_E1.1730.86
15_S65_E1.1550.86
35_S153_Y1.1400.85
98_S101_V1.1380.85
169_T172_P1.1250.84
188_L196_L1.1200.84
210_R218_I1.1070.83
74_S77_E1.1000.83
219_E222_I1.0970.83
61_D80_K1.0820.82
210_R215_H1.0750.81
146_V151_Y1.0730.81
106_F110_E1.0730.81
202_G206_D1.0670.81
33_F37_D1.0640.81
216_Q220_T1.0620.80
45_I81_T1.0600.80
137_V154_V1.0560.80
31_W38_S1.0320.78
168_G225_I1.0320.78
43_R80_K1.0290.78
25_E31_W1.0200.78
65_E183_V1.0050.77
29_R38_S1.0010.76
16_Y112_L0.9970.76
213_V219_E0.9970.76
97_S173_M0.9920.76
29_R102_Y0.9910.76
161_C221_E0.9910.76
125_S164_I0.9900.76
61_D76_W0.9870.75
32_G43_R0.9820.75
57_E73_I0.9640.74
38_S94_E0.9600.73
58_Q83_R0.9590.73
26_S37_D0.9560.73
117_T201_R0.9560.73
108_T115_L0.9520.73
99_D102_Y0.9520.73
197_E200_R0.9520.73
54_F72_D0.9480.72
162_Q198_R0.9470.72
223_E226_M0.9460.72
88_S125_S0.9450.72
40_Y53_Y0.9440.72
111_Q186_P0.9410.72
84_L90_P0.9320.71
42_V102_Y0.9300.71
198_R208_E0.9280.71
193_E196_L0.9270.71
45_I111_Q0.9200.70
129_Y160_A0.9170.70
26_S33_F0.9160.70
136_N140_Y0.9120.69
26_S95_W0.9100.69
90_P121_K0.8940.68
153_Y204_E0.8860.67
219_E223_E0.8790.66
23_A46_Y0.8760.66
39_D72_D0.8740.66
24_V99_D0.8590.65
19_K47_V0.8540.64
197_E201_R0.8510.64
53_Y95_W0.8490.64
39_D149_K0.8480.64
79_R83_R0.8420.63
187_E190_A0.8360.63
138_K154_V0.8350.62
28_S39_D0.8290.62
110_E216_Q0.8270.62
93_L119_A0.8250.62
161_C225_I0.8240.61
194_T198_R0.8210.61
19_K110_E0.8100.60
24_V95_W0.8100.60
139_D215_H0.8090.60
15_S176_T0.8070.60
34_P37_D0.8050.60
61_D160_A0.8050.60
24_V29_R0.8050.60
30_A173_M0.8030.59
41_D149_K0.7970.59
190_A197_E0.7910.58
120_F123_E0.7840.58
34_P148_I0.7820.57
170_I173_M0.7790.57
16_Y49_K0.7790.57
176_T197_E0.7790.57
38_S133_A0.7760.57
50_K73_I0.7730.57
52_W59_E0.7720.56
63_I82_L0.7690.56
38_S41_D0.7680.56
155_L188_L0.7610.55
40_Y102_Y0.7570.55
20_I75_G0.7550.55
40_Y63_I0.7530.55
29_R34_P0.7500.54
26_S43_R0.7480.54
15_S118_E0.7480.54
102_Y204_E0.7470.54
178_L184_A0.7340.53
74_S81_T0.7320.52
72_D149_K0.7290.52
89_N149_K0.7250.52
209_A212_D0.7230.52
197_E216_Q0.7230.52
151_Y210_R0.7100.50
26_S160_A0.7050.50
81_T85_F0.7030.50
210_R213_V0.7010.49
100_I131_N0.6980.49
54_F61_D0.6970.49
197_E223_E0.6920.48
35_S199_K0.6910.48
152_F157_P0.6860.48
37_D153_Y0.6850.48
68_H73_I0.6820.47
92_L125_S0.6790.47
137_V192_M0.6760.47
108_T112_L0.6740.47
83_R86_K0.6720.46
148_I202_G0.6720.46
98_S102_Y0.6680.46
116_R225_I0.6650.46
152_F178_L0.6610.45
183_V192_M0.6580.45
36_Q202_G0.6580.45
17_G194_T0.6570.45
91_P122_P0.6540.45
140_Y150_K0.6530.45
75_G82_L0.6490.44
61_D129_Y0.6480.44
189_K193_E0.6470.44
27_G41_D0.6470.44
34_P182_L0.6460.44
33_F77_E0.6460.44
77_E94_E0.6390.43
45_I78_L0.6360.43
144_Q220_T0.6310.42
168_G198_R0.6300.42
140_Y154_V0.6300.42
31_W160_A0.6280.42
76_W146_V0.6280.42
65_E69_D0.6270.42
46_Y54_F0.6250.42
45_I108_T0.6240.42
43_R152_F0.6230.42
187_E197_E0.6220.42
43_R178_L0.6220.42
141_L193_E0.6190.41
90_P136_N0.6150.41
196_L199_K0.6140.41
47_V191_E0.6060.40
161_C188_L0.6050.40
118_E223_E0.6030.40
31_W34_P0.6020.40
170_I175_F0.6020.40
23_A102_Y0.5990.39
213_V220_T0.5990.39
30_A56_I0.5990.39
85_F116_R0.5960.39
23_A129_Y0.5960.39
51_E110_E0.5950.39
81_T92_L0.5920.39
76_W98_S0.5890.38
90_P131_N0.5880.38
135_R205_L0.5880.38
158_I165_E0.5870.38
31_W163_W0.5870.38
53_Y76_W0.5870.38
165_E221_E0.5810.38
217_F220_T0.5770.37
180_N186_P0.5730.37
162_Q194_T0.5730.37
195_L199_K0.5710.37
192_M196_L0.5700.37
114_K117_T0.5700.37
17_G20_I0.5690.37
55_S58_Q0.5690.37
112_L171_P0.5690.37
113_R116_R0.5680.36
212_D221_E0.5660.36
186_P190_A0.5650.36
94_E158_I0.5640.36
76_W95_W0.5620.36
36_Q148_I0.5610.36
177_V181_E0.5550.35
105_A108_T0.5540.35
17_G52_W0.5530.35
33_F182_L0.5530.35
94_E129_Y0.5530.35
140_Y145_E0.5500.35
115_L193_E0.5490.35
17_G145_E0.5480.35
57_E221_E0.5460.34
94_E133_A0.5430.34
93_L125_S0.5430.34
103_Y107_T0.5420.34
155_L172_P0.5400.34
31_W152_F0.5390.34
45_I212_D0.5370.34
118_E187_E0.5360.34
116_R119_A0.5350.33
166_K198_R0.5350.33
136_N141_L0.5350.33
201_R216_Q0.5340.33
90_P151_Y0.5310.33
46_Y61_D0.5260.33
19_K49_K0.5240.32
142_Q147_K0.5230.32
28_S102_Y0.5220.32
126_V171_P0.5220.32
79_R112_L0.5220.32
36_Q131_N0.5200.32
57_E87_K0.5190.32
171_P196_L0.5180.32
206_D212_D0.5180.32
96_L125_S0.5170.32
202_G209_A0.5170.32
28_S149_K0.5170.32
139_D223_E0.5150.32
159_L178_L0.5130.32
68_H143_G0.5100.31
170_I212_D0.5090.31
94_E128_H0.5070.31
93_L131_N0.5060.31
114_K216_Q0.5050.31
135_R140_Y0.5020.31
91_P132_M0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c18A 2 0.9577 97.3 0.891 Contact Map
1knyA 2 0.8615 97.1 0.895 Contact Map
4ebjA 2 0.9115 96 0.907 Contact Map
2rffA 1 0.3692 95.9 0.908 Contact Map
1wotA 1 0.35 95.7 0.909 Contact Map
4cs6A 1 0.85 95.6 0.91 Contact Map
1no5A 4 0.3538 93.9 0.918 Contact Map
2pbeA 1 0.8538 92.2 0.923 Contact Map
3jz0A 2 0.8923 90.2 0.926 Contact Map
1ylqA 2 0.3346 87.9 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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