GREMLIN Database
CAH - Cephalosporin-C deacetylase
UniProt: P94388 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (247)
Sequences: 13846 (9951)
Seq/√Len: 633.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_A200_A3.6731.00
118_R156_D3.5001.00
60_T68_R3.2481.00
62_K68_R3.1221.00
64_F159_R3.0851.00
176_G199_A3.0331.00
57_Y75_V2.7361.00
82_H111_A2.7331.00
163_V167_F2.6531.00
110_Y313_K2.5451.00
171_D174_R2.4971.00
187_T200_A2.4491.00
176_G312_F2.3791.00
84_A170_V2.3701.00
59_L71_G2.2851.00
162_E196_I2.2801.00
61_Y160_A2.2671.00
108_H309_L2.2521.00
281_Y288_K2.2231.00
289_E307_E2.2111.00
291_K307_E2.1981.00
202_A205_P2.1471.00
108_H313_K2.1421.00
278_F292_V2.0271.00
163_V166_S2.0081.00
267_L294_R1.9981.00
71_G113_F1.9091.00
274_P292_V1.8621.00
61_Y71_G1.8211.00
73_Y113_F1.8011.00
238_E241_A1.7921.00
75_V111_A1.7801.00
113_F160_A1.7751.00
177_V190_A1.7721.00
161_L175_I1.7161.00
188_I202_A1.6631.00
201_V312_F1.6571.00
267_L292_V1.6521.00
201_V308_K1.6481.00
76_P82_H1.6471.00
73_Y111_A1.6291.00
253_L256_R1.5921.00
90_G181_S1.5831.00
84_A111_A1.5711.00
177_V187_T1.5701.00
289_E314_Q1.5701.00
76_P111_A1.5701.00
104_N108_H1.5581.00
293_Y303_A1.5551.00
180_G203_D1.5481.00
293_Y307_E1.5281.00
78_K82_H1.5241.00
64_F155_L1.4921.00
180_G204_Y1.4731.00
306_T310_A1.4681.00
158_V194_S1.4641.00
113_F164_I1.4341.00
155_L193_L1.4241.00
84_A164_I1.4121.00
239_V243_K1.4111.00
287_K315_H1.4071.00
74_A114_G1.3831.00
71_G160_A1.3621.00
158_V162_E1.3561.00
148_Y151_R1.3561.00
58_R70_T1.3521.00
263_M281_Y1.3441.00
191_A259_V1.3251.00
198_K205_P1.3211.00
150_Y153_V1.3201.00
88_Y157_A1.3111.00
162_E166_S1.2951.00
78_K81_P1.2891.00
246_S249_D1.2761.00
281_Y290_L1.2701.00
268_I295_Y1.2661.00
174_R198_K1.2581.00
303_A307_E1.2541.00
274_P278_F1.2511.00
59_L163_V1.2491.00
55_K75_V1.2461.00
165_S196_I1.2101.00
57_Y167_F1.2091.00
89_H117_V1.2011.00
81_P171_D1.1981.00
56_V74_A1.1891.00
263_M280_A1.1831.00
65_G118_R1.1451.00
201_V262_L1.1431.00
60_T70_T1.1421.00
157_A190_A1.1361.00
86_V161_L1.1331.00
261_V284_L1.1321.00
240_Q243_K1.1291.00
162_E194_S1.1231.00
200_A261_V1.1211.00
98_E101_E1.1061.00
173_T198_K1.1061.00
177_V200_A1.1041.00
84_A175_I1.0981.00
293_Y296_F1.0911.00
165_S170_V1.0881.00
159_R162_E1.0861.00
267_L295_Y1.0851.00
265_I274_P1.0821.00
309_L313_K1.0771.00
307_E310_A1.0771.00
205_P208_S1.0721.00
195_D258_K1.0661.00
158_V193_L1.0641.00
267_L274_P1.0621.00
102_M114_G1.0601.00
84_A113_F1.0571.00
111_A170_V1.0531.00
85_I110_Y1.0481.00
61_Y115_M1.0471.00
151_R155_L1.0381.00
85_I105_W1.0361.00
242_M246_S1.0301.00
242_M245_L1.0301.00
125_D129_S1.0291.00
155_L159_R1.0251.00
241_A244_T1.0211.00
74_A106_A1.0171.00
278_F282_N1.0161.00
263_M277_V1.0151.00
115_M160_A1.0131.00
87_K102_M1.0121.00
192_A257_V1.0121.00
189_A193_L1.0111.00
265_I277_V1.0101.00
239_V242_M1.0081.00
188_I205_P1.0061.00
87_K178_T1.0051.00
111_A169_E1.0031.00
264_S304_F0.9961.00
83_P174_R0.9891.00
103_V107_L0.9861.00
102_M106_A0.9781.00
204_Y300_Y0.9761.00
244_T247_Y0.9691.00
262_L291_K0.9621.00
200_A259_V0.9611.00
246_S252_N0.9511.00
202_A263_M0.9491.00
42_P45_Q0.9471.00
154_Y189_A0.9451.00
151_R193_L0.9441.00
199_A311_F0.9431.00
243_K247_Y0.9371.00
104_N309_L0.9371.00
278_F290_L0.9341.00
209_N212_R0.9271.00
148_Y152_G0.9241.00
63_S159_R0.9231.00
55_K77_D0.9151.00
86_V157_A0.9131.00
152_G155_L0.9011.00
304_F308_K0.8991.00
285_E288_K0.8911.00
236_E239_V0.8881.00
50_P53_G0.8811.00
75_V169_E0.8781.00
181_S298_H0.8751.00
199_A312_F0.8671.00
70_T123_S0.8651.00
153_V182_Q0.8591.00
88_Y177_V0.8591.00
277_V290_L0.8581.00
117_V153_V0.8571.00
165_S172_E0.8531.00
192_A280_A0.8511.00
42_P46_P0.8481.00
63_S67_A0.8451.00
302_P306_T0.8411.00
81_P169_E0.8341.00
178_T201_V0.8331.00
192_A253_L0.8321.00
205_P272_T0.8311.00
83_P171_D0.8291.00
199_A260_P0.8291.00
199_A315_H0.8231.00
85_I178_T0.8201.00
89_H120_Q0.8161.00
198_K260_P0.8141.00
201_V264_S0.8001.00
165_S168_D0.8001.00
96_D99_I0.7991.00
255_D283_H0.7891.00
71_G115_M0.7841.00
213_A217_A0.7831.00
79_E82_H0.7821.00
74_A102_M0.7811.00
251_M254_A0.7801.00
264_S293_Y0.7791.00
102_M112_T0.7781.00
110_Y312_F0.7751.00
106_A112_T0.7751.00
283_H286_T0.7711.00
265_I292_V0.7681.00
264_S291_K0.7651.00
161_L197_P0.7621.00
184_G205_P0.7621.00
193_L253_L0.7581.00
61_Y159_R0.7571.00
188_I208_S0.7561.00
212_R215_D0.7551.00
178_T203_D0.7551.00
281_Y285_E0.7521.00
191_A261_V0.7501.00
54_V103_V0.7491.00
280_A284_L0.7481.00
162_E165_S0.7471.00
43_D46_P0.7471.00
88_Y187_T0.7461.00
96_D101_E0.7451.00
116_L121_Q0.7401.00
61_Y69_I0.7371.00
228_F231_R0.7351.00
236_E241_A0.7341.00
311_F315_H0.7341.00
257_V284_L0.7341.00
85_I312_F0.7291.00
157_A186_L0.7281.00
203_D264_S0.7181.00
153_V186_L0.7151.00
170_V175_I0.7141.00
187_T191_A0.7131.00
70_T116_L0.7131.00
229_F232_N0.7111.00
95_Y122_S0.7051.00
269_D298_H0.7041.00
97_G100_H0.7001.00
68_R124_E0.6991.00
91_Y182_Q0.6981.00
67_A118_R0.6981.00
254_A257_V0.6971.00
74_A112_T0.6971.00
212_R276_T0.6971.00
171_D198_K0.6971.00
63_S69_I0.6961.00
158_V190_A0.6951.00
149_Y210_F0.6931.00
116_L123_S0.6901.00
243_K246_S0.6891.00
63_S118_R0.6841.00
160_A163_V0.6831.00
238_E242_M0.6811.00
87_K114_G0.6791.00
279_A282_N0.6791.00
310_A314_Q0.6781.00
61_Y163_V0.6781.00
86_V113_F0.6761.00
257_V280_A0.6741.00
158_V161_L0.6741.00
69_I115_M0.6741.00
205_P265_I0.6741.00
282_N286_T0.6731.00
254_A280_A0.6721.00
214_I217_A0.6681.00
277_V281_Y0.6671.00
53_G77_D0.6671.00
187_T202_A0.6661.00
65_G155_L0.6651.00
88_Y115_M0.6651.00
165_S175_I0.6631.00
188_I261_V0.6601.00
189_A192_A0.6571.00
104_N107_L0.6501.00
85_I112_T0.6451.00
73_Y169_E0.6451.00
289_E292_V0.6451.00
56_V72_W0.6431.00
110_Y176_G0.6421.00
75_V78_K0.6421.00
85_I176_G0.6411.00
288_K291_K0.6361.00
88_Y186_L0.6351.00
96_D100_H0.6341.00
178_T308_K0.6331.00
198_K201_V0.6321.00
154_Y158_V0.6321.00
105_W178_T0.6311.00
58_R72_W0.6301.00
201_V205_P0.6281.00
188_I280_A0.6251.00
59_L167_F0.6241.00
279_A283_H0.6191.00
154_Y190_A0.6161.00
86_V115_M0.6151.00
151_R247_Y0.6151.00
199_A202_A0.6131.00
97_G101_E0.6111.00
310_A313_K0.6111.00
203_D304_F0.6101.00
178_T312_F0.6061.00
106_A111_A0.6061.00
105_W308_K0.6051.00
185_G189_A0.5991.00
194_S197_P0.5991.00
296_F300_Y0.5971.00
218_L271_V0.5961.00
227_S232_N0.5951.00
182_Q185_G0.5931.00
303_A306_T0.5911.00
87_K112_T0.5911.00
154_Y186_L0.5911.00
184_G202_A0.5891.00
88_Y117_V0.5871.00
262_L311_F0.5861.00
158_V197_P0.5861.00
63_S155_L0.5841.00
176_G198_K0.5831.00
189_A253_L0.5831.00
249_D252_N0.5821.00
57_Y169_E0.5811.00
124_E127_S0.5801.00
202_A280_A0.5781.00
180_G299_E0.5761.00
254_A283_H0.5761.00
263_M284_L0.5751.00
213_A219_E0.5731.00
265_I290_L0.5731.00
105_W309_L0.5721.00
226_N229_F0.5711.00
54_V106_A0.5711.00
104_N305_Q0.5701.00
71_G163_V0.5701.00
75_V82_H0.5661.00
260_P287_K0.5661.00
199_A205_P0.5641.00
265_I272_T0.5581.00
262_L307_E0.5561.00
182_Q186_L0.5551.00
204_Y266_G0.5551.00
117_V120_Q0.5541.00
204_Y265_I0.5531.00
211_E246_S0.5511.00
291_K294_R0.5511.00
179_G184_G0.5471.00
211_E242_M0.5461.00
204_Y299_E0.5461.00
203_D308_K0.5431.00
208_S280_A0.5400.99
191_A257_V0.5390.99
59_L113_F0.5380.99
62_K163_V0.5370.99
67_A124_E0.5370.99
44_L47_V0.5340.99
241_A245_L0.5300.99
270_K297_G0.5300.99
275_S279_A0.5300.99
289_E294_R0.5270.99
288_K292_V0.5240.99
269_D272_T0.5230.99
228_F232_N0.5220.99
220_Q227_S0.5140.99
105_W110_Y0.5140.99
59_L73_Y0.5130.99
57_Y78_K0.5130.99
238_E243_K0.5130.99
209_N279_A0.5130.99
287_K294_R0.5090.99
240_Q244_T0.5090.99
82_H169_E0.5080.99
184_G272_T0.5080.99
211_E215_D0.5030.99
62_K66_N0.5030.99
274_P290_L0.5030.99
200_A205_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l7aA 5 1 100 0.283 Contact Map
1vlqA 5 0.9843 100 0.291 Contact Map
3fcyA 5 0.9843 100 0.339 Contact Map
3iiiA 1 0.8648 100 0.411 Contact Map
3azoA 1 0.934 100 0.412 Contact Map
2b9vA 5 0.8428 100 0.414 Contact Map
4q1vA 2 0.8994 100 0.419 Contact Map
4hxfB 4 0.9151 100 0.42 Contact Map
2z3zA 2 0.8711 100 0.42 Contact Map
1mpxA 4 0.8553 100 0.421 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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