GREMLIN Database
YCGK - Uncharacterized HTH-type transcriptional regulator YcgK
UniProt: P94387 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (286)
Sequences: 79283 (57302)
Seq/√Len: 3388.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_D74_S3.6821.00
15_R24_H3.4521.00
158_T305_R2.7361.00
67_K81_E2.5041.00
96_G141_V2.5011.00
11_E24_H2.3951.00
249_V256_T2.2991.00
162_T282_T2.2671.00
173_K207_V2.2481.00
92_K123_Q2.2411.00
159_P162_T2.2371.00
112_Q307_S2.2171.00
159_P282_T2.2131.00
164_P260_N2.1421.00
45_L60_H2.1311.00
8_Y35_Q2.1021.00
92_K121_E2.1001.00
20_K23_E2.0771.00
162_T280_S2.0671.00
10_A69_E2.0531.00
67_K74_S2.0191.00
14_R69_E2.0191.00
10_A14_R2.0171.00
200_P203_M2.0151.00
112_Q303_L2.0051.00
94_S123_Q1.9871.00
10_A65_I1.9751.00
166_V260_N1.9681.00
11_E15_R1.9651.00
11_E14_R1.9491.00
13_A57_L1.9321.00
210_I254_G1.9251.00
8_Y32_L1.9251.00
132_L144_S1.9171.00
71_I75_R1.8921.00
65_I69_E1.8471.00
208_P236_A1.7681.00
18_F36_I1.7551.00
64_F78_L1.7301.00
49_H56_T1.7281.00
157_I284_V1.7151.00
63_R81_E1.7001.00
13_A65_I1.6811.00
135_M140_E1.6551.00
15_R20_K1.6281.00
156_S289_K1.5931.00
14_R24_H1.5901.00
10_A68_A1.5801.00
113_F300_F1.5611.00
169_V273_L1.5481.00
5_V35_Q1.5431.00
9_A65_I1.5361.00
67_K70_D1.5281.00
158_T287_F1.5221.00
134_K138_K1.5151.00
8_Y27_I1.5121.00
17_S20_K1.5111.00
113_F120_V1.4881.00
5_V42_E1.4881.00
5_V38_K1.4851.00
28_A31_S1.4841.00
196_Q203_M1.4661.00
19_T29_Q1.4651.00
88_G119_H1.4491.00
46_T49_H1.4491.00
301_M305_R1.4391.00
146_L286_V1.4361.00
59_P62_R1.4311.00
11_E25_L1.4301.00
219_R223_L1.4241.00
103_R243_E1.4171.00
156_S287_F1.4161.00
293_V297_A1.4111.00
67_K77_D1.4041.00
10_A72_I1.3961.00
71_I78_L1.3851.00
148_L284_V1.3811.00
287_F301_M1.3791.00
51_S56_T1.3731.00
94_S125_V1.3571.00
250_A269_G1.3451.00
299_A302_E1.3451.00
90_G119_H1.3411.00
136_T144_S1.3401.00
112_Q116_R1.3311.00
64_F79_L1.3301.00
135_M141_V1.3301.00
127_K131_S1.3291.00
74_S77_D1.3251.00
116_R303_L1.3191.00
285_F301_M1.3141.00
163_E261_M1.3111.00
137_A154_R1.3081.00
169_V255_V1.2931.00
245_A256_T1.2891.00
3_I75_R1.2841.00
143_L297_A1.2801.00
66_E70_D1.2771.00
143_L285_F1.2681.00
207_V255_V1.2661.00
42_E79_L1.2641.00
114_L236_A1.2621.00
67_K78_L1.2541.00
159_P284_V1.2321.00
114_L208_P1.2271.00
247_S250_A1.2261.00
27_I31_S1.2151.00
63_R66_E1.2041.00
111_K115_A1.2001.00
9_A48_F1.1941.00
174_Q207_V1.1881.00
34_Q38_K1.1781.00
171_K269_G1.1751.00
273_L276_Q1.1691.00
62_R66_E1.1691.00
111_K251_N1.1621.00
9_A13_A1.1571.00
37_K41_A1.1521.00
271_I274_S1.1461.00
157_I286_V1.1421.00
260_N264_R1.1351.00
123_Q238_K1.1261.00
198_C276_Q1.1171.00
112_Q115_A1.1141.00
9_A47_L1.1111.00
34_Q37_K1.1101.00
117_Y299_A1.1101.00
63_R67_K1.1071.00
226_C231_F1.1051.00
208_P234_N1.1031.00
171_K271_I1.1001.00
210_I245_A1.0981.00
70_D77_D1.0971.00
266_K269_G1.0951.00
102_G126_E1.0821.00
303_L307_S1.0791.00
12_I21_A1.0791.00
127_K135_M1.0781.00
108_P251_N1.0781.00
18_F55_V1.0761.00
11_E21_A1.0741.00
6_M68_A1.0721.00
199_V203_M1.0711.00
93_L300_F1.0711.00
33_S37_K1.0681.00
71_I74_S1.0661.00
158_T301_M1.0651.00
113_F303_L1.0641.00
302_E305_R1.0631.00
298_Q302_E1.0471.00
247_S251_N1.0431.00
35_Q38_K1.0401.00
170_P252_G1.0391.00
239_T245_A1.0291.00
109_L304_S1.0261.00
7_E76_D1.0241.00
4_K7_E1.0161.00
246_Q250_A1.0151.00
79_L83_Q1.0111.00
168_A263_R0.9981.00
164_P280_S0.9961.00
57_L61_G0.9951.00
73_R77_D0.9911.00
137_A152_D0.9881.00
211_L235_A0.9871.00
303_L306_E0.9831.00
8_Y25_L0.9801.00
166_V272_Y0.9791.00
13_A48_F0.9751.00
169_V173_K0.9731.00
125_V135_M0.9721.00
167_L255_V0.9711.00
250_A270_V0.9691.00
12_I18_F0.9681.00
64_F68_A0.9661.00
27_I32_L0.9611.00
113_F117_Y0.9611.00
220_R223_L0.9571.00
239_T248_L0.9491.00
76_D79_L0.9411.00
76_D80_R0.9391.00
9_A57_L0.9341.00
38_K41_A0.9311.00
21_A32_L0.9301.00
116_R306_E0.9301.00
9_A39_L0.9281.00
135_M138_K0.9171.00
63_R85_R0.9131.00
48_F55_V0.9071.00
294_S297_A0.8981.00
96_G132_L0.8951.00
20_K24_H0.8941.00
109_L303_L0.8931.00
70_D73_R0.8821.00
45_L82_M0.8781.00
99_A241_H0.8761.00
168_A272_Y0.8761.00
141_V144_S0.8741.00
16_Q56_T0.8671.00
66_E69_E0.8661.00
13_A61_G0.8631.00
173_K208_P0.8561.00
121_E234_N0.8491.00
19_T23_E0.8481.00
148_L282_T0.8471.00
208_P235_A0.8461.00
95_I143_L0.8441.00
96_G146_L0.8361.00
203_M206_N0.8351.00
120_V296_T0.8341.00
25_L32_L0.8331.00
169_V174_Q0.8331.00
156_S159_P0.8311.00
288_L291_R0.8301.00
51_S54_S0.8291.00
111_K253_L0.8291.00
175_R207_V0.8271.00
60_H85_R0.8261.00
133_E137_A0.8241.00
91_H296_T0.8221.00
164_P274_S0.8201.00
155_L286_V0.8191.00
75_R79_L0.8191.00
174_Q197_P0.8151.00
222_V226_C0.8151.00
220_R224_D0.8111.00
125_V141_V0.8091.00
96_G144_S0.8081.00
202_D205_R0.8071.00
13_A16_Q0.8061.00
168_A256_T0.8051.00
60_H82_M0.8031.00
293_V298_Q0.8021.00
75_R78_L0.8011.00
60_H63_R0.8011.00
9_A64_F0.8001.00
109_L307_S0.7991.00
127_K132_L0.7971.00
74_S78_L0.7961.00
176_W195_R0.7931.00
77_D81_E0.7911.00
37_K46_T0.7881.00
265_D268_P0.7881.00
16_Q62_R0.7881.00
12_I48_F0.7861.00
4_K35_Q0.7851.00
195_R208_P0.7851.00
225_L229_S0.7841.00
14_R65_I0.7841.00
302_E306_E0.7831.00
12_I36_I0.7821.00
114_L253_L0.7821.00
170_P253_L0.7811.00
131_S134_K0.7771.00
16_Q54_S0.7761.00
29_Q33_S0.7751.00
15_R21_A0.7751.00
154_R289_K0.7731.00
264_R267_D0.7731.00
3_I72_I0.7721.00
295_L299_A0.7721.00
164_P278_A0.7651.00
200_P276_Q0.7651.00
7_E11_E0.7611.00
91_H120_V0.7601.00
5_V8_Y0.7461.00
143_L300_F0.7411.00
18_F32_L0.7411.00
78_L82_M0.7411.00
248_L253_L0.7371.00
113_F299_A0.7321.00
69_E73_R0.7291.00
266_K270_V0.7291.00
260_N272_Y0.7271.00
224_D228_E0.7251.00
89_I117_Y0.7251.00
12_I32_L0.7251.00
168_A258_A0.7221.00
68_A71_I0.7221.00
197_P272_Y0.7221.00
49_H54_S0.7221.00
116_R299_A0.7211.00
225_L228_E0.7201.00
137_A155_L0.7201.00
170_P173_K0.7161.00
97_I102_G0.7161.00
270_V274_S0.7161.00
241_H244_T0.7141.00
83_Q86_S0.7131.00
49_H58_T0.7091.00
166_V273_L0.7061.00
176_W271_I0.7041.00
112_Q306_E0.7031.00
62_R65_I0.7021.00
60_H64_F0.6971.00
246_Q265_D0.6971.00
205_R231_F0.6911.00
142_D297_A0.6901.00
31_S35_Q0.6891.00
56_T62_R0.6891.00
259_P262_V0.6881.00
57_L62_R0.6881.00
131_S135_M0.6871.00
202_D229_S0.6871.00
209_F233_P0.6851.00
213_K238_K0.6841.00
221_T225_L0.6831.00
169_V175_R0.6821.00
299_A303_L0.6811.00
139_G288_L0.6801.00
94_S141_V0.6791.00
172_E252_G0.6771.00
103_R247_S0.6771.00
7_E10_A0.6761.00
219_R238_K0.6751.00
59_P63_R0.6751.00
94_S142_D0.6731.00
223_L227_A0.6681.00
224_D227_A0.6631.00
212_L245_A0.6581.00
209_F255_V0.6551.00
237_F248_L0.6541.00
64_F82_M0.6511.00
172_E175_R0.6501.00
222_V225_L0.6471.00
121_E238_K0.6461.00
77_D80_R0.6421.00
40_E45_L0.6401.00
23_E26_H0.6341.00
167_L257_M0.6341.00
40_E50_R0.6301.00
97_I106_F0.6281.00
67_K71_I0.6271.00
291_R294_S0.6251.00
73_R76_D0.6251.00
173_K176_W0.6231.00
167_L204_V0.6221.00
68_A72_I0.6191.00
126_E240_S0.6171.00
36_I40_E0.6151.00
12_I17_S0.6141.00
93_L296_T0.6101.00
295_L298_Q0.6091.00
206_N234_N0.6091.00
220_R225_L0.6051.00
147_S281_R0.6021.00
18_F54_S0.5971.00
108_P111_K0.5951.00
143_L301_M0.5931.00
300_F304_S0.5901.00
108_P112_Q0.5901.00
21_A25_L0.5891.00
99_A128_D0.5881.00
145_V304_S0.5871.00
7_E72_I0.5861.00
80_R84_E0.5861.00
4_K38_K0.5851.00
195_R198_C0.5851.00
106_F109_L0.5831.00
163_E281_R0.5821.00
93_L143_L0.5811.00
213_K240_S0.5811.00
218_F222_V0.5811.00
43_L64_F0.5781.00
136_T286_V0.5751.00
31_S34_Q0.5741.00
226_C233_P0.5741.00
63_R82_M0.5711.00
221_T224_D0.5701.00
4_K8_Y0.5681.00
9_A61_G0.5681.00
126_E241_H0.5681.00
167_L209_F0.5651.00
245_A249_V0.5631.00
30_P34_Q0.5621.00
250_A267_D0.5611.00
165_V257_M0.5611.00
90_G121_E0.5581.00
161_L283_L0.5581.00
172_E271_I0.5571.00
239_T244_T0.5571.00
223_L226_C0.5561.00
287_F298_Q0.5551.00
48_F57_L0.5551.00
28_A34_Q0.5531.00
43_L82_M0.5531.00
136_T155_L0.5531.00
270_V275_I0.5501.00
267_D270_V0.5451.00
248_L254_G0.5451.00
72_I76_D0.5451.00
57_L65_I0.5441.00
117_Y120_V0.5441.00
45_L49_H0.5441.00
214_E238_K0.5401.00
173_K255_V0.5391.00
84_E89_I0.5351.00
101_T105_L0.5351.00
91_H119_H0.5311.00
169_V271_I0.5311.00
110_L122_V0.5291.00
96_G125_V0.5291.00
43_L46_T0.5291.00
156_S290_N0.5261.00
200_P277_S0.5221.00
13_A62_R0.5221.00
160_L285_F0.5201.00
258_A263_R0.5201.00
66_E81_E0.5191.00
198_C203_M0.5171.00
174_Q196_Q0.5171.00
8_Y36_I0.5161.00
175_R199_V0.5141.00
168_A266_K0.5111.00
8_Y21_A0.5101.00
148_L157_I0.5091.00
274_S277_S0.5071.00
46_T60_H0.5071.00
103_R241_H0.5071.00
18_F29_Q0.5061.00
16_Q55_V0.5051.00
81_E84_E0.5041.00
80_R83_Q0.5041.00
134_K140_E0.5031.00
242_I259_P0.5011.00
27_I35_Q0.5011.00
175_R196_Q0.5011.00
266_K271_I0.5001.00
198_C274_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ixcA 4 0.8981 100 0.149 Contact Map
2h98A 2 0.6512 100 0.16 Contact Map
1al3A 1 0.6821 100 0.161 Contact Map
2esnA 3 0.8951 100 0.161 Contact Map
4x6gA 4 0.9259 100 0.163 Contact Map
1uthA 2 0.6914 100 0.163 Contact Map
3fzvA 4 0.8765 100 0.167 Contact Map
2h9bA 2 0.6512 100 0.169 Contact Map
3fxqA 3 0.892 100 0.17 Contact Map
3szpA 3 0.8858 100 0.188 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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