GREMLIN Database
YCGH - Uncharacterized transporter YcgH
UniProt: P94383 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (416)
Sequences: 24830 (16256)
Seq/√Len: 797.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_L338_F4.3671.00
320_C332_P4.3591.00
54_G243_A3.2571.00
323_L332_P3.1251.00
230_E233_K2.9491.00
14_A226_K2.9221.00
94_G311_M2.7421.00
78_C314_D2.7351.00
225_L231_A2.6991.00
312_A322_T2.6451.00
325_E331_W2.6411.00
169_A252_L2.5961.00
130_S342_V2.4971.00
19_S237_L2.4671.00
320_C323_L2.4501.00
227_K230_E2.4141.00
167_V171_L2.4081.00
15_W237_L2.4051.00
223_V313_D2.3661.00
280_I284_I2.3621.00
393_Y397_V2.3561.00
82_R90_G2.2821.00
224_H306_T2.2021.00
18_L225_L2.1801.00
335_G339_A2.1721.00
138_L142_T2.1431.00
309_C313_D2.1181.00
15_W19_S2.0951.00
145_S149_K2.0941.00
134_V342_V2.0941.00
15_W231_A2.0871.00
141_F331_W2.0821.00
66_K382_T2.0791.00
137_L334_L2.0521.00
85_F380_K2.0381.00
233_K237_L2.0071.00
129_A345_I1.9971.00
14_A17_Q1.9821.00
82_R87_K1.9811.00
130_S345_I1.9791.00
395_A399_I1.9661.00
271_T274_K1.9661.00
63_Q375_L1.9581.00
398_L402_A1.9441.00
261_T275_G1.9301.00
9_P324_K1.9261.00
315_G319_K1.9141.00
98_W337_T1.9121.00
428_I432_I1.9021.00
156_V160_A1.8791.00
321_F336_L1.8641.00
426_I429_V1.8601.00
55_I59_F1.8551.00
258_P261_T1.8401.00
38_A46_V1.8391.00
394_L398_L1.8381.00
383_D386_G1.8291.00
85_F376_F1.8261.00
397_V401_A1.8051.00
271_T275_G1.7871.00
372_L401_A1.7711.00
17_Q152_N1.7491.00
397_V404_S1.7361.00
236_K240_A1.7351.00
134_V338_F1.7311.00
140_I298_V1.7271.00
45_S201_L1.7091.00
427_A431_M1.6871.00
49_S204_G1.6871.00
81_A93_N1.6831.00
325_E329_I1.6781.00
13_L17_Q1.6681.00
105_T341_L1.6671.00
109_L297_L1.6621.00
88_W430_T1.6621.00
404_S407_L1.6591.00
160_A164_M1.6561.00
141_F335_G1.6531.00
133_A341_L1.6471.00
227_K231_A1.6451.00
19_S241_T1.6271.00
93_N373_F1.6071.00
95_W426_I1.5811.00
22_G238_M1.5661.00
240_A244_I1.5321.00
394_L397_V1.5191.00
161_A288_I1.5161.00
183_G186_V1.5151.00
86_G89_A1.5111.00
308_L333_A1.5111.00
116_T128_F1.4981.00
304_V337_T1.4951.00
9_P309_C1.4821.00
402_A406_T1.4751.00
53_A208_A1.4751.00
227_K233_K1.4751.00
124_P127_V1.4701.00
221_M302_F1.4691.00
184_I187_P1.4661.00
109_L133_A1.4601.00
380_K384_P1.4571.00
332_P336_L1.4531.00
375_L400_A1.4441.00
309_C324_K1.4391.00
85_F89_A1.4311.00
137_L335_G1.4241.00
384_P388_G1.4121.00
274_K282_L1.4091.00
319_K322_T1.4061.00
10_K328_K1.4001.00
112_I290_I1.3971.00
228_P232_S1.3891.00
170_I252_L1.3871.00
319_K323_L1.3791.00
74_K223_V1.3771.00
61_F239_L1.3761.00
305_T334_L1.3691.00
133_A338_F1.3641.00
17_Q148_E1.3611.00
71_Q83_K1.3561.00
420_I424_V1.3521.00
81_A373_F1.3511.00
429_V433_Y1.3511.00
283_D287_G1.3451.00
265_Q271_T1.3451.00
112_I132_Y1.3421.00
159_T163_F1.3401.00
130_S134_V1.3401.00
323_L331_W1.3171.00
166_I248_I1.3131.00
26_T242_L1.3111.00
60_V375_L1.2951.00
62_E236_K1.2861.00
417_F421_G1.2831.00
61_F235_G1.2811.00
244_I248_I1.2811.00
380_K383_D1.2801.00
84_A377_S1.2761.00
398_L401_A1.2761.00
413_R416_F1.2701.00
267_S271_T1.2601.00
13_L148_E1.2561.00
15_W233_K1.2561.00
79_A83_K1.2531.00
33_L111_A1.2371.00
376_F380_K1.2351.00
173_L255_L1.2341.00
403_V407_L1.2331.00
108_Q296_T1.2301.00
13_L18_L1.2291.00
409_E412_S1.2271.00
66_K69_A1.2261.00
136_G297_L1.2241.00
45_S194_F1.2121.00
384_P387_M1.2061.00
47_L251_G1.2051.00
169_A256_L1.2001.00
16_W20_L1.1911.00
422_F426_I1.1841.00
308_L317_A1.1841.00
395_A398_L1.1821.00
171_L176_I1.1811.00
165_F169_A1.1791.00
421_G424_V1.1771.00
393_Y398_L1.1691.00
413_R417_F1.1651.00
274_K279_E1.1561.00
64_L77_F1.1541.00
170_I174_C1.1451.00
81_A89_A1.1421.00
98_W308_L1.1401.00
18_L234_S1.1351.00
73_E79_A1.1311.00
91_F95_W1.1311.00
22_G218_M1.1291.00
139_I150_T1.1241.00
88_W427_A1.1211.00
68_S80_Y1.1201.00
150_T154_L1.1191.00
174_C177_L1.1161.00
186_V189_K1.1161.00
393_Y396_M1.1161.00
127_V131_I1.1071.00
395_A404_S1.1031.00
151_E298_V1.0981.00
164_M168_I1.0921.00
12_N226_K1.0901.00
332_P335_G1.0871.00
226_K231_A1.0811.00
400_A404_S1.0801.00
23_V241_T1.0771.00
116_T290_I1.0761.00
339_A343_L1.0761.00
131_I135_L1.0681.00
113_S128_F1.0631.00
123_V127_V1.0631.00
324_K328_K1.0621.00
149_K153_V1.0611.00
21_I221_M1.0611.00
395_A406_T1.0591.00
78_C310_T1.0571.00
137_L141_F1.0541.00
397_V407_L1.0521.00
412_S415_G1.0501.00
258_P275_G1.0431.00
388_G391_Q1.0401.00
163_F167_V1.0351.00
73_E83_K1.0301.00
126_W130_S1.0241.00
313_D322_T1.0191.00
144_L302_F1.0131.00
70_K388_G1.0111.00
141_F329_I1.0091.00
70_K386_G1.0081.00
385_E388_G1.0071.00
383_D387_M1.0031.00
185_H188_N1.0031.00
134_V138_L1.0031.00
400_A406_T0.9991.00
410_K413_R0.9981.00
159_T245_I0.9941.00
116_T120_F0.9931.00
23_V242_L0.9911.00
186_V190_T0.9851.00
389_K392_I0.9841.00
388_G392_I0.9831.00
372_L376_F0.9831.00
51_L247_I0.9791.00
191_S194_F0.9791.00
403_V406_T0.9721.00
414_P417_F0.9691.00
154_L295_S0.9691.00
141_F325_E0.9651.00
379_K382_T0.9651.00
279_E283_D0.9631.00
113_S129_A0.9621.00
39_I46_V0.9611.00
213_G367_L0.9591.00
393_Y404_S0.9581.00
421_G425_I0.9561.00
412_S416_F0.9531.00
54_G212_F0.9511.00
396_M400_A0.9491.00
136_G298_V0.9491.00
47_L254_L0.9431.00
243_A247_I0.9421.00
189_K192_E0.9411.00
398_L406_T0.9391.00
55_I399_I0.9381.00
365_L419_S0.9301.00
216_E220_L0.9291.00
166_I170_I0.9231.00
394_L403_V0.9211.00
424_V428_I0.9171.00
187_P190_T0.9171.00
251_G255_L0.9161.00
88_W92_S0.9151.00
20_L152_N0.9151.00
418_V421_G0.9131.00
9_P224_H0.9081.00
171_L175_G0.9061.00
166_I252_L0.9011.00
158_K292_A0.8991.00
95_W317_A0.8931.00
75_G78_C0.8911.00
411_S415_G0.8901.00
107_S210_Y0.8881.00
9_P306_T0.8851.00
301_L338_F0.8831.00
12_N145_S0.8831.00
75_G79_A0.8811.00
393_Y400_A0.8801.00
401_A405_G0.8791.00
408_F411_S0.8791.00
323_L326_G0.8781.00
416_F419_S0.8781.00
184_I188_N0.8761.00
277_N281_I0.8761.00
414_P418_V0.8741.00
82_R314_D0.8741.00
268_P273_L0.8691.00
27_I30_G0.8671.00
122_Q125_L0.8651.00
135_L294_F0.8641.00
394_L401_A0.8611.00
338_F342_V0.8581.00
128_F131_I0.8561.00
321_F332_P0.8521.00
400_A403_V0.8501.00
317_A321_F0.8481.00
197_G200_G0.8451.00
397_V400_A0.8441.00
183_G187_P0.8441.00
203_T207_Y0.8441.00
430_T434_Q0.8431.00
97_Y101_E0.8431.00
237_L241_T0.8431.00
339_A342_V0.8421.00
194_F197_G0.8411.00
394_L406_T0.8401.00
17_Q149_K0.8401.00
86_G431_M0.8391.00
411_S416_F0.8391.00
59_F399_I0.8381.00
58_Y62_E0.8351.00
89_A373_F0.8341.00
425_I429_V0.8341.00
56_G403_V0.8331.00
398_L407_L0.8291.00
107_S360_T0.8281.00
149_K152_N0.8271.00
393_Y399_I0.8261.00
331_W335_G0.8261.00
16_W152_N0.8211.00
411_S414_P0.8201.00
112_I293_G0.8191.00
217_V303_A0.8171.00
59_F63_Q0.8161.00
417_F420_I0.8151.00
110_T359_M0.8151.00
273_L278_L0.8141.00
184_I255_L0.8141.00
401_A404_S0.8121.00
385_E391_Q0.8121.00
51_L55_I0.8121.00
256_L272_S0.8111.00
194_F201_L0.8101.00
173_L176_I0.8081.00
401_A406_T0.8061.00
138_L141_F0.8061.00
408_F416_F0.8061.00
278_L281_I0.8011.00
408_F412_S0.7971.00
112_I294_F0.7961.00
133_A345_I0.7961.00
63_Q397_V0.7941.00
397_V406_T0.7941.00
58_Y236_K0.7911.00
170_I248_I0.7881.00
171_L174_C0.7871.00
419_S423_L0.7851.00
265_Q268_P0.7821.00
48_L52_I0.7811.00
362_A366_M0.7801.00
190_T195_P0.7781.00
27_I158_K0.7781.00
213_G371_W0.7771.00
378_S382_T0.7761.00
165_F273_L0.7721.00
102_M340_G0.7681.00
228_P231_A0.7681.00
136_G301_L0.7681.00
81_A377_S0.7681.00
198_A201_L0.7681.00
48_L201_L0.7661.00
394_L399_I0.7651.00
267_S270_I0.7641.00
12_N144_L0.7641.00
396_M404_S0.7581.00
67_L378_S0.7581.00
185_H189_K0.7561.00
326_G331_W0.7541.00
387_M391_Q0.7521.00
410_K414_P0.7491.00
142_T146_V0.7471.00
395_A400_A0.7471.00
27_I245_I0.7451.00
402_A405_G0.7451.00
396_M401_A0.7451.00
67_L80_Y0.7441.00
227_K232_S0.7431.00
126_W345_I0.7421.00
31_F249_S0.7421.00
15_W234_S0.7411.00
429_V432_I0.7341.00
78_C82_R0.7311.00
9_P12_N0.7251.00
26_T238_M0.7241.00
431_M435_K0.7221.00
140_I334_L0.7171.00
394_L400_A0.7161.00
16_W149_K0.7131.00
273_L276_Y0.7121.00
85_F377_S0.7111.00
432_I435_K0.7101.00
173_L252_L0.7101.00
123_V126_W0.7091.00
57_T215_I0.7071.00
19_S234_S0.7071.00
393_Y403_V0.7061.00
166_I249_S0.7021.00
104_I363_A0.7011.00
183_G188_N0.7011.00
325_E328_K0.7001.00
305_T333_A0.7001.00
422_F425_I0.6991.00
418_V422_F0.6981.00
241_T245_I0.6911.00
140_I302_F0.6891.00
312_A321_F0.6881.00
382_T386_G0.6881.00
100_S367_L0.6851.00
64_L374_I0.6851.00
101_E300_S0.6821.00
280_I283_D0.6801.00
103_L362_A0.6801.00
393_Y401_A0.6791.00
301_L305_T0.6751.00
423_L427_A0.6731.00
136_G294_F0.6721.00
47_L51_L0.6711.00
252_L255_L0.6701.00
35_S250_I0.6701.00
141_F334_L0.6681.00
113_S116_T0.6671.00
48_L51_L0.6651.00
306_T309_C0.6651.00
249_S253_A0.6651.00
106_G359_M0.6651.00
397_V403_V0.6631.00
24_G155_A0.6621.00
194_F198_A0.6621.00
232_S235_G0.6611.00
46_V250_I0.6591.00
44_F254_L0.6591.00
173_L177_L0.6581.00
28_G246_Y0.6581.00
268_P272_S0.6581.00
394_L407_L0.6581.00
115_F289_F0.6571.00
108_Q297_L0.6531.00
148_E152_N0.6521.00
385_E390_T0.6521.00
122_Q126_W0.6521.00
397_V402_A0.6511.00
394_L402_A0.6501.00
12_N16_W0.6491.00
393_Y406_T0.6461.00
38_A42_S0.6461.00
86_G90_G0.6461.00
130_S346_I0.6431.00
116_T132_Y0.6421.00
106_G344_S0.6411.00
304_V308_L0.6411.00
19_S22_G0.6391.00
50_F211_A0.6391.00
148_E298_V0.6371.00
393_Y407_L0.6371.00
223_V309_C0.6361.00
377_S381_L0.6351.00
134_V137_L0.6351.00
78_C94_G0.6351.00
219_G235_G0.6341.00
47_L247_I0.6321.00
132_Y297_L0.6311.00
118_H286_N0.6301.00
372_L405_G0.6301.00
320_C336_L0.6301.00
396_M407_L0.6291.00
61_F215_I0.6291.00
249_S269_F0.6281.00
52_I205_L0.6271.00
410_K416_F0.6261.00
74_K309_C0.6261.00
385_E389_K0.6231.00
157_I288_I0.6211.00
67_L84_A0.6211.00
37_I357_E0.6191.00
117_K125_L0.6191.00
428_I431_M0.6191.00
66_K70_K0.6181.00
25_C299_A0.6181.00
168_I172_A0.6171.00
34_G360_T0.6161.00
96_V370_T0.6161.00
65_A69_A0.6151.00
308_L336_L0.6141.00
25_C300_S0.6131.00
84_A381_L0.6131.00
357_E360_T0.6111.00
422_F429_V0.6101.00
189_K193_F0.6091.00
224_H330_C0.6091.00
146_V149_K0.6081.00
366_M370_T0.6081.00
16_W19_S0.6061.00
146_V150_T0.6041.00
241_T244_I0.6031.00
104_I107_S0.6001.00
68_S219_G0.6001.00
155_A158_K0.5991.00
143_G146_V0.5981.00
213_G216_E0.5981.00
56_G59_F0.5961.00
330_C333_A0.5941.00
376_F401_A0.5941.00
336_L340_G0.5931.00
321_F333_A0.5921.00
144_L221_M0.5911.00
415_G419_S0.5901.00
416_F420_I0.5871.00
77_F216_E0.5861.00
402_A407_L0.5861.00
109_L113_S0.5861.00
78_C90_G0.5841.00
237_L240_A0.5821.00
192_E195_P0.5821.00
183_G255_L0.5811.00
96_V369_Y0.5801.00
119_W287_G0.5791.00
248_I252_L0.5791.00
23_V155_A0.5781.00
327_K331_W0.5781.00
396_M399_I0.5761.00
401_A407_L0.5761.00
35_S39_I0.5761.00
200_G203_T0.5751.00
173_L256_L0.5731.00
81_A90_G0.5721.00
9_P74_K0.5721.00
133_A342_V0.5721.00
229_E233_K0.5711.00
37_I40_V0.5701.00
61_F65_A0.5701.00
142_T327_K0.5671.00
70_K389_K0.5661.00
269_F272_S0.5661.00
53_A212_F0.5651.00
220_L303_A0.5651.00
168_I278_L0.5641.00
101_E303_A0.5641.00
409_E414_P0.5611.00
41_K203_T0.5611.00
287_G291_I0.5601.00
386_G389_K0.5601.00
84_A380_K0.5601.00
108_Q111_A0.5591.00
425_I428_I0.5591.00
77_F220_L0.5571.00
284_I288_I0.5551.00
431_M434_Q0.5551.00
108_Q293_G0.5551.00
347_L351_L0.5541.00
31_F34_G0.5541.00
147_F302_F0.5541.00
292_A295_S0.5531.00
268_P276_Y0.5501.00
113_S125_L0.5481.00
198_A202_W0.5481.00
395_A407_L0.5471.00
426_I430_T0.5451.00
38_A208_A0.5441.00
137_L301_L0.5441.00
184_I189_K0.5441.00
421_G428_I0.5431.00
395_A403_V0.5431.00
53_A209_F0.5411.00
395_A401_A0.5411.00
320_C324_K0.5411.00
412_S419_S0.5401.00
160_A163_F0.5391.00
414_P419_S0.5391.00
102_M344_S0.5391.00
93_N370_T0.5391.00
88_W431_M0.5381.00
152_N156_V0.5361.00
63_Q378_S0.5291.00
257_V261_T0.5291.00
102_M337_T0.5291.00
416_F430_T0.5271.00
35_S38_A0.5251.00
201_L205_L0.5241.00
347_L352_P0.5241.00
135_L139_I0.5241.00
37_I41_K0.5231.00
31_F35_S0.5221.00
33_L37_I0.5211.00
241_T248_I0.5201.00
409_E416_F0.5201.00
269_F273_L0.5201.00
134_V335_G0.5201.00
119_W286_N0.5201.00
91_F426_I0.5191.00
417_F426_I0.5191.00
331_W334_L0.5181.00
306_T330_C0.5171.00
104_I108_Q0.5171.00
76_S219_G0.5161.00
273_L281_I0.5161.00
23_V26_T0.5151.00
301_L334_L0.5141.00
109_L136_G0.5141.00
172_A177_L0.5131.00
73_E223_V0.5131.00
161_A284_I0.5111.00
225_L234_S0.5111.00
60_V216_E0.5111.00
151_E295_S0.5111.00
106_G109_L0.5111.00
38_A204_G0.5111.00
47_L50_F0.5111.00
100_S366_M0.5101.00
31_F162_I0.5101.00
50_F250_I0.5091.00
151_E158_K0.5091.00
28_G158_K0.5091.00
25_C217_V0.5081.00
132_Y294_F0.5081.00
131_I134_V0.5061.00
308_L312_A0.5051.00
12_N328_K0.5051.00
65_A235_G0.5031.00
270_I274_K0.5031.00
383_D388_G0.5031.00
69_A389_K0.5031.00
67_L70_K0.5021.00
414_P421_G0.5021.00
49_S208_A0.5021.00
420_I423_L0.5021.00
263_T266_D0.5021.00
297_L300_S0.5011.00
85_F90_G0.5001.00
153_V156_V0.5001.00
22_G26_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9327 100 0.263 Contact Map
3giaA 1 0.9395 100 0.35 Contact Map
4djkA 2 0.8969 100 0.363 Contact Map
3dh4A 3 0.9395 99.2 0.834 Contact Map
2xq2A 2 0.9417 99.1 0.841 Contact Map
2jlnA 1 0.9013 98.8 0.859 Contact Map
4wgvA 2 0.8274 97.9 0.892 Contact Map
2a65A 2 0.9372 96.9 0.91 Contact Map
4us3A 1 0.8857 96.7 0.911 Contact Map
4xp4A 1 0.9305 96.5 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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