GREMLIN Database
YCGF - Putative amino acid efflux protein YcgF
UniProt: P94381 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (194)
Sequences: 12909 (9224)
Seq/√Len: 662.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_T110_F5.2231.00
84_G193_L3.5671.00
85_I89_K3.2741.00
4_F153_G2.9561.00
183_G186_G2.8661.00
70_T73_W2.6961.00
81_T196_G2.6161.00
107_R111_A2.4221.00
182_R186_G2.3641.00
39_I106_Y2.2381.00
82_Y86_E2.2081.00
50_L114_F2.1951.00
74_L78_F2.1801.00
77_F200_G2.1531.00
29_G37_A2.1341.00
88_L186_G2.1331.00
88_L189_G2.0461.00
24_A40_F1.9761.00
86_E89_K1.8981.00
10_L130_I1.8691.00
47_A118_L1.8411.00
190_V194_V1.8361.00
84_G189_G1.7921.00
8_I157_G1.7611.00
21_V44_A1.7431.00
77_F196_G1.7071.00
81_T193_L1.7061.00
22_N165_M1.7011.00
67_F70_T1.6951.00
143_N146_Q1.6861.00
28_K32_N1.6841.00
37_A166_A1.6511.00
36_H109_T1.6451.00
91_V186_G1.6391.00
69_K73_W1.5661.00
15_S157_G1.5151.00
16_A161_W1.4931.00
70_T74_L1.4811.00
49_G155_M1.4741.00
81_T85_I1.4731.00
42_L110_F1.4641.00
52_M151_S1.4641.00
111_A115_L1.4621.00
92_R186_G1.4391.00
8_I153_G1.4371.00
29_G166_A1.4351.00
40_F113_G1.4281.00
37_A41_G1.4081.00
26_I169_A1.3881.00
28_K40_F1.3861.00
110_F114_F1.3511.00
158_I162_D1.3331.00
114_F118_L1.3271.00
74_L77_F1.3141.00
67_F71_F1.3071.00
41_G166_A1.2991.00
183_G187_I1.2991.00
105_S108_K1.2741.00
79_V83_T1.2631.00
127_W154_I1.2581.00
180_L183_G1.2531.00
38_W167_I1.2511.00
7_Y11_G1.2471.00
71_F75_F1.2181.00
7_Y150_Y1.2091.00
179_K183_G1.1981.00
34_F167_I1.1881.00
108_K111_A1.1851.00
32_N36_H1.1771.00
28_K112_S1.1681.00
177_H180_L1.1641.00
84_G196_G1.1581.00
21_V117_S1.1551.00
161_W165_M1.1371.00
24_A28_K1.1291.00
5_L9_V1.1221.00
45_M155_M1.1221.00
74_L200_G1.1171.00
25_Q162_D1.1081.00
45_M159_L1.1001.00
43_G110_F1.0991.00
15_S158_I1.0991.00
24_A116_I1.0941.00
38_W163_F1.0921.00
21_V116_I1.0901.00
53_L57_F1.0821.00
22_N162_D1.0791.00
47_A114_F1.0781.00
34_F170_S1.0691.00
189_G193_L1.0691.00
79_V82_Y1.0661.00
164_C168_T1.0541.00
171_T174_N1.0521.00
193_L197_F1.0521.00
25_Q29_G1.0501.00
194_V198_Y1.0451.00
21_V158_I1.0391.00
11_G154_I1.0351.00
92_R95_M1.0311.00
27_D31_K1.0301.00
90_N185_T1.0211.00
31_K35_W1.0211.00
89_K92_R1.0161.00
35_W39_I1.0121.00
6_S9_V1.0081.00
139_A146_Q1.0081.00
58_G63_L1.0031.00
171_T175_L1.0031.00
48_D117_S1.0021.00
108_K112_S0.9991.00
30_I169_A0.9971.00
136_A139_A0.9771.00
48_D123_S0.9581.00
21_V48_D0.9541.00
187_I190_V0.9521.00
50_L118_L0.9521.00
186_G190_V0.9441.00
34_F163_F0.9361.00
179_K182_R0.9241.00
34_F166_A0.9211.00
4_F156_I0.9191.00
23_A188_A0.9171.00
6_S10_L0.9161.00
12_L157_G0.9151.00
104_P108_K0.9131.00
115_L119_S0.9071.00
51_Y124_I0.9001.00
11_G15_S0.8961.00
48_D51_Y0.8761.00
25_Q166_A0.8661.00
46_T114_F0.8621.00
21_V162_D0.8601.00
35_W106_Y0.8601.00
144_M147_L0.8571.00
193_L196_G0.8551.00
181_L185_T0.8491.00
197_F201_Y0.8491.00
22_N161_W0.8461.00
52_M127_W0.8451.00
51_Y118_L0.8411.00
144_M148_L0.8381.00
77_F81_T0.8341.00
163_F167_I0.8261.00
23_A27_D0.8151.00
65_A69_K0.8151.00
78_F81_T0.8091.00
136_A146_Q0.8051.00
103_K107_R0.8031.00
8_I12_L0.8011.00
75_F78_F0.7971.00
119_S128_L0.7921.00
88_L193_L0.7891.00
82_Y85_I0.7861.00
10_L13_S0.7821.00
41_G163_F0.7781.00
129_G133_S0.7751.00
68_V71_F0.7721.00
159_L163_F0.7711.00
38_W166_A0.7671.00
60_S64_T0.7621.00
43_G114_F0.7621.00
85_I193_L0.7581.00
39_I109_T0.7561.00
184_L188_A0.7541.00
9_V13_S0.7531.00
87_T189_G0.7521.00
65_A68_V0.7481.00
15_S162_D0.7471.00
51_Y123_S0.7461.00
45_M158_I0.7441.00
10_L14_L0.7431.00
168_T171_T0.7401.00
162_D165_M0.7391.00
25_Q40_F0.7371.00
86_E90_N0.7361.00
175_L180_L0.7361.00
145_N148_L0.7341.00
29_G169_A0.7271.00
109_T112_S0.7261.00
44_A48_D0.7181.00
44_A117_S0.7161.00
61_Q64_T0.7101.00
51_Y128_L0.7101.00
57_F61_Q0.7091.00
52_M162_D0.7081.00
89_K93_E0.7061.00
148_L151_S0.7041.00
22_N26_I0.7031.00
26_I165_M0.7021.00
13_S17_P0.7011.00
36_H39_I0.6921.00
56_Y147_L0.6921.00
75_F119_S0.6911.00
32_N109_T0.6891.00
4_F8_I0.6881.00
76_G125_L0.6871.00
51_Y117_S0.6801.00
22_N116_I0.6791.00
66_P70_T0.6791.00
46_T50_L0.6781.00
38_W41_G0.6781.00
18_V122_L0.6781.00
41_G45_M0.6771.00
28_K31_K0.6761.00
15_S22_N0.6721.00
25_Q44_A0.6681.00
198_Y201_Y0.6651.00
51_Y55_I0.6641.00
17_P22_N0.6621.00
117_S123_S0.6591.00
48_D158_I0.6571.00
78_F82_Y0.6541.00
47_A117_S0.6531.00
187_I191_S0.6511.00
48_D154_I0.6511.00
50_L53_L0.6491.00
48_D127_W0.6421.00
127_W158_I0.6401.00
71_F74_L0.6401.00
180_L184_L0.6401.00
33_G36_H0.6381.00
36_H106_Y0.6381.00
91_V94_P0.6341.00
148_L152_S0.6291.00
55_I124_I0.6261.00
149_I153_G0.6251.00
92_R182_R0.6231.00
123_S158_I0.6211.00
167_I171_T0.6201.00
5_L8_I0.6191.00
40_F109_T0.6181.00
20_P120_N0.6121.00
48_D155_M0.6111.00
56_Y151_S0.6101.00
7_Y132_G0.6081.00
155_M159_L0.6081.00
15_S161_W0.6051.00
117_S162_D0.6041.00
169_A172_F0.6011.00
160_I164_C0.5991.00
55_I60_S0.5951.00
36_H105_S0.5921.00
123_S162_D0.5831.00
168_T172_F0.5811.00
106_Y110_F0.5791.00
51_Y60_S0.5731.00
55_I127_W0.5721.00
40_F116_I0.5681.00
130_I154_I0.5681.00
52_M155_M0.5641.00
12_L16_A0.5641.00
97_V100_S0.5591.00
88_L92_R0.5591.00
100_S103_K0.5551.00
34_F171_T0.5541.00
156_I160_I0.5531.00
53_L151_S0.5511.00
86_E112_S0.5471.00
27_D185_T0.5471.00
45_M162_D0.5461.00
65_A70_T0.5441.00
42_L45_M0.5411.00
44_A123_S0.5401.00
17_P185_T0.5341.00
126_F130_I0.5341.00
21_V123_S0.5321.00
11_G153_G0.5301.00
154_I158_I0.5280.99
63_L72_L0.5280.99
7_Y153_G0.5270.99
176_L180_L0.5260.99
37_A40_F0.5260.99
172_F175_L0.5260.99
124_I128_L0.5250.99
152_S156_I0.5240.99
11_G157_G0.5230.99
15_S48_D0.5230.99
45_M48_D0.5230.99
112_S116_I0.5220.99
139_A145_N0.5160.99
107_R110_F0.5160.99
15_S123_S0.5150.99
84_G89_K0.5140.99
43_G113_G0.5120.99
25_Q41_G0.5090.99
41_G162_D0.5070.99
20_P87_T0.5060.99
84_G88_L0.5040.99
77_F193_L0.5030.99
92_R185_T0.5020.99
24_A27_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o7qA 1 0.9426 32.4 0.922 Contact Map
2cfqA 1 0.9139 26.5 0.925 Contact Map
4m64A 1 0.933 16.8 0.932 Contact Map
1pw4A 1 0.4928 12.5 0.935 Contact Map
3wdoA 1 0.4928 11.4 0.936 Contact Map
2gfpA 2 0.9282 11.4 0.936 Contact Map
4tphA 2 0.4641 10.5 0.937 Contact Map
4w6vA 1 0.512 9.8 0.938 Contact Map
3j1zP 8 0.8421 6.6 0.943 Contact Map
4xnjA 1 0.488 5.9 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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