GREMLIN Database
3MGH - Putative 3-methyladenine DNA glycosylase
UniProt: P94378 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (182)
Sequences: 1780 (1205)
Seq/√Len: 89.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_G106_I3.7331.00
15_K23_S3.4941.00
69_I145_Y3.4401.00
63_R68_E3.3691.00
168_G187_W3.0221.00
116_E124_P2.8811.00
166_S189_T2.6201.00
25_L188_V2.6171.00
28_L39_S2.4111.00
49_M184_W2.3471.00
20_L92_A2.3111.00
16_T19_E2.2941.00
129_N133_K2.1681.00
179_A182_Y2.1601.00
90_V156_I2.1021.00
27_C158_S2.0421.00
28_L109_H2.0311.00
81_V84_T2.0161.00
18_L186_F1.9841.00
15_K20_L1.9651.00
10_I148_W1.9631.00
86_T142_M1.9341.00
38_A118_R1.8801.00
81_V132_G1.8191.00
33_T36_G1.8091.00
77_V88_L1.7771.00
54_R179_A1.7581.00
41_Y107_E1.7421.00
70_M100_A1.7151.00
87_L135_T1.6991.00
91_V100_A1.6701.00
17_A99_Q1.6531.00
88_L103_I1.6481.00
43_V191_N1.6331.00
123_S126_E1.6211.00
141_T144_D1.6171.00
108_P115_M1.5801.00
126_E129_N1.5511.00
17_A49_M1.5061.00
12_F15_K1.5001.00
187_W194_V1.4881.00
90_V149_I1.4851.00
73_E95_E1.4660.99
164_A189_T1.4640.99
166_S187_W1.4630.99
85_H136_K1.4350.99
20_L23_S1.4290.99
18_L184_W1.4230.99
93_A99_Q1.3890.99
58_S70_M1.3870.99
30_V39_S1.3510.99
13_Y156_I1.3510.99
88_L140_V1.3430.99
58_S98_P1.3360.99
144_D147_R1.3270.99
69_I146_G1.2800.99
31_K144_D1.2760.99
82_M87_L1.2660.98
72_A76_R1.2510.98
17_A93_A1.2420.98
173_I180_R1.2160.98
42_I103_I1.2110.98
65_K68_E1.2020.98
74_A94_E1.1980.98
37_T110_E1.1900.98
22_P167_T1.1820.98
41_Y109_H1.1820.98
43_V193_Y1.1610.97
49_M99_Q1.1580.97
49_M52_G1.1410.97
107_E191_N1.1400.97
57_H78_Y1.1260.97
13_Y20_L1.1260.97
188_V191_N1.1200.97
40_G108_P1.1160.97
82_M132_G1.1130.97
112_Q124_P1.1020.96
32_E37_T1.0980.96
14_Q74_A1.0910.96
39_S109_H1.0880.96
31_K139_G1.0580.95
38_A114_L1.0500.95
66_R70_M1.0470.95
54_R60_N1.0270.95
28_L41_Y1.0250.95
55_A175_N1.0230.94
126_E133_K1.0150.94
39_S110_E1.0040.94
77_V148_W0.9960.94
56_A100_A0.9920.94
54_R175_N0.9770.93
120_P123_S0.9770.93
73_E76_R0.9740.93
22_P186_F0.9670.93
44_E102_L0.9580.92
79_T86_T0.9570.92
16_T49_M0.9530.92
54_R174_D0.9460.92
55_A181_D0.9450.92
40_G115_M0.9430.92
111_G115_M0.9390.92
128_T137_A0.9320.91
77_V154_L0.9290.91
82_M85_H0.9260.91
10_I73_E0.9250.91
41_Y159_G0.9180.91
106_I138_L0.9170.91
115_M127_W0.9160.90
12_F23_S0.9110.90
50_G98_P0.9100.90
169_P187_W0.9050.90
55_A179_A0.9000.90
30_V155_Y0.9000.90
118_R139_G0.8890.89
179_A184_W0.8840.89
108_P128_T0.8590.87
43_V105_A0.8570.87
40_G138_L0.8560.87
58_S100_A0.8560.87
114_L117_E0.8550.87
122_R126_E0.8540.87
53_D182_Y0.8510.87
40_G43_V0.8480.87
25_L165_I0.8460.87
10_I150_T0.8350.86
10_I76_R0.8340.86
63_R96_D0.8260.85
79_T140_V0.8200.85
66_R84_T0.8130.84
17_A22_P0.8120.84
68_E72_A0.8090.84
159_G163_E0.8080.84
106_I128_T0.8060.84
114_L118_R0.8030.84
28_L157_E0.8020.84
81_V86_T0.7970.83
149_I156_I0.7890.83
147_R153_P0.7830.82
55_A173_I0.7810.82
174_D180_R0.7790.82
39_S157_E0.7760.82
27_C159_G0.7750.81
15_K19_E0.7740.81
69_I76_R0.7730.81
175_N180_R0.7720.81
56_A99_Q0.7710.81
33_T114_L0.7710.81
12_F20_L0.7670.81
31_K38_A0.7650.81
17_A92_A0.7570.80
103_I134_L0.7550.80
79_T142_M0.7540.80
132_G135_T0.7540.80
111_G119_R0.7540.80
36_G114_L0.7530.80
142_M145_Y0.7520.79
43_V108_P0.7500.79
76_R100_A0.7490.79
54_R59_F0.7470.79
35_E114_L0.7430.79
86_T141_T0.7330.78
175_N179_A0.7310.78
108_P193_Y0.7310.78
116_E121_G0.7270.77
120_P136_K0.7200.76
119_R136_K0.7200.76
13_Y150_T0.7190.76
144_D153_P0.7160.76
31_K154_L0.7130.76
45_T87_L0.7110.76
119_R137_A0.7090.75
86_T135_T0.7080.75
165_I189_T0.7060.75
108_P137_A0.7020.75
74_A93_A0.7000.74
81_V135_T0.6980.74
107_E195_S0.6980.74
121_G129_N0.6970.74
148_W151_E0.6970.74
33_T38_A0.6970.74
115_M128_T0.6950.74
38_A138_L0.6950.74
100_A135_T0.6730.72
134_L138_L0.6720.71
57_H66_R0.6700.71
94_E97_V0.6700.71
77_V90_V0.6700.71
40_G171_I0.6700.71
82_M175_N0.6680.71
161_T164_A0.6680.71
67_T71_F0.6680.71
31_K118_R0.6680.71
27_C160_Y0.6670.71
32_E155_Y0.6650.71
25_L187_W0.6640.71
175_N182_Y0.6550.69
42_I45_T0.6520.69
83_H142_M0.6510.69
32_E153_P0.6500.69
41_Y160_Y0.6480.69
111_G137_A0.6420.68
18_L182_Y0.6390.68
18_L49_M0.6320.67
82_M86_T0.6290.66
14_Q94_E0.6160.65
55_A180_R0.6120.64
162_P188_V0.6110.64
124_P193_Y0.6060.63
128_T193_Y0.6050.63
112_Q127_W0.6030.63
125_R192_R0.6010.63
51_A97_V0.5980.62
81_V142_M0.5940.62
67_T145_Y0.5940.62
72_A91_V0.5930.62
42_I90_V0.5930.62
112_Q115_M0.5920.62
43_V107_E0.5890.61
82_M135_T0.5890.61
56_A70_M0.5890.61
78_Y89_N0.5860.61
51_A184_W0.5840.61
72_A95_E0.5830.61
25_L191_N0.5820.60
51_A98_P0.5780.60
57_H64_T0.5770.60
85_H132_G0.5770.60
77_V149_I0.5690.59
115_M137_A0.5690.59
49_M182_Y0.5670.58
53_D70_M0.5660.58
85_H91_V0.5660.58
147_R151_E0.5590.57
168_G183_P0.5580.57
13_Y149_I0.5570.57
108_P191_N0.5530.57
57_H71_F0.5530.57
51_A61_N0.5490.56
116_E127_W0.5480.56
52_G59_F0.5450.55
67_T174_D0.5430.55
54_R87_L0.5420.55
31_K153_P0.5420.55
79_T85_H0.5420.55
157_E160_Y0.5390.55
104_R131_P0.5370.54
80_Y100_A0.5360.54
19_E23_S0.5360.54
113_L116_E0.5320.54
43_V55_A0.5280.53
74_A172_G0.5250.53
161_T190_G0.5240.53
163_E188_V0.5240.53
45_T56_A0.5230.52
106_I115_M0.5210.52
76_R145_Y0.5190.52
43_V106_I0.5180.52
125_R129_N0.5170.52
49_M93_A0.5170.52
85_H135_T0.5140.51
108_P112_Q0.5130.51
55_A182_Y0.5120.51
111_G118_R0.5100.51
41_Y188_V0.5100.51
88_L144_D0.5070.50
22_P55_A0.5050.50
67_T128_T0.5050.50
187_W195_S0.5050.50
51_A58_S0.5030.50
100_A149_I0.5030.50
79_T83_H0.5010.49
113_L161_T0.5010.49
107_E193_Y0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ubyA 1 0.9745 100 0.074 Contact Map
3hi7A 2 0.3163 7 0.97 Contact Map
1hymB 1 0.1224 4.5 0.972 Contact Map
2fmlA 2 0.2959 4.1 0.973 Contact Map
1syqB 1 0.1173 4 0.973 Contact Map
1vqzA 1 0.3112 3.3 0.974 Contact Map
3dlmA 1 0.3214 2.9 0.975 Contact Map
4yn1A 2 0.5867 2.8 0.975 Contact Map
1w7cA 2 0.3316 2.8 0.975 Contact Map
2hw4A 1 0.1786 2.7 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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