GREMLIN Database
YXLG - Uncharacterized transmembrane protein YxlG
UniProt: P94375 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (242)
Sequences: 2310 (1893)
Seq/√Len: 121.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_I248_S4.6281.00
7_L117_S3.8841.00
119_W169_T3.6011.00
8_L120_L3.5991.00
8_L124_V3.5651.00
142_R147_D3.4611.00
20_K90_G3.1061.00
116_V249_V3.0381.00
12_W121_I2.8601.00
10_K14_E2.7971.00
95_E118_K2.7671.00
123_S165_I2.7471.00
173_A247_F2.7091.00
44_E47_A2.5961.00
115_I249_V2.5921.00
112_A249_V2.5731.00
104_I114_Y2.5531.00
127_I161_A2.4931.00
9_Q13_L2.4651.00
119_W172_L2.4381.00
210_P213_I2.4301.00
154_A158_G2.3981.00
231_G235_T2.3701.00
169_T241_I2.3501.00
13_L17_K2.3321.00
173_A244_L2.1291.00
158_G162_L2.0831.00
95_E100_V2.0331.00
176_T248_S2.0041.00
92_V176_T1.9541.00
91_S121_I1.9281.00
85_I171_G1.9101.00
88_V171_G1.8831.00
96_R255_Y1.8401.00
90_G109_V1.8121.00
155_A158_G1.8071.00
240_C244_L1.7651.00
238_I242_M1.7611.00
213_I233_S1.6671.00
93_A184_A1.6121.00
8_L121_I1.6061.00
96_R101_T1.5921.00
84_V126_G1.5911.00
186_A190_G1.5731.00
29_M136_L1.5471.00
59_S63_P1.5281.00
12_W124_V1.5111.00
12_W16_W1.5091.00
39_I45_I1.5071.00
8_L117_S1.5071.00
94_N98_Q1.5021.00
234_L238_I1.4991.00
117_S120_L1.4921.00
112_A253_R1.4511.00
15_G121_I1.4481.00
173_A248_S1.4451.00
100_V118_K1.4371.00
86_F186_A1.4301.00
235_T239_L1.4281.00
171_G188_G1.4011.00
174_G178_F1.3881.00
246_V250_W1.3701.00
6_A9_Q1.3491.00
251_R254_R1.3401.00
10_K102_A1.2971.00
105_M252_F1.2961.00
105_M114_Y1.2821.00
174_G191_L1.2751.00
108_P175_S1.2661.00
173_A251_R1.2490.99
91_S122_Q1.2340.99
130_F157_L1.2320.99
195_V211_A1.2270.99
115_I176_T1.2090.99
111_A252_F1.2080.99
67_E71_S1.2050.99
92_V115_I1.2010.99
88_V122_Q1.1770.99
93_A181_V1.1730.99
19_G22_I1.1700.99
37_L44_E1.1650.99
206_A212_E1.1630.99
21_L234_L1.1600.99
100_V104_I1.1580.99
81_M130_F1.1480.99
122_Q168_V1.1480.99
209_L212_E1.1410.99
16_W22_I1.1300.99
61_T64_S1.1240.99
166_F241_I1.1210.99
166_F237_S1.1190.99
30_I242_M1.1060.99
15_G125_I1.1040.99
32_G39_I1.1010.99
92_V175_S1.0950.99
167_I192_T1.0920.99
36_P39_I1.0780.98
18_S21_L1.0740.98
46_I49_G1.0730.98
83_L185_A1.0660.98
251_R255_Y1.0630.98
247_F250_W1.0560.98
119_W241_I1.0540.98
116_V245_A1.0520.98
215_K219_H1.0450.98
120_L124_V1.0320.98
219_H222_L1.0240.98
162_L234_L1.0190.98
39_I42_M1.0050.98
199_V212_E1.0000.97
161_A221_L0.9950.97
166_F244_L0.9930.97
236_F240_C0.9910.97
250_W253_R0.9860.97
174_G187_C0.9830.97
68_V72_T0.9800.97
144_L216_Q0.9800.97
69_M73_L0.9760.97
27_A109_V0.9750.97
34_T38_T0.9750.97
35_Q39_I0.9640.97
59_S62_M0.9590.97
176_T181_V0.9560.97
92_V172_L0.9550.97
89_M156_S0.9380.96
213_I220_I0.9310.96
151_S155_A0.9300.96
97_N180_S0.9290.96
42_M46_I0.9260.96
209_L213_I0.9230.96
71_S75_Q0.9220.96
207_K216_Q0.9150.96
58_I62_M0.9150.96
33_L37_L0.9120.96
14_E89_M0.9120.96
180_S193_A0.9090.96
134_Y157_L0.9080.96
126_G198_A0.9060.96
99_G102_A0.9000.95
115_I119_W0.8980.95
37_L41_Y0.8940.95
218_E224_G0.8940.95
103_L107_R0.8930.95
73_L156_S0.8930.95
167_I256_E0.8870.95
213_I228_D0.8850.95
10_K18_S0.8830.95
211_A215_K0.8820.95
8_L12_W0.8820.95
166_F210_P0.8820.95
206_A209_L0.8780.95
90_G175_S0.8680.94
134_Y153_F0.8630.94
15_G113_H0.8590.94
241_I245_A0.8540.94
88_V172_L0.8530.94
161_A164_V0.8490.94
26_I169_T0.8480.94
11_E118_K0.8480.94
7_L109_V0.8460.94
209_L248_S0.8450.93
32_G76_F0.8330.93
28_M129_S0.8300.93
43_P46_I0.8260.93
208_W213_I0.8190.92
90_G94_N0.8170.92
35_Q38_T0.8160.92
125_I129_S0.8160.92
210_P214_C0.8130.92
230_F233_S0.8100.92
30_I33_L0.8080.92
130_F146_E0.8050.92
82_A186_A0.8020.92
25_P28_M0.8010.92
218_E222_L0.7990.91
169_T173_A0.7950.91
80_G164_V0.7930.91
173_A176_T0.7900.91
15_G21_L0.7880.91
182_G186_A0.7870.91
115_I252_F0.7830.91
89_M185_A0.7800.90
18_S103_L0.7750.90
64_S68_V0.7730.90
14_E18_S0.7730.90
45_I48_H0.7680.90
228_D231_G0.7590.89
172_L175_S0.7580.89
166_F245_A0.7570.89
43_P131_A0.7560.89
213_I216_Q0.7530.89
68_V73_L0.7530.89
179_R255_Y0.7510.89
91_S195_V0.7490.89
158_G190_G0.7410.88
152_R155_A0.7410.88
103_L106_S0.7380.88
68_V248_S0.7360.88
232_W242_M0.7360.88
201_L242_M0.7360.88
142_R151_S0.7330.88
205_G208_W0.7320.87
135_G139_Y0.7310.87
32_G35_Q0.7290.87
35_Q75_Q0.7290.87
90_G181_V0.7260.87
90_G108_P0.7250.87
22_I25_P0.7240.87
66_S69_M0.7180.86
38_T42_M0.7170.86
239_L243_L0.7160.86
84_V88_V0.7150.86
220_I227_A0.7110.86
225_E254_R0.7070.86
216_Q220_I0.7030.85
216_Q221_L0.7000.85
41_Y45_I0.7000.85
169_T175_S0.7000.85
238_I245_A0.6990.85
72_T75_Q0.6980.85
171_G178_F0.6950.85
120_L160_Y0.6910.84
92_V112_A0.6910.84
66_S71_S0.6880.84
18_S107_R0.6780.83
208_W215_K0.6740.83
30_I34_T0.6720.83
163_W167_I0.6680.82
71_S221_L0.6680.82
159_L195_V0.6650.82
149_S225_E0.6640.82
78_T108_P0.6630.82
8_L167_I0.6630.82
92_V108_P0.6620.82
45_I49_G0.6530.81
63_P141_V0.6520.81
253_R256_E0.6520.81
212_E215_K0.6520.81
177_I248_S0.6490.80
34_T254_R0.6490.80
136_L189_I0.6470.80
134_Y178_F0.6440.80
103_L108_P0.6420.80
69_M134_Y0.6420.80
158_G215_K0.6410.80
140_Y144_L0.6400.79
32_G140_Y0.6400.79
7_L15_G0.6390.79
40_Y45_I0.6320.79
209_L216_Q0.6310.79
33_L140_Y0.6280.78
174_G188_G0.6280.78
87_S125_I0.6270.78
170_A191_L0.6270.78
176_T255_Y0.6260.78
96_R179_R0.6200.77
87_S93_A0.6200.77
74_S77_N0.6200.77
207_K213_I0.6200.77
132_A227_A0.6190.77
156_S168_V0.6160.77
44_E49_G0.6160.77
136_L239_L0.6120.76
67_E73_L0.6120.76
76_F163_W0.6120.76
172_L195_V0.6110.76
88_V91_S0.6100.76
200_S203_P0.6100.76
61_T135_G0.6080.76
207_K212_E0.6080.76
19_G26_I0.6070.76
104_I255_Y0.6030.75
67_E72_T0.6000.75
88_V168_V0.5980.75
82_A190_G0.5970.75
139_Y142_R0.5970.75
101_T115_I0.5960.74
178_F187_C0.5950.74
212_E242_M0.5940.74
167_I178_F0.5940.74
177_I251_R0.5930.74
219_H224_G0.5920.74
42_M48_H0.5890.74
238_I247_F0.5890.74
67_E247_F0.5860.73
64_S67_E0.5830.73
189_I216_Q0.5830.73
199_V209_L0.5830.73
20_K175_S0.5830.73
31_V70_V0.5770.72
37_L42_M0.5740.72
9_Q16_W0.5740.72
227_A232_W0.5730.72
206_A216_Q0.5720.71
226_R239_L0.5710.71
83_L188_G0.5700.71
162_L172_L0.5680.71
28_M34_T0.5670.71
141_V145_F0.5670.71
93_A176_T0.5650.71
108_P176_T0.5630.70
47_A128_M0.5630.70
79_L105_M0.5620.70
133_G162_L0.5610.70
11_E14_E0.5610.70
45_I247_F0.5600.70
14_E256_E0.5580.70
102_A105_M0.5580.70
136_L222_L0.5570.69
96_R108_P0.5570.69
11_E95_E0.5520.69
163_W237_S0.5520.69
43_P48_H0.5490.68
82_A150_F0.5480.68
63_P66_S0.5470.68
220_I223_H0.5470.68
143_L249_V0.5450.68
24_L184_A0.5450.68
108_P115_I0.5450.68
106_S163_W0.5440.68
114_Y118_K0.5440.68
26_I128_M0.5440.68
210_P219_H0.5420.67
128_M132_A0.5420.67
58_I61_T0.5400.67
99_G134_Y0.5370.67
135_G155_A0.5360.67
22_I83_L0.5350.66
208_W232_W0.5350.66
20_K25_P0.5340.66
79_L210_P0.5320.66
104_I108_P0.5320.66
67_E78_T0.5320.66
23_W27_A0.5310.66
113_H168_V0.5300.66
76_F129_S0.5300.66
88_V111_A0.5300.66
89_M173_A0.5290.66
178_F188_G0.5290.66
89_M96_R0.5270.65
20_K109_V0.5270.65
230_F234_L0.5250.65
89_M175_S0.5240.65
14_E182_G0.5210.64
72_T76_F0.5190.64
84_V168_V0.5180.64
19_G97_N0.5180.64
110_T113_H0.5170.64
122_Q172_L0.5160.64
93_A175_S0.5150.63
112_A250_W0.5120.63
32_G221_L0.5100.63
33_L255_Y0.5090.63
94_N181_V0.5080.62
208_W246_V0.5080.62
248_S252_F0.5070.62
60_F135_G0.5060.62
15_G133_G0.5050.62
95_E252_F0.5050.62
178_F183_A0.5040.62
14_E102_A0.5030.62
141_V233_S0.5000.61
22_I166_F0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx3A 2 0.3953 20.2 0.938 Contact Map
4humA 1 0.8566 9.8 0.946 Contact Map
3dl8G 1 0.8178 9.4 0.946 Contact Map
3mktA 1 0.8488 8 0.948 Contact Map
1qleD 1 0.1667 7 0.949 Contact Map
3wdoA 1 0.7829 7 0.949 Contact Map
4lz6A 1 0.8488 6.5 0.95 Contact Map
2cfqA 1 0.7946 6.4 0.95 Contact Map
4r0cA 3 0.7946 5.8 0.951 Contact Map
3dinC 1 0.7984 5.4 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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