YXLG - BACSU - GREMLIN Contacts

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YXLG - Uncharacterized transmembrane protein YxlG

UniProt:	P94375	Sequences: MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPEIIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTALIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLYALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAEHILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	258 (242)
Sequences:	2310 (1893)
Seq/√Len:	121.7

BACSU - YXLG YDBK YHCI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
115_I	248_S	4.628	1.00
7_L	117_S	3.884	1.00
119_W	169_T	3.601	1.00
8_L	120_L	3.599	1.00
8_L	124_V	3.565	1.00
142_R	147_D	3.461	1.00
20_K	90_G	3.106	1.00
116_V	249_V	3.038	1.00
12_W	121_I	2.860	1.00
10_K	14_E	2.797	1.00
95_E	118_K	2.767	1.00
123_S	165_I	2.747	1.00
173_A	247_F	2.709	1.00
44_E	47_A	2.596	1.00
115_I	249_V	2.592	1.00
112_A	249_V	2.573	1.00
104_I	114_Y	2.553	1.00
127_I	161_A	2.493	1.00
9_Q	13_L	2.465	1.00
119_W	172_L	2.438	1.00
210_P	213_I	2.430	1.00
154_A	158_G	2.398	1.00
231_G	235_T	2.370	1.00
169_T	241_I	2.350	1.00
13_L	17_K	2.332	1.00
173_A	244_L	2.129	1.00
158_G	162_L	2.083	1.00
95_E	100_V	2.033	1.00
176_T	248_S	2.004	1.00
92_V	176_T	1.954	1.00
91_S	121_I	1.928	1.00
85_I	171_G	1.910	1.00
88_V	171_G	1.883	1.00
96_R	255_Y	1.840	1.00
90_G	109_V	1.812	1.00
155_A	158_G	1.807	1.00
240_C	244_L	1.765	1.00
238_I	242_M	1.761	1.00
213_I	233_S	1.667	1.00
93_A	184_A	1.612	1.00
8_L	121_I	1.606	1.00
96_R	101_T	1.592	1.00
84_V	126_G	1.591	1.00
186_A	190_G	1.573	1.00
29_M	136_L	1.547	1.00
59_S	63_P	1.528	1.00
12_W	124_V	1.511	1.00
12_W	16_W	1.509	1.00
39_I	45_I	1.507	1.00
8_L	117_S	1.507	1.00
94_N	98_Q	1.502	1.00
234_L	238_I	1.499	1.00
117_S	120_L	1.492	1.00
112_A	253_R	1.451	1.00
15_G	121_I	1.448	1.00
173_A	248_S	1.445	1.00
100_V	118_K	1.437	1.00
86_F	186_A	1.430	1.00
235_T	239_L	1.428	1.00
171_G	188_G	1.401	1.00
174_G	178_F	1.388	1.00
246_V	250_W	1.370	1.00
6_A	9_Q	1.349	1.00
251_R	254_R	1.340	1.00
10_K	102_A	1.297	1.00
105_M	252_F	1.296	1.00
105_M	114_Y	1.282	1.00
174_G	191_L	1.275	1.00
108_P	175_S	1.266	1.00
173_A	251_R	1.249	0.99
91_S	122_Q	1.234	0.99
130_F	157_L	1.232	0.99
195_V	211_A	1.227	0.99
115_I	176_T	1.209	0.99
111_A	252_F	1.208	0.99
67_E	71_S	1.205	0.99
92_V	115_I	1.201	0.99
88_V	122_Q	1.177	0.99
93_A	181_V	1.173	0.99
19_G	22_I	1.170	0.99
37_L	44_E	1.165	0.99
206_A	212_E	1.163	0.99
21_L	234_L	1.160	0.99
100_V	104_I	1.158	0.99
81_M	130_F	1.148	0.99
122_Q	168_V	1.148	0.99
209_L	212_E	1.141	0.99
16_W	22_I	1.130	0.99
61_T	64_S	1.124	0.99
166_F	241_I	1.121	0.99
166_F	237_S	1.119	0.99
30_I	242_M	1.106	0.99
15_G	125_I	1.104	0.99
32_G	39_I	1.101	0.99
92_V	175_S	1.095	0.99
167_I	192_T	1.092	0.99
36_P	39_I	1.078	0.98
18_S	21_L	1.074	0.98
46_I	49_G	1.073	0.98
83_L	185_A	1.066	0.98
251_R	255_Y	1.063	0.98
247_F	250_W	1.056	0.98
119_W	241_I	1.054	0.98
116_V	245_A	1.052	0.98
215_K	219_H	1.045	0.98
120_L	124_V	1.032	0.98
219_H	222_L	1.024	0.98
162_L	234_L	1.019	0.98
39_I	42_M	1.005	0.98
199_V	212_E	1.000	0.97
161_A	221_L	0.995	0.97
166_F	244_L	0.993	0.97
236_F	240_C	0.991	0.97
250_W	253_R	0.986	0.97
174_G	187_C	0.983	0.97
68_V	72_T	0.980	0.97
144_L	216_Q	0.980	0.97
69_M	73_L	0.976	0.97
27_A	109_V	0.975	0.97
34_T	38_T	0.975	0.97
35_Q	39_I	0.964	0.97
59_S	62_M	0.959	0.97
176_T	181_V	0.956	0.97
92_V	172_L	0.955	0.97
89_M	156_S	0.938	0.96
213_I	220_I	0.931	0.96
151_S	155_A	0.930	0.96
97_N	180_S	0.929	0.96
42_M	46_I	0.926	0.96
209_L	213_I	0.923	0.96
71_S	75_Q	0.922	0.96
207_K	216_Q	0.915	0.96
58_I	62_M	0.915	0.96
33_L	37_L	0.912	0.96
14_E	89_M	0.912	0.96
180_S	193_A	0.909	0.96
134_Y	157_L	0.908	0.96
126_G	198_A	0.906	0.96
99_G	102_A	0.900	0.95
115_I	119_W	0.898	0.95
37_L	41_Y	0.894	0.95
218_E	224_G	0.894	0.95
103_L	107_R	0.893	0.95
73_L	156_S	0.893	0.95
167_I	256_E	0.887	0.95
213_I	228_D	0.885	0.95
10_K	18_S	0.883	0.95
211_A	215_K	0.882	0.95
8_L	12_W	0.882	0.95
166_F	210_P	0.882	0.95
206_A	209_L	0.878	0.95
90_G	175_S	0.868	0.94
134_Y	153_F	0.863	0.94
15_G	113_H	0.859	0.94
241_I	245_A	0.854	0.94
88_V	172_L	0.853	0.94
161_A	164_V	0.849	0.94
26_I	169_T	0.848	0.94
11_E	118_K	0.848	0.94
7_L	109_V	0.846	0.94
209_L	248_S	0.845	0.93
32_G	76_F	0.833	0.93
28_M	129_S	0.830	0.93
43_P	46_I	0.826	0.93
208_W	213_I	0.819	0.92
90_G	94_N	0.817	0.92
35_Q	38_T	0.816	0.92
125_I	129_S	0.816	0.92
210_P	214_C	0.813	0.92
230_F	233_S	0.810	0.92
30_I	33_L	0.808	0.92
130_F	146_E	0.805	0.92
82_A	186_A	0.802	0.92
25_P	28_M	0.801	0.92
218_E	222_L	0.799	0.91
169_T	173_A	0.795	0.91
80_G	164_V	0.793	0.91
173_A	176_T	0.790	0.91
15_G	21_L	0.788	0.91
182_G	186_A	0.787	0.91
115_I	252_F	0.783	0.91
89_M	185_A	0.780	0.90
18_S	103_L	0.775	0.90
64_S	68_V	0.773	0.90
14_E	18_S	0.773	0.90
45_I	48_H	0.768	0.90
228_D	231_G	0.759	0.89
172_L	175_S	0.758	0.89
166_F	245_A	0.757	0.89
43_P	131_A	0.756	0.89
213_I	216_Q	0.753	0.89
68_V	73_L	0.753	0.89
179_R	255_Y	0.751	0.89
91_S	195_V	0.749	0.89
158_G	190_G	0.741	0.88
152_R	155_A	0.741	0.88
103_L	106_S	0.738	0.88
68_V	248_S	0.736	0.88
232_W	242_M	0.736	0.88
201_L	242_M	0.736	0.88
142_R	151_S	0.733	0.88
205_G	208_W	0.732	0.87
135_G	139_Y	0.731	0.87
32_G	35_Q	0.729	0.87
35_Q	75_Q	0.729	0.87
90_G	181_V	0.726	0.87
90_G	108_P	0.725	0.87
22_I	25_P	0.724	0.87
66_S	69_M	0.718	0.86
38_T	42_M	0.717	0.86
239_L	243_L	0.716	0.86
84_V	88_V	0.715	0.86
220_I	227_A	0.711	0.86
225_E	254_R	0.707	0.86
216_Q	220_I	0.703	0.85
216_Q	221_L	0.700	0.85
41_Y	45_I	0.700	0.85
169_T	175_S	0.700	0.85
238_I	245_A	0.699	0.85
72_T	75_Q	0.698	0.85
171_G	178_F	0.695	0.85
120_L	160_Y	0.691	0.84
92_V	112_A	0.691	0.84
66_S	71_S	0.688	0.84
18_S	107_R	0.678	0.83
208_W	215_K	0.674	0.83
30_I	34_T	0.672	0.83
163_W	167_I	0.668	0.82
71_S	221_L	0.668	0.82
159_L	195_V	0.665	0.82
149_S	225_E	0.664	0.82
78_T	108_P	0.663	0.82
8_L	167_I	0.663	0.82
92_V	108_P	0.662	0.82
45_I	49_G	0.653	0.81
63_P	141_V	0.652	0.81
253_R	256_E	0.652	0.81
212_E	215_K	0.652	0.81
177_I	248_S	0.649	0.80
34_T	254_R	0.649	0.80
136_L	189_I	0.647	0.80
134_Y	178_F	0.644	0.80
103_L	108_P	0.642	0.80
69_M	134_Y	0.642	0.80
158_G	215_K	0.641	0.80
140_Y	144_L	0.640	0.79
32_G	140_Y	0.640	0.79
7_L	15_G	0.639	0.79
40_Y	45_I	0.632	0.79
209_L	216_Q	0.631	0.79
33_L	140_Y	0.628	0.78
174_G	188_G	0.628	0.78
87_S	125_I	0.627	0.78
170_A	191_L	0.627	0.78
176_T	255_Y	0.626	0.78
96_R	179_R	0.620	0.77
87_S	93_A	0.620	0.77
74_S	77_N	0.620	0.77
207_K	213_I	0.620	0.77
132_A	227_A	0.619	0.77
156_S	168_V	0.616	0.77
44_E	49_G	0.616	0.77
136_L	239_L	0.612	0.76
67_E	73_L	0.612	0.76
76_F	163_W	0.612	0.76
172_L	195_V	0.611	0.76
88_V	91_S	0.610	0.76
200_S	203_P	0.610	0.76
61_T	135_G	0.608	0.76
207_K	212_E	0.608	0.76
19_G	26_I	0.607	0.76
104_I	255_Y	0.603	0.75
67_E	72_T	0.600	0.75
88_V	168_V	0.598	0.75
82_A	190_G	0.597	0.75
139_Y	142_R	0.597	0.75
101_T	115_I	0.596	0.74
178_F	187_C	0.595	0.74
212_E	242_M	0.594	0.74
167_I	178_F	0.594	0.74
177_I	251_R	0.593	0.74
219_H	224_G	0.592	0.74
42_M	48_H	0.589	0.74
238_I	247_F	0.589	0.74
67_E	247_F	0.586	0.73
64_S	67_E	0.583	0.73
189_I	216_Q	0.583	0.73
199_V	209_L	0.583	0.73
20_K	175_S	0.583	0.73
31_V	70_V	0.577	0.72
37_L	42_M	0.574	0.72
9_Q	16_W	0.574	0.72
227_A	232_W	0.573	0.72
206_A	216_Q	0.572	0.71
226_R	239_L	0.571	0.71
83_L	188_G	0.570	0.71
162_L	172_L	0.568	0.71
28_M	34_T	0.567	0.71
141_V	145_F	0.567	0.71
93_A	176_T	0.565	0.71
108_P	176_T	0.563	0.70
47_A	128_M	0.563	0.70
79_L	105_M	0.562	0.70
133_G	162_L	0.561	0.70
11_E	14_E	0.561	0.70
45_I	247_F	0.560	0.70
14_E	256_E	0.558	0.70
102_A	105_M	0.558	0.70
136_L	222_L	0.557	0.69
96_R	108_P	0.557	0.69
11_E	95_E	0.552	0.69
163_W	237_S	0.552	0.69
43_P	48_H	0.549	0.68
82_A	150_F	0.548	0.68
63_P	66_S	0.547	0.68
220_I	223_H	0.547	0.68
143_L	249_V	0.545	0.68
24_L	184_A	0.545	0.68
108_P	115_I	0.545	0.68
106_S	163_W	0.544	0.68
114_Y	118_K	0.544	0.68
26_I	128_M	0.544	0.68
210_P	219_H	0.542	0.67
128_M	132_A	0.542	0.67
58_I	61_T	0.540	0.67
99_G	134_Y	0.537	0.67
135_G	155_A	0.536	0.67
22_I	83_L	0.535	0.66
208_W	232_W	0.535	0.66
20_K	25_P	0.534	0.66
79_L	210_P	0.532	0.66
104_I	108_P	0.532	0.66
67_E	78_T	0.532	0.66
23_W	27_A	0.531	0.66
113_H	168_V	0.530	0.66
76_F	129_S	0.530	0.66
88_V	111_A	0.530	0.66
89_M	173_A	0.529	0.66
178_F	188_G	0.529	0.66
89_M	96_R	0.527	0.65
20_K	109_V	0.527	0.65
230_F	234_L	0.525	0.65
89_M	175_S	0.524	0.65
14_E	182_G	0.521	0.64
72_T	76_F	0.519	0.64
84_V	168_V	0.518	0.64
19_G	97_N	0.518	0.64
110_T	113_H	0.517	0.64
122_Q	172_L	0.516	0.64
93_A	175_S	0.515	0.63
112_A	250_W	0.512	0.63
32_G	221_L	0.510	0.63
33_L	255_Y	0.509	0.63
94_N	181_V	0.508	0.62
208_W	246_V	0.508	0.62
248_S	252_F	0.507	0.62
60_F	135_G	0.506	0.62
15_G	133_G	0.505	0.62
95_E	252_F	0.505	0.62
178_F	183_A	0.504	0.62
14_E	102_A	0.503	0.62
141_V	233_S	0.500	0.61
22_I	166_F	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tx3A	2	0.3953	20.2	0.938	Contact Map
4humA	1	0.8566	9.8	0.946	Contact Map
3dl8G	1	0.8178	9.4	0.946	Contact Map
3mktA	1	0.8488	8	0.948	Contact Map
1qleD	1	0.1667	7	0.949	Contact Map
3wdoA	1	0.7829	7	0.949	Contact Map
4lz6A	1	0.8488	6.5	0.95	Contact Map
2cfqA	1	0.7946	6.4	0.95	Contact Map
4r0cA	3	0.7946	5.8	0.951	Contact Map
3dinC	1	0.7984	5.4	0.952	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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