GREMLIN Database
YXLA - Putative purine-cytosine permease YxlA
UniProt: P94369 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 457 (419)
Sequences: 4806 (3126)
Seq/√Len: 152.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
361_V433_S6.9721.00
372_Q375_A5.9001.00
361_V437_Y5.6711.00
75_G212_A4.3541.00
396_L435_L4.1751.00
13_N220_V4.1581.00
54_V244_L4.0781.00
393_A435_L3.5461.00
397_S432_P3.2201.00
393_A397_S3.2141.00
171_I175_Q3.2101.00
365_F433_S3.1261.00
397_S435_L2.9581.00
193_F197_V2.9031.00
357_A361_V2.8131.00
362_D367_R2.7951.00
393_A439_L2.7801.00
375_A378_D2.7701.00
43_P196_A2.7271.00
259_N262_S2.6641.00
59_C197_V2.5941.00
400_L431_V2.5931.00
12_P15_E2.5841.00
56_A193_F2.5821.00
77_Q224_A2.5501.00
49_N52_W2.5281.00
388_W392_I2.5041.00
391_T395_V2.3781.00
365_F437_Y2.3211.00
30_A289_F2.2811.00
287_N290_N2.2751.00
167_F171_I2.2141.00
53_S247_A2.2001.00
170_T241_W2.1761.00
358_I394_F2.1571.00
357_A429_L2.1181.00
435_L439_L2.1101.00
63_I201_A2.1011.00
16_R79_G2.0601.00
431_V435_L2.0321.00
401_E428_G2.0291.00
72_S215_S1.9761.00
97_L391_T1.9731.00
6_R15_E1.9631.00
426_I430_A1.9261.00
93_I96_I1.8921.00
109_F112_S1.8911.00
44_V250_T1.8881.00
131_W135_G1.8771.00
357_A432_P1.8641.00
114_T140_C1.8611.00
110_F287_N1.8331.00
138_A142_L1.8251.00
20_A226_K1.8151.00
392_I439_L1.8111.00
372_Q382_P1.8001.00
74_Q85_Q1.7881.00
117_A136_L1.7731.00
89_Q362_D1.7561.00
327_T330_S1.7491.00
397_S431_V1.7401.00
6_R9_E1.7301.00
225_S229_W1.7291.00
437_Y441_K1.7221.00
434_V438_V1.7151.00
52_W189_D1.7121.00
43_P53_S1.7031.00
50_L54_V1.7021.00
219_P226_K1.6961.00
164_A168_A1.6831.00
88_A371_Y1.6761.00
153_K156_K1.6611.00
69_A232_Y1.6591.00
146_F150_L1.6591.00
95_A300_T1.6581.00
55_A193_F1.6451.00
140_C287_N1.6431.00
438_V441_K1.6281.00
430_A433_S1.6141.00
412_G415_A1.6111.00
358_I393_A1.5601.00
433_S437_Y1.5521.00
51_F55_A1.5441.00
122_S132_S1.5351.00
22_D156_K1.5261.00
85_Q212_A1.5221.00
57_I243_M1.5181.00
108_G344_F1.5081.00
97_L386_V1.4961.00
390_T393_A1.4911.00
399_L403_P1.4651.00
396_L431_V1.4621.00
75_G215_S1.4591.00
375_A382_P1.4471.00
119_G259_N1.4381.00
430_A434_V1.4291.00
90_F390_T1.4281.00
320_L324_L1.4101.00
255_D266_Q1.4091.00
134_I138_A1.3911.00
358_I390_T1.3801.00
179_P182_S1.3701.00
220_V225_S1.3671.00
226_K230_Y1.3641.00
44_V53_S1.3531.00
386_V391_T1.3521.00
110_F326_G1.3481.00
354_P428_G1.3461.00
362_D366_V1.3291.00
358_I397_S1.3071.00
19_K22_D1.3061.00
357_A433_S1.2971.00
73_A77_Q1.2941.00
48_L56_A1.2871.00
178_I181_G1.2821.00
307_K310_V1.2721.00
438_V442_P1.2711.00
229_W233_A1.2671.00
254_P258_A1.2591.00
56_A196_A1.2551.00
90_F94_G1.2491.00
170_T245_L1.2401.00
110_F323_T1.2371.00
174_F248_L1.2251.00
245_L249_L1.2241.00
395_V399_L1.2221.00
428_G432_P1.2221.00
89_Q359_N1.2211.00
404_F427_I1.2191.00
70_S364_Y1.2121.00
168_A171_I1.2101.00
143_L154_M1.2091.00
113_S290_N1.2051.00
255_D262_S1.1971.00
88_A376_M1.1931.00
236_S240_I1.1861.00
111_A323_T1.1861.00
180_A183_W1.1811.00
384_G388_W1.1781.00
360_L364_Y1.1761.00
141_F323_T1.1691.00
263_Q267_L1.1681.00
390_T436_Y1.1621.00
114_T137_S1.1561.00
217_Y296_M1.1541.00
423_I427_I1.1491.00
214_Y293_G1.1461.00
55_A59_C1.1451.00
153_K157_I1.1441.00
63_I197_V1.1391.00
56_A197_V1.1391.00
328_V332_L1.1341.00
389_I439_L1.1331.00
366_V437_Y1.1291.00
124_F273_F1.1271.00
193_F196_A1.1251.00
71_H359_N1.1160.99
436_Y440_M1.1150.99
93_I385_K1.1130.99
106_Y210_Y1.1100.99
375_A381_G1.0960.99
130_S134_I1.0920.99
87_R95_A1.0880.99
179_P184_I1.0870.99
193_F200_V1.0870.99
6_R11_I1.0850.99
356_T360_L1.0850.99
118_A132_S1.0780.99
431_V434_V1.0770.99
190_L194_L1.0750.99
61_T243_M1.0690.99
373_V377_F1.0680.99
108_G345_I1.0660.99
101_L352_L1.0660.99
57_I61_T1.0620.99
389_I393_A1.0610.99
59_C193_F1.0500.99
241_W245_L1.0470.99
410_Y413_P1.0390.99
181_G184_I1.0380.99
389_I440_M1.0360.99
73_A224_A1.0340.99
57_I240_I1.0300.99
212_A215_S1.0290.99
66_I70_S1.0280.99
400_L403_P1.0270.99
28_F238_S1.0250.99
84_I87_R1.0240.99
65_A69_A1.0230.99
389_I392_I1.0200.99
262_S266_Q1.0180.99
6_R12_P1.0140.99
113_S287_N1.0120.99
58_I240_I1.0100.99
34_I283_Q1.0040.99
57_I247_A0.9990.99
72_S75_G0.9950.99
180_A184_I0.9920.99
434_V437_Y0.9890.99
411_I415_A0.9860.99
208_A356_T0.9830.99
282_G286_I0.9800.99
205_L353_I0.9780.99
74_Q78_L0.9770.99
306_L310_V0.9770.99
56_A60_G0.9750.99
393_A436_Y0.9720.99
255_D258_A0.9670.99
149_D153_K0.9670.99
124_F276_L0.9640.99
378_D381_G0.9600.98
173_I177_P0.9600.98
220_V226_K0.9580.98
173_I249_L0.9560.98
240_I244_L0.9540.98
229_W232_Y0.9500.98
299_T318_M0.9490.98
60_G200_V0.9420.98
398_I401_E0.9410.98
64_G204_Q0.9400.98
52_W55_A0.9350.98
90_F98_P0.9340.98
94_G391_T0.9320.98
124_F277_I0.9270.98
60_G197_V0.9250.98
107_L322_V0.9190.98
361_V366_V0.9170.98
198_S426_I0.9160.98
23_L215_S0.9150.98
263_Q266_Q0.9150.98
40_G246_G0.9140.98
115_I118_A0.9090.98
67_F208_A0.9070.98
109_F345_I0.9060.98
305_F310_V0.9060.98
32_M162_S0.9060.98
155_Q285_A0.9040.98
73_A364_Y0.9030.98
168_A172_L0.9010.98
293_G297_S0.9000.98
27_W83_M0.8990.98
127_I132_S0.8970.98
292_Y296_M0.8940.98
54_V58_I0.8930.98
182_S185_P0.8910.97
78_L371_Y0.8850.97
200_V203_W0.8840.97
320_L323_T0.8820.97
210_Y214_Y0.8820.97
227_T231_S0.8790.97
400_L427_I0.8790.97
82_Q212_A0.8770.97
31_N238_S0.8770.97
137_S327_T0.8770.97
160_W164_A0.8750.97
197_V201_A0.8740.97
389_I443_R0.8720.97
117_A283_Q0.8710.97
179_P183_W0.8700.97
294_A322_V0.8660.97
433_S436_Y0.8640.97
410_Y414_L0.8630.97
162_S286_I0.8630.97
326_G329_L0.8600.97
186_G189_D0.8590.97
361_V365_F0.8580.97
41_T116_L0.8540.97
228_F232_Y0.8540.97
226_K229_W0.8500.97
392_I396_L0.8500.97
110_F291_L0.8480.97
167_F396_L0.8470.97
113_S283_Q0.8470.97
160_W163_F0.8470.97
412_G422_D0.8440.97
101_L348_I0.8440.97
38_V41_T0.8430.97
87_R300_T0.8400.96
396_L403_P0.8390.96
435_L438_V0.8390.96
398_I403_P0.8360.96
36_T39_T0.8330.96
12_P16_R0.8330.96
58_I135_G0.8320.96
32_M286_I0.8300.96
392_I395_V0.8270.96
388_W443_R0.8260.96
234_G238_S0.8240.96
83_M297_S0.8210.96
316_I320_L0.8140.96
163_F167_F0.8120.96
216_R292_Y0.8100.96
41_T250_T0.8100.96
235_T239_S0.8090.96
282_G285_A0.8070.96
65_A236_S0.8070.96
90_F394_F0.8060.95
37_L249_L0.8010.95
74_Q359_N0.8000.95
71_H211_V0.7990.95
196_A200_V0.7990.95
118_A122_S0.7940.95
262_S265_V0.7920.95
350_Y405_I0.7920.95
406_N411_I0.7910.95
131_W134_I0.7890.95
319_I323_T0.7890.95
73_A369_G0.7880.95
114_T287_N0.7860.95
145_I317_I0.7850.95
169_A267_L0.7850.95
189_D193_F0.7830.95
141_F320_L0.7810.95
62_L236_S0.7800.95
388_W391_T0.7760.94
440_M443_R0.7760.94
103_M298_T0.7750.94
294_A297_S0.7730.94
194_L198_S0.7720.94
387_N440_M0.7660.94
110_F113_S0.7640.94
89_Q358_I0.7620.94
148_H217_Y0.7620.94
155_Q288_V0.7620.94
61_T203_W0.7610.94
260_S267_L0.7610.94
387_N390_T0.7600.94
76_P218_L0.7580.94
61_T239_S0.7570.94
393_A432_P0.7570.94
358_I432_P0.7570.94
185_P188_I0.7570.94
35_T283_Q0.7560.94
24_F28_F0.7550.94
377_F383_Y0.7530.94
82_Q293_G0.7510.93
87_R362_D0.7490.93
424_A428_G0.7470.93
100_F301_T0.7450.93
53_S57_I0.7410.93
395_V398_I0.7410.93
68_M206_A0.7410.93
21_K25_P0.7400.93
366_V440_M0.7380.93
327_T331_L0.7370.93
206_A352_L0.7360.93
142_L400_L0.7350.93
143_L284_M0.7300.92
68_M71_H0.7280.92
168_A271_F0.7270.92
115_I119_G0.7250.92
393_A433_S0.7250.92
288_V291_L0.7220.92
123_S262_S0.7180.92
303_E306_L0.7180.92
87_R92_V0.7160.92
125_V132_S0.7110.91
31_N239_S0.7110.91
396_L399_L0.7100.91
340_L344_F0.7100.91
99_L297_S0.7100.91
232_Y236_S0.7070.91
207_Y210_Y0.7070.91
398_I402_I0.7070.91
164_A171_I0.7050.91
93_I384_G0.7040.91
201_A205_L0.7040.91
117_A143_L0.7030.91
189_D194_L0.7010.91
397_S433_S0.6990.91
97_L395_V0.6980.91
371_Y377_F0.6950.91
411_I414_L0.6920.90
93_I386_V0.6910.90
410_Y415_A0.6890.90
316_I319_I0.6880.90
185_P192_I0.6870.90
76_P227_T0.6870.90
140_C284_M0.6870.90
224_A228_F0.6860.90
121_L132_S0.6860.90
18_G148_H0.6850.90
80_I85_Q0.6850.90
306_L318_M0.6840.90
33_H36_T0.6840.90
30_A207_Y0.6840.90
69_A228_F0.6780.89
397_S400_L0.6780.89
48_L52_W0.6760.89
279_V283_Q0.6740.89
427_I430_A0.6730.89
9_E12_P0.6730.89
76_P224_A0.6720.89
250_T253_L0.6710.89
365_F368_H0.6690.89
24_F233_A0.6680.89
42_I342_L0.6680.89
144_T316_I0.6660.89
8_I84_I0.6650.89
80_I377_F0.6650.89
167_F241_W0.6640.88
127_I131_W0.6630.88
118_A242_M0.6630.88
362_D440_M0.6610.88
401_E405_I0.6610.88
22_D152_H0.6600.88
340_L343_N0.6590.88
106_Y294_A0.6580.88
108_G348_I0.6580.88
283_Q286_I0.6570.88
204_Q235_T0.6570.88
34_I37_L0.6560.88
111_A115_I0.6560.88
276_L285_A0.6540.88
102_V210_Y0.6540.88
326_G330_S0.6530.88
127_I135_G0.6520.88
86_S89_Q0.6510.87
65_A283_Q0.6510.87
198_S207_Y0.6490.87
86_S95_A0.6490.87
249_L253_L0.6460.87
111_A329_L0.6460.87
60_G64_G0.6440.87
46_M192_I0.6420.87
11_I79_G0.6420.87
199_A342_L0.6410.87
19_K219_P0.6390.86
88_A367_R0.6380.86
191_P194_L0.6380.86
110_F140_C0.6370.86
72_S227_T0.6350.86
71_H360_L0.6340.86
233_A237_V0.6340.86
431_V440_M0.6340.86
147_G292_Y0.6330.86
318_M329_L0.6330.86
140_C143_L0.6320.86
225_S228_F0.6320.86
162_S282_G0.6290.86
35_T118_A0.6270.85
354_P397_S0.6270.85
367_R371_Y0.6260.85
30_A283_Q0.6250.85
189_D195_V0.6240.85
120_T124_F0.6220.85
365_F377_F0.6220.85
31_N83_M0.6220.85
154_M285_A0.6210.85
17_H149_D0.6210.85
230_Y234_G0.6200.85
36_T203_W0.6200.85
397_S428_G0.6190.85
172_L175_Q0.6190.85
204_Q207_Y0.6180.85
61_T105_I0.6170.85
50_L251_T0.6170.85
12_P217_Y0.6160.84
98_P109_F0.6150.84
38_V116_L0.6140.84
92_V379_V0.6140.84
403_P407_T0.6140.84
317_I321_G0.6140.84
281_F285_A0.6140.84
153_K158_L0.6120.84
110_F141_F0.6120.84
40_G43_P0.6120.84
427_I431_V0.6100.84
130_S396_L0.6090.84
193_F399_L0.6080.84
370_K373_V0.6040.83
30_A204_Q0.6030.83
111_A326_G0.6020.83
39_T342_L0.6010.83
23_L218_L0.6010.83
393_A396_L0.6000.83
96_I301_T0.6000.83
65_A232_Y0.6000.83
97_L394_F0.6000.83
324_L328_V0.5990.83
224_A227_T0.5990.83
204_Q208_A0.5990.83
260_S264_I0.5980.83
184_I188_I0.5980.83
102_V293_G0.5950.82
30_A239_S0.5950.82
27_W34_I0.5900.82
144_T291_L0.5900.82
101_L355_W0.5890.82
329_L337_F0.5870.82
106_Y290_N0.5870.82
36_T246_G0.5860.81
295_F300_T0.5860.81
106_Y293_G0.5830.81
52_W193_F0.5830.81
375_A380_N0.5820.81
197_V200_V0.5810.81
18_G218_L0.5800.81
176_L184_I0.5800.81
35_T112_S0.5800.81
413_P422_D0.5800.81
188_I192_I0.5790.81
207_Y289_F0.5780.81
301_T322_V0.5780.81
155_Q286_I0.5770.80
184_I431_V0.5760.80
29_G159_S0.5760.80
309_K331_L0.5740.80
321_G325_V0.5730.80
438_V443_R0.5720.80
116_L348_I0.5720.80
141_F145_I0.5710.80
157_I160_W0.5710.80
58_I244_L0.5700.80
125_V128_P0.5700.80
80_I84_I0.5700.80
165_V278_I0.5700.80
124_F280_L0.5680.79
37_L242_M0.5680.79
194_L374_K0.5680.79
99_L301_T0.5660.79
77_Q369_G0.5650.79
358_I436_Y0.5640.79
49_N53_S0.5640.79
114_T117_A0.5640.79
138_A358_I0.5630.79
125_V332_L0.5610.79
68_M211_V0.5610.79
237_V241_W0.5610.79
134_I180_A0.5600.78
68_M208_A0.5600.78
33_H37_L0.5600.78
131_W389_I0.5590.78
137_S323_T0.5570.78
92_V383_Y0.5570.78
169_A249_L0.5560.78
324_L400_L0.5560.78
145_I280_L0.5540.78
93_I392_I0.5530.78
39_T203_W0.5520.77
13_N277_I0.5520.77
170_T248_L0.5520.77
119_G262_S0.5510.77
179_P185_P0.5510.77
51_F186_G0.5500.77
126_P132_S0.5490.77
20_A230_Y0.5480.77
121_L267_L0.5480.77
142_L146_F0.5470.77
202_T353_I0.5470.77
218_L230_Y0.5460.77
118_A133_I0.5460.77
69_A238_S0.5450.77
397_S401_E0.5450.77
44_V247_A0.5440.76
82_Q102_V0.5420.76
425_W429_L0.5410.76
303_E310_V0.5400.76
273_F277_I0.5400.76
402_I406_N0.5390.76
220_V224_A0.5390.76
83_M300_T0.5380.76
135_G142_L0.5370.76
306_L309_K0.5370.76
260_S263_Q0.5360.75
199_A202_T0.5340.75
9_E15_E0.5340.75
206_A425_W0.5340.75
107_L348_I0.5320.75
80_I87_R0.5310.75
8_I87_R0.5300.75
105_I345_I0.5270.74
151_I288_V0.5270.74
103_M111_A0.5260.74
210_Y213_D0.5260.74
64_G68_M0.5250.74
374_K379_V0.5250.74
32_M163_F0.5240.74
49_N359_N0.5240.74
143_L288_V0.5240.74
43_P200_V0.5240.74
166_F282_G0.5220.73
59_C262_S0.5220.73
350_Y401_E0.5210.73
39_T235_T0.5210.73
61_T240_I0.5200.73
361_V436_Y0.5190.73
41_T75_G0.5180.73
190_L193_F0.5170.73
113_S285_A0.5170.73
50_L248_L0.5170.73
138_A396_L0.5160.73
294_A319_I0.5140.72
59_C125_V0.5140.72
380_N383_Y0.5140.72
31_N234_G0.5140.72
135_G395_V0.5120.72
263_Q351_F0.5120.72
402_I405_I0.5120.72
141_F433_S0.5110.72
162_S350_Y0.5100.72
97_L403_P0.5100.72
27_W33_H0.5090.72
104_F344_F0.5090.72
289_F293_G0.5090.72
34_I263_Q0.5080.71
88_A383_Y0.5080.71
345_I367_R0.5070.71
106_Y243_M0.5070.71
136_L284_M0.5070.71
99_L300_T0.5060.71
62_L240_I0.5060.71
29_G155_Q0.5060.71
134_I331_L0.5060.71
303_E307_K0.5050.71
368_H384_G0.5050.71
71_H74_Q0.5050.71
203_W206_A0.5040.71
107_L298_T0.5040.71
162_S239_S0.5040.71
30_A212_A0.5040.71
90_F358_I0.5030.71
309_K316_I0.5030.71
102_V106_Y0.5020.71
204_Q239_S0.5020.71
109_F207_Y0.5020.71
193_F391_T0.5010.70
304_P309_K0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.9344 100 0.229 Contact Map
4djkA 2 0.8753 99.3 0.858 Contact Map
3l1lA 2 0.8709 99.3 0.863 Contact Map
3giaA 1 0.8993 99.2 0.865 Contact Map
3dh4A 3 0.8906 99 0.88 Contact Map
2xq2A 2 0.8972 98.9 0.883 Contact Map
4wgvA 2 0.7834 98.8 0.886 Contact Map
4us3A 1 0.8206 95.9 0.934 Contact Map
2a65A 2 0.9059 95.6 0.936 Contact Map
2wswA 3 0.8009 94.8 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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