GREMLIN Database
NNRD - ADP-dependent (S)-NAD(P)H-hydrate dehydratase
UniProt: P94368 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (257)
Sequences: 4643 (3584)
Seq/√Len: 223.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_A219_T4.2461.00
100_A223_L4.1471.00
184_V240_V3.9341.00
34_A43_A3.1031.00
30_A223_L3.0381.00
222_I239_A3.0001.00
106_P130_G2.9851.00
167_K170_E2.9281.00
53_S221_M2.6661.00
29_T59_V2.5901.00
204_T244_G2.5401.00
206_N248_E2.4951.00
53_S224_G2.2451.00
127_L131_A2.2031.00
200_W237_L2.1751.00
209_L214_T2.1351.00
140_R144_V2.0101.00
253_E267_I1.9911.00
30_A55_L1.9561.00
172_A191_V1.9551.00
57_K212_G1.9301.00
145_I222_I1.9281.00
22_S27_Y1.9031.00
153_F175_W1.8951.00
233_K237_L1.8861.00
47_G77_A1.8751.00
47_G60_I1.8721.00
153_F157_T1.8571.00
172_A193_A1.8341.00
32_L43_A1.8201.00
231_D234_H1.8081.00
249_L271_V1.8061.00
52_R263_E1.8051.00
175_W183_I1.7971.00
209_L247_A1.7951.00
74_L77_A1.7881.00
182_V236_V1.7611.00
146_L183_I1.7531.00
30_A50_A1.7521.00
52_R260_L1.7451.00
145_I226_L1.7421.00
174_E178_Q1.7421.00
214_T264_L1.6901.00
45_L217_T1.6651.00
249_L267_I1.6611.00
45_L262_H1.6431.00
18_R27_Y1.6201.00
200_W233_K1.6051.00
175_W179_L1.6041.00
34_A103_P1.5931.00
226_L232_P1.5931.00
221_M268_L1.5901.00
31_L96_Y1.5641.00
169_A199_C1.5601.00
76_E262_H1.5281.00
173_K199_C1.5081.00
16_P230_E1.5081.00
202_N244_G1.4801.00
153_F185_L1.4731.00
31_L61_G1.4721.00
250_W267_I1.4701.00
103_P219_T1.4661.00
184_V222_I1.4481.00
48_L266_D1.4361.00
241_Y245_A1.4341.00
48_L74_L1.4291.00
211_K261_A1.4271.00
160_P163_E1.4241.00
101_I127_L1.4171.00
245_A248_E1.3941.00
154_F164_L1.3911.00
157_T175_W1.3851.00
98_A223_L1.3611.00
55_L58_L1.3611.00
253_E270_R1.3471.00
170_E174_E1.3461.00
107_Q130_G1.3451.00
59_V80_W1.3431.00
217_T265_S1.3321.00
30_A227_C1.3291.00
194_F233_K1.3201.00
193_A196_D1.3161.00
62_T66_V1.3141.00
49_G265_S1.3001.00
146_L181_T1.2951.00
208_A259_L1.2891.00
135_R138_P1.2861.00
126_I226_L1.2681.00
207_G256_A1.2531.00
40_P71_V1.2461.00
250_W259_L1.2361.00
32_L46_A1.2321.00
133_A136_T1.2311.00
219_T223_L1.2121.00
151_G154_F1.2081.00
172_A176_A1.2011.00
145_I236_V1.2011.00
44_L73_V1.2001.00
260_L263_E1.1911.00
169_A201_L1.1881.00
174_E177_A1.1871.00
141_E144_V1.1831.00
30_A98_A1.1781.00
31_L99_I1.1771.00
176_A193_A1.1771.00
55_L224_G1.1671.00
62_T70_I1.1591.00
29_T97_R1.1331.00
229_H235_A1.1241.00
48_L73_V1.1201.00
267_I270_R1.1141.00
67_I79_Y1.1111.00
161_V165_Q1.1051.00
51_M260_L1.1021.00
221_M239_A1.0961.00
193_A199_C1.0891.00
46_A100_A1.0881.00
140_R143_P1.0871.00
69_L72_P1.0751.00
191_V199_C1.0691.00
194_F198_D1.0681.00
198_D233_K1.0671.00
126_I219_T1.0611.00
247_A250_W1.0521.00
159_V163_E1.0481.00
191_V201_L1.0451.00
29_T57_K1.0431.00
50_A58_L1.0431.00
108_T111_V1.0321.00
241_Y244_G1.0301.00
36_S108_T1.0241.00
205_G248_E1.0231.00
190_T240_V1.0171.00
202_N240_V1.0131.00
150_P168_R1.0121.00
242_L271_V1.0001.00
126_I239_A0.9951.00
125_V144_V0.9931.00
204_T241_Y0.9801.00
204_T245_A0.9761.00
59_V78_T0.9641.00
39_M78_T0.9611.00
40_P66_V0.9581.00
182_V194_F0.9531.00
211_K214_T0.9471.00
250_W263_E0.9451.00
67_I71_V0.9451.00
34_A46_A0.9421.00
60_I70_I0.9381.00
173_K177_A0.9351.00
153_F171_Y0.9291.00
150_P165_Q0.9160.99
29_T95_T0.9110.99
43_A60_I0.9100.99
51_M58_L0.9090.99
175_W181_T0.9090.99
212_G261_A0.9060.99
172_A185_L0.9040.99
107_Q155_R0.9010.99
165_Q168_R0.8960.99
230_E238_N0.8950.99
157_T164_L0.8850.99
67_I81_R0.8840.99
101_I131_A0.8830.99
55_L227_C0.8820.99
133_A138_P0.8800.99
100_A103_P0.8760.99
176_A183_I0.8680.99
133_A137_Y0.8640.99
150_P187_G0.8630.99
22_S26_T0.8620.99
245_A249_L0.8610.99
169_A173_K0.8590.99
228_C257_H0.8570.99
247_A251_T0.8550.99
124_P226_L0.8540.99
134_K138_P0.8530.99
49_G221_M0.8500.99
192_I240_V0.8490.99
48_L265_S0.8440.99
46_A103_P0.8430.99
113_Q116_D0.8420.99
30_A100_A0.8420.99
153_F183_I0.8400.99
202_N241_Y0.8280.99
134_K137_Y0.8270.99
98_A227_C0.8240.99
32_L100_A0.8230.99
150_P161_V0.8220.99
52_R266_D0.8210.99
119_L125_V0.8180.99
101_I105_L0.8100.99
36_S63_S0.8080.99
101_I118_V0.8080.99
101_I115_V0.8060.99
217_T261_A0.8040.99
246_C271_V0.7940.99
184_V236_V0.7910.98
189_Q201_L0.7870.98
249_L270_R0.7820.98
39_M57_K0.7810.98
59_V95_T0.7800.98
37_D65_N0.7750.98
160_P164_L0.7740.98
144_V181_T0.7730.98
85_K88_A0.7680.98
25_G150_P0.7620.98
248_E251_T0.7580.98
249_L252_D0.7570.98
182_V232_P0.7560.98
57_K78_T0.7560.98
88_A91_Q0.7530.98
65_N68_P0.7530.98
154_F160_P0.7450.98
164_L167_K0.7440.98
236_V239_A0.7420.98
136_T139_K0.7420.98
209_L264_L0.7410.98
224_G228_C0.7390.98
53_S268_L0.7370.98
14_T234_H0.7320.97
225_M242_L0.7290.97
132_L146_L0.7280.97
171_Y175_W0.7270.97
204_T248_E0.7270.97
145_I184_V0.7270.97
98_A124_P0.7260.97
168_R185_L0.7250.97
258_T269_P0.7250.97
76_E211_K0.7240.97
190_T236_V0.7190.97
116_D120_T0.7180.97
211_K260_L0.7170.97
44_L74_L0.7130.97
145_I182_V0.7120.97
182_V233_K0.7080.97
44_L48_L0.7070.97
172_A183_I0.7060.97
168_R187_G0.7060.97
33_L61_G0.7050.97
205_G244_G0.7050.97
91_Q94_E0.7030.97
18_R208_A0.7000.97
62_T79_Y0.6990.97
153_F164_L0.6990.97
208_A248_E0.6990.97
25_G29_T0.6980.97
98_A226_L0.6970.97
127_L144_V0.6960.97
157_T171_Y0.6940.97
153_F193_A0.6900.96
46_A219_T0.6860.96
19_D22_S0.6820.96
60_I77_A0.6800.96
206_N251_T0.6780.96
176_A180_Q0.6720.96
36_S39_M0.6710.96
250_W265_S0.6660.96
168_R189_Q0.6610.95
246_C267_I0.6590.95
230_E235_A0.6580.95
246_C250_W0.6560.95
217_T221_M0.6550.95
44_L71_V0.6530.95
51_M76_E0.6500.95
29_T96_Y0.6480.95
245_A271_V0.6470.95
25_G212_G0.6450.95
64_E81_R0.6430.95
99_I125_V0.6420.95
92_L96_Y0.6420.95
99_I121_A0.6410.95
80_W92_L0.6410.95
202_N248_E0.6390.95
154_F161_V0.6380.94
151_G161_V0.6330.94
23_H26_T0.6320.94
190_T243_H0.6320.94
89_D93_E0.6290.94
97_R123_C0.6270.94
59_V96_Y0.6270.94
89_D92_L0.6240.94
247_A259_L0.6230.94
154_F159_V0.6220.94
224_G227_C0.6220.94
137_Y140_R0.6210.94
20_A188_N0.6200.94
33_L105_L0.6160.93
193_A197_G0.6140.93
20_A256_A0.6110.93
112_Q133_A0.6080.93
99_I118_V0.6060.93
232_P235_A0.6040.93
22_S210_A0.6020.93
232_P236_V0.6010.93
56_G190_T0.6000.92
48_L262_H0.5980.92
32_L223_L0.5940.92
209_L248_E0.5940.92
164_L171_Y0.5920.92
34_A42_A0.5890.92
56_G243_H0.5870.92
44_L70_I0.5860.92
88_A92_L0.5850.92
126_I222_I0.5850.92
63_S66_V0.5840.91
212_G260_L0.5840.91
121_A124_P0.5830.91
168_R191_V0.5830.91
90_A93_E0.5820.91
135_R139_K0.5820.91
211_K264_L0.5820.91
203_P241_Y0.5810.91
111_V114_A0.5790.91
122_D143_P0.5780.91
167_K171_Y0.5760.91
113_Q117_H0.5750.91
263_E266_D0.5740.91
70_I74_L0.5720.91
112_Q116_D0.5680.90
56_G210_A0.5650.90
225_M228_C0.5640.90
163_E166_K0.5630.90
192_I200_W0.5630.90
243_H247_A0.5610.90
20_A207_G0.5600.90
229_H236_V0.5600.90
48_L52_R0.5600.90
71_V75_P0.5580.90
177_A197_G0.5560.89
14_T238_N0.5560.89
61_G80_W0.5560.89
30_A58_L0.5540.89
145_I232_P0.5530.89
105_L111_V0.5520.89
61_G81_R0.5510.89
161_V164_L0.5500.89
68_P72_P0.5500.89
233_K236_V0.5500.89
73_V77_A0.5490.89
33_L101_I0.5490.89
25_G57_K0.5490.89
242_L268_L0.5450.88
244_G247_A0.5440.88
194_F237_L0.5410.88
270_R273_K0.5400.88
159_V164_L0.5380.88
66_V70_I0.5380.88
169_A191_V0.5370.88
111_V115_V0.5360.88
66_V71_V0.5360.88
250_W258_T0.5340.87
32_L58_L0.5320.87
158_G161_V0.5310.87
242_L272_W0.5310.87
251_T256_A0.5300.87
61_G89_D0.5290.87
119_L127_L0.5270.87
40_P69_L0.5240.86
150_P164_L0.5240.86
114_A118_V0.5230.86
184_V192_I0.5210.86
251_T255_S0.5190.86
118_V125_V0.5190.86
262_H265_S0.5190.86
90_A117_H0.5180.86
118_V121_A0.5170.86
47_G58_L0.5160.86
96_Y99_I0.5160.86
40_P75_P0.5150.85
146_L156_M0.5140.85
230_E234_H0.5120.85
208_A251_T0.5120.85
175_W178_Q0.5120.85
265_S268_L0.5100.85
117_H120_T0.5100.85
126_I145_I0.5070.85
33_L99_I0.5070.85
168_R171_Y0.5060.84
208_A211_K0.5060.84
222_I235_A0.5060.84
133_A139_K0.5050.84
153_F179_L0.5020.84
58_L77_A0.5020.84
225_M235_A0.5020.84
165_Q187_G0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bgkA 3 0.9638 100 0.344 Contact Map
3rssA 4 0.9855 100 0.347 Contact Map
3rpzA 3 1 100 0.352 Contact Map
3k5wA 4 0.8986 100 0.381 Contact Map
2r3bA 3 0.9746 100 0.393 Contact Map
3nl6A 4 0.9601 100 0.6 Contact Map
3rm5A 2 0.9312 100 0.639 Contact Map
3mbhA 5 0.8841 100 0.648 Contact Map
1ekqA 3 0.8188 100 0.659 Contact Map
3h74A 2 0.8732 100 0.66 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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