GREMLIN Database
CIMH - Citrate/malate transporter
UniProt: P94363 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 450 (419)
Sequences: 380 (254)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_A105_Y4.9671.00
290_L316_I4.5711.00
77_Q81_S4.2281.00
97_F230_L4.0891.00
238_L242_I4.0240.99
169_L179_F3.7390.99
129_F342_T3.6450.99
229_S406_Q3.2710.98
171_V373_S3.1590.97
403_H431_T3.0970.97
126_L196_G2.9440.96
231_C372_L2.9300.95
412_V424_M2.7110.93
398_I418_A2.6920.93
172_G182_T2.6370.92
294_G309_M2.6070.92
168_G187_V2.5450.91
120_T348_A2.5090.90
335_R339_T2.4980.90
240_N244_K2.4950.90
190_I228_G2.4580.89
58_K63_T2.4330.88
379_M397_A2.3940.88
247_P250_T2.3580.87
281_A340_A2.3350.86
298_H305_A2.2470.84
317_K327_E2.1000.79
108_L287_A2.0990.79
377_T381_V2.0590.78
296_L311_L2.0340.77
166_I369_I2.0320.77
311_L315_L2.0090.76
223_P317_K2.0010.76
222_L227_L1.9920.76
192_A431_T1.9780.75
149_A426_F1.9770.75
250_T395_E1.9710.75
119_F346_L1.9620.74
141_M317_K1.9610.74
296_L300_F1.9570.74
317_K425_P1.9260.73
219_A433_I1.9240.73
169_L187_V1.9210.73
398_I421_L1.9180.73
224_S406_Q1.9160.73
128_L433_I1.9110.72
351_V354_T1.9100.72
125_F345_L1.8980.72
117_T352_S1.8920.72
199_A225_I1.8800.71
300_F416_S1.8690.71
239_L354_T1.8580.70
46_I315_L1.8570.70
162_V441_L1.8460.70
281_A337_F1.8390.69
101_A360_V1.8310.69
247_P252_N1.8010.68
46_I376_V1.7970.68
304_P431_T1.7940.67
342_T409_T1.7860.67
110_N114_K1.7680.66
128_L302_G1.7650.66
61_I129_F1.7500.65
205_G439_V1.7480.65
46_I170_A1.7060.63
377_T405_G1.6980.63
173_T179_F1.6810.62
350_G402_C1.6800.62
378_M403_H1.6780.62
137_S294_G1.6760.62
42_A162_V1.6760.62
287_A397_A1.6720.62
227_L371_I1.6680.62
248_E252_N1.6350.60
75_F98_I1.6050.58
96_T354_T1.5790.57
76_A343_Y1.5640.56
105_Y356_W1.5440.55
157_L403_H1.5350.55
175_L366_S1.5180.54
42_A78_I1.5110.54
404_S431_T1.5060.53
418_A422_E1.5030.53
61_I291_Y1.5020.53
161_S378_M1.4990.53
223_P426_F1.4950.53
252_N422_E1.4940.53
360_V430_S1.4930.53
186_I317_K1.4890.53
346_L374_V1.4860.52
135_V433_I1.4830.52
285_I418_A1.4780.52
280_F329_G1.4560.51
184_L439_V1.4430.50
152_K186_I1.4310.50
163_T377_T1.4040.48
352_S409_T1.4040.48
376_V384_F1.4030.48
85_V220_L1.3780.47
154_F399_I1.3770.47
154_F161_S1.3760.47
400_N403_H1.3710.47
191_M199_A1.3690.46
414_I431_T1.3590.46
41_Y74_T1.3540.46
315_L397_A1.3500.45
126_L428_Q1.3430.45
293_V312_L1.3420.45
116_T345_L1.3400.45
95_A199_A1.3360.45
261_E419_E1.3350.45
197_E306_P1.3040.43
387_K393_P1.2850.42
33_V227_L1.2820.42
85_V94_L1.2810.42
341_V440_S1.2730.42
250_T337_F1.2580.41
239_L394_I1.2570.41
65_I78_I1.2550.41
404_S411_D1.2410.40
132_G333_V1.2370.40
112_I365_L1.2360.40
90_G428_Q1.2310.40
414_I439_V1.2300.40
319_F330_A1.2230.39
243_G247_P1.2150.39
61_I348_A1.2130.39
195_V391_M1.2130.39
413_A428_Q1.2090.39
96_T119_F1.2080.38
429_V433_I1.2080.38
333_V395_E1.2080.38
284_G341_V1.1940.38
212_I216_E1.1890.38
175_L178_G1.1870.37
222_L395_E1.1840.37
224_S344_P1.1820.37
100_S355_P1.1800.37
218_F426_F1.1720.37
308_A443_L1.1690.37
403_H414_I1.1690.37
298_H315_L1.1680.37
366_S370_T1.1680.37
90_G133_I1.1680.37
33_V302_G1.1660.36
219_A316_I1.1650.36
338_S346_L1.1570.36
201_P428_Q1.1550.36
152_K317_K1.1460.36
235_L376_V1.1430.35
46_I212_I1.1280.35
49_T102_V1.1280.35
41_Y60_D1.1230.34
97_F208_D1.1220.34
332_G340_A1.1200.34
67_V291_Y1.1190.34
372_L376_V1.1150.34
86_R210_M1.1080.34
49_T53_M1.1080.34
281_A310_L1.1060.34
91_P345_L1.1060.34
116_T211_P1.1050.34
121_E353_M1.1040.34
41_Y395_E1.1040.34
342_T345_L1.1000.33
102_V107_L1.0970.33
99_P307_V1.0960.33
82_I369_I1.0960.33
72_G156_P1.0930.33
190_I430_S1.0920.33
171_V433_I1.0800.32
167_V377_T1.0770.32
305_A355_P1.0730.32
186_I224_S1.0710.32
208_D384_F1.0710.32
134_V203_S1.0670.32
199_A243_G1.0670.32
381_V405_G1.0610.32
400_N414_I1.0610.32
46_I166_I1.0590.32
195_V349_I1.0580.32
239_L250_T1.0570.31
304_P404_S1.0560.31
214_Q359_L1.0560.31
191_M196_G1.0550.31
207_S214_Q1.0500.31
425_P429_V1.0480.31
93_I444_L1.0480.31
412_V436_A1.0470.31
190_I411_D1.0470.31
109_P191_M1.0460.31
255_V429_V1.0450.31
233_I395_E1.0440.31
55_H321_L1.0400.31
261_E392_Y1.0320.30
97_F218_F1.0270.30
33_V38_L1.0250.30
363_F396_T1.0210.30
223_P413_A1.0210.30
328_N389_L1.0170.30
36_I162_V1.0150.30
128_L284_G1.0110.29
32_K78_I1.0090.29
263_P433_I1.0080.29
78_I82_I1.0030.29
307_V439_V1.0010.29
239_L243_G1.0010.29
101_A363_F1.0000.29
141_M426_F1.0000.29
82_I243_G0.9980.29
228_G428_Q0.9970.29
182_T186_I0.9970.29
130_I309_M0.9960.29
48_I52_V0.9940.29
429_V438_T0.9870.28
134_V429_V0.9810.28
403_H411_D0.9790.28
118_E238_L0.9760.28
307_V414_I0.9750.28
228_G409_T0.9740.28
338_S440_S0.9740.28
154_F158_I0.9730.28
119_F195_V0.9700.28
192_A367_N0.9700.28
48_I394_I0.9680.28
411_D431_T0.9670.28
310_L344_P0.9670.28
47_L139_L0.9670.28
321_L395_E0.9650.28
269_Q326_I0.9650.28
290_L303_F0.9610.27
239_L367_N0.9540.27
301_F368_I0.9540.27
169_L183_L0.9530.27
211_P311_L0.9520.27
203_S211_P0.9500.27
102_V329_G0.9480.27
71_F145_T0.9470.27
172_G413_A0.9460.27
403_H430_S0.9450.27
301_F438_T0.9420.27
306_P439_V0.9420.27
121_E419_E0.9400.27
142_K280_F0.9380.26
141_M236_A0.9380.26
216_E249_W0.9360.26
424_M436_A0.9330.26
316_I322_V0.9330.26
378_M431_T0.9330.26
76_A370_T0.9300.26
297_A308_A0.9240.26
170_A174_L0.9210.26
430_S433_I0.9140.26
45_F93_I0.9140.26
309_M336_F0.9140.26
416_S439_V0.9120.25
143_R147_V0.9100.25
159_V388_W0.9100.25
166_I312_L0.9080.25
116_T234_I0.9000.25
252_N351_V0.8970.25
128_L281_A0.8950.25
242_I246_K0.8950.25
198_G201_P0.8900.25
225_I391_M0.8890.25
75_F166_I0.8890.25
238_L271_G0.8880.25
124_N127_Y0.8870.24
213_S300_F0.8870.24
238_L321_L0.8850.24
98_I397_A0.8780.24
46_I50_V0.8780.24
39_P43_L0.8760.24
232_A354_T0.8720.24
156_P233_I0.8670.24
67_V301_F0.8660.24
157_L161_S0.8660.24
182_T313_A0.8610.24
348_A433_I0.8610.24
197_E439_V0.8590.23
195_V327_E0.8580.23
99_P414_I0.8580.23
310_L443_L0.8530.23
167_V418_A0.8530.23
322_V327_E0.8530.23
411_D430_S0.8510.23
235_L379_M0.8510.23
222_L416_S0.8500.23
116_T173_T0.8500.23
365_L369_I0.8500.23
106_H422_E0.8490.23
225_I406_Q0.8490.23
320_R327_E0.8480.23
197_E405_G0.8460.23
169_L213_S0.8450.23
142_K165_A0.8430.23
302_G447_H0.8430.23
378_M414_I0.8410.23
128_L215_G0.8360.23
118_E396_T0.8360.23
353_M359_L0.8340.23
116_T418_A0.8340.23
376_V442_T0.8290.22
103_V365_L0.8270.22
57_V261_E0.8240.22
293_V297_A0.8220.22
222_L440_S0.8210.22
37_P40_V0.8210.22
72_G233_I0.8210.22
72_G95_A0.8190.22
170_A173_T0.8190.22
206_Y236_A0.8170.22
306_P383_F0.8150.22
63_T120_T0.8120.22
223_P446_L0.8070.22
26_A430_S0.8020.21
218_F406_Q0.7950.21
408_G412_V0.7940.21
76_A99_P0.7940.21
133_I430_S0.7930.21
188_I439_V0.7920.21
57_V63_T0.7920.21
250_T298_H0.7910.21
349_I406_Q0.7910.21
195_V426_F0.7900.21
99_P157_L0.7890.21
119_F218_F0.7880.21
162_V354_T0.7880.21
223_P406_Q0.7860.21
114_K173_T0.7850.21
58_K348_A0.7820.21
239_L411_D0.7820.21
242_I249_W0.7820.21
186_I221_V0.7810.21
96_T346_L0.7780.21
179_F370_T0.7750.21
96_T406_Q0.7740.20
286_L369_I0.7710.20
147_V206_Y0.7710.20
315_L447_H0.7700.20
77_Q374_V0.7700.20
90_G229_S0.7680.20
129_F364_N0.7680.20
355_P399_I0.7660.20
104_Y357_D0.7660.20
61_I357_D0.7650.20
130_I196_G0.7650.20
350_G364_N0.7640.20
186_I416_S0.7640.20
102_V216_E0.7630.20
228_G406_Q0.7620.20
402_C427_A0.7620.20
135_V309_M0.7610.20
183_L419_E0.7610.20
94_L228_G0.7610.20
157_L179_F0.7590.20
294_G412_V0.7590.20
226_M406_Q0.7580.20
218_F223_P0.7560.20
106_H179_F0.7540.20
257_R290_L0.7540.20
116_T438_T0.7490.20
127_Y303_F0.7470.20
228_G237_G0.7470.20
63_T350_G0.7450.20
315_L319_F0.7440.20
139_L155_I0.7440.20
175_L246_K0.7440.20
174_L245_K0.7430.19
65_I244_K0.7410.19
160_G202_L0.7410.19
49_T257_R0.7400.19
210_M227_L0.7390.19
143_R246_K0.7380.19
66_A160_G0.7380.19
221_V317_K0.7350.19
208_D301_F0.7350.19
240_N384_F0.7340.19
32_K274_M0.7330.19
197_E304_P0.7310.19
38_L155_I0.7310.19
46_I380_A0.7290.19
134_V290_L0.7280.19
87_S217_A0.7250.19
383_F414_I0.7240.19
378_M399_I0.7230.19
40_V384_F0.7220.19
195_V223_P0.7220.19
177_L416_S0.7220.19
108_L412_V0.7220.19
351_V445_L0.7210.19
82_I213_S0.7170.19
399_I431_T0.7160.19
404_S430_S0.7160.19
107_L117_T0.7140.19
182_T228_G0.7130.19
42_A174_L0.7120.18
71_F78_I0.7110.18
195_V218_F0.7100.18
63_T232_A0.7090.18
276_N373_S0.7090.18
363_F433_I0.7080.18
204_I304_P0.7080.18
232_A239_L0.7060.18
410_G435_G0.7050.18
142_K322_V0.7050.18
128_L337_F0.7050.18
260_E392_Y0.7020.18
100_S418_A0.7010.18
260_E263_P0.7000.18
96_T224_S0.6990.18
66_A285_I0.6990.18
95_A352_S0.6990.18
197_E414_I0.6980.18
322_V385_T0.6970.18
37_P50_V0.6970.18
55_H388_W0.6950.18
142_K409_T0.6950.18
106_H321_L0.6950.18
296_L301_F0.6940.18
67_V116_T0.6920.18
304_P439_V0.6920.18
49_T437_I0.6900.18
192_A217_A0.6880.18
32_K98_I0.6880.18
57_V233_I0.6860.18
298_H302_G0.6860.18
45_F285_I0.6860.18
378_M430_S0.6800.18
98_I307_V0.6790.18
47_L214_Q0.6770.17
202_L215_G0.6760.17
154_F430_S0.6760.17
133_I310_L0.6760.17
284_G416_S0.6720.17
75_F283_G0.6720.17
116_T127_Y0.6720.17
55_H111_D0.6680.17
160_G385_T0.6660.17
73_F343_Y0.6660.17
196_G428_Q0.6640.17
134_V233_I0.6630.17
175_L365_L0.6610.17
114_K360_V0.6600.17
243_G394_I0.6590.17
99_P226_M0.6590.17
170_A290_L0.6580.17
46_I262_S0.6580.17
250_T354_T0.6580.17
279_L322_V0.6560.17
201_P417_A0.6560.17
347_F443_L0.6550.17
291_Y398_I0.6520.17
167_V373_S0.6510.17
393_P427_A0.6500.17
412_V426_F0.6500.17
182_T326_I0.6490.17
190_I442_T0.6480.17
48_I92_A0.6480.17
354_T394_I0.6450.17
55_H107_L0.6450.17
99_P405_G0.6450.17
229_S330_A0.6430.16
223_P428_Q0.6430.16
174_L182_T0.6400.16
124_N306_P0.6380.16
43_L316_I0.6370.16
199_A218_F0.6360.16
274_M361_A0.6340.16
152_K417_A0.6340.16
141_M223_P0.6330.16
140_G310_L0.6320.16
154_F403_H0.6320.16
248_E375_V0.6320.16
310_L413_A0.6310.16
47_L230_L0.6300.16
345_L412_V0.6290.16
51_F347_F0.6280.16
41_Y93_I0.6270.16
405_G411_D0.6270.16
415_L434_G0.6250.16
141_M413_A0.6240.16
68_M353_M0.6220.16
64_S115_S0.6210.16
424_M428_Q0.6190.16
129_F412_V0.6190.16
314_V353_M0.6170.16
317_K346_L0.6170.16
224_S228_G0.6170.16
390_N441_L0.6150.16
164_A329_G0.6140.16
257_R283_G0.6140.16
411_D434_G0.6130.16
103_V127_Y0.6130.16
342_T412_V0.6120.16
61_I364_N0.6100.16
345_L436_A0.6100.16
60_D124_N0.6100.16
256_D338_S0.6100.16
108_L351_V0.6090.16
212_I296_L0.6090.16
94_L308_A0.6080.16
119_F227_L0.6080.16
50_V289_S0.6060.15
209_I446_L0.6040.15
291_Y363_F0.6010.15
187_V439_V0.6000.15
205_G443_L0.5980.15
228_G436_A0.5970.15
338_S364_N0.5960.15
36_I53_M0.5950.15
304_P403_H0.5940.15
135_V219_A0.5930.15
60_D320_R0.5920.15
310_L337_F0.5910.15
242_I444_L0.5910.15
202_L439_V0.5910.15
68_M349_I0.5900.15
382_G448_Q0.5890.15
135_V330_A0.5890.15
252_N289_S0.5880.15
140_G281_A0.5860.15
172_G417_A0.5860.15
91_P214_Q0.5860.15
99_P197_E0.5810.15
216_E263_P0.5810.15
75_F78_I0.5810.15
108_L447_H0.5780.15
197_E355_P0.5780.15
113_V242_I0.5780.15
210_M296_L0.5770.15
106_H283_G0.5760.15
37_P104_Y0.5760.15
127_Y355_P0.5750.15
221_V310_L0.5740.15
74_T115_S0.5710.15
36_I55_H0.5710.15
234_I283_G0.5710.15
383_F386_G0.5710.15
195_V406_Q0.5710.15
43_L320_R0.5690.14
342_T436_A0.5690.14
52_V66_A0.5680.14
345_L353_M0.5680.14
356_W374_V0.5670.14
158_I161_S0.5660.14
68_M350_G0.5640.14
192_A439_V0.5640.14
117_T353_M0.5620.14
238_L369_I0.5620.14
38_L41_Y0.5610.14
391_M414_I0.5610.14
149_A327_E0.5600.14
44_L292_L0.5600.14
281_A285_I0.5590.14
284_G310_L0.5580.14
152_K291_Y0.5570.14
107_L360_V0.5570.14
154_F157_L0.5560.14
408_G428_Q0.5560.14
219_A383_F0.5540.14
154_F162_V0.5530.14
286_L327_E0.5530.14
50_V315_L0.5510.14
148_K322_V0.5500.14
61_I387_K0.5500.14
213_S238_L0.5480.14
44_L280_F0.5470.14
322_V389_L0.5470.14
211_P217_A0.5460.14
169_L173_T0.5450.14
100_S431_T0.5450.14
100_S414_I0.5440.14
190_I287_A0.5440.14
221_V374_V0.5430.14
400_N405_G0.5420.14
297_A395_E0.5410.14
145_T380_A0.5410.14
323_P394_I0.5400.14
50_V396_T0.5400.14
298_H430_S0.5400.14
226_M349_I0.5390.14
70_F395_E0.5370.14
413_A426_F0.5370.14
28_A171_V0.5370.14
356_W414_I0.5360.14
115_S123_S0.5340.14
123_S207_S0.5340.14
307_V400_N0.5310.14
248_E444_L0.5310.14
94_L98_I0.5300.14
42_A80_K0.5290.14
405_G431_T0.5290.14
57_V72_G0.5280.13
42_A234_I0.5280.13
65_I178_G0.5260.13
199_A404_S0.5240.13
82_I94_L0.5240.13
368_I395_E0.5230.13
87_S158_I0.5210.13
146_L398_I0.5210.13
69_A284_G0.5200.13
140_G367_N0.5180.13
209_I375_V0.5180.13
226_M371_I0.5170.13
86_R321_L0.5150.13
65_I265_L0.5140.13
125_F353_M0.5140.13
219_A351_V0.5130.13
72_G395_E0.5130.13
111_D418_A0.5120.13
233_I251_G0.5120.13
232_A405_G0.5100.13
48_I53_M0.5100.13
195_V438_T0.5100.13
303_F387_K0.5090.13
76_A148_K0.5090.13
51_F57_V0.5060.13
28_A286_L0.5060.13
329_G368_I0.5050.13
241_R244_K0.5050.13
97_F222_L0.5050.13
191_M434_G0.5020.13
147_V396_T0.5020.13
402_C405_G0.5010.13
355_P414_I0.5010.13
59_S145_T0.5010.13
252_N387_K0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwzA 2 0.7756 95.2 0.962 Contact Map
4czbA 2 0.3689 92 0.967 Contact Map
4cz8A 2 0.3622 88 0.969 Contact Map
1zcdA 1 0.7178 62.4 0.976 Contact Map
4f35D 2 0.8156 44.4 0.978 Contact Map
4r0cA 3 0.8222 27.7 0.98 Contact Map
3zuxA 1 0.3311 21.7 0.981 Contact Map
4r1iA 2 0.8822 17.5 0.982 Contact Map
1pw4A 1 0.3822 11.3 0.984 Contact Map
2nwlA 3 0.6644 9.8 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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