GREMLIN Database
YXKH - Putative polysaccharide deacetylase YxkH
UniProt: P94361 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 279 (216)
Sequences: 2193 (1765)
Seq/√Len: 120.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_G182_I3.1401.00
140_L147_A3.0631.00
87_E142_K3.0601.00
164_E209_M2.9781.00
191_T194_Q2.7181.00
90_M139_V2.5531.00
73_I125_F2.5411.00
197_S201_D2.5271.00
207_D213_Q2.5141.00
141_K173_H2.4651.00
151_M167_M2.4351.00
183_D198_E2.4341.00
179_S202_S2.2431.00
200_A204_K2.1501.00
91_K143_Y2.1311.00
91_K95_D2.1271.00
192_P227_E2.0791.00
196_Q234_K2.0721.00
137_Y170_M2.0481.00
195_Q228_T2.0151.00
169_E173_H2.0111.00
203_K207_D2.0021.00
70_Y89_H1.9641.00
190_L194_Q1.9401.00
151_M177_I1.9381.00
86_F90_M1.8861.00
100_T145_M1.8801.00
171_A212_Q1.8781.00
122_L148_T1.8431.00
167_M177_I1.8211.00
100_T146_K1.7761.00
150_F218_S1.7661.00
168_K172_Q1.7581.00
92_W96_N1.7551.00
137_Y173_H1.7491.00
132_N149_I1.7401.00
186_E223_R1.7391.00
138_P169_E1.7301.00
203_K237_Y1.6741.00
171_A210_F1.6601.00
130_T166_Q1.6571.00
87_E143_Y1.6411.00
182_I201_D1.6251.00
147_A175_I1.6251.00
217_I232_A1.6081.00
199_M232_A1.6071.00
146_K175_I1.5971.00
168_K209_M1.5711.00
207_D214_T1.5521.00
182_I198_E1.5211.00
133_Y169_E1.5141.00
149_I175_I1.4941.00
185_L198_E1.4791.00
188_N223_R1.4681.00
72_S131_D1.4621.00
67_I257_L1.4521.00
248_A258_H1.4501.00
232_A235_T1.4411.00
217_I240_G1.4261.00
162_L170_M1.4201.00
150_F241_V1.4181.00
205_L209_M1.4151.00
130_T134_Q1.4101.00
139_V143_Y1.4091.00
87_E91_K1.4011.00
69_M243_T1.3941.00
204_K208_N1.3731.00
150_F216_I1.3681.00
133_Y137_Y1.3631.00
165_E168_K1.3431.00
268_G271_F1.3421.00
103_P122_L1.3291.00
125_F140_L1.3271.00
186_E221_V1.3191.00
192_P230_K1.3061.00
230_K234_K1.3051.00
137_Y141_K1.3031.00
181_T217_I1.2971.00
90_M145_M1.2600.99
179_S203_K1.2480.99
154_K182_I1.2460.99
67_I241_V1.2410.99
152_I181_T1.2340.99
231_A234_K1.2180.99
104_K176_S1.2170.99
69_M261_R1.2170.99
85_E88_A1.2160.99
153_G202_S1.2100.99
203_K214_T1.1960.99
117_S120_C1.1870.99
171_A177_I1.1850.99
187_L228_T1.1840.99
137_Y169_E1.1760.99
267_S270_A1.1650.99
182_I205_L1.1640.99
133_Y166_Q1.1600.99
157_G205_L1.1280.99
180_H184_H1.1220.99
170_M177_I1.1130.99
65_L106_A1.1130.99
215_T238_Q1.0810.98
164_E210_F1.0770.98
224_Y229_L1.0740.98
195_Q199_M1.0720.98
106_A122_L1.0530.98
133_Y170_M1.0510.98
149_I177_I1.0480.98
163_T166_Q1.0470.98
186_E189_G1.0450.98
219_Y232_A1.0400.98
192_P196_Q1.0390.98
101_L106_A1.0320.98
102_T105_E1.0280.98
216_I241_V1.0140.98
92_W271_F0.9960.97
219_Y240_G0.9930.97
206_F214_T0.9920.97
246_G258_H0.9850.97
190_L195_Q0.9790.97
216_I239_M0.9760.97
196_Q231_A0.9730.97
65_L120_C0.9690.97
225_N228_T0.9690.97
108_L112_Q0.9670.97
83_K135_D0.9520.96
67_I70_Y0.9460.96
164_E205_L0.9450.96
87_E139_V0.9390.96
179_S199_M0.9240.96
123_I136_A0.9230.96
90_M143_Y0.9160.96
104_K108_L0.9150.96
94_H143_Y0.9120.95
136_A139_V0.9100.95
125_F136_A0.9100.95
97_G119_K0.8970.95
253_G256_A0.8970.95
148_T176_S0.8950.95
177_I210_F0.8880.95
137_Y175_I0.8870.95
162_L167_M0.8840.95
167_M210_F0.8820.95
181_T185_L0.8770.94
105_E108_L0.8750.94
156_I209_M0.8700.94
231_A235_T0.8570.94
122_L241_V0.8550.94
89_H271_F0.8450.93
170_M174_G0.8420.93
151_M170_M0.8410.93
242_T246_G0.8380.93
107_S239_M0.8380.93
196_Q200_A0.8340.93
75_S135_D0.8330.93
90_M100_T0.8270.93
116_P120_C0.8150.92
201_D204_K0.8090.92
124_T128_G0.8060.92
70_Y86_F0.8050.91
93_L98_Y0.8030.91
82_P85_E0.7990.91
65_L101_L0.7990.91
85_E89_H0.7960.91
190_L198_E0.7930.91
196_Q235_T0.7930.91
195_Q231_A0.7890.91
73_I86_F0.7860.90
77_N80_R0.7850.90
90_M121_V0.7800.90
68_L71_H0.7790.90
104_K216_I0.7700.90
184_H198_E0.7700.90
139_V145_M0.7600.89
266_M270_A0.7600.89
128_G132_N0.7540.89
133_Y138_P0.7480.88
227_E230_K0.7460.88
91_K94_H0.7460.88
193_Q197_S0.7400.88
149_I162_L0.7400.88
218_S241_V0.7380.88
193_Q196_Q0.7230.86
73_I81_V0.7180.86
92_W268_G0.7180.86
240_G255_Y0.7120.86
150_F178_E0.7060.85
57_I60_E0.7020.85
264_P267_S0.6970.84
209_M212_Q0.6960.84
71_H127_D0.6950.84
125_F128_G0.6950.84
79_L261_R0.6940.84
105_E146_K0.6930.84
176_S216_I0.6910.84
222_G242_T0.6890.84
198_E201_D0.6880.84
262_V271_F0.6870.84
71_H259_R0.6860.83
72_S80_R0.6810.83
243_T261_R0.6810.83
199_M217_I0.6810.83
84_K88_A0.6780.83
135_D139_V0.6710.82
156_I164_E0.6690.82
87_E90_M0.6600.81
68_L86_F0.6570.81
156_I160_H0.6550.81
229_L256_A0.6540.80
188_N228_T0.6520.80
127_D221_V0.6510.80
99_Q105_E0.6500.80
195_Q227_E0.6490.80
154_K183_D0.6490.80
70_Y73_I0.6480.80
73_I131_D0.6460.80
132_N147_A0.6450.80
156_I167_M0.6430.79
192_P195_Q0.6420.79
123_I145_M0.6420.79
66_P72_S0.6400.79
63_A66_P0.6350.78
226_E230_K0.6350.78
205_L208_N0.6340.78
194_Q197_S0.6240.77
197_S200_A0.6240.77
103_P216_I0.6230.77
93_L121_V0.6210.77
195_Q198_E0.6190.77
242_T245_P0.6190.77
89_H262_V0.6160.76
233_E255_Y0.6160.76
154_K181_T0.6140.76
127_D180_H0.6130.76
134_Q166_Q0.6120.76
194_Q198_E0.6120.76
219_Y243_T0.6120.76
109_M116_P0.6120.76
128_G151_M0.6100.76
218_S243_T0.6080.75
197_S204_K0.6070.75
248_A257_L0.6070.75
78_S81_V0.6060.75
98_Y119_K0.6000.74
228_T231_A0.5980.74
86_F89_H0.5980.74
67_I106_A0.5980.74
195_Q225_N0.5980.74
252_Q260_V0.5970.74
170_M175_I0.5940.74
185_L190_L0.5930.74
90_M94_H0.5920.73
90_M93_L0.5910.73
166_Q169_E0.5900.73
187_L190_L0.5890.73
230_K233_E0.5880.73
78_S261_R0.5860.73
111_T238_Q0.5850.73
239_M254_M0.5850.73
157_G164_E0.5840.72
74_S83_K0.5820.72
71_H93_L0.5810.72
81_V262_V0.5790.72
232_A237_Y0.5720.71
229_L233_E0.5700.71
206_F210_F0.5700.71
66_P146_K0.5670.70
157_G160_H0.5670.70
224_Y244_E0.5660.70
101_L105_E0.5640.70
141_K169_E0.5630.70
86_F136_A0.5630.70
161_H178_E0.5600.69
104_K215_T0.5580.69
125_F149_I0.5570.69
99_Q120_C0.5550.69
100_T120_C0.5540.69
93_L97_G0.5520.68
99_Q117_S0.5490.68
252_Q258_H0.5470.68
168_K211_H0.5460.67
125_F147_A0.5450.67
101_L120_C0.5440.67
94_H144_G0.5430.67
187_L191_T0.5430.67
134_Q138_P0.5400.67
150_F239_M0.5390.66
73_I89_H0.5390.66
249_S252_Q0.5390.66
102_T106_A0.5380.66
224_Y228_T0.5380.66
174_G211_H0.5370.66
93_L259_R0.5370.66
178_E271_F0.5350.66
122_L140_L0.5350.66
199_M235_T0.5350.66
70_Y90_M0.5300.65
228_T236_G0.5270.65
123_I147_A0.5250.64
81_V85_E0.5250.64
93_L96_N0.5250.64
82_P224_Y0.5240.64
200_A235_T0.5230.64
90_M147_A0.5200.64
187_L221_V0.5200.64
252_Q257_L0.5200.64
149_I242_T0.5190.64
86_F93_L0.5180.63
71_H86_F0.5160.63
251_D254_M0.5150.63
187_L194_Q0.5150.63
56_W59_T0.5140.63
133_Y218_S0.5120.62
187_L198_E0.5120.62
95_D172_Q0.5120.62
68_L121_V0.5120.62
72_S79_L0.5060.62
88_A142_K0.5060.62
148_T178_E0.5050.61
182_I197_S0.5040.61
206_F209_M0.5030.61
137_Y177_I0.5030.61
81_V89_H0.5020.61
152_I221_V0.5010.61
245_P261_R0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4v33A 1 0.7885 100 0.242 Contact Map
3vusA 1 0.7921 100 0.267 Contact Map
4f9dA 1 0.7885 100 0.269 Contact Map
4u10A 1 0.7634 100 0.27 Contact Map
5bu6A 2 0.7563 100 0.273 Contact Map
4wcjA 1 0.7814 100 0.276 Contact Map
4l1gA 1 0.6308 100 0.317 Contact Map
2w3zA 1 0.681 100 0.393 Contact Map
2c1iA 1 0.8674 100 0.422 Contact Map
4m1bA 1 0.5986 100 0.455 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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