GREMLIN Database
MSMX - Maltodextrin import ATP-binding protein MsmX
UniProt: P94360 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (310)
Sequences: 18131 (13198)
Seq/√Len: 749.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_G221_D4.5281.00
60_D67_R4.1191.00
34_V202_A3.9831.00
8_H22_D3.9521.00
31_E204_R3.7681.00
7_E60_D3.7101.00
5_R26_H3.6511.00
120_K125_E3.5191.00
18_P21_D3.2561.00
112_K116_E3.2021.00
21_D212_K2.8231.00
214_Q228_N2.7881.00
218_T221_D2.6831.00
33_I206_V2.6681.00
94_Y98_A2.6431.00
127_Y130_R2.6181.00
107_P110_E2.5531.00
7_E62_Y2.4591.00
10_Y18_P2.4381.00
94_Y129_H2.4371.00
5_R62_Y2.4221.00
28_A31_E2.4101.00
10_Y58_K2.4011.00
8_H24_N2.3931.00
6_M9_I2.3921.00
94_Y112_K2.2941.00
114_R152_D2.2851.00
11_K49_M2.2811.00
10_Y22_D2.2001.00
12_F18_P2.1961.00
94_Y116_E2.1531.00
77_D154_K2.1521.00
4_L155_V2.1411.00
123_G172_Q2.0701.00
20_V49_M2.0661.00
62_Y67_R2.0511.00
64_E154_K2.0441.00
47_L191_V2.0051.00
199_L220_K1.9791.00
206_V216_I1.9691.00
49_M56_I1.9531.00
119_A128_L1.9431.00
209_K214_Q1.9141.00
9_I56_I1.9121.00
229_V280_I1.9071.00
50_V189_I1.8921.00
11_K57_S1.8571.00
113_K117_E1.8391.00
206_V213_I1.8171.00
110_E113_K1.7631.00
109_P113_K1.7401.00
48_R54_E1.6841.00
11_K54_E1.6681.00
68_V71_V1.6611.00
229_V242_F1.6511.00
114_R117_E1.6291.00
158_M188_T1.6231.00
63_I68_V1.6231.00
49_M61_F1.5951.00
122_L146_G1.5761.00
6_M50_V1.5551.00
233_G242_F1.5401.00
6_M25_L1.5231.00
23_F46_T1.4981.00
118_A150_V1.4871.00
66_K154_K1.4771.00
98_A115_V1.4731.00
94_Y115_V1.4671.00
67_R70_D1.4661.00
12_F57_S1.4571.00
117_E120_K1.4461.00
66_K71_V1.4091.00
256_S259_L1.4051.00
16_K19_A1.4041.00
106_M111_I1.3981.00
33_I216_I1.3901.00
56_I61_F1.3851.00
252_I256_S1.3641.00
259_L262_P1.3621.00
220_K224_E1.3601.00
274_Y277_K1.3581.00
116_E120_K1.3561.00
246_K278_E1.3451.00
110_E114_R1.3301.00
47_L157_L1.3301.00
25_L206_V1.3221.00
106_M110_E1.3171.00
10_Y21_D1.3151.00
229_V233_G1.3041.00
20_V23_F1.2851.00
27_I33_I1.2821.00
98_A111_I1.2791.00
181_H186_T1.2781.00
6_M46_T1.2701.00
92_T131_K1.2481.00
60_D69_N1.2481.00
111_I115_V1.2441.00
33_I204_R1.2341.00
310_A319_I1.2311.00
242_F280_I1.2181.00
48_R53_L1.2151.00
92_T95_D1.2091.00
12_F58_K1.2021.00
20_V46_T1.2021.00
91_M99_F1.1991.00
95_D98_A1.1931.00
7_E24_N1.1921.00
79_A148_A1.1891.00
95_D102_K1.1851.00
254_I257_A1.1821.00
178_I201_M1.1761.00
252_I255_G1.1531.00
181_H188_T1.1501.00
12_F19_A1.1501.00
28_A204_R1.1391.00
93_V135_L1.1231.00
204_R216_I1.1221.00
263_E266_M1.1011.00
41_C208_M1.0911.00
71_V75_D1.0901.00
90_H133_K1.0841.00
221_D225_F1.0741.00
244_K278_E1.0671.00
296_E299_K1.0661.00
88_Y100_G1.0661.00
257_A260_T1.0621.00
9_I61_F1.0531.00
116_E128_L1.0521.00
117_E152_D1.0461.00
258_A261_V1.0391.00
261_V264_G1.0351.00
273_G277_K1.0321.00
108_K112_K1.0311.00
9_I49_M1.0311.00
25_L216_I1.0281.00
253_K256_S1.0271.00
117_E121_I1.0261.00
273_G276_G1.0251.00
61_F68_V1.0231.00
213_I216_I1.0161.00
312_L317_I1.0161.00
299_K302_S1.0081.00
207_V231_V1.0001.00
87_L132_P0.9971.00
72_A75_D0.9851.00
96_N147_R0.9801.00
79_A153_A0.9751.00
46_T208_M0.9741.00
207_V222_V0.9701.00
100_G151_R0.9701.00
56_I69_N0.9681.00
97_I146_G0.9671.00
260_T263_E0.9651.00
262_P265_K0.9641.00
99_F103_L0.9621.00
257_A261_V0.9601.00
8_H58_K0.9601.00
62_Y65_G0.9581.00
88_Y91_M0.9521.00
253_K257_A0.9511.00
178_I182_Q0.9461.00
29_D64_E0.9451.00
116_E125_E0.9441.00
12_F15_Q0.9431.00
27_I187_T0.9421.00
297_S300_N0.9381.00
178_I200_T0.9351.00
32_F201_M0.9331.00
241_N245_G0.9321.00
305_A308_N0.9291.00
102_K108_K0.9221.00
31_E203_T0.9211.00
264_G267_K0.9171.00
36_V207_V0.9171.00
224_E312_L0.9141.00
258_A263_E0.9091.00
220_K312_L0.9051.00
98_A102_K0.8971.00
94_Y128_L0.8971.00
104_R151_R0.8931.00
118_A121_I0.8931.00
170_R194_D0.8921.00
131_K134_A0.8891.00
223_Y286_E0.8871.00
5_R65_G0.8861.00
34_V198_A0.8831.00
30_K185_Q0.8791.00
51_A157_L0.8781.00
244_K280_I0.8741.00
258_A262_P0.8731.00
307_I319_I0.8641.00
269_L272_K0.8641.00
162_L190_Y0.8631.00
91_M95_D0.8551.00
30_K187_T0.8541.00
296_E300_N0.8491.00
192_T198_A0.8471.00
118_A149_I0.8401.00
272_K276_G0.8391.00
6_M61_F0.8391.00
35_F206_V0.8381.00
32_F181_H0.8371.00
13_Y19_A0.8331.00
219_P223_Y0.8301.00
145_L158_M0.8181.00
97_I119_A0.8161.00
259_L264_G0.8121.00
97_I150_V0.8121.00
245_G279_V0.8081.00
156_F186_T0.8071.00
123_G126_E0.8061.00
285_P289_H0.8061.00
97_I100_G0.8021.00
190_Y202_A0.8011.00
252_I257_A0.8001.00
152_D186_T0.7991.00
259_L263_E0.7971.00
32_F188_T0.7941.00
262_P266_M0.7931.00
49_M57_S0.7931.00
130_R134_A0.7911.00
223_Y226_P0.7881.00
283_I288_I0.7861.00
253_K258_A0.7841.00
78_I155_V0.7841.00
276_G279_V0.7791.00
283_I286_E0.7781.00
87_L96_N0.7771.00
7_E26_H0.7761.00
12_F16_K0.7701.00
209_K230_F0.7681.00
269_L273_G0.7661.00
256_S260_T0.7651.00
160_E193_H0.7631.00
79_A151_R0.7611.00
196_T313_L0.7591.00
38_P41_C0.7591.00
162_L177_I0.7571.00
118_A122_L0.7531.00
256_S262_P0.7531.00
239_A242_F0.7471.00
251_L256_S0.7461.00
171_V175_A0.7451.00
108_K111_I0.7441.00
167_A171_V0.7411.00
179_K309_V0.7391.00
255_G259_L0.7391.00
49_M54_E0.7381.00
276_G283_I0.7381.00
119_A124_L0.7371.00
261_V265_K0.7361.00
266_M270_R0.7351.00
14_D18_P0.7321.00
283_I287_D0.7241.00
83_Q164_N0.7181.00
154_K186_T0.7181.00
158_M190_Y0.7121.00
209_K212_K0.7121.00
180_L186_T0.7111.00
267_K270_R0.7041.00
41_C46_T0.7011.00
173_M176_E0.7001.00
249_D252_I0.6991.00
233_G237_S0.6991.00
282_G285_P0.6981.00
44_S48_R0.6971.00
313_L318_M0.6961.00
250_G253_K0.6951.00
85_Y164_N0.6941.00
260_T264_G0.6901.00
263_E269_L0.6901.00
15_Q18_P0.6881.00
274_Y279_V0.6881.00
284_R288_I0.6881.00
198_A202_A0.6871.00
243_F247_L0.6871.00
258_A264_G0.6821.00
63_I78_I0.6791.00
91_M96_N0.6781.00
252_I259_L0.6761.00
257_A265_K0.6751.00
132_P143_V0.6731.00
254_I258_A0.6721.00
266_M269_L0.6681.00
102_K111_I0.6681.00
281_F285_P0.6671.00
29_D154_K0.6651.00
241_N244_K0.6641.00
281_F284_R0.6641.00
157_L189_I0.6631.00
222_V226_P0.6631.00
240_M243_F0.6621.00
242_F245_G0.6611.00
115_V118_A0.6591.00
301_S305_A0.6581.00
208_M213_I0.6571.00
156_F188_T0.6571.00
261_V266_M0.6571.00
257_A262_P0.6561.00
255_G258_A0.6551.00
176_E179_K0.6531.00
282_G286_E0.6511.00
295_V299_K0.6501.00
172_Q176_E0.6491.00
112_K115_V0.6471.00
274_Y278_E0.6471.00
35_F208_M0.6471.00
127_Y139_Q0.6461.00
35_F46_T0.6461.00
256_S261_V0.6431.00
270_R273_G0.6431.00
276_G284_R0.6421.00
79_A188_T0.6421.00
309_V312_L0.6371.00
106_M114_R0.6371.00
296_E301_S0.6361.00
248_T253_K0.6361.00
81_V148_A0.6331.00
51_A80_M0.6291.00
240_M282_G0.6291.00
255_G261_V0.6281.00
33_I189_I0.6251.00
175_A320_Y0.6251.00
251_L254_I0.6241.00
96_N132_P0.6241.00
121_I149_I0.6241.00
204_R215_Q0.6231.00
238_P282_G0.6221.00
308_N320_Y0.6211.00
245_G252_I0.6211.00
175_A309_V0.6191.00
286_E290_D0.6171.00
94_Y111_I0.6161.00
153_A156_F0.6151.00
101_L104_R0.6151.00
276_G288_I0.6131.00
307_I314_G0.6131.00
178_I312_L0.6131.00
263_E268_V0.6131.00
300_N306_K0.6121.00
77_D104_R0.6121.00
247_L250_G0.6111.00
285_P288_I0.6101.00
276_G280_I0.6101.00
306_K309_V0.6091.00
119_A122_L0.6091.00
256_S264_G0.6041.00
238_P242_F0.6041.00
21_D210_D0.6001.00
281_F288_I0.5971.00
300_N303_I0.5971.00
317_I320_Y0.5961.00
121_I179_K0.5961.00
114_R118_A0.5961.00
253_K262_P0.5961.00
196_T200_T0.5951.00
302_S305_A0.5941.00
232_G236_G0.5941.00
100_G103_L0.5931.00
271_E274_Y0.5931.00
301_S304_K0.5911.00
235_I238_P0.5911.00
168_K233_G0.5901.00
295_V298_Y0.5901.00
260_T265_K0.5891.00
100_G104_R0.5871.00
231_V235_I0.5871.00
126_E139_Q0.5861.00
23_F213_I0.5851.00
142_R165_L0.5851.00
35_F189_I0.5851.00
295_V301_S0.5841.00
94_Y97_I0.5831.00
307_I310_A0.5821.00
264_G268_V0.5811.00
207_V226_P0.5791.00
251_L258_A0.5781.00
13_Y54_E0.5781.00
298_Y302_S0.5751.00
11_K45_T0.5741.00
22_D58_K0.5731.00
267_K271_E0.5721.00
251_L255_G0.5721.00
254_I259_L0.5711.00
295_V300_N0.5701.00
93_V143_V0.5701.00
83_Q137_G0.5701.00
171_V237_S0.5691.00
202_A205_I0.5691.00
271_E275_I0.5671.00
241_N246_K0.5661.00
259_L265_K0.5661.00
170_R197_E0.5661.00
255_G263_E0.5641.00
119_A125_E0.5641.00
125_E128_L0.5641.00
297_S303_I0.5631.00
304_K307_I0.5621.00
219_P222_V0.5621.00
163_S167_A0.5611.00
99_F102_K0.5611.00
124_L127_Y0.5611.00
298_Y301_S0.5601.00
167_A174_R0.5551.00
268_V271_E0.5541.00
88_Y96_N0.5521.00
31_E216_I0.5491.00
179_K308_N0.5491.00
190_Y198_A0.5481.00
297_S301_S0.5471.00
265_K269_L0.5471.00
280_I284_R0.5461.00
6_M23_F0.5441.00
281_F286_E0.5421.00
155_V187_T0.5421.00
248_T251_L0.5411.00
257_A263_E0.5411.00
300_N307_I0.5411.00
313_L316_E0.5411.00
118_A146_G0.5401.00
124_L128_L0.5391.00
251_L259_L0.5381.00
62_Y69_N0.5371.00
39_S160_E0.5361.00
286_E289_H0.5351.00
178_I203_T0.5351.00
12_F21_D0.5331.00
89_P133_K0.5331.00
280_I286_E0.5311.00
163_S174_R0.5311.00
232_G237_S0.5301.00
39_S193_H0.5281.00
311_E314_G0.5281.00
27_I189_I0.5281.00
259_L266_M0.5271.00
109_P112_K0.5271.00
164_N174_R0.5261.00
50_V157_L0.5251.00
113_K116_E0.5251.00
171_V196_T0.5251.00
305_A309_V0.5231.00
277_K280_I0.5211.00
255_G260_T0.5201.00
92_T96_N0.5191.00
111_I114_R0.5181.00
106_M150_V0.5171.00
268_V272_K0.5171.00
252_I258_A0.5161.00
88_Y151_R0.5141.00
252_I260_T0.5131.00
270_R274_Y0.5131.00
145_L201_M0.5131.00
107_P111_I0.5121.00
8_H11_K0.5111.00
81_V141_Q0.5111.00
21_D24_N0.5101.00
241_N247_L0.5091.00
191_V195_Q0.5061.00
100_G147_R0.5061.00
310_A314_G0.5051.00
299_K307_I0.5051.00
164_N170_R0.5031.00
283_I290_D0.5021.00
260_T266_M0.5011.00
177_I188_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v43A 2 0.9562 100 0.121 Contact Map
2it1A 1 0.9781 100 0.125 Contact Map
1g291 4 0.989 100 0.134 Contact Map
2yyzA 1 0.9699 100 0.134 Contact Map
3rlfA 2 0.9808 100 0.14 Contact Map
1oxxK 1 0.9452 100 0.153 Contact Map
4tquS 2 0.9918 100 0.173 Contact Map
3fvqA 2 0.9452 100 0.181 Contact Map
3d31A 2 0.9425 100 0.182 Contact Map
1z47A 2 0.9342 100 0.191 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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