GREMLIN Database
YXKF - Uncharacterized protein YxkF
UniProt: P94359 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (250)
Sequences: 6481 (5311)
Seq/√Len: 335.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_G177_H5.4201.00
244_N254_K5.2571.00
233_E236_K3.0631.00
279_S282_G3.0501.00
270_I276_D2.9391.00
257_L261_S2.7491.00
236_K240_L2.6211.00
251_T262_L2.6181.00
257_L262_L2.6041.00
238_I269_F2.4011.00
53_F56_P2.3821.00
243_E254_K2.3821.00
240_L244_N2.3531.00
93_F97_H2.3231.00
163_Y181_E2.3131.00
166_R180_R2.2711.00
239_K243_E2.2491.00
259_R263_Q2.2481.00
281_K291_L2.2461.00
163_Y184_Y2.1721.00
244_N251_T2.1541.00
219_L223_E2.1421.00
250_L253_K2.0801.00
275_I282_G1.9471.00
87_I91_T1.9101.00
270_I277_I1.9041.00
128_R182_Q1.8931.00
227_L232_S1.8881.00
245_N279_S1.8701.00
258_H261_S1.8411.00
246_S283_A1.8391.00
226_L230_S1.8331.00
90_R93_F1.8091.00
240_L251_T1.8081.00
237_T265_R1.7921.00
188_A198_V1.7641.00
130_V178_Y1.7631.00
199_T202_M1.7231.00
168_Y180_R1.7021.00
178_Y182_Q1.6781.00
227_L230_S1.6731.00
267_D270_I1.6621.00
240_L254_K1.6421.00
175_R179_A1.6111.00
170_P173_C1.6091.00
163_Y185_F1.6091.00
173_C176_K1.5941.00
269_F273_S1.5911.00
283_A287_Y1.5821.00
267_D271_E1.5581.00
241_F248_V1.5541.00
249_T259_R1.5441.00
248_V263_Q1.5411.00
242_I283_A1.5111.00
273_S282_G1.4971.00
249_T263_Q1.4901.00
142_K146_E1.4821.00
95_H181_E1.4761.00
164_A199_T1.4751.00
237_T269_F1.4651.00
50_L53_F1.4441.00
284_L287_Y1.4421.00
89_K93_F1.4271.00
249_T253_K1.4181.00
275_I285_L1.4021.00
237_T251_T1.3901.00
104_R108_T1.3881.00
108_T112_R1.3811.00
237_T262_L1.3811.00
268_K271_E1.3701.00
226_L232_S1.3681.00
244_N250_L1.3411.00
64_S67_S1.3411.00
270_I278_K1.3391.00
250_L254_K1.3321.00
241_F246_S1.3311.00
75_S125_H1.3301.00
166_R201_E1.3171.00
168_Y177_H1.3161.00
177_H181_E1.3111.00
247_N250_L1.2791.00
225_E229_G1.2761.00
168_Y173_C1.2671.00
92_R97_H1.2631.00
234_L237_T1.2571.00
97_H189_E1.2541.00
240_L255_L1.2321.00
91_T95_H1.2271.00
76_F81_G1.2271.00
88_K91_T1.2231.00
146_E150_K1.2041.00
255_L262_L1.1951.00
264_Y268_K1.1831.00
39_K43_S1.1821.00
234_L269_F1.1671.00
242_I246_S1.1641.00
97_H128_R1.1631.00
234_L272_R1.1611.00
268_K272_R1.1581.00
223_E226_L1.1461.00
132_V174_L1.1391.00
75_S79_S1.1381.00
43_S53_F1.1301.00
221_S225_E1.1291.00
245_N280_Y1.1111.00
220_L224_A1.1031.00
43_S47_V1.0911.00
239_K293_N1.0751.00
147_S151_V1.0501.00
260_N263_Q1.0471.00
89_K92_R1.0391.00
246_S251_T1.0391.00
66_K70_E1.0371.00
184_Y188_A1.0351.00
49_V57_A1.0331.00
219_L222_E1.0311.00
183_A211_T1.0311.00
225_E228_F1.0201.00
82_E86_Y1.0191.00
71_N75_S1.0161.00
163_Y188_A1.0151.00
248_V266_I1.0121.00
243_E287_Y1.0101.00
55_T58_D1.0081.00
163_Y180_R1.0061.00
97_H161_R1.0031.00
142_K199_T1.0031.00
43_S50_L1.0021.00
97_H185_F0.9941.00
93_F177_H0.9851.00
247_N259_R0.9821.00
239_K291_L0.9771.00
206_F281_K0.9761.00
111_V114_F0.9691.00
287_Y291_L0.9681.00
248_V260_N0.9661.00
65_M68_P0.9641.00
87_I93_F0.9631.00
259_R287_Y0.9631.00
204_F207_L0.9571.00
114_F117_V0.9551.00
241_F266_I0.9471.00
247_N262_L0.9451.00
228_F232_S0.9441.00
112_R116_P0.9431.00
122_V131_I0.9421.00
91_T97_H0.9291.00
68_P71_N0.9271.00
235_R290_C0.9201.00
240_L243_E0.9151.00
235_R293_N0.9131.00
110_A113_H0.9131.00
91_T98_L0.9051.00
243_E291_L0.9021.00
235_R239_K0.9001.00
96_F162_F0.8991.00
99_F161_R0.8981.00
266_I269_F0.8911.00
142_K145_L0.8891.00
50_L54_L0.8881.00
205_P288_F0.8831.00
282_G285_L0.8771.00
164_A197_S0.8741.00
168_Y174_L0.8741.00
259_R267_D0.8671.00
48_L52_S0.8671.00
266_I270_I0.8661.00
270_I273_S0.8621.00
280_Y287_Y0.8611.00
47_V51_Q0.8611.00
218_T222_E0.8591.00
216_L292_Q0.8561.00
241_F251_T0.8461.00
168_Y176_K0.8401.00
217_E220_L0.8401.00
184_Y200_F0.8351.00
143_D147_S0.8351.00
184_Y203_I0.8341.00
68_P72_K0.8301.00
39_K42_I0.8291.00
142_K202_M0.8241.00
92_R135_E0.8231.00
242_I287_Y0.8211.00
244_N262_L0.8191.00
239_K290_C0.8121.00
51_Q54_L0.8101.00
56_P59_E0.8101.00
64_S68_P0.8081.00
150_K154_S0.8061.00
238_I242_I0.7991.00
281_K285_L0.7851.00
220_L223_E0.7781.00
217_E223_E0.7781.00
43_S51_Q0.7761.00
218_T223_E0.7761.00
223_E285_L0.7761.00
99_F189_E0.7751.00
277_I283_A0.7731.00
276_D282_G0.7651.00
105_T108_T0.7551.00
205_P285_L0.7531.00
284_L288_F0.7511.00
181_E184_Y0.7511.00
125_H130_V0.7491.00
256_H264_Y0.7440.99
92_R167_F0.7400.99
95_H178_Y0.7390.99
83_L86_Y0.7390.99
217_E221_S0.7380.99
90_R97_H0.7380.99
144_E152_L0.7330.99
92_R98_L0.7320.99
44_E48_L0.7310.99
130_V182_Q0.7270.99
218_T221_S0.7240.99
278_K283_A0.7190.99
237_T257_L0.7180.99
277_I282_G0.7170.99
247_N263_Q0.7160.99
80_R175_R0.7150.99
165_G181_E0.7120.99
229_G232_S0.7110.99
281_K284_L0.7080.99
45_K48_L0.7070.99
276_D279_S0.7060.99
228_F231_E0.7020.99
227_L231_E0.6990.99
51_Q55_T0.6970.99
51_Q56_P0.6950.99
110_A114_F0.6950.99
280_Y283_A0.6940.99
50_L56_P0.6940.99
41_E45_K0.6900.99
69_E72_K0.6880.99
146_E149_A0.6870.99
208_L219_L0.6810.99
205_P284_L0.6790.99
280_Y284_L0.6770.99
94_V98_L0.6750.99
256_H259_R0.6730.99
284_L291_L0.6720.99
107_F110_A0.6710.99
43_S52_S0.6710.99
209_L292_Q0.6690.99
236_K239_K0.6690.99
245_N283_A0.6690.99
150_K153_E0.6670.99
273_S286_A0.6660.99
149_A162_F0.6630.99
91_T96_F0.6630.99
216_L219_L0.6610.99
209_L288_F0.6590.99
207_L211_T0.6590.99
206_F291_L0.6570.99
179_A182_Q0.6480.99
211_T215_K0.6480.99
243_E281_K0.6440.99
93_F99_F0.6440.99
179_A183_A0.6440.99
148_L152_L0.6430.98
180_R200_F0.6420.98
264_Y271_E0.6420.98
107_F111_V0.6390.98
58_D64_S0.6390.98
94_V164_A0.6360.98
91_T94_V0.6310.98
45_K49_V0.6300.98
53_F57_A0.6280.98
42_I46_E0.6270.98
117_V120_V0.6250.98
88_K93_F0.6240.98
151_V155_D0.6220.98
176_K180_R0.6220.98
103_E106_S0.6220.98
109_E112_R0.6220.98
46_E49_V0.6210.98
162_F197_S0.6200.98
45_K56_P0.6190.98
106_S110_A0.6190.98
161_R189_E0.6190.98
200_F207_L0.6180.98
248_V258_H0.6180.98
213_K217_E0.6180.98
204_F285_L0.6150.98
94_V133_E0.6140.98
113_H117_V0.6120.98
216_L220_L0.6100.98
49_V58_D0.6080.98
110_A115_W0.6080.98
45_K55_T0.6040.98
43_S56_P0.6030.98
182_Q186_L0.6000.98
147_S150_K0.5990.98
237_T264_Y0.5970.98
237_T255_L0.5940.97
149_A153_E0.5930.97
203_I207_L0.5930.97
259_R262_L0.5910.97
230_S268_K0.5910.97
203_I206_F0.5870.97
62_Q65_M0.5860.97
89_K97_H0.5850.97
165_G168_Y0.5830.97
143_D146_E0.5800.97
88_K92_R0.5800.97
77_L171_D0.5770.97
124_I129_G0.5760.97
58_D63_L0.5750.97
123_W129_G0.5720.97
124_I128_R0.5690.97
87_I92_R0.5690.97
93_F96_F0.5670.97
124_I127_D0.5670.97
256_H261_S0.5670.97
54_L58_D0.5660.97
269_F286_A0.5640.97
45_K53_F0.5640.97
153_E196_Q0.5630.97
183_A186_L0.5620.96
198_V205_P0.5620.96
108_T114_F0.5620.96
260_N287_Y0.5600.96
282_G286_A0.5600.96
89_K98_L0.5540.96
248_V259_R0.5530.96
93_F181_E0.5510.96
169_E173_C0.5500.96
95_H182_Q0.5480.96
242_I290_C0.5480.96
288_F291_L0.5460.96
95_H130_V0.5460.96
87_I97_H0.5450.96
226_L234_L0.5440.96
193_P196_Q0.5440.96
223_E282_G0.5440.96
144_E148_L0.5440.96
137_E140_A0.5430.96
123_W127_D0.5420.96
123_W126_E0.5400.96
87_I98_L0.5380.96
48_L51_Q0.5350.95
43_S46_E0.5290.95
147_S152_L0.5280.95
154_S157_Y0.5280.95
107_F115_W0.5280.95
106_S109_E0.5270.95
40_T44_E0.5270.95
54_L59_E0.5260.95
251_T259_R0.5250.95
85_A172_E0.5250.95
116_P119_F0.5230.95
106_S113_H0.5230.95
187_F191_R0.5230.95
142_K147_S0.5220.95
246_S278_K0.5220.95
43_S48_L0.5210.95
277_I286_A0.5210.95
188_A192_L0.5210.95
198_V203_I0.5180.95
75_S123_W0.5170.94
223_E275_I0.5170.94
109_E113_H0.5160.94
248_V251_T0.5150.94
258_H264_Y0.5130.94
149_A197_S0.5120.94
171_D174_L0.5110.94
93_F98_L0.5090.94
275_I286_A0.5090.94
260_N280_Y0.5080.94
260_N292_Q0.5070.94
264_Y273_S0.5060.94
115_W118_S0.5050.94
226_L233_E0.5040.94
42_I45_K0.5040.94
104_R118_S0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3onqA 5 0.8081 100 0.406 Contact Map
3hvaA 1 0.4276 94.9 0.894 Contact Map
1al3A 1 0 94.7 0.895 Contact Map
4urgA 1 0.4613 94.3 0.896 Contact Map
4eu0A 1 0.5993 94.3 0.897 Contact Map
3hhgA 3 0.2323 94.2 0.897 Contact Map
3mz1A 2 0 94.1 0.897 Contact Map
1etoA 2 0.2525 94.1 0.897 Contact Map
3fzvA 4 0.2121 94.1 0.898 Contact Map
2esnA 3 0.2458 93.9 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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