GREMLIN Database
ALDY - Uncharacterized aldehyde dehydrogenase AldY
UniProt: P94358 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 485 (452)
Sequences: 36347 (21751)
Seq/√Len: 1023.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
297_Q393_G4.8721.00
241_E245_R3.9161.00
297_Q391_K3.1091.00
269_D306_K3.0721.00
300_Y391_K2.9551.00
25_D37_T2.8841.00
357_K364_T2.7831.00
54_Q223_I2.7751.00
264_S296_H2.6911.00
344_Q376_K2.6311.00
273_D310_R2.6021.00
372_D375_S2.5751.00
332_E336_E2.5521.00
189_I192_K2.5001.00
264_S298_D2.4821.00
343_E347_T2.4701.00
304_V389_I2.4371.00
25_D34_V2.4171.00
82_N85_D2.4121.00
415_T421_G2.3561.00
195_E201_A2.3361.00
80_H113_D2.3061.00
78_Y196_H2.1971.00
42_T45_Q2.1841.00
83_R106_E2.1801.00
339_L343_E2.1691.00
54_Q225_R2.1381.00
406_E453_A2.1071.00
342_I363_L2.1031.00
84_D102_T2.1001.00
220_T242_I2.0761.00
395_D420_K2.0681.00
216_D220_T2.0601.00
181_Q331_N1.9971.00
351_E370_G1.9871.00
142_L472_K1.9811.00
344_Q348_D1.9671.00
339_L358_R1.9651.00
75_A194_F1.9461.00
141_R466_E1.9441.00
423_K427_Q1.9361.00
339_L363_L1.9261.00
308_T312_K1.9221.00
302_E306_K1.9101.00
260_F275_A1.9071.00
353_A369_V1.9021.00
47_E217_G1.8901.00
238_H241_E1.8641.00
237_R453_A1.8581.00
329_L338_A1.8231.00
78_Y81_E1.8201.00
71_V199_L1.8161.00
346_K352_L1.8121.00
51_D223_I1.8061.00
265_D420_K1.7791.00
85_D189_I1.7681.00
378_A390_I1.7631.00
294_I401_M1.7541.00
34_V37_T1.7501.00
82_N196_H1.7371.00
47_E51_D1.7171.00
429_D452_K1.6901.00
141_R469_T1.6691.00
308_T353_A1.6461.00
73_Q113_D1.6441.00
393_G397_E1.6321.00
373_N401_M1.6271.00
397_E400_D1.6251.00
351_E369_V1.6101.00
395_D423_K1.6071.00
296_H392_A1.6021.00
80_H109_I1.5981.00
98_I102_T1.5911.00
306_K309_A1.5831.00
332_E361_N1.5811.00
368_F377_I1.5791.00
305_E309_A1.5751.00
64_T67_D1.5691.00
311_V367_V1.5651.00
210_D213_E1.5631.00
23_T37_T1.5621.00
74_K77_G1.5551.00
280_F311_V1.5531.00
340_E376_K1.5511.00
300_Y304_V1.5501.00
112_L165_A1.5491.00
275_A303_F1.5291.00
77_G81_E1.5211.00
272_V306_K1.5201.00
191_A206_V1.5201.00
78_Y197_A1.4981.00
57_Q61_A1.4941.00
376_K380_T1.4891.00
47_E221_N1.4851.00
294_I398_A1.4841.00
62_K427_Q1.4801.00
192_K196_H1.4791.00
67_D70_A1.4771.00
263_L420_K1.4751.00
268_V306_K1.4711.00
173_S203_V1.4671.00
63_S67_D1.4651.00
88_M92_R1.4531.00
83_R102_T1.4521.00
78_Y193_A1.4431.00
126_K462_P1.4371.00
274_A414_F1.4301.00
310_R313_Q1.4301.00
76_R113_D1.4211.00
300_Y369_V1.4191.00
397_E401_M1.4141.00
343_E346_K1.4111.00
293_I387_A1.4101.00
294_I392_A1.4081.00
301_D391_K1.4071.00
27_L34_V1.4001.00
315_P323_K1.3971.00
275_A293_I1.3961.00
73_Q120_G1.3951.00
302_E305_E1.3931.00
89_M189_I1.3871.00
295_V303_F1.3831.00
22_R40_L1.3821.00
140_Y426_L1.3791.00
84_D88_M1.3771.00
216_D242_I1.3671.00
118_Y121_E1.3661.00
352_L368_F1.3641.00
112_L161_M1.3631.00
411_S430_S1.3571.00
338_A384_A1.3431.00
149_S174_V1.3391.00
45_Q48_D1.3321.00
240_G456_V1.3301.00
88_M320_T1.3301.00
264_S420_K1.3281.00
335_I339_L1.3241.00
396_Q427_Q1.3191.00
226_L251_A1.3151.00
82_N189_I1.3071.00
332_E335_I1.3031.00
335_I358_R1.2961.00
43_G217_G1.2961.00
301_D305_E1.2891.00
341_I382_L1.2851.00
394_S397_E1.2841.00
348_D376_K1.2761.00
28_N31_D1.2751.00
304_V308_T1.2741.00
336_E340_E1.2731.00
77_G113_D1.2721.00
160_S176_H1.2681.00
392_A401_M1.2651.00
263_L424_F1.2641.00
315_P325_V1.2491.00
263_L392_A1.2491.00
261_A398_A1.2471.00
57_Q173_S1.2441.00
335_I363_L1.2411.00
309_A312_K1.2411.00
220_T245_R1.2401.00
299_V302_E1.2401.00
340_E344_Q1.2391.00
91_A101_S1.2361.00
76_R80_H1.2281.00
40_L210_D1.2251.00
463_W466_E1.2251.00
306_K310_R1.2231.00
462_P466_E1.2171.00
296_H394_S1.2141.00
374_N379_Q1.2111.00
309_A313_Q1.2031.00
51_D55_K1.2011.00
312_K354_V1.2001.00
399_I424_F1.1941.00
191_A204_L1.1921.00
350_I368_F1.1841.00
141_R471_T1.1781.00
296_H299_V1.1761.00
88_M98_I1.1741.00
216_D238_H1.1641.00
317_G324_T1.1631.00
304_V369_V1.1581.00
138_K422_E1.1571.00
50_F223_I1.1561.00
63_S71_V1.1551.00
425_A474_I1.1511.00
396_Q423_K1.1481.00
238_H242_I1.1481.00
50_F224_P1.1391.00
144_L226_L1.1381.00
50_F221_N1.1381.00
307_F387_A1.1291.00
74_K78_Y1.1221.00
373_N404_D1.1201.00
24_E40_L1.1191.00
411_S433_T1.1171.00
91_A319_Q1.1121.00
202_G205_N1.1101.00
234_A238_H1.1081.00
303_F307_F1.1071.00
421_G435_V1.1051.00
32_Q361_N1.0991.00
359_V364_T1.0981.00
46_L214_I1.0981.00
396_Q400_D1.0941.00
52_I205_N1.0931.00
463_W471_T1.0911.00
304_V353_A1.0901.00
180_I212_K1.0881.00
260_F290_I1.0791.00
40_L213_E1.0761.00
192_K195_E1.0761.00
180_I210_D1.0761.00
73_Q117_T1.0691.00
188_T208_L1.0671.00
36_T184_I1.0661.00
240_G250_M1.0651.00
235_V238_H1.0641.00
379_Q406_E1.0611.00
442_D445_N1.0581.00
164_I204_L1.0571.00
335_I361_N1.0551.00
75_A199_L1.0541.00
126_K463_W1.0541.00
75_A193_A1.0531.00
449_G458_R1.0521.00
148_S218_M1.0491.00
458_R470_V1.0481.00
312_K364_T1.0481.00
148_S224_P1.0461.00
395_D424_F1.0461.00
194_F204_L1.0411.00
261_A424_F1.0401.00
164_I174_V1.0331.00
399_I427_Q1.0311.00
28_N318_D1.0291.00
267_D416_S1.0281.00
217_G221_N1.0271.00
267_D270_R1.0231.00
237_R247_F1.0221.00
149_S228_S1.0221.00
308_T354_V1.0191.00
82_N192_K1.0191.00
75_A112_L1.0191.00
348_D375_S1.0161.00
69_K120_G1.0161.00
379_Q404_D1.0161.00
392_A398_A1.0071.00
417_D420_K1.0071.00
345_A368_F0.9941.00
54_Q58_K0.9921.00
146_V173_S0.9901.00
276_I310_R0.9891.00
270_R274_A0.9881.00
56_A173_S0.9881.00
261_A402_A0.9841.00
86_I189_I0.9811.00
30_Y319_Q0.9791.00
108_T161_M0.9791.00
73_Q116_M0.9791.00
43_G213_E0.9771.00
144_L249_R0.9741.00
119_T169_A0.9721.00
180_I211_V0.9721.00
155_F286_I0.9691.00
85_D88_M0.9681.00
87_I102_T0.9671.00
140_Y474_I0.9651.00
451_N470_V0.9651.00
58_K429_D0.9651.00
344_Q347_T0.9651.00
78_Y82_N0.9571.00
58_K400_D0.9541.00
43_G47_E0.9541.00
92_R320_T0.9501.00
81_E196_H0.9491.00
191_A195_E0.9451.00
340_E343_E0.9371.00
400_D404_D0.9311.00
314_L326_V0.9311.00
147_I226_L0.9261.00
341_I344_Q0.9261.00
257_N291_N0.9231.00
318_D321_D0.9221.00
240_G244_G0.9211.00
237_R241_E0.9181.00
269_D302_E0.9181.00
355_E364_T0.9161.00
188_T192_K0.9121.00
278_G290_I0.9111.00
69_K73_Q0.9111.00
371_A375_S0.9111.00
412_A438_Q0.9101.00
48_D52_I0.9071.00
108_T157_M0.9061.00
142_L426_L0.9061.00
28_N92_R0.9031.00
268_V272_V0.9021.00
259_P411_S0.9021.00
355_E366_Y0.9001.00
70_A74_K0.9001.00
27_L361_N0.9001.00
65_T69_K0.8991.00
181_Q333_R0.8951.00
225_R429_D0.8921.00
260_F414_F0.8911.00
61_A429_D0.8901.00
86_I193_A0.8891.00
422_E426_L0.8871.00
338_A386_I0.8851.00
300_Y389_I0.8821.00
137_N446_I0.8791.00
142_L451_N0.8791.00
94_T182_T0.8781.00
30_Y362_V0.8781.00
188_T206_V0.8751.00
82_N193_A0.8741.00
279_K291_N0.8721.00
46_L148_S0.8631.00
301_D304_V0.8631.00
62_K426_L0.8621.00
123_G126_K0.8611.00
263_L415_T0.8591.00
138_K476_I0.8591.00
96_G104_E0.8591.00
263_L395_D0.8571.00
390_I401_M0.8561.00
446_I473_W0.8541.00
170_L469_T0.8531.00
76_R116_M0.8511.00
336_E339_L0.8491.00
341_I376_K0.8481.00
146_V224_P0.8451.00
58_K62_K0.8441.00
240_G243_A0.8431.00
44_K48_D0.8431.00
79_L108_T0.8421.00
346_K368_F0.8391.00
227_I243_A0.8311.00
338_A382_L0.8281.00
41_A45_Q0.8281.00
373_N390_I0.8231.00
272_V307_F0.8221.00
44_K47_E0.8221.00
48_D51_D0.8221.00
272_V310_R0.8211.00
305_E308_T0.8201.00
411_S428_I0.8161.00
144_L470_V0.8161.00
24_E210_D0.8151.00
176_H186_G0.8141.00
240_G247_F0.8101.00
249_R470_V0.8101.00
418_L421_G0.8091.00
356_G366_Y0.8081.00
212_K216_D0.8081.00
333_R336_E0.8081.00
69_K116_M0.8071.00
167_A174_V0.8061.00
232_S235_V0.8061.00
53_A205_N0.8051.00
56_A203_V0.8041.00
166_P464_V0.8021.00
73_Q77_G0.8001.00
52_I202_G0.8001.00
178_P208_L0.7961.00
60_W203_V0.7951.00
160_S164_I0.7881.00
342_I386_I0.7851.00
80_H83_R0.7841.00
350_I375_S0.7841.00
413_V424_F0.7831.00
32_Q332_E0.7821.00
349_G375_S0.7801.00
272_V303_F0.7791.00
92_R184_I0.7791.00
144_L172_N0.7791.00
163_S459_F0.7791.00
236_G254_L0.7771.00
399_I403_N0.7761.00
271_A275_A0.7761.00
161_M190_I0.7741.00
233_T453_A0.7711.00
430_S433_T0.7701.00
262_V303_F0.7691.00
209_T214_I0.7691.00
268_V299_V0.7671.00
91_A98_I0.7661.00
392_A397_E0.7651.00
35_I92_R0.7651.00
237_R245_R0.7631.00
27_L32_Q0.7631.00
217_G220_T0.7621.00
307_F367_V0.7621.00
55_K59_E0.7611.00
55_K58_K0.7611.00
219_L239_I0.7581.00
71_V197_A0.7581.00
219_L242_I0.7561.00
94_T330_I0.7561.00
199_L203_V0.7551.00
236_G252_L0.7521.00
398_A401_M0.7511.00
157_M185_S0.7501.00
99_I325_V0.7491.00
41_A49_A0.7481.00
316_Y359_V0.7461.00
242_I245_R0.7461.00
72_L169_A0.7451.00
66_E120_G0.7451.00
227_I239_I0.7441.00
259_P402_A0.7441.00
80_H106_E0.7431.00
369_V391_K0.7391.00
269_D310_R0.7381.00
337_K340_E0.7381.00
243_A250_M0.7361.00
296_H395_D0.7341.00
300_Y370_G0.7311.00
58_K61_A0.7301.00
59_E63_S0.7281.00
28_N320_T0.7271.00
53_A173_S0.7271.00
98_I320_T0.7261.00
87_I98_I0.7251.00
229_F235_V0.7241.00
149_S163_S0.7201.00
219_L227_I0.7191.00
338_A363_L0.7181.00
314_L325_V0.7171.00
341_I380_T0.7161.00
144_L225_R0.7141.00
102_T322_P0.7091.00
418_L476_I0.7091.00
160_S186_G0.7051.00
137_N473_W0.7041.00
181_Q330_I0.7041.00
311_V354_V0.7031.00
148_S227_I0.7021.00
176_H204_L0.7011.00
271_A303_F0.6991.00
258_N291_N0.6991.00
346_K357_K0.6991.00
308_T311_V0.6981.00
87_I91_A0.6971.00
89_M184_I0.6971.00
418_L422_E0.6971.00
84_D98_I0.6951.00
416_S419_E0.6931.00
23_T39_S0.6901.00
61_A427_Q0.6871.00
54_Q57_Q0.6841.00
151_S160_S0.6831.00
283_Q326_V0.6811.00
295_V299_V0.6811.00
22_R213_E0.6811.00
276_I307_F0.6801.00
241_E244_G0.6791.00
130_S137_N0.6781.00
60_W71_V0.6781.00
28_N33_S0.6751.00
435_V476_I0.6731.00
199_L204_L0.6721.00
331_N334_Q0.6711.00
275_A307_F0.6701.00
46_L217_G0.6701.00
85_D192_K0.6691.00
334_Q337_K0.6691.00
60_W168_I0.6661.00
79_L109_I0.6651.00
262_V271_A0.6641.00
272_V276_I0.6641.00
83_R87_I0.6631.00
466_E471_T0.6621.00
65_T119_T0.6621.00
249_R467_E0.6611.00
276_I314_L0.6611.00
466_E469_T0.6581.00
268_V302_E0.6551.00
76_R109_I0.6551.00
77_G80_H0.6551.00
401_M404_D0.6551.00
140_Y472_K0.6551.00
67_D71_V0.6541.00
270_R273_D0.6531.00
90_I93_E0.6531.00
265_D415_T0.6521.00
46_L50_F0.6501.00
263_L296_H0.6491.00
136_T422_E0.6481.00
429_D451_N0.6481.00
321_D324_T0.6471.00
335_I359_V0.6471.00
373_N378_A0.6471.00
172_N469_T0.6461.00
137_N475_S0.6451.00
270_R416_S0.6431.00
294_I378_A0.6411.00
52_I201_A0.6401.00
307_F389_I0.6361.00
332_E358_R0.6361.00
294_I373_N0.6351.00
61_A142_L0.6351.00
122_L469_T0.6341.00
47_E223_I0.6341.00
213_E216_D0.6331.00
74_K197_A0.6321.00
56_A59_E0.6311.00
311_V314_L0.6311.00
194_F199_L0.6311.00
348_D374_N0.6311.00
316_Y326_V0.6301.00
61_A143_P0.6291.00
59_E62_K0.6291.00
160_S190_I0.6271.00
425_A435_V0.6271.00
293_I303_F0.6261.00
422_E476_I0.6241.00
49_A207_M0.6241.00
148_S215_G0.6231.00
122_L465_V0.6231.00
58_K427_Q0.6231.00
394_S400_D0.6221.00
333_R337_K0.6211.00
39_S208_L0.6201.00
96_G100_K0.6201.00
318_D324_T0.6191.00
395_D399_I0.6191.00
26_I36_T0.6191.00
265_D416_S0.6161.00
26_I93_E0.6151.00
211_V215_G0.6141.00
356_G364_T0.6131.00
363_L366_Y0.6121.00
251_A467_E0.6101.00
415_T420_K0.6071.00
105_L109_I0.6061.00
421_G425_A0.6051.00
288_M442_D0.6051.00
240_G252_L0.6041.00
190_I194_F0.6041.00
43_G220_T0.6011.00
233_T237_R0.6001.00
212_K238_H0.6001.00
189_I193_A0.5981.00
90_I185_S0.5971.00
79_L112_L0.5961.00
51_D54_Q0.5951.00
419_E422_E0.5951.00
91_A320_T0.5951.00
78_Y198_G0.5951.00
52_I56_A0.5951.00
180_I337_K0.5931.00
163_S228_S0.5931.00
269_D309_A0.5931.00
345_A382_L0.5931.00
371_A378_A0.5921.00
114_E118_Y0.5911.00
342_I368_F0.5911.00
329_L334_Q0.5911.00
316_Y325_V0.5891.00
419_E423_K0.5891.00
164_I176_H0.5881.00
279_K387_A0.5881.00
180_I238_H0.5851.00
265_D417_D0.5851.00
399_I423_K0.5851.00
382_L386_I0.5841.00
90_I101_S0.5841.00
88_M91_A0.5831.00
373_N400_D0.5831.00
295_V300_Y0.5821.00
65_T169_A0.5811.00
278_G438_Q0.5801.00
339_L346_K0.5761.00
354_V367_V0.5761.00
358_R364_T0.5751.00
87_I105_L0.5741.00
147_I172_N0.5741.00
35_I184_I0.5731.00
90_I104_E0.5721.00
71_V198_G0.5711.00
268_V303_F0.5711.00
66_E70_A0.5711.00
146_V225_R0.5701.00
86_I157_M0.5701.00
342_I366_Y0.5691.00
117_T120_G0.5691.00
96_G155_F0.5681.00
295_V389_I0.5661.00
413_V435_V0.5661.00
370_G391_K0.5651.00
138_K474_I0.5651.00
38_A183_A0.5651.00
175_V205_N0.5641.00
432_M441_N0.5641.00
260_F412_A0.5641.00
170_L465_V0.5641.00
339_L342_I0.5641.00
70_A73_Q0.5611.00
49_A205_N0.5601.00
371_A377_I0.5591.00
54_Q146_V0.5591.00
268_V271_A0.5581.00
250_M456_V0.5581.00
76_R112_L0.5571.00
79_L157_M0.5551.00
341_I345_A0.5551.00
41_A207_M0.5551.00
260_F293_I0.5551.00
226_L467_E0.5541.00
22_R42_T0.5541.00
413_V421_G0.5531.00
168_I204_L0.5531.00
118_Y462_P0.5521.00
215_G219_L0.5491.00
395_D427_Q0.5491.00
402_A428_I0.5471.00
352_L366_Y0.5441.00
105_L157_M0.5431.00
65_T123_G0.5421.00
434_H437_D0.5401.00
273_D277_F0.5401.00
293_I389_I0.5391.00
53_A175_V0.5391.00
286_I289_I0.5391.00
142_L429_D0.5371.00
308_T367_V0.5361.00
173_S205_N0.5361.00
398_A402_A0.5331.00
106_E109_I0.5311.00
115_A166_P0.5301.00
377_I382_L0.5301.00
399_I428_I0.5301.00
368_F371_A0.5301.00
264_S392_A0.5291.00
429_D470_V0.5281.00
222_P406_E0.5271.00
147_I174_V0.5271.00
297_Q300_Y0.5261.00
102_T106_E0.5261.00
433_T472_K0.5251.00
139_I471_T0.5221.00
107_Q158_N0.5211.00
158_N162_R0.5211.00
424_F428_I0.5211.00
209_T215_G0.5201.00
38_A184_I0.5191.00
337_K341_I0.5191.00
353_A370_G0.5181.00
348_D372_D0.5171.00
94_T282_H0.5171.00
258_N410_S0.5161.00
43_G216_D0.5161.00
228_S468_F0.5151.00
53_A146_V0.5151.00
266_A271_A0.5141.00
75_A78_Y0.5131.00
290_I412_A0.5131.00
86_I105_L0.5121.00
220_T246_A0.5121.00
157_M190_I0.5121.00
352_L356_G0.5111.00
280_F314_L0.5111.00
307_F311_V0.5101.00
162_R460_G0.5101.00
83_R109_I0.5101.00
233_T406_E0.5091.00
168_I199_L0.5081.00
329_L363_L0.5071.00
52_I55_K0.5061.00
79_L190_I0.5061.00
40_L180_I0.5051.00
111_I460_G0.5021.00
149_S164_I0.5001.00
234_A333_R0.5001.00
71_V75_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a4sA 4 0.9897 100 0.032 Contact Map
4qtoA 4 0.9938 100 0.032 Contact Map
4o5hA 4 0.9814 100 0.033 Contact Map
2d4eA 4 0.9918 100 0.035 Contact Map
4qf6A 4 0.9794 100 0.037 Contact Map
4yweA 5 0.9649 100 0.037 Contact Map
3ek1A 5 0.9835 100 0.038 Contact Map
3u4jA 4 0.9938 100 0.038 Contact Map
4jz6A 2 0.9897 100 0.038 Contact Map
3r31A 4 0.967 100 0.04 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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