GREMLIN Database
YXKD - UPF0750 membrane protein YxkD
UniProt: P94357 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (270)
Sequences: 3718 (2719)
Seq/√Len: 165.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_V80_I5.8871.00
202_N205_E4.9921.00
222_S231_S3.9001.00
223_G234_I3.8091.00
208_E212_T3.4691.00
201_E232_K3.3461.00
200_S206_I3.1501.00
16_F88_F2.9321.00
108_F170_M2.7851.00
196_I247_L2.7431.00
224_K229_G2.5801.00
36_V58_L2.5741.00
209_Q250_I2.3691.00
204_S208_E2.3681.00
200_S203_K2.3541.00
221_L234_I2.3461.00
224_K233_E2.2691.00
209_Q213_L2.2101.00
194_K264_D2.2031.00
218_V226_N2.1411.00
43_L47_F2.1301.00
8_V80_I2.0801.00
222_S233_E2.0601.00
23_N92_T2.0061.00
7_D77_Y1.9941.00
14_G116_G1.9541.00
83_A87_L1.9291.00
216_R243_E1.9151.00
12_V84_A1.9151.00
161_Y169_M1.8971.00
21_A113_A1.8771.00
20_L24_L1.8481.00
18_F85_N1.8451.00
19_A88_F1.8441.00
181_K185_F1.8311.00
10_M123_V1.8211.00
52_G90_H1.8161.00
101_E171_F1.7841.00
120_I127_T1.7821.00
207_A226_N1.7351.00
146_S184_D1.7161.00
210_V247_L1.7151.00
251_I258_A1.7031.00
161_Y166_A1.6991.00
43_L54_T1.6901.00
220_I235_L1.6531.00
29_N105_N1.6351.00
218_V235_L1.6241.00
203_K233_E1.6031.00
201_E230_Q1.5891.00
7_D123_V1.5851.00
251_I260_V1.5501.00
165_G168_K1.5281.00
224_K231_S1.5121.00
64_L68_K1.4991.00
214_M247_L1.4831.00
209_Q254_C1.4821.00
201_E257_K1.4761.00
207_A229_G1.4601.00
118_G186_I1.4601.00
74_T126_T1.4531.00
236_Y261_I1.4381.00
20_L92_T1.4331.00
204_S229_G1.4231.00
195_A263_H1.4121.00
151_F155_I1.3931.00
103_I174_V1.3921.00
155_I159_S1.3821.00
16_F92_T1.3801.00
11_L81_A1.3681.00
197_T236_Y1.3581.00
207_A220_I1.3541.00
14_G120_I1.3521.00
257_K271_E1.3371.00
23_N93_H1.3311.00
36_V62_L1.3161.00
60_A64_L1.3011.00
223_G232_K1.3011.00
26_A109_A1.2891.00
239_I247_L1.2871.00
39_I43_L1.2821.00
70_L74_T1.2761.00
157_V176_L1.2711.00
55_N89_L1.2681.00
210_V237_I1.2661.00
52_G86_S1.2641.00
30_D168_K1.2601.00
205_E254_C1.2401.00
150_L180_T1.2221.00
50_S90_H1.2181.00
195_A261_I1.2161.00
76_V80_I1.2031.00
66_G75_T1.2021.00
114_G118_G1.2021.00
134_A149_L1.1801.00
21_A116_G1.1771.00
244_L262_V1.1641.00
15_A84_A1.1581.00
8_V77_Y1.1571.00
11_L125_G1.1491.00
248_K267_D1.1451.00
137_A141_L1.1431.00
177_Y181_K1.1431.00
195_A265_V1.1351.00
63_L82_V1.1321.00
211_N226_N1.1301.00
21_A112_F1.1291.00
67_Y72_G1.1191.00
102_L168_K1.1161.00
84_A88_F1.1111.00
27_I51_P1.1111.00
154_L158_F1.1071.00
111_V182_V1.1051.00
209_Q253_S1.0961.00
220_I233_E1.0951.00
219_T223_G1.0931.00
104_I108_F1.0841.00
255_D258_A1.0821.00
56_F86_S1.0801.00
197_T263_H1.0730.99
49_W54_T1.0720.99
198_V251_I1.0590.99
52_G56_F1.0590.99
196_I244_L1.0500.99
67_Y75_T1.0430.99
106_T110_G1.0430.99
39_I159_S1.0370.99
250_I253_S1.0330.99
9_L13_I1.0300.99
8_V12_V1.0270.99
207_A218_V1.0180.99
32_G160_S1.0170.99
5_M9_L1.0170.99
101_E167_E1.0090.99
220_I226_N1.0070.99
80_I84_A0.9960.99
70_L135_R0.9960.99
6_L10_M0.9940.99
10_M119_M0.9910.99
69_F140_Y0.9900.99
210_V216_R0.9880.99
225_G228_T0.9880.99
197_T221_L0.9850.99
41_L44_Y0.9840.99
81_A125_G0.9760.99
25_F108_F0.9680.99
53_V90_H0.9650.99
247_L251_I0.9550.99
195_A238_V0.9460.99
32_G153_D0.9410.99
194_K267_D0.9390.99
184_D241_K0.9330.99
111_V177_Y0.9250.98
146_S180_T0.9250.98
37_T89_L0.9190.98
206_I250_I0.9090.98
146_S183_M0.9070.98
15_A81_A0.9050.98
69_F136_I0.9040.98
261_I265_V0.9030.98
54_T58_L0.8990.98
245_S249_K0.8910.98
195_A236_Y0.8910.98
106_T174_V0.8890.98
197_T261_I0.8850.98
26_A175_M0.8710.98
30_D45_Y0.8710.98
102_L106_T0.8700.98
73_K77_Y0.8670.98
61_F64_L0.8660.98
211_N218_V0.8620.98
65_I69_F0.8610.98
211_N217_G0.8560.98
221_L236_Y0.8520.97
240_N243_E0.8470.97
70_L126_T0.8420.97
143_W148_A0.8360.97
208_E229_G0.8360.97
250_I254_C0.8300.97
110_G114_G0.8300.97
21_A25_F0.8280.97
115_V186_I0.8270.97
149_L153_D0.8250.97
196_I251_I0.8240.97
220_I224_K0.8240.97
104_I170_M0.8240.97
32_G172_T0.8230.97
15_A120_I0.8210.97
193_K237_I0.8180.97
117_I121_I0.8160.97
31_L106_T0.8120.97
126_T135_R0.8110.97
63_L78_T0.8100.97
121_I135_R0.8090.97
179_G183_M0.8080.96
196_I239_I0.8080.96
117_I183_M0.8050.96
90_H93_H0.7890.96
16_F84_A0.7840.96
238_V261_I0.7840.96
42_I164_I0.7820.96
102_L105_N0.7820.96
42_I46_L0.7810.96
57_I61_F0.7800.96
62_L133_L0.7800.96
17_F115_V0.7780.96
53_V57_I0.7770.96
203_K206_I0.7770.96
18_F116_G0.7700.95
39_I42_I0.7670.95
200_S255_D0.7650.95
136_I140_Y0.7640.95
44_Y51_P0.7630.95
144_N184_D0.7580.95
213_L250_I0.7560.95
76_V79_I0.7550.95
118_G122_R0.7540.95
127_T131_A0.7530.95
107_I178_I0.7510.95
151_F154_L0.7440.94
150_L177_Y0.7340.94
137_A148_A0.7320.94
207_A211_N0.7260.94
56_F83_A0.7260.94
176_L180_T0.7240.94
130_S152_F0.7240.94
24_L92_T0.7230.94
42_I159_S0.7210.93
61_F65_I0.7200.93
63_L79_I0.7200.93
209_Q212_T0.7200.93
6_L123_V0.7170.93
15_A85_N0.7140.93
248_K269_F0.7130.93
62_L78_T0.7130.93
22_V85_N0.7110.93
47_F54_T0.7100.93
133_L137_A0.7090.93
44_Y48_Q0.7080.93
249_K253_S0.7080.93
181_K184_D0.7050.93
213_L246_M0.7030.93
105_N167_E0.7030.93
144_N147_Y0.7030.93
66_G74_T0.7010.93
88_F91_L0.6980.92
217_G227_Y0.6980.92
202_N255_D0.6950.92
155_I158_F0.6930.92
39_I58_L0.6920.92
99_S167_E0.6900.92
216_R240_N0.6880.92
63_L66_G0.6880.92
218_V237_I0.6880.92
107_I174_V0.6880.92
194_K262_V0.6870.92
77_Y124_G0.6870.92
56_F60_A0.6830.92
106_T178_I0.6820.91
40_T55_N0.6820.91
196_I262_V0.6800.91
38_G171_F0.6790.91
225_G232_K0.6730.91
130_S153_D0.6720.91
120_I125_G0.6720.91
64_L67_Y0.6710.91
18_F113_A0.6700.91
5_M8_V0.6700.91
128_A131_A0.6700.91
219_T225_G0.6700.91
130_S164_I0.6680.91
31_L99_S0.6670.91
82_V86_S0.6670.91
117_I127_T0.6660.90
22_V40_T0.6650.90
206_I254_C0.6640.90
216_R273_F0.6630.90
113_A179_G0.6610.90
202_N254_C0.6610.90
132_I146_S0.6610.90
10_M13_I0.6600.90
17_F112_F0.6590.90
119_M123_V0.6590.90
101_E106_T0.6570.90
22_V27_I0.6550.90
74_T135_R0.6540.90
159_S162_F0.6530.90
43_L58_L0.6530.90
216_R272_G0.6520.90
135_R145_I0.6500.89
43_L49_W0.6460.89
199_I236_Y0.6430.89
19_A85_N0.6390.89
149_L183_M0.6380.89
157_V160_S0.6370.88
100_D167_E0.6350.88
147_Y184_D0.6350.88
108_F173_I0.6350.88
213_L253_S0.6320.88
121_I131_A0.6300.88
246_M249_K0.6300.88
50_S53_V0.6290.88
198_V237_I0.6280.88
37_T85_N0.6250.87
27_I41_L0.6240.87
13_I17_F0.6230.87
135_R139_K0.6200.87
192_T241_K0.6180.87
110_G178_I0.6160.87
238_V265_V0.6130.86
54_T57_I0.6110.86
71_D193_K0.6110.86
262_V267_D0.6100.86
252_R269_F0.6080.86
198_V247_L0.6070.86
33_E131_A0.6060.86
172_T239_I0.6060.86
158_F162_F0.6010.85
204_S233_E0.6010.85
160_S169_M0.6000.85
197_T234_I0.5970.85
153_D272_G0.5960.85
153_D172_T0.5960.85
106_T175_M0.5940.85
259_F268_V0.5910.84
188_E266_R0.5910.84
117_I179_G0.5910.84
68_K86_S0.5900.84
27_I44_Y0.5900.84
77_Y172_T0.5880.84
65_I68_K0.5850.84
78_T132_I0.5820.84
87_L91_L0.5800.83
248_K252_R0.5800.83
249_K252_R0.5780.83
97_I103_I0.5780.83
169_M175_M0.5740.83
32_G41_L0.5730.83
239_I244_L0.5720.82
79_I82_V0.5690.82
203_K207_A0.5690.82
147_Y150_L0.5650.82
99_S105_N0.5630.82
102_L171_F0.5610.81
114_G183_M0.5580.81
24_L28_P0.5580.81
29_N170_M0.5490.80
65_I136_I0.5490.80
18_F117_I0.5480.80
63_L101_E0.5470.80
132_I183_M0.5450.79
121_I187_I0.5440.79
104_I177_Y0.5430.79
197_T265_V0.5420.79
40_T236_Y0.5420.79
164_I168_K0.5410.79
219_T259_F0.5400.79
182_V268_V0.5400.79
78_T82_V0.5380.79
46_L61_F0.5380.79
228_T257_K0.5370.78
81_A127_T0.5360.78
125_G138_N0.5350.78
152_F156_V0.5340.78
201_E206_I0.5330.78
48_Q54_T0.5330.78
194_K232_K0.5320.78
114_G220_I0.5300.78
41_L45_Y0.5280.77
40_T58_L0.5270.77
145_I184_D0.5270.77
135_R153_D0.5260.77
207_A233_E0.5260.77
41_L104_I0.5250.77
205_E208_E0.5240.77
61_F181_K0.5240.77
102_L167_E0.5230.77
50_S94_G0.5190.76
107_I232_K0.5190.76
220_I229_G0.5170.76
36_V40_T0.5170.76
84_A91_L0.5160.76
190_L193_K0.5160.76
72_G75_T0.5150.75
16_F95_W0.5140.75
44_Y54_T0.5130.75
200_S233_E0.5130.75
121_I145_I0.5120.75
7_D73_K0.5120.75
31_L34_G0.5110.75
22_V37_T0.5110.75
51_P55_N0.5100.75
41_L51_P0.5090.75
6_L122_R0.5080.75
31_L102_L0.5080.75
216_R225_G0.5070.74
6_L253_S0.5050.74
143_W147_Y0.5040.74
26_A160_S0.5040.74
63_L132_I0.5020.74
214_M243_E0.5020.74
151_F159_S0.5010.74
206_I251_I0.5010.74
96_S99_S0.5000.73
161_Y165_G0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hluA 2 0.2626 99.9 0.687 Contact Map
2dclA 5 0.3201 85.7 0.938 Contact Map
2gw8A 3 0.3129 80.9 0.942 Contact Map
3l7pA 4 0.2986 80.5 0.942 Contact Map
4affA 3 0.3165 79.3 0.943 Contact Map
2eg2A 5 0.3022 78.9 0.943 Contact Map
4co3A 3 0.3094 78.9 0.943 Contact Map
3ncqA 4 0.3165 78.6 0.943 Contact Map
3t9zA 3 0.3094 77.4 0.944 Contact Map
4rwwA 3 0.3022 75.5 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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