GREMLIN Database
YODC - Putative NAD(P)H nitroreductase YodC
UniProt: P81102 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 202 (181)
Sequences: 8928 (6676)
Seq/√Len: 496.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_D21_A4.4731.00
30_E147_K3.8041.00
24_S27_E3.2291.00
25_K53_H3.0751.00
21_A182_K2.8131.00
25_K29_T2.6501.00
49_F136_A2.5341.00
150_D183_A2.3411.00
31_L144_A2.3261.00
149_Y182_K2.2561.00
33_D36_T2.1241.00
55_D59_A2.1211.00
60_E165_Q2.0691.00
34_L143_A2.0091.00
163_Q174_P2.0021.00
16_E184_V1.9771.00
27_E149_Y1.9601.00
137_A176_M1.9271.00
6_D10_A1.9011.00
27_E147_K1.8851.00
18_D184_V1.8611.00
141_M151_T1.8591.00
10_A145_K1.8551.00
35_A140_L1.7271.00
141_M153_A1.7161.00
57_S60_E1.6791.00
158_N161_Q1.6571.00
161_Q164_K1.6461.00
64_V161_Q1.6081.00
61_L162_F1.6031.00
9_K37_K1.5821.00
144_A180_I1.5751.00
145_K150_D1.5381.00
4_T7_V1.5301.00
141_M178_I1.5221.00
31_L140_L1.5151.00
64_V165_Q1.4851.00
57_S165_Q1.4691.00
54_S57_S1.4671.00
29_T196_S1.4671.00
131_L134_S1.4481.00
62_L72_V1.4381.00
59_A63_P1.4171.00
4_T8_L1.4031.00
193_L197_K1.3871.00
137_A178_I1.3771.00
144_A151_T1.3701.00
31_L180_I1.3691.00
27_E182_K1.3421.00
149_Y180_I1.3411.00
31_L149_Y1.3341.00
195_L199_S1.3251.00
48_H172_Y1.3191.00
5_L34_L1.3081.00
49_F78_V1.3031.00
5_L9_K1.3011.00
34_L147_K1.2941.00
17_Y179_S1.2941.00
69_K73_E1.2931.00
60_E63_P1.2681.00
5_L30_E1.2631.00
22_P53_H1.2621.00
56_E59_A1.2561.00
133_A175_V1.2401.00
32_L199_S1.2221.00
27_E30_E1.2151.00
55_D58_K1.2031.00
81_L172_Y1.1951.00
29_T33_D1.1761.00
36_T198_V1.1641.00
29_T195_L1.1611.00
13_S152_C1.1551.00
151_T180_I1.1421.00
78_V140_L1.1371.00
69_K72_V1.1371.00
5_L147_K1.1341.00
38_A139_Q1.1161.00
135_L138_M1.1151.00
8_L139_Q1.1071.00
59_A72_V1.0991.00
9_K33_D1.0831.00
161_Q165_Q1.0691.00
23_I149_Y1.0681.00
151_T178_I1.0571.00
160_E164_K1.0561.00
4_T142_I1.0551.00
26_E29_T1.0531.00
98_A101_G1.0411.00
152_C179_S1.0301.00
130_F175_V1.0221.00
51_V199_S1.0141.00
6_D9_K1.0141.00
140_L180_I1.0111.00
18_D182_K1.0001.00
126_R173_V1.0001.00
89_N92_E0.9931.00
131_L155_G0.9881.00
51_V76_A0.9821.00
92_E95_A0.9731.00
80_I140_L0.9631.00
33_D195_L0.9581.00
139_Q142_I0.9551.00
153_A176_M0.9541.00
30_E34_L0.9501.00
157_F177_L0.9471.00
32_L35_A0.9451.00
23_I182_K0.9371.00
85_K88_E0.9351.00
95_A99_S0.9331.00
17_Y152_C0.9301.00
117_G120_Q0.9281.00
41_A128_S0.9101.00
56_E60_E0.9071.00
63_P67_N0.9061.00
140_L178_I0.9061.00
30_E33_D0.9051.00
91_E95_A0.9041.00
127_D130_F0.9001.00
49_F80_I0.8821.00
28_L180_I0.8791.00
163_Q173_V0.8771.00
50_T81_L0.8671.00
23_I26_E0.8621.00
31_L147_K0.8611.00
8_L142_I0.8541.00
96_E100_Q0.8531.00
41_A155_G0.8471.00
85_K89_N0.8441.00
59_A62_L0.8421.00
137_A153_A0.8401.00
4_T146_A0.8371.00
24_S182_K0.8331.00
16_E185_K0.8321.00
86_A90_G0.8291.00
194_P197_K0.8241.00
50_T172_Y0.8191.00
94_Y97_L0.8191.00
82_G129_A0.8121.00
74_S77_V0.8101.00
130_F134_S0.8091.00
159_K174_P0.8071.00
70_Q73_E0.8041.00
168_I172_Y0.8031.00
143_A146_A0.7951.00
23_I27_E0.7901.00
132_N155_G0.7871.00
83_D86_A0.7861.00
14_V187_A0.7851.00
88_E92_E0.7781.00
50_T166_F0.7771.00
127_D131_L0.7741.00
60_E64_V0.7691.00
92_E197_K0.7681.00
39_P151_T0.7651.00
94_Y98_A0.7631.00
97_L100_Q0.7571.00
128_S155_G0.7511.00
121_S124_F0.7491.00
93_V96_E0.7481.00
96_E99_S0.7431.00
68_Q72_V0.7401.00
94_Y99_S0.7391.00
47_W133_A0.7351.00
32_L51_V0.7321.00
72_V75_S0.7221.00
162_F165_Q0.7211.00
28_L32_L0.7201.00
28_L76_A0.7201.00
14_V183_A0.7181.00
73_E76_A0.7181.00
16_E187_A0.7151.00
90_G94_Y0.7101.00
40_S47_W0.7091.00
22_P55_D0.7041.00
77_V179_S0.6991.00
84_L88_E0.6981.00
7_V146_A0.6971.00
28_L51_V0.6951.00
130_F173_V0.6951.00
89_N93_V0.6951.00
131_L176_M0.6951.00
52_F57_S0.6941.00
52_F166_F0.6921.00
154_I179_S0.6861.00
183_A186_P0.6851.00
5_L146_A0.6841.00
143_A147_K0.6831.00
95_A98_A0.6751.00
138_M142_I0.6741.00
37_K189_Q0.6741.00
131_L175_V0.6661.00
80_I137_A0.6641.00
87_N93_V0.6561.00
65_A177_L0.6541.00
35_A49_F0.6531.00
163_Q168_I0.6531.00
135_L139_Q0.6501.00
91_E98_A0.6501.00
169_S172_Y0.6481.00
79_A177_L0.6431.00
93_V97_L0.6421.00
159_K163_Q0.6421.00
58_K62_L0.6421.00
26_E30_E0.6411.00
71_I74_S0.6391.00
8_L146_A0.6381.00
67_N70_Q0.6371.00
160_E163_Q0.6371.00
41_A132_N0.6351.00
99_S102_Y0.6241.00
121_S125_A0.6241.00
90_G95_A0.6221.00
9_K34_L0.6221.00
136_A198_V0.6211.00
91_E100_Q0.6181.00
15_K70_Q0.6181.00
162_F174_P0.6151.00
36_T49_F0.6141.00
57_S166_F0.6120.99
31_L143_A0.6120.99
131_L135_L0.6070.99
65_A71_I0.6050.99
61_L166_F0.6020.99
168_I174_P0.5950.99
23_I28_L0.5900.99
62_L68_Q0.5850.99
157_F162_F0.5810.99
65_A156_G0.5810.99
27_E31_L0.5780.99
18_D185_K0.5710.99
193_L198_V0.5660.99
7_V142_I0.5610.99
98_A102_Y0.5600.99
21_A24_S0.5590.99
8_L34_L0.5590.99
70_Q74_S0.5560.99
47_W136_A0.5560.99
52_F61_L0.5560.99
136_A140_L0.5550.99
32_L198_V0.5530.99
80_I84_L0.5530.99
91_E94_Y0.5520.99
31_L34_L0.5520.99
134_S153_A0.5500.99
145_K183_A0.5500.99
68_Q71_I0.5460.99
128_S132_N0.5450.99
18_D22_P0.5450.99
142_I146_A0.5450.99
163_Q170_E0.5430.99
184_V187_A0.5380.99
8_L37_K0.5360.99
83_D89_N0.5350.99
4_T143_A0.5280.99
71_I75_S0.5260.98
93_V98_A0.5260.98
15_K152_C0.5240.98
90_G93_V0.5200.98
89_N96_E0.5180.98
14_V17_Y0.5160.98
137_A141_M0.5140.98
65_A162_F0.5110.98
5_L33_D0.5110.98
62_L67_N0.5100.98
12_A187_A0.5100.98
92_E97_L0.5090.98
87_N91_E0.5050.98
87_N90_G0.5030.98
39_P139_Q0.5030.98
7_V148_G0.5030.98
36_T47_W0.5020.98
123_Q126_R0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bemA 2 1 100 0.161 Contact Map
3gagA 4 0.995 100 0.166 Contact Map
3ge6A 2 1 100 0.171 Contact Map
3gbhA 3 1 100 0.184 Contact Map
4qlxA 2 1 100 0.184 Contact Map
3of4A 3 0.9901 100 0.189 Contact Map
2h0uA 2 0.901 100 0.191 Contact Map
2hayA 2 0.995 100 0.193 Contact Map
1noxA 2 0.9703 100 0.196 Contact Map
1zchA 2 0.9059 100 0.197 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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