GREMLIN Database
SCP2 - Stress response protein SCP2
UniProt: P81100 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (178)
Sequences: 2739 (1465)
Seq/√Len: 109.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_V115_L5.4611.00
60_E113_D3.5741.00
168_A179_F3.5071.00
65_T69_N3.3681.00
188_D193_D3.3071.00
149_E152_K3.2341.00
104_D107_K3.0481.00
58_M83_V2.9551.00
171_Y178_K2.8521.00
28_G138_F2.7161.00
114_K169_E2.6101.00
77_K84_Q2.5731.00
10_R180_A2.5301.00
58_M112_I2.4861.00
24_M100_Q2.3971.00
69_N79_R2.3161.00
30_D136_N2.3071.00
192_E196_S2.2111.00
3_I11_I2.1391.00
86_T102_M2.1071.00
140_R149_E2.0401.00
118_V194_I2.0301.00
173_S178_K2.0211.00
21_S106_D1.9031.00
22_K104_D1.8751.00
86_T100_Q1.8231.00
108_V115_L1.7701.00
143_D148_E1.7461.00
139_I168_A1.7351.00
56_V101_I1.7161.00
10_R178_K1.7011.00
103_I117_F1.6511.00
21_S145_S1.6301.00
80_C109_P1.5971.00
73_F122_Y1.5661.00
59_L116_V1.5421.00
55_S118_V1.5151.00
84_Q102_M1.4631.00
116_V169_E1.4331.00
26_G97_D1.4171.00
143_D146_N1.4171.00
55_S120_N1.4151.00
57_L64_F1.3981.00
169_E180_A1.3951.00
82_G108_V1.3941.00
153_Y183_G1.3491.00
20_L23_L1.3311.00
97_D140_R1.3301.00
51_D99_E1.3291.00
89_N98_D1.3230.99
24_M144_Q1.3170.99
171_Y180_A1.3020.99
58_M108_V1.2900.99
6_E9_Q1.2780.99
33_S135_Q1.2500.99
56_V117_F1.2470.99
117_F170_I1.2310.99
52_C134_I1.2230.99
51_D88_D1.2200.99
65_T111_N1.2150.99
25_V117_F1.2130.99
161_G187_N1.1960.99
22_K144_Q1.1820.99
62_G114_K1.1750.99
164_S186_T1.1700.99
78_S82_G1.1650.99
88_D92_G1.1430.99
23_L170_I1.1380.98
14_T17_K1.1240.98
12_D16_G1.1110.98
58_M69_N1.0980.98
59_L114_K1.0800.98
190_R193_D1.0730.98
25_V141_V1.0700.98
103_I170_I1.0620.98
66_D69_N1.0620.98
24_M142_V1.0590.98
22_K106_D1.0480.97
88_D99_E1.0460.97
139_I179_F1.0290.97
58_M115_L1.0220.97
138_F152_K1.0160.97
62_G113_D1.0150.97
69_N78_S1.0120.97
102_M144_Q1.0090.97
71_I78_S1.0060.97
24_M102_M0.9990.97
25_V103_I0.9820.96
51_D85_H0.9500.95
74_G122_Y0.9410.95
87_G94_G0.9390.95
73_F120_N0.9380.95
57_L120_N0.9330.95
173_S176_E0.9290.95
12_D15_K0.9140.94
67_K70_L0.9130.94
142_V149_E0.9070.94
87_G101_I0.9030.94
65_T112_I0.9010.94
130_D133_M0.8880.93
91_T94_G0.8850.93
186_T193_D0.8850.93
58_M78_S0.8730.93
58_M65_T0.8560.92
174_G178_K0.8500.92
50_I134_I0.8500.92
89_N94_G0.8480.92
11_I151_L0.8460.92
10_R171_Y0.8430.91
192_E195_I0.8410.91
7_K15_K0.8310.91
52_C99_E0.8260.91
26_G140_R0.8220.90
28_G140_R0.8190.90
191_L195_I0.8180.90
3_I12_D0.8090.90
12_D17_K0.7990.89
21_S104_D0.7910.89
22_K102_M0.7860.88
166_I169_E0.7800.88
9_Q161_G0.7730.88
51_D92_G0.7670.87
70_L75_N0.7600.87
162_R184_E0.7590.87
172_R177_W0.7560.86
31_P93_D0.7550.86
162_R186_T0.7530.86
55_S73_F0.7480.86
74_G191_L0.7470.86
87_G99_E0.7460.86
90_L123_D0.7420.85
119_V139_I0.7390.85
120_N186_T0.7370.85
69_N80_C0.7340.85
138_F142_V0.7330.85
8_G178_K0.7320.85
32_V50_I0.7310.84
20_L143_D0.7290.84
113_D172_R0.7280.84
137_A155_L0.7270.84
108_V112_I0.7270.84
23_L105_L0.7200.84
113_D175_S0.7170.83
119_V167_T0.7130.83
108_V172_R0.7090.83
128_K131_F0.7030.82
193_D196_S0.6910.81
120_N193_D0.6900.81
169_E182_V0.6870.81
53_D73_F0.6860.81
76_L85_H0.6840.80
75_N78_S0.6820.80
58_M82_G0.6810.80
164_S188_D0.6790.80
29_W99_E0.6770.80
69_N109_P0.6770.80
30_D135_Q0.6750.79
54_A119_V0.6740.79
58_M80_C0.6720.79
10_R173_S0.6720.79
77_K107_K0.6700.79
29_W51_D0.6700.79
108_V177_W0.6680.79
57_L67_K0.6670.79
4_S11_I0.6660.79
8_G185_G0.6650.78
28_G152_K0.6610.78
85_H99_E0.6600.78
118_V195_I0.6600.78
188_D194_I0.6580.78
153_Y181_A0.6530.77
91_T95_A0.6520.77
9_Q180_A0.6520.77
8_G181_A0.6510.77
118_V188_D0.6500.77
131_F134_I0.6490.77
93_D96_G0.6460.76
64_F195_I0.6440.76
89_N95_A0.6430.76
99_E121_I0.6420.76
5_L99_E0.6390.76
3_I6_E0.6370.75
25_V101_I0.6330.75
64_F70_L0.6310.75
20_L150_M0.6290.75
12_D176_E0.6280.74
28_G149_E0.6230.74
59_L169_E0.6200.73
157_D160_A0.6190.73
10_R184_E0.6180.73
92_G98_D0.6170.73
165_L188_D0.6120.72
129_Q133_M0.6120.72
114_K171_Y0.6120.72
169_E185_G0.6110.72
166_I186_T0.6110.72
170_I179_F0.6100.72
162_R185_G0.6060.72
105_L177_W0.6060.72
127_R131_F0.6040.72
14_T176_E0.6010.71
71_I83_V0.6000.71
84_Q104_D0.5970.71
22_K145_S0.5970.71
30_D91_T0.5970.71
65_T79_R0.5910.70
129_Q134_I0.5870.69
27_L54_A0.5870.69
30_D96_G0.5860.69
142_V150_M0.5850.69
28_G97_D0.5840.69
30_D93_D0.5820.69
30_D94_G0.5780.68
70_L191_L0.5740.68
53_D88_D0.5740.68
88_D98_D0.5730.68
75_N79_R0.5700.67
166_I194_I0.5690.67
159_Y165_L0.5640.66
22_K148_E0.5620.66
29_W88_D0.5620.66
116_V166_I0.5590.66
97_D138_F0.5580.65
27_L121_I0.5580.65
117_F139_I0.5540.65
86_T141_V0.5540.65
100_Q142_V0.5530.65
49_N90_L0.5490.64
155_L167_T0.5490.64
89_N92_G0.5480.64
159_Y162_R0.5480.64
75_N122_Y0.5470.64
14_T18_A0.5460.64
72_Y75_N0.5460.64
52_C88_D0.5460.64
7_K131_F0.5440.64
5_L88_D0.5410.63
143_D150_M0.5390.63
141_V168_A0.5360.62
72_Y191_L0.5360.62
25_V179_F0.5340.62
92_G99_E0.5330.62
30_D98_D0.5330.62
76_L96_G0.5310.62
7_K27_L0.5300.62
5_L9_Q0.5280.61
64_F116_V0.5280.61
31_P135_Q0.5270.61
186_T195_I0.5260.61
92_G97_D0.5260.61
57_L70_L0.5210.60
120_N194_I0.5210.60
102_M142_V0.5210.60
59_L64_F0.5210.60
14_T19_G0.5180.60
55_S85_H0.5180.60
34_S47_G0.5170.60
83_V117_F0.5150.59
48_P128_K0.5130.59
89_N93_D0.5130.59
50_I129_Q0.5120.59
8_G171_Y0.5070.58
105_L172_R0.5070.58
114_K166_I0.5030.58
112_I145_S0.5020.57
131_F137_A0.5010.57
61_N64_F0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kxtA 1 0.8492 100 0.051 Contact Map
3ibzA 1 0.8693 100 0.052 Contact Map
2qngA 1 0.8342 100 0.119 Contact Map
2qz7A 1 0.8241 100 0.127 Contact Map
4pj0O 1 0.3719 12.9 0.949 Contact Map
3wu2O 1 0.3719 12.4 0.949 Contact Map
2pe4A 1 0.8794 10.2 0.951 Contact Map
2bm3A 1 0.4724 4.4 0.959 Contact Map
2ciuA 1 0.4975 3.6 0.96 Contact Map
3kcpB 1 0.4623 3.5 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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