GREMLIN Database
SUCC - Succinyl-CoA ligase [ADP-forming] subunit beta
UniProt: P80886 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (376)
Sequences: 2737 (1464)
Seq/√Len: 75.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
359_K363_E5.6471.00
333_V360_I5.2881.00
313_G381_I4.3531.00
21_E100_E4.1511.00
135_E139_K4.1441.00
186_K190_E3.3471.00
23_K37_S3.1331.00
277_K282_E3.0301.00
157_G182_L3.0021.00
32_V70_K2.9711.00
241_K254_S2.9631.00
23_K34_S2.9251.00
128_E143_K2.7661.00
179_K183_G2.7081.00
356_L359_K2.7031.00
15_Y190_E2.5771.00
300_E303_K2.4731.00
76_L79_K2.4211.00
64_K68_E2.4011.00
103_D205_G2.3881.00
176_K208_N2.3831.00
140_T143_K2.3391.00
26_F30_E2.3331.00
105_K205_G2.3181.00
63_A72_Y2.2911.00
18_S180_F2.2861.00
315_F377_G2.2641.00
42_V101_G2.2231.00
125_A163_I2.2061.00
233_R238_E2.1981.00
147_A159_Q2.1941.00
26_F95_R2.1871.00
9_K99_E2.1281.00
132_E135_E2.0971.00
11_V187_A2.0801.00
108_Y203_V2.0481.00
14_K191_K2.0231.00
145_K166_A2.0231.00
65_S68_E1.9981.00
147_A162_E1.9901.00
3_I218_F1.9891.00
31_A35_A1.9671.00
379_Q383_S1.9531.00
299_T338_Q1.9471.00
17_V211_A1.9381.00
110_I181_M1.9221.00
295_A334_E1.8991.00
29_E70_K1.8691.00
72_Y75_E1.8561.00
42_V64_K1.8131.00
32_V36_K1.8131.00
12_L214_A1.8061.00
281_G382_V1.7911.00
13_R21_E1.7791.00
10_E14_K1.7651.00
165_F174_V1.7541.00
380_K383_S1.7471.00
353_N356_L1.7401.00
295_A330_E1.7371.00
187_A191_K1.7341.00
25_A35_A1.7181.00
218_F229_I1.7061.00
244_E247_K1.7041.00
123_L181_M1.6931.00
33_E36_K1.6801.00
32_V69_V1.6751.00
33_E37_S1.6711.00
150_D154_G1.6711.00
279_Y379_Q1.6631.00
8_G214_A1.6481.00
160_A164_A1.6251.00
369_T380_K1.6191.00
40_S43_Y1.6171.00
248_Y300_E1.6131.00
376_D380_K1.6101.00
12_L187_A1.6081.00
25_A30_E1.6020.99
330_E334_E1.6000.99
155_L160_A1.5910.99
94_K236_D1.5900.99
158_Y161_R1.5650.99
103_D206_D1.5570.99
73_A96_L1.5570.99
25_A31_A1.5460.99
279_Y375_A1.5450.99
22_G97_L1.5370.99
31_A69_V1.5330.99
330_E360_I1.5080.99
323_M327_V1.4980.99
70_K74_E1.4980.99
44_V62_I1.4930.99
350_E354_V1.4840.99
36_K66_L1.4740.99
172_E175_G1.4610.99
263_V269_A1.4480.99
66_L69_V1.4380.99
30_E33_E1.4280.99
28_A32_V1.4220.99
346_V381_I1.4130.99
43_Y69_V1.4100.99
243_I247_K1.4080.99
193_C196_A1.3960.99
45_V96_L1.3850.99
356_L360_I1.3810.98
358_K372_E1.3770.98
303_K338_Q1.3690.98
161_R165_F1.3640.98
244_E300_E1.3600.98
68_E71_A1.3590.98
56_K132_E1.3570.98
71_A75_E1.3540.98
373_S376_D1.3460.98
114_L188_F1.3300.98
112_L121_I1.3150.98
13_R19_V1.3050.98
157_G161_R1.3020.98
262_M305_I1.2950.98
25_A34_S1.2900.98
125_A167_I1.2880.98
375_A379_Q1.2870.98
104_I202_V1.2850.98
156_Q159_Q1.2810.98
12_L17_V1.2750.97
191_K228_D1.2680.97
173_L207_G1.2410.97
354_V358_K1.2380.97
316_V332_V1.2360.97
32_V67_D1.2340.97
192_D225_R1.2340.97
14_K228_D1.2300.97
359_K362_S1.2250.97
61_K75_E1.2160.97
123_L149_I1.2160.97
371_A376_D1.2000.96
327_V330_E1.1940.96
123_L163_I1.1770.96
80_T92_V1.1760.96
72_Y76_L1.1750.96
4_H50_H1.1710.96
42_V62_I1.1650.96
296_E300_E1.1620.96
124_M144_I1.1570.95
29_E33_E1.1570.95
110_I125_A1.1560.95
128_E140_T1.1560.95
102_C212_L1.1510.95
77_L96_L1.1460.95
75_E79_K1.1400.95
106_K203_V1.1360.95
35_A43_Y1.1330.95
32_V66_L1.1310.95
332_V347_V1.1190.95
58_G61_K1.1160.94
183_G186_K1.1150.94
196_A216_L1.1070.94
345_L368_I1.1050.94
15_Y191_K1.1020.94
162_E166_A1.0990.94
27_T30_E1.0900.94
111_G124_M1.0890.94
337_R365_G1.0820.94
2_N217_N1.0810.94
258_N312_K1.0710.93
102_C202_V1.0620.93
66_L70_K1.0560.93
120_R151_P1.0550.93
28_A69_V1.0540.93
118_T148_V1.0510.93
177_A181_M1.0450.92
52_G55_G1.0390.92
323_M354_V1.0380.92
28_A31_A1.0360.92
56_K131_T1.0360.92
57_A76_L1.0350.92
371_A380_K1.0270.92
29_E32_V1.0270.92
195_I217_N1.0270.92
20_P102_C1.0230.91
122_V146_K1.0170.91
45_V72_Y1.0150.91
51_A89_D1.0140.91
20_P99_E1.0110.91
187_A196_A1.0080.91
281_G381_I1.0080.91
235_L243_I1.0020.91
28_A66_L1.0000.91
149_I185_Y1.0000.91
17_V183_G0.9990.90
71_A74_E0.9860.90
204_T208_N0.9780.90
10_E232_Y0.9690.89
149_I154_G0.9670.89
61_K72_Y0.9650.89
193_C216_L0.9650.89
160_A178_A0.9630.89
324_K352_T0.9590.89
20_P100_E0.9570.89
330_E356_L0.9490.88
334_E338_Q0.9480.88
45_V98_I0.9440.88
323_M328_I0.9380.87
191_K229_I0.9350.87
362_S370_S0.9350.87
10_E13_R0.9310.87
156_Q161_R0.9290.87
137_A141_P0.9280.87
57_A79_K0.9270.87
92_V237_E0.9270.87
24_V95_R0.9260.87
101_G212_L0.9190.86
69_V73_A0.9180.86
102_C210_M0.9140.86
275_I279_Y0.9110.86
35_A66_L0.9110.86
355_D359_K0.9100.86
31_A98_I0.9090.86
361_L368_I0.9070.86
100_E208_N0.9030.85
239_D254_S0.9020.85
313_G346_V0.9020.85
164_A174_V0.9020.85
234_D237_E0.8960.85
24_V96_L0.8960.85
67_D71_A0.8960.85
191_K226_Q0.8950.85
289_V293_A0.8880.84
157_G178_A0.8850.84
147_A166_A0.8840.84
202_V212_L0.8770.84
204_T210_M0.8770.84
299_T303_K0.8770.84
25_A98_I0.8760.84
161_R174_V0.8740.84
122_V148_V0.8730.83
28_A74_E0.8710.83
308_D311_V0.8670.83
136_V140_T0.8560.82
174_V178_A0.8540.82
155_L181_M0.8520.82
125_A177_A0.8520.82
28_A96_L0.8510.82
61_K76_L0.8470.82
249_D297_K0.8470.82
21_E37_S0.8440.81
159_Q162_E0.8440.81
27_T31_A0.8350.81
130_G199_N0.8350.81
256_D282_E0.8350.81
127_E168_N0.8300.80
228_D231_E0.8270.80
17_V20_P0.8230.80
227_K231_E0.8220.80
261_C269_A0.8210.80
293_A323_M0.8200.79
99_E212_L0.8170.79
16_G183_G0.8170.79
127_E143_K0.8170.79
35_A69_V0.8140.79
130_G213_D0.8080.78
244_E307_S0.8080.78
11_V216_L0.8060.78
153_V159_Q0.8030.78
327_V354_V0.7990.78
173_L176_K0.7970.77
112_L188_F0.7970.77
240_P244_E0.7960.77
4_H234_D0.7940.77
22_G99_E0.7940.77
158_Y162_E0.7920.77
227_K230_M0.7910.77
111_G196_A0.7870.77
7_Q50_H0.7860.76
155_L159_Q0.7840.76
68_E72_Y0.7830.76
358_K370_S0.7770.76
295_A327_V0.7760.76
121_I188_F0.7750.75
111_G122_V0.7750.75
254_S310_N0.7700.75
321_G348_R0.7680.75
130_G134_E0.7660.75
264_N288_D0.7640.74
132_E136_V0.7630.74
242_E245_A0.7600.74
334_E337_R0.7590.74
175_G178_A0.7590.74
258_N281_G0.7580.74
25_A32_V0.7560.74
196_A214_A0.7530.73
297_K301_A0.7530.73
324_K327_V0.7530.73
1_M223_L0.7520.73
173_L203_V0.7510.73
128_E131_T0.7460.73
160_A182_L0.7450.73
237_E243_I0.7440.72
99_E102_C0.7420.72
315_F374_M0.7410.72
42_V100_E0.7370.72
108_Y169_I0.7360.72
302_F316_V0.7360.72
34_S37_S0.7360.72
259_I281_G0.7350.72
203_V209_V0.7350.72
45_V69_V0.7330.71
254_S308_D0.7280.71
64_K101_G0.7250.71
336_T366_L0.7240.70
32_V35_A0.7230.70
264_N317_N0.7230.70
43_Y63_A0.7230.70
124_M146_K0.7220.70
331_G335_A0.7220.70
297_K323_M0.7210.70
118_T122_V0.7190.70
223_L230_M0.7170.70
107_E130_G0.7130.69
376_D379_Q0.7120.69
47_A93_I0.7110.69
120_R150_D0.7090.69
76_L97_L0.7090.69
123_L155_L0.7080.69
28_A35_A0.7080.69
49_I93_I0.7050.68
374_M377_G0.7030.68
131_T140_T0.7020.68
25_A28_A0.7010.68
160_A181_M0.6990.68
316_V328_I0.6990.68
39_S43_Y0.6990.68
35_A98_I0.6970.68
105_K207_G0.6970.68
163_I166_A0.6970.68
62_I68_E0.6950.67
81_L90_G0.6940.67
266_A286_F0.6930.67
297_K327_V0.6860.66
41_S65_S0.6850.66
367_N370_S0.6840.66
49_I81_L0.6840.66
295_A338_Q0.6840.66
264_N268_L0.6820.66
179_K182_L0.6790.65
362_S372_E0.6780.65
12_L216_L0.6760.65
127_E140_T0.6760.65
51_A263_V0.6730.65
59_G81_L0.6720.65
12_L180_F0.6710.65
164_A171_K0.6700.64
62_I101_G0.6700.64
15_Y186_K0.6680.64
182_L186_K0.6660.64
20_P212_L0.6600.63
259_I328_I0.6600.63
298_V331_G0.6590.63
273_M283_P0.6590.63
9_K97_L0.6590.63
324_K356_L0.6580.63
164_A177_A0.6580.63
256_D310_N0.6580.63
289_V328_I0.6570.63
1_M230_M0.6570.63
112_L123_L0.6570.63
193_C218_F0.6560.63
140_T146_K0.6560.63
332_V361_L0.6560.63
322_I325_C0.6530.62
150_D160_A0.6530.62
244_E248_Y0.6530.62
153_V158_Y0.6520.62
12_L196_A0.6520.62
1_M50_H0.6510.62
156_Q165_F0.6500.62
51_A57_A0.6470.62
129_G213_D0.6460.62
47_A76_L0.6450.62
326_D353_N0.6450.62
3_I216_L0.6430.61
328_I349_L0.6430.61
155_L383_S0.6420.61
169_I203_V0.6410.61
42_V103_D0.6390.61
107_E129_G0.6360.60
52_G215_K0.6360.60
238_E243_I0.6330.60
340_G369_T0.6320.60
170_P173_L0.6320.60
323_M349_L0.6300.60
173_L209_V0.6300.60
134_E199_N0.6290.60
177_A209_V0.6280.59
1_M8_G0.6270.59
129_G199_N0.6270.59
31_A66_L0.6260.59
25_A70_K0.6260.59
35_A39_S0.6250.59
20_P210_M0.6250.59
110_I201_L0.6240.59
46_K199_N0.6240.59
18_S208_N0.6230.59
171_K174_V0.6230.59
350_E376_D0.6230.59
178_A182_L0.6210.59
63_A69_V0.6190.58
176_K209_V0.6170.58
114_L194_S0.6160.58
243_I246_S0.6150.58
259_I382_V0.6120.58
127_E136_V0.6120.58
283_P290_G0.6120.58
105_K204_T0.6120.58
372_E376_D0.6120.58
45_V77_L0.6100.57
151_P154_G0.6070.57
120_R148_V0.6070.57
158_Y165_F0.6060.57
233_R246_S0.6050.57
36_K39_S0.6040.57
356_L363_E0.6030.56
29_E74_E0.6020.56
161_R164_A0.6020.56
27_T35_A0.6000.56
13_R99_E0.5980.56
177_A180_F0.5970.56
376_D383_S0.5970.56
323_M357_G0.5960.56
111_G262_M0.5940.55
266_A270_M0.5940.55
8_G216_L0.5940.55
147_A163_I0.5940.55
261_C276_I0.5930.55
51_A215_K0.5930.55
194_S217_N0.5910.55
3_I8_G0.5910.55
33_E139_K0.5880.55
321_G325_C0.5870.54
105_K202_V0.5860.54
107_E199_N0.5860.54
295_A299_T0.5850.54
63_A68_E0.5840.54
288_D322_I0.5840.54
279_Y301_A0.5840.54
9_K13_R0.5820.54
286_F291_G0.5820.54
180_F201_L0.5820.54
259_I295_A0.5790.53
3_I97_L0.5750.53
325_C347_V0.5730.53
111_G185_Y0.5730.53
288_D291_G0.5730.53
17_V187_A0.5720.53
245_A249_D0.5710.52
116_R321_G0.5700.52
252_Y304_I0.5670.52
104_I212_L0.5660.52
184_L188_F0.5640.52
259_I354_V0.5640.52
3_I7_Q0.5630.51
55_G131_T0.5620.51
47_A79_K0.5620.51
36_K67_D0.5610.51
164_A181_M0.5610.51
219_D267_G0.5600.51
341_L345_L0.5600.51
49_I59_G0.5590.51
270_M319_F0.5590.51
161_R178_A0.5580.51
112_L185_Y0.5580.51
109_Y265_G0.5560.51
264_N272_T0.5540.50
27_T70_K0.5540.50
73_A77_L0.5540.50
158_Y175_G0.5520.50
21_E38_L0.5510.50
107_E200_P0.5500.50
354_V376_D0.5490.50
317_N325_C0.5480.50
28_A253_I0.5440.49
133_I319_F0.5440.49
92_V209_V0.5440.49
148_V166_A0.5440.49
62_I205_G0.5430.49
16_G74_E0.5420.49
8_G180_F0.5420.49
115_D148_V0.5410.49
125_A166_A0.5400.48
169_I209_V0.5400.48
169_I177_A0.5400.48
129_G134_E0.5390.48
12_L198_I0.5380.48
192_D222_A0.5380.48
67_D153_V0.5360.48
4_H7_Q0.5360.48
246_S253_I0.5360.48
269_A273_M0.5350.48
318_I325_C0.5350.48
233_R243_I0.5350.48
264_N286_F0.5340.48
99_E169_I0.5320.47
4_H237_E0.5310.47
53_G56_K0.5300.47
111_G132_E0.5290.47
115_D122_V0.5290.47
354_V371_A0.5280.47
33_E71_A0.5270.47
317_N320_G0.5260.47
35_A38_L0.5260.47
270_M286_F0.5250.47
265_G291_G0.5250.47
268_L286_F0.5240.46
272_T317_N0.5240.46
336_T340_G0.5240.46
116_R348_R0.5240.46
327_V358_K0.5220.46
41_S100_E0.5220.46
234_D238_E0.5210.46
31_A34_S0.5210.46
269_A286_F0.5200.46
130_G200_P0.5190.46
31_A39_S0.5180.46
79_K92_V0.5180.46
56_K135_E0.5180.46
347_V368_I0.5180.46
341_L354_V0.5170.46
336_T367_N0.5170.46
341_L366_L0.5170.46
176_K180_F0.5160.45
283_P286_F0.5160.45
173_L177_A0.5150.45
116_R311_V0.5150.45
240_P243_I0.5150.45
269_A276_I0.5150.45
184_L196_A0.5140.45
169_I173_L0.5130.45
318_I321_G0.5130.45
110_I123_L0.5130.45
218_F226_Q0.5120.45
187_A230_M0.5120.45
5_E9_K0.5110.45
110_I163_I0.5110.45
288_D321_G0.5090.45
71_A186_K0.5090.45
334_E356_L0.5090.45
15_Y187_A0.5090.45
286_F293_A0.5090.45
46_K130_G0.5090.45
369_T376_D0.5080.44
47_A59_G0.5070.44
136_V141_P0.5070.44
288_D317_N0.5070.44
176_K179_K0.5070.44
167_I177_A0.5060.44
51_A59_G0.5050.44
62_I67_D0.5040.44
80_T91_Q0.5040.44
9_K22_G0.5040.44
13_R97_L0.5040.44
164_A167_I0.5030.44
8_G18_S0.5030.44
136_V144_I0.5030.44
51_A327_V0.5020.44
266_A317_N0.5000.43
264_N293_A0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pffA 2 0.9662 100 0.173 Contact Map
2nu8B 2 0.9974 100 0.257 Contact Map
2fp4B 1 1 100 0.27 Contact Map
3mwdA 2 0.9636 100 0.276 Contact Map
3ufxB 2 0.9714 100 0.318 Contact Map
1wr2A 1 0.5299 100 0.69 Contact Map
2csuA 2 0.9013 99.9 0.762 Contact Map
3dmyA 2 0.4883 99.6 0.842 Contact Map
3mwdB 1 0.5844 99.6 0.849 Contact Map
3va7A 1 0.7117 99.4 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0111 seconds.