GREMLIN Database
KPYK - Pyruvate kinase
UniProt: P80885 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 585 (468)
Sequences: 4035 (2256)
Seq/√Len: 104.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_T56_K4.4251.00
219_P237_S4.3791.00
133_L145_K4.2691.00
231_D266_K4.0791.00
17_I52_E3.4451.00
230_I263_L3.4241.00
44_G48_K3.3401.00
78_E100_T3.1641.00
131_E145_K3.1621.00
8_C28_M3.1021.00
201_L236_V3.0911.00
65_L181_G3.0181.00
276_T306_T2.9651.00
204_R217_I2.9171.00
227_V259_V2.8231.00
200_V219_P2.7811.00
28_M31_A2.7691.00
62_G412_A2.7671.00
255_E334_R2.7411.00
131_E147_L2.5811.00
16_S19_M2.5791.00
134_D143_K2.5091.00
19_M22_K2.5081.00
44_G184_Q2.4641.00
89_E143_K2.4351.00
76_T155_K2.3981.00
85_E88_K2.3361.00
89_E133_L2.3241.00
200_V217_I2.3121.00
254_E330_N2.2841.00
90_L104_I2.2721.00
42_E46_R2.2461.00
15_E46_R2.1951.00
178_I189_I2.1771.00
47_I184_Q2.1721.00
24_M61_V2.1701.00
374_A449_D2.1631.00
235_E270_L2.1501.00
286_R319_S2.1331.00
402_T408_S2.0901.00
78_E98_V2.0651.00
251_I259_V2.0591.00
218_I239_G2.0291.00
25_E57_L2.0251.00
198_T202_E2.0251.00
309_I332_A1.9921.00
205_E209_E1.9651.00
110_G113_H1.9641.00
17_I49_N1.9611.00
329_H333_S1.9471.00
123_L152_L1.9211.00
185_G406_S1.9201.00
88_K101_T1.9121.00
80_G154_N1.9011.00
89_E145_K1.8721.00
261_K304_D1.8531.00
182_I215_I1.8491.00
103_K141_E1.8451.00
95_D140_R1.8371.00
19_M322_V1.8231.00
264_I276_T1.8121.00
179_V210_H1.8051.00
197_S232_A1.7851.00
51_R54_S1.7831.00
216_Q410_K1.7741.00
377_V451_I1.7571.00
33_L47_I1.7421.00
84_L146_V1.7411.00
29_N59_K1.7341.00
117_Q135_V1.7211.00
81_G151_T1.7201.00
10_I20_L1.7181.00
172_E176_R1.7151.00
230_I234_L1.7091.00
90_L144_T1.7071.00
47_I63_I1.7051.00
92_I130_L1.7051.00
198_T201_L1.7031.00
367_T467_M1.6831.00
21_T25_E1.6741.00
408_S421_S1.6721.00
7_V275_I1.6701.00
120_T129_G1.6611.00
173_K177_D1.6601.00
114_D166_N1.6561.00
83_E151_T1.6401.00
240_L263_L1.6361.00
437_Q441_N1.6331.00
130_L144_T1.6251.00
67_T71_E1.6171.00
175_A179_V1.6041.00
88_K146_V1.6001.00
224_Q228_D1.5861.00
41_E44_G1.5811.00
262_E266_K1.5801.00
95_D103_K1.5761.00
77_M154_N1.5721.00
7_V30_V1.5711.00
17_I56_K1.5671.00
164_S225_E1.5611.00
82_I101_T1.5591.00
323_E326_Q1.5561.00
22_K25_E1.5551.00
91_I141_E1.5501.00
24_M53_A1.5401.00
30_V64_L1.5341.00
52_E56_K1.5261.00
91_I143_K1.5251.00
191_P203_I1.5181.00
175_A202_E1.4961.00
116_E119_S1.4951.00
120_T131_E1.4881.00
218_I275_I1.4731.00
17_I53_A1.4631.00
65_L186_V1.4621.00
31_A50_I1.4591.00
2_R329_H1.4411.00
137_A140_R1.4401.00
45_A48_K1.4391.00
94_M112_V1.4371.00
438_K441_N1.4291.00
136_D140_R1.4281.00
33_L50_I1.3941.00
40_F180_F1.3911.00
411_L414_V1.3861.00
95_D141_E1.3811.00
21_T57_L1.3791.00
320_Y323_E1.3731.00
136_D141_E1.3701.00
112_V142_I1.3701.00
285_Q313_G1.3611.00
63_I186_V1.3580.99
136_D143_K1.3470.99
124_D127_L1.3440.99
380_T400_A1.3400.99
253_A327_T1.3340.99
176_R179_V1.3300.99
44_G183_E1.3230.99
256_V296_S1.3180.99
53_A57_L1.3110.99
373_A452_V1.3010.99
93_S103_K1.3000.99
26_S326_Q1.2990.99
39_D42_E1.2960.99
38_G43_H1.2960.99
45_A49_N1.2810.99
74_T104_I1.2800.99
282_D286_R1.2720.99
74_T128_I1.2580.99
326_Q330_N1.2570.99
438_K442_S1.2550.99
135_V142_I1.2530.99
19_M23_L1.2500.99
93_S141_E1.2470.99
119_S163_V1.2460.99
197_S236_V1.2430.99
214_D406_S1.2360.99
8_C31_A1.2350.99
175_A206_L1.2330.99
75_H105_S1.2290.99
223_N226_G1.2280.99
182_I210_H1.2230.99
48_K52_E1.2230.99
440_L447_H1.2200.99
302_I332_A1.2170.99
359_A367_T1.2170.99
229_N232_A1.2150.99
182_I207_L1.2060.99
266_K270_L1.2000.99
16_S49_N1.2000.99
123_L130_L1.1990.99
23_L325_V1.1900.99
14_S19_M1.1890.99
10_I14_S1.1860.99
400_A411_L1.1860.99
10_I46_R1.1850.99
18_E21_T1.1820.99
334_R337_E1.1750.99
4_T332_A1.1720.99
234_L266_K1.1680.98
21_T53_A1.1680.98
109_E112_V1.1550.98
298_V331_I1.1500.98
115_V142_I1.1470.98
86_T149_N1.1430.98
181_G186_V1.1420.98
264_I306_T1.1390.98
43_H46_R1.1380.98
24_M59_K1.1360.98
47_I180_F1.1340.98
356_I450_L1.1320.98
179_V183_E1.1250.98
55_K405_D1.1210.98
49_N52_E1.1170.98
33_L186_V1.1160.98
259_V263_L1.1160.98
15_E49_N1.1130.98
427_S430_E1.1100.98
82_I152_L1.1080.98
280_M298_V1.1010.98
40_F177_D1.1010.98
160_V163_V1.0990.98
367_T469_V1.0910.98
22_K326_Q1.0870.98
15_E45_A1.0810.97
207_L213_Q1.0810.97
74_T153_K1.0770.97
201_L205_E1.0750.97
14_S23_L1.0750.97
183_E210_H1.0740.97
375_A399_V1.0680.97
17_I21_T1.0620.97
33_L63_I1.0590.97
110_G114_D1.0530.97
76_T98_V1.0520.97
10_I50_I1.0510.97
179_V209_E1.0500.97
133_L143_K1.0480.97
81_G153_K1.0470.97
35_F65_L1.0420.97
258_L303_F1.0420.97
68_K71_E1.0310.97
85_E149_N1.0300.97
282_D285_Q1.0290.97
129_G147_L1.0260.97
358_D391_K1.0230.96
378_T389_I1.0210.96
400_A417_V1.0120.96
450_L471_T1.0110.96
7_V308_A1.0110.96
282_D313_G1.0110.96
49_N53_A1.0030.96
112_V135_V1.0030.96
197_S229_N1.0020.96
146_V149_N1.0020.96
71_E223_N0.9990.96
76_T154_N0.9970.96
374_A446_K0.9950.96
197_S201_L0.9940.96
130_L146_V0.9930.96
445_V472_V0.9860.96
204_R238_D0.9830.96
231_D234_L0.9810.96
22_K322_V0.9800.95
387_R414_V0.9780.95
455_A466_L0.9760.95
111_L142_I0.9750.95
85_E101_T0.9750.95
390_A414_V0.9670.95
50_I63_I0.9670.95
47_I186_V0.9520.95
92_I106_V0.9520.95
295_A331_I0.9460.95
172_E175_A0.9440.94
207_L215_I0.9440.94
187_D409_R0.9430.94
108_Y114_D0.9420.94
124_D153_K0.9410.94
288_P320_Y0.9400.94
399_V439_S0.9400.94
137_A141_E0.9390.94
42_E45_A0.9390.94
96_E109_E0.9350.94
160_V165_V0.9310.94
170_I175_A0.9300.94
30_V308_A0.9290.94
124_D282_D0.9260.94
123_L144_T0.9250.94
202_E205_E0.9250.94
237_S240_L0.9240.94
68_K173_K0.9220.94
86_T319_S0.9190.94
89_E134_D0.9180.94
26_S325_V0.9140.93
227_V247_L0.9120.93
234_L267_C0.9110.93
230_I266_K0.9110.93
175_A205_E0.9110.93
48_K184_Q0.9100.93
4_T302_I0.9060.93
68_K177_D0.9050.93
120_T147_L0.9050.93
100_T103_K0.9000.93
298_V309_I0.8970.93
20_L53_A0.8960.93
44_G180_F0.8930.93
104_I152_L0.8920.93
253_A295_A0.8910.93
196_R199_D0.8900.93
53_A56_K0.8890.92
26_S322_V0.8890.92
265_K269_A0.8880.92
99_G104_I0.8850.92
195_R225_E0.8840.92
36_S177_D0.8830.92
208_E213_Q0.8820.92
83_E149_N0.8820.92
401_V422_G0.8800.92
77_M152_L0.8790.92
14_S315_T0.8770.92
362_Q366_H0.8750.92
79_N82_I0.8710.92
234_L270_L0.8700.92
186_V215_I0.8670.92
129_G289_R0.8670.92
115_V121_I0.8660.91
92_I144_T0.8630.91
77_M90_L0.8610.91
178_I203_I0.8600.91
106_V158_V0.8590.91
281_L324_A0.8580.91
87_G145_K0.8570.91
159_N250_E0.8570.91
92_I104_I0.8540.91
360_I454_T0.8540.91
133_L144_T0.8520.91
320_Y324_A0.8520.91
64_L190_A0.8480.91
117_Q134_D0.8430.90
232_A235_E0.8410.90
77_M153_K0.8400.90
224_Q255_E0.8390.90
54_S61_V0.8370.90
178_I206_L0.8360.90
234_L263_L0.8360.90
93_S97_V0.8360.90
322_V326_Q0.8290.90
258_L335_S0.8270.90
71_E226_G0.8250.89
361_G389_I0.8230.89
20_L50_I0.8220.89
117_Q133_L0.8200.89
40_F44_G0.8200.89
182_I189_I0.8180.89
264_I274_V0.8160.89
128_I152_L0.8150.89
231_D270_L0.8130.89
200_V237_S0.8090.88
97_V103_K0.8010.88
360_I467_M0.8010.88
60_N408_S0.8000.88
71_E157_G0.7980.88
119_S132_V0.7960.88
24_M57_L0.7950.88
180_F184_Q0.7910.87
67_T223_N0.7900.87
125_D157_G0.7890.87
436_V451_I0.7870.87
188_F218_I0.7860.87
57_L60_N0.7850.87
16_S23_L0.7850.87
41_E45_A0.7830.87
62_G188_F0.7820.87
407_I411_L0.7820.87
303_F338_A0.7810.87
165_V168_P0.7810.87
402_T421_S0.7810.87
20_L49_N0.7750.86
362_Q370_N0.7740.86
78_E101_T0.7720.86
92_I121_I0.7710.86
86_T145_K0.7700.86
60_N419_A0.7640.85
125_D279_Q0.7600.85
432_L468_K0.7580.85
378_T385_T0.7570.85
387_R410_K0.7570.85
386_A400_A0.7570.85
10_I33_L0.7560.85
218_I413_L0.7550.85
65_L71_E0.7540.85
124_D157_G0.7540.85
432_L453_I0.7520.85
89_E102_D0.7520.85
230_I262_E0.7510.84
91_I103_K0.7490.84
268_N307_D0.7430.84
406_S410_K0.7420.84
366_H370_N0.7410.84
50_I54_S0.7390.84
77_M104_I0.7380.83
179_V206_L0.7370.83
203_I217_I0.7350.83
116_E135_V0.7330.83
30_V62_G0.7330.83
303_F335_S0.7330.83
74_T77_M0.7320.83
204_R208_E0.7320.83
14_S322_V0.7320.83
380_T386_A0.7310.83
106_V110_G0.7310.83
375_A445_V0.7300.83
113_H140_R0.7290.83
162_G224_Q0.7250.82
118_G131_E0.7250.82
364_V368_A0.7250.82
384_H388_M0.7230.82
167_L171_T0.7220.82
373_A469_V0.7220.82
110_G166_N0.7200.82
7_V28_M0.7190.82
39_D155_K0.7160.82
381_E404_N0.7160.82
112_V140_R0.7140.81
82_I104_I0.7140.81
179_V182_I0.7140.81
124_D313_G0.7130.81
358_D388_M0.7120.81
364_V452_V0.7080.81
401_V439_S0.7080.81
62_G409_R0.7070.81
181_G189_I0.7040.80
40_F176_R0.7020.80
52_E55_K0.7020.80
90_L100_T0.7010.80
436_V472_V0.7000.80
405_D421_S0.6990.80
357_T384_H0.6980.80
21_T52_E0.6960.80
280_M309_I0.6950.80
24_M54_S0.6950.80
35_F177_D0.6950.80
239_G273_P0.6950.80
68_K313_G0.6950.80
439_S445_V0.6930.79
188_F414_V0.6910.79
10_I31_A0.6900.79
182_I213_Q0.6900.79
90_L99_G0.6890.79
364_V454_T0.6890.79
15_E20_L0.6870.79
161_P250_E0.6850.79
280_M328_M0.6840.79
221_I230_I0.6830.78
465_N468_K0.6820.78
334_R338_A0.6800.78
371_L450_L0.6780.78
241_M312_S0.6780.78
230_I267_C0.6770.78
315_T328_M0.6750.78
317_A324_A0.6730.77
367_T371_L0.6720.77
30_V412_A0.6720.77
54_S57_L0.6690.77
91_I136_D0.6680.77
235_E272_K0.6680.77
33_L43_H0.6670.77
93_S112_V0.6660.77
108_Y111_L0.6650.77
74_T158_V0.6650.77
436_V470_H0.6640.76
75_H107_T0.6640.76
22_K26_S0.6620.76
114_D195_R0.6610.76
88_K102_D0.6610.76
398_I417_V0.6590.76
231_D262_E0.6570.76
90_L105_S0.6570.76
24_M50_I0.6540.75
258_L338_A0.6530.75
261_K300_N0.6520.75
2_R29_N0.6520.75
128_I146_V0.6520.75
128_I150_G0.6520.75
19_M49_N0.6500.75
77_M128_I0.6490.75
230_I240_L0.6480.75
35_F43_H0.6480.75
252_P256_V0.6480.75
248_G289_R0.6480.75
153_K317_A0.6470.75
128_I149_N0.6450.74
67_T191_P0.6450.74
412_A419_A0.6440.74
258_L334_R0.6440.74
37_H246_D0.6440.74
221_I227_V0.6420.74
452_V467_M0.6420.74
378_T386_A0.6420.74
88_K130_L0.6420.74
197_S221_I0.6410.74
377_V445_V0.6410.74
256_V295_A0.6410.74
127_L287_N0.6400.74
6_I325_V0.6380.74
355_T358_D0.6370.73
364_V376_I0.6340.73
43_H181_G0.6340.73
15_E42_E0.6340.73
437_Q440_L0.6330.73
280_M312_S0.6330.73
86_T320_Y0.6330.73
440_L445_V0.6330.73
169_G194_I0.6320.73
115_V132_V0.6320.73
91_I140_R0.6320.73
91_I94_M0.6300.73
268_N276_T0.6300.73
77_M81_G0.6300.73
408_S419_A0.6290.73
385_T456_G0.6290.73
300_N304_D0.6280.72
405_D409_R0.6280.72
452_V469_V0.6280.72
54_S60_N0.6280.72
262_E338_A0.6280.72
368_A376_I0.6270.72
10_I49_N0.6200.71
48_K183_E0.6200.71
329_H332_A0.6180.71
6_I328_M0.6180.71
404_N407_I0.6170.71
356_I378_T0.6170.71
181_G185_G0.6170.71
454_T464_T0.6160.71
84_L88_K0.6160.71
2_R6_I0.6150.71
196_R229_N0.6140.71
38_G42_E0.6120.70
194_I200_V0.6110.70
188_F413_L0.6110.70
303_F339_L0.6090.70
72_I158_V0.6080.70
365_A394_P0.6080.70
368_A373_A0.6070.70
456_G462_G0.6060.70
47_I50_I0.6060.70
381_E424_N0.6060.70
68_K226_G0.6040.69
77_M99_G0.6030.69
315_T324_A0.6020.69
74_T92_I0.6020.69
84_L128_I0.6010.69
226_G234_L0.6010.69
206_L209_E0.6010.69
178_I213_Q0.6000.69
302_I358_D0.6000.69
108_Y195_R0.5990.69
23_L322_V0.5990.69
216_Q387_R0.5990.69
379_P431_M0.5980.69
10_I28_M0.5980.69
81_G154_N0.5970.69
357_T388_M0.5960.68
90_L146_V0.5960.68
221_I263_L0.5950.68
436_V445_V0.5950.68
302_I309_I0.5940.68
68_K223_N0.5940.68
462_G465_N0.5930.68
170_I206_L0.5930.68
375_A397_P0.5920.68
381_E403_V0.5920.68
425_A430_E0.5910.68
97_V105_S0.5910.68
92_I123_L0.5900.68
259_V262_E0.5890.68
89_E131_E0.5880.67
25_E59_K0.5870.67
377_V401_V0.5860.67
327_T331_I0.5840.67
273_P413_L0.5840.67
302_I335_S0.5840.67
281_L327_T0.5830.67
456_G464_T0.5810.67
53_A58_G0.5790.66
65_L180_F0.5790.66
90_L101_T0.5780.66
369_I395_Q0.5780.66
79_N100_T0.5780.66
54_S59_K0.5770.66
74_T152_L0.5770.66
18_E49_N0.5760.66
152_L155_K0.5740.66
34_N37_H0.5730.65
71_E167_L0.5730.65
308_A413_L0.5730.65
72_I173_K0.5720.65
67_T157_G0.5710.65
221_I239_G0.5710.65
208_E214_D0.5680.65
238_D272_K0.5680.65
241_M310_M0.5680.65
257_P415_S0.5670.65
266_K269_A0.5670.65
428_T466_L0.5670.65
205_E208_E0.5660.65
271_G394_P0.5660.65
203_I206_L0.5660.65
401_V420_E0.5640.64
425_A434_D0.5640.64
20_L23_L0.5630.64
271_G391_K0.5620.64
428_T455_A0.5620.64
453_I470_H0.5610.64
106_V142_I0.5610.64
339_L344_I0.5600.64
253_A296_S0.5600.64
393_R415_S0.5600.64
364_V373_A0.5600.64
94_M137_A0.5600.64
113_H166_N0.5600.64
119_S162_G0.5600.64
198_T205_E0.5590.64
10_I63_I0.5590.64
388_M432_L0.5580.63
2_R296_S0.5570.63
389_I454_T0.5570.63
207_L216_Q0.5570.63
188_F216_Q0.5560.63
189_I207_L0.5550.63
6_I329_H0.5540.63
198_T232_A0.5530.63
355_T388_M0.5520.63
391_K462_G0.5510.62
23_L28_M0.5500.62
206_L210_H0.5490.62
124_D195_R0.5490.62
202_E206_L0.5480.62
25_E56_K0.5480.62
241_M277_A0.5470.62
170_I178_I0.5470.62
386_A419_A0.5470.62
10_I15_E0.5460.62
14_S317_A0.5460.62
327_T330_N0.5440.61
50_I61_V0.5440.61
425_A431_M0.5430.61
400_A419_A0.5430.61
35_F186_V0.5420.61
446_K449_D0.5420.61
108_Y112_V0.5410.61
407_I456_G0.5410.61
169_G195_R0.5400.61
275_I310_M0.5380.61
14_S316_A0.5380.61
16_S20_L0.5380.61
133_L136_D0.5370.60
170_I203_I0.5360.60
275_I413_L0.5360.60
90_L153_K0.5360.60
84_L152_L0.5350.60
371_L469_V0.5340.60
111_L121_I0.5340.60
194_I219_P0.5330.60
394_P398_I0.5320.60
36_S65_L0.5320.60
371_L452_V0.5310.60
47_I51_R0.5300.59
44_G47_I0.5300.59
280_M306_T0.5300.59
241_M280_M0.5300.59
15_E18_E0.5290.59
39_D76_T0.5290.59
189_I213_Q0.5270.59
90_L103_K0.5260.59
106_V160_V0.5250.59
64_L413_L0.5250.59
75_H154_N0.5250.59
82_I88_K0.5250.59
157_G249_V0.5240.59
390_A398_I0.5240.59
33_L38_G0.5230.58
418_F444_I0.5230.58
113_H135_V0.5230.58
273_P307_D0.5220.58
268_N304_D0.5220.58
31_A54_S0.5220.58
415_S455_A0.5220.58
193_F250_E0.5210.58
185_G215_I0.5210.58
153_K156_K0.5190.58
122_L190_A0.5190.58
276_T305_G0.5160.57
18_E22_K0.5150.57
159_N171_T0.5140.57
309_I329_H0.5140.57
46_R49_N0.5130.57
367_T452_V0.5130.57
382_S461_S0.5120.57
193_F246_D0.5100.57
240_L270_L0.5100.57
107_T154_N0.5090.56
457_T468_K0.5090.56
399_V444_I0.5090.56
86_T147_L0.5090.56
210_H215_I0.5070.56
84_L123_L0.5070.56
191_P194_I0.5070.56
92_I111_L0.5060.56
204_R236_V0.5050.56
95_D98_V0.5050.56
135_V143_K0.5040.56
64_L308_A0.5040.56
112_V137_A0.5040.56
234_L272_K0.5040.56
24_M227_V0.5020.55
178_I212_A0.5020.55
135_V140_R0.5020.55
262_E265_K0.5010.55
167_L194_I0.5000.55
88_K149_N0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e28A 3 0.9966 100 0.166 Contact Map
3t05A 3 0.9897 100 0.169 Contact Map
3gr4A 4 0.8034 100 0.287 Contact Map
1e0tA 3 0.759 100 0.288 Contact Map
1a3wA 3 0.7983 100 0.29 Contact Map
3gg8A 3 0.8 100 0.293 Contact Map
3khdA 3 0.8034 100 0.295 Contact Map
4kctB 3 0.8034 100 0.305 Contact Map
4drsA 3 0.7897 100 0.322 Contact Map
3qtgA 3 0.759 100 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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