KPYK - BACSU - GREMLIN Contacts

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KPYK - Pyruvate kinase

UniProt:	P80885	Sequences: MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHGARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTDKISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNVPGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGAVLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQDITVDASRGAVYQGRASVL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	585 (468)
Sequences:	4035 (2256)
Seq/√Len:	104.3

ECOLI - KPYK1 KPYK2
BACSU - KPYK
HALSA - Q9HSA5
SULSO - Q97ZD7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
21_T	56_K	4.425	1.00
219_P	237_S	4.379	1.00
133_L	145_K	4.269	1.00
231_D	266_K	4.079	1.00
17_I	52_E	3.445	1.00
230_I	263_L	3.424	1.00
44_G	48_K	3.340	1.00
78_E	100_T	3.164	1.00
131_E	145_K	3.162	1.00
8_C	28_M	3.102	1.00
201_L	236_V	3.091	1.00
65_L	181_G	3.018	1.00
276_T	306_T	2.965	1.00
204_R	217_I	2.917	1.00
227_V	259_V	2.823	1.00
200_V	219_P	2.781	1.00
28_M	31_A	2.769	1.00
62_G	412_A	2.767	1.00
255_E	334_R	2.741	1.00
131_E	147_L	2.581	1.00
16_S	19_M	2.579	1.00
134_D	143_K	2.509	1.00
19_M	22_K	2.508	1.00
44_G	184_Q	2.464	1.00
89_E	143_K	2.435	1.00
76_T	155_K	2.398	1.00
85_E	88_K	2.336	1.00
89_E	133_L	2.324	1.00
200_V	217_I	2.312	1.00
254_E	330_N	2.284	1.00
90_L	104_I	2.272	1.00
42_E	46_R	2.246	1.00
15_E	46_R	2.195	1.00
178_I	189_I	2.177	1.00
47_I	184_Q	2.172	1.00
24_M	61_V	2.170	1.00
374_A	449_D	2.163	1.00
235_E	270_L	2.150	1.00
286_R	319_S	2.133	1.00
402_T	408_S	2.090	1.00
78_E	98_V	2.065	1.00
251_I	259_V	2.059	1.00
218_I	239_G	2.029	1.00
25_E	57_L	2.025	1.00
198_T	202_E	2.025	1.00
309_I	332_A	1.992	1.00
205_E	209_E	1.965	1.00
110_G	113_H	1.964	1.00
17_I	49_N	1.961	1.00
329_H	333_S	1.947	1.00
123_L	152_L	1.921	1.00
185_G	406_S	1.920	1.00
88_K	101_T	1.912	1.00
80_G	154_N	1.901	1.00
89_E	145_K	1.872	1.00
261_K	304_D	1.853	1.00
182_I	215_I	1.849	1.00
103_K	141_E	1.845	1.00
95_D	140_R	1.837	1.00
19_M	322_V	1.823	1.00
264_I	276_T	1.812	1.00
179_V	210_H	1.805	1.00
197_S	232_A	1.785	1.00
51_R	54_S	1.783	1.00
216_Q	410_K	1.774	1.00
377_V	451_I	1.757	1.00
33_L	47_I	1.742	1.00
84_L	146_V	1.741	1.00
29_N	59_K	1.734	1.00
117_Q	135_V	1.721	1.00
81_G	151_T	1.720	1.00
10_I	20_L	1.718	1.00
172_E	176_R	1.715	1.00
230_I	234_L	1.709	1.00
90_L	144_T	1.707	1.00
47_I	63_I	1.705	1.00
92_I	130_L	1.705	1.00
198_T	201_L	1.703	1.00
367_T	467_M	1.683	1.00
21_T	25_E	1.674	1.00
408_S	421_S	1.672	1.00
7_V	275_I	1.670	1.00
120_T	129_G	1.661	1.00
173_K	177_D	1.660	1.00
114_D	166_N	1.656	1.00
83_E	151_T	1.640	1.00
240_L	263_L	1.636	1.00
437_Q	441_N	1.633	1.00
130_L	144_T	1.625	1.00
67_T	71_E	1.617	1.00
175_A	179_V	1.604	1.00
88_K	146_V	1.600	1.00
224_Q	228_D	1.586	1.00
41_E	44_G	1.581	1.00
262_E	266_K	1.580	1.00
95_D	103_K	1.576	1.00
77_M	154_N	1.572	1.00
7_V	30_V	1.571	1.00
17_I	56_K	1.567	1.00
164_S	225_E	1.561	1.00
82_I	101_T	1.559	1.00
323_E	326_Q	1.556	1.00
22_K	25_E	1.555	1.00
91_I	141_E	1.550	1.00
24_M	53_A	1.540	1.00
30_V	64_L	1.534	1.00
52_E	56_K	1.526	1.00
91_I	143_K	1.525	1.00
191_P	203_I	1.518	1.00
175_A	202_E	1.496	1.00
116_E	119_S	1.495	1.00
120_T	131_E	1.488	1.00
218_I	275_I	1.473	1.00
17_I	53_A	1.463	1.00
65_L	186_V	1.462	1.00
31_A	50_I	1.459	1.00
2_R	329_H	1.441	1.00
137_A	140_R	1.440	1.00
45_A	48_K	1.439	1.00
94_M	112_V	1.437	1.00
438_K	441_N	1.429	1.00
136_D	140_R	1.428	1.00
33_L	50_I	1.394	1.00
40_F	180_F	1.391	1.00
411_L	414_V	1.386	1.00
95_D	141_E	1.381	1.00
21_T	57_L	1.379	1.00
320_Y	323_E	1.373	1.00
136_D	141_E	1.370	1.00
112_V	142_I	1.370	1.00
285_Q	313_G	1.361	1.00
63_I	186_V	1.358	0.99
136_D	143_K	1.347	0.99
124_D	127_L	1.344	0.99
380_T	400_A	1.340	0.99
253_A	327_T	1.334	0.99
176_R	179_V	1.330	0.99
44_G	183_E	1.323	0.99
256_V	296_S	1.318	0.99
53_A	57_L	1.311	0.99
373_A	452_V	1.301	0.99
93_S	103_K	1.300	0.99
26_S	326_Q	1.299	0.99
39_D	42_E	1.296	0.99
38_G	43_H	1.296	0.99
45_A	49_N	1.281	0.99
74_T	104_I	1.280	0.99
282_D	286_R	1.272	0.99
74_T	128_I	1.258	0.99
326_Q	330_N	1.257	0.99
438_K	442_S	1.255	0.99
135_V	142_I	1.253	0.99
19_M	23_L	1.250	0.99
93_S	141_E	1.247	0.99
119_S	163_V	1.246	0.99
197_S	236_V	1.243	0.99
214_D	406_S	1.236	0.99
8_C	31_A	1.235	0.99
175_A	206_L	1.233	0.99
75_H	105_S	1.229	0.99
223_N	226_G	1.228	0.99
182_I	210_H	1.223	0.99
48_K	52_E	1.223	0.99
440_L	447_H	1.220	0.99
302_I	332_A	1.217	0.99
359_A	367_T	1.217	0.99
229_N	232_A	1.215	0.99
182_I	207_L	1.206	0.99
266_K	270_L	1.200	0.99
16_S	49_N	1.200	0.99
123_L	130_L	1.199	0.99
23_L	325_V	1.190	0.99
14_S	19_M	1.189	0.99
10_I	14_S	1.186	0.99
400_A	411_L	1.186	0.99
10_I	46_R	1.185	0.99
18_E	21_T	1.182	0.99
334_R	337_E	1.175	0.99
4_T	332_A	1.172	0.99
234_L	266_K	1.168	0.98
21_T	53_A	1.168	0.98
109_E	112_V	1.155	0.98
298_V	331_I	1.150	0.98
115_V	142_I	1.147	0.98
86_T	149_N	1.143	0.98
181_G	186_V	1.142	0.98
264_I	306_T	1.139	0.98
43_H	46_R	1.138	0.98
24_M	59_K	1.136	0.98
47_I	180_F	1.134	0.98
356_I	450_L	1.132	0.98
179_V	183_E	1.125	0.98
55_K	405_D	1.121	0.98
49_N	52_E	1.117	0.98
33_L	186_V	1.116	0.98
259_V	263_L	1.116	0.98
15_E	49_N	1.113	0.98
427_S	430_E	1.110	0.98
82_I	152_L	1.108	0.98
280_M	298_V	1.101	0.98
40_F	177_D	1.101	0.98
160_V	163_V	1.099	0.98
367_T	469_V	1.091	0.98
22_K	326_Q	1.087	0.98
15_E	45_A	1.081	0.97
207_L	213_Q	1.081	0.97
74_T	153_K	1.077	0.97
201_L	205_E	1.075	0.97
14_S	23_L	1.075	0.97
183_E	210_H	1.074	0.97
375_A	399_V	1.068	0.97
17_I	21_T	1.062	0.97
33_L	63_I	1.059	0.97
110_G	114_D	1.053	0.97
76_T	98_V	1.052	0.97
10_I	50_I	1.051	0.97
179_V	209_E	1.050	0.97
133_L	143_K	1.048	0.97
81_G	153_K	1.047	0.97
35_F	65_L	1.042	0.97
258_L	303_F	1.042	0.97
68_K	71_E	1.031	0.97
85_E	149_N	1.030	0.97
282_D	285_Q	1.029	0.97
129_G	147_L	1.026	0.97
358_D	391_K	1.023	0.96
378_T	389_I	1.021	0.96
400_A	417_V	1.012	0.96
450_L	471_T	1.011	0.96
7_V	308_A	1.011	0.96
282_D	313_G	1.011	0.96
49_N	53_A	1.003	0.96
112_V	135_V	1.003	0.96
197_S	229_N	1.002	0.96
146_V	149_N	1.002	0.96
71_E	223_N	0.999	0.96
76_T	154_N	0.997	0.96
374_A	446_K	0.995	0.96
197_S	201_L	0.994	0.96
130_L	146_V	0.993	0.96
445_V	472_V	0.986	0.96
204_R	238_D	0.983	0.96
231_D	234_L	0.981	0.96
22_K	322_V	0.980	0.95
387_R	414_V	0.978	0.95
455_A	466_L	0.976	0.95
111_L	142_I	0.975	0.95
85_E	101_T	0.975	0.95
390_A	414_V	0.967	0.95
50_I	63_I	0.967	0.95
47_I	186_V	0.952	0.95
92_I	106_V	0.952	0.95
295_A	331_I	0.946	0.95
172_E	175_A	0.944	0.94
207_L	215_I	0.944	0.94
187_D	409_R	0.943	0.94
108_Y	114_D	0.942	0.94
124_D	153_K	0.941	0.94
288_P	320_Y	0.940	0.94
399_V	439_S	0.940	0.94
137_A	141_E	0.939	0.94
42_E	45_A	0.939	0.94
96_E	109_E	0.935	0.94
160_V	165_V	0.931	0.94
170_I	175_A	0.930	0.94
30_V	308_A	0.929	0.94
124_D	282_D	0.926	0.94
123_L	144_T	0.925	0.94
202_E	205_E	0.925	0.94
237_S	240_L	0.924	0.94
68_K	173_K	0.922	0.94
86_T	319_S	0.919	0.94
89_E	134_D	0.918	0.94
26_S	325_V	0.914	0.93
227_V	247_L	0.912	0.93
234_L	267_C	0.911	0.93
230_I	266_K	0.911	0.93
175_A	205_E	0.911	0.93
48_K	184_Q	0.910	0.93
4_T	302_I	0.906	0.93
68_K	177_D	0.905	0.93
120_T	147_L	0.905	0.93
100_T	103_K	0.900	0.93
298_V	309_I	0.897	0.93
20_L	53_A	0.896	0.93
44_G	180_F	0.893	0.93
104_I	152_L	0.892	0.93
253_A	295_A	0.891	0.93
196_R	199_D	0.890	0.93
53_A	56_K	0.889	0.92
26_S	322_V	0.889	0.92
265_K	269_A	0.888	0.92
99_G	104_I	0.885	0.92
195_R	225_E	0.884	0.92
36_S	177_D	0.883	0.92
208_E	213_Q	0.882	0.92
83_E	149_N	0.882	0.92
401_V	422_G	0.880	0.92
77_M	152_L	0.879	0.92
14_S	315_T	0.877	0.92
362_Q	366_H	0.875	0.92
79_N	82_I	0.871	0.92
234_L	270_L	0.870	0.92
186_V	215_I	0.867	0.92
129_G	289_R	0.867	0.92
115_V	121_I	0.866	0.91
92_I	144_T	0.863	0.91
77_M	90_L	0.861	0.91
178_I	203_I	0.860	0.91
106_V	158_V	0.859	0.91
281_L	324_A	0.858	0.91
87_G	145_K	0.857	0.91
159_N	250_E	0.857	0.91
92_I	104_I	0.854	0.91
360_I	454_T	0.854	0.91
133_L	144_T	0.852	0.91
320_Y	324_A	0.852	0.91
64_L	190_A	0.848	0.91
117_Q	134_D	0.843	0.90
232_A	235_E	0.841	0.90
77_M	153_K	0.840	0.90
224_Q	255_E	0.839	0.90
54_S	61_V	0.837	0.90
178_I	206_L	0.836	0.90
234_L	263_L	0.836	0.90
93_S	97_V	0.836	0.90
322_V	326_Q	0.829	0.90
258_L	335_S	0.827	0.90
71_E	226_G	0.825	0.89
361_G	389_I	0.823	0.89
20_L	50_I	0.822	0.89
117_Q	133_L	0.820	0.89
40_F	44_G	0.820	0.89
182_I	189_I	0.818	0.89
264_I	274_V	0.816	0.89
128_I	152_L	0.815	0.89
231_D	270_L	0.813	0.89
200_V	237_S	0.809	0.88
97_V	103_K	0.801	0.88
360_I	467_M	0.801	0.88
60_N	408_S	0.800	0.88
71_E	157_G	0.798	0.88
119_S	132_V	0.796	0.88
24_M	57_L	0.795	0.88
180_F	184_Q	0.791	0.87
67_T	223_N	0.790	0.87
125_D	157_G	0.789	0.87
436_V	451_I	0.787	0.87
188_F	218_I	0.786	0.87
57_L	60_N	0.785	0.87
16_S	23_L	0.785	0.87
41_E	45_A	0.783	0.87
62_G	188_F	0.782	0.87
407_I	411_L	0.782	0.87
303_F	338_A	0.781	0.87
165_V	168_P	0.781	0.87
402_T	421_S	0.781	0.87
20_L	49_N	0.775	0.86
362_Q	370_N	0.774	0.86
78_E	101_T	0.772	0.86
92_I	121_I	0.771	0.86
86_T	145_K	0.770	0.86
60_N	419_A	0.764	0.85
125_D	279_Q	0.760	0.85
432_L	468_K	0.758	0.85
378_T	385_T	0.757	0.85
387_R	410_K	0.757	0.85
386_A	400_A	0.757	0.85
10_I	33_L	0.756	0.85
218_I	413_L	0.755	0.85
65_L	71_E	0.754	0.85
124_D	157_G	0.754	0.85
432_L	453_I	0.752	0.85
89_E	102_D	0.752	0.85
230_I	262_E	0.751	0.84
91_I	103_K	0.749	0.84
268_N	307_D	0.743	0.84
406_S	410_K	0.742	0.84
366_H	370_N	0.741	0.84
50_I	54_S	0.739	0.84
77_M	104_I	0.738	0.83
179_V	206_L	0.737	0.83
203_I	217_I	0.735	0.83
116_E	135_V	0.733	0.83
30_V	62_G	0.733	0.83
303_F	335_S	0.733	0.83
74_T	77_M	0.732	0.83
204_R	208_E	0.732	0.83
14_S	322_V	0.732	0.83
380_T	386_A	0.731	0.83
106_V	110_G	0.731	0.83
375_A	445_V	0.730	0.83
113_H	140_R	0.729	0.83
162_G	224_Q	0.725	0.82
118_G	131_E	0.725	0.82
364_V	368_A	0.725	0.82
384_H	388_M	0.723	0.82
167_L	171_T	0.722	0.82
373_A	469_V	0.722	0.82
110_G	166_N	0.720	0.82
7_V	28_M	0.719	0.82
39_D	155_K	0.716	0.82
381_E	404_N	0.716	0.82
112_V	140_R	0.714	0.81
82_I	104_I	0.714	0.81
179_V	182_I	0.714	0.81
124_D	313_G	0.713	0.81
358_D	388_M	0.712	0.81
364_V	452_V	0.708	0.81
401_V	439_S	0.708	0.81
62_G	409_R	0.707	0.81
181_G	189_I	0.704	0.80
40_F	176_R	0.702	0.80
52_E	55_K	0.702	0.80
90_L	100_T	0.701	0.80
436_V	472_V	0.700	0.80
405_D	421_S	0.699	0.80
357_T	384_H	0.698	0.80
21_T	52_E	0.696	0.80
280_M	309_I	0.695	0.80
24_M	54_S	0.695	0.80
35_F	177_D	0.695	0.80
239_G	273_P	0.695	0.80
68_K	313_G	0.695	0.80
439_S	445_V	0.693	0.79
188_F	414_V	0.691	0.79
10_I	31_A	0.690	0.79
182_I	213_Q	0.690	0.79
90_L	99_G	0.689	0.79
364_V	454_T	0.689	0.79
15_E	20_L	0.687	0.79
161_P	250_E	0.685	0.79
280_M	328_M	0.684	0.79
221_I	230_I	0.683	0.78
465_N	468_K	0.682	0.78
334_R	338_A	0.680	0.78
371_L	450_L	0.678	0.78
241_M	312_S	0.678	0.78
230_I	267_C	0.677	0.78
315_T	328_M	0.675	0.78
317_A	324_A	0.673	0.77
367_T	371_L	0.672	0.77
30_V	412_A	0.672	0.77
54_S	57_L	0.669	0.77
91_I	136_D	0.668	0.77
235_E	272_K	0.668	0.77
33_L	43_H	0.667	0.77
93_S	112_V	0.666	0.77
108_Y	111_L	0.665	0.77
74_T	158_V	0.665	0.77
436_V	470_H	0.664	0.76
75_H	107_T	0.664	0.76
22_K	26_S	0.662	0.76
114_D	195_R	0.661	0.76
88_K	102_D	0.661	0.76
398_I	417_V	0.659	0.76
231_D	262_E	0.657	0.76
90_L	105_S	0.657	0.76
24_M	50_I	0.654	0.75
258_L	338_A	0.653	0.75
261_K	300_N	0.652	0.75
2_R	29_N	0.652	0.75
128_I	146_V	0.652	0.75
128_I	150_G	0.652	0.75
19_M	49_N	0.650	0.75
77_M	128_I	0.649	0.75
230_I	240_L	0.648	0.75
35_F	43_H	0.648	0.75
252_P	256_V	0.648	0.75
248_G	289_R	0.648	0.75
153_K	317_A	0.647	0.75
128_I	149_N	0.645	0.74
67_T	191_P	0.645	0.74
412_A	419_A	0.644	0.74
258_L	334_R	0.644	0.74
37_H	246_D	0.644	0.74
221_I	227_V	0.642	0.74
452_V	467_M	0.642	0.74
378_T	386_A	0.642	0.74
88_K	130_L	0.642	0.74
197_S	221_I	0.641	0.74
377_V	445_V	0.641	0.74
256_V	295_A	0.641	0.74
127_L	287_N	0.640	0.74
6_I	325_V	0.638	0.74
355_T	358_D	0.637	0.73
364_V	376_I	0.634	0.73
43_H	181_G	0.634	0.73
15_E	42_E	0.634	0.73
437_Q	440_L	0.633	0.73
280_M	312_S	0.633	0.73
86_T	320_Y	0.633	0.73
440_L	445_V	0.633	0.73
169_G	194_I	0.632	0.73
115_V	132_V	0.632	0.73
91_I	140_R	0.632	0.73
91_I	94_M	0.630	0.73
268_N	276_T	0.630	0.73
77_M	81_G	0.630	0.73
408_S	419_A	0.629	0.73
385_T	456_G	0.629	0.73
300_N	304_D	0.628	0.72
405_D	409_R	0.628	0.72
452_V	469_V	0.628	0.72
54_S	60_N	0.628	0.72
262_E	338_A	0.628	0.72
368_A	376_I	0.627	0.72
10_I	49_N	0.620	0.71
48_K	183_E	0.620	0.71
329_H	332_A	0.618	0.71
6_I	328_M	0.618	0.71
404_N	407_I	0.617	0.71
356_I	378_T	0.617	0.71
181_G	185_G	0.617	0.71
454_T	464_T	0.616	0.71
84_L	88_K	0.616	0.71
2_R	6_I	0.615	0.71
196_R	229_N	0.614	0.71
38_G	42_E	0.612	0.70
194_I	200_V	0.611	0.70
188_F	413_L	0.611	0.70
303_F	339_L	0.609	0.70
72_I	158_V	0.608	0.70
365_A	394_P	0.608	0.70
368_A	373_A	0.607	0.70
456_G	462_G	0.606	0.70
47_I	50_I	0.606	0.70
381_E	424_N	0.606	0.70
68_K	226_G	0.604	0.69
77_M	99_G	0.603	0.69
315_T	324_A	0.602	0.69
74_T	92_I	0.602	0.69
84_L	128_I	0.601	0.69
226_G	234_L	0.601	0.69
206_L	209_E	0.601	0.69
178_I	213_Q	0.600	0.69
302_I	358_D	0.600	0.69
108_Y	195_R	0.599	0.69
23_L	322_V	0.599	0.69
216_Q	387_R	0.599	0.69
379_P	431_M	0.598	0.69
10_I	28_M	0.598	0.69
81_G	154_N	0.597	0.69
357_T	388_M	0.596	0.68
90_L	146_V	0.596	0.68
221_I	263_L	0.595	0.68
436_V	445_V	0.595	0.68
302_I	309_I	0.594	0.68
68_K	223_N	0.594	0.68
462_G	465_N	0.593	0.68
170_I	206_L	0.593	0.68
375_A	397_P	0.592	0.68
381_E	403_V	0.592	0.68
425_A	430_E	0.591	0.68
97_V	105_S	0.591	0.68
92_I	123_L	0.590	0.68
259_V	262_E	0.589	0.68
89_E	131_E	0.588	0.67
25_E	59_K	0.587	0.67
377_V	401_V	0.586	0.67
327_T	331_I	0.584	0.67
273_P	413_L	0.584	0.67
302_I	335_S	0.584	0.67
281_L	327_T	0.583	0.67
456_G	464_T	0.581	0.67
53_A	58_G	0.579	0.66
65_L	180_F	0.579	0.66
90_L	101_T	0.578	0.66
369_I	395_Q	0.578	0.66
79_N	100_T	0.578	0.66
54_S	59_K	0.577	0.66
74_T	152_L	0.577	0.66
18_E	49_N	0.576	0.66
152_L	155_K	0.574	0.66
34_N	37_H	0.573	0.65
71_E	167_L	0.573	0.65
308_A	413_L	0.573	0.65
72_I	173_K	0.572	0.65
67_T	157_G	0.571	0.65
221_I	239_G	0.571	0.65
208_E	214_D	0.568	0.65
238_D	272_K	0.568	0.65
241_M	310_M	0.568	0.65
257_P	415_S	0.567	0.65
266_K	269_A	0.567	0.65
428_T	466_L	0.567	0.65
205_E	208_E	0.566	0.65
271_G	394_P	0.566	0.65
203_I	206_L	0.566	0.65
401_V	420_E	0.564	0.64
425_A	434_D	0.564	0.64
20_L	23_L	0.563	0.64
271_G	391_K	0.562	0.64
428_T	455_A	0.562	0.64
453_I	470_H	0.561	0.64
106_V	142_I	0.561	0.64
339_L	344_I	0.560	0.64
253_A	296_S	0.560	0.64
393_R	415_S	0.560	0.64
364_V	373_A	0.560	0.64
94_M	137_A	0.560	0.64
113_H	166_N	0.560	0.64
119_S	162_G	0.560	0.64
198_T	205_E	0.559	0.64
10_I	63_I	0.559	0.64
388_M	432_L	0.558	0.63
2_R	296_S	0.557	0.63
389_I	454_T	0.557	0.63
207_L	216_Q	0.557	0.63
188_F	216_Q	0.556	0.63
189_I	207_L	0.555	0.63
6_I	329_H	0.554	0.63
198_T	232_A	0.553	0.63
355_T	388_M	0.552	0.63
391_K	462_G	0.551	0.62
23_L	28_M	0.550	0.62
206_L	210_H	0.549	0.62
124_D	195_R	0.549	0.62
202_E	206_L	0.548	0.62
25_E	56_K	0.548	0.62
241_M	277_A	0.547	0.62
170_I	178_I	0.547	0.62
386_A	419_A	0.547	0.62
10_I	15_E	0.546	0.62
14_S	317_A	0.546	0.62
327_T	330_N	0.544	0.61
50_I	61_V	0.544	0.61
425_A	431_M	0.543	0.61
400_A	419_A	0.543	0.61
35_F	186_V	0.542	0.61
446_K	449_D	0.542	0.61
108_Y	112_V	0.541	0.61
407_I	456_G	0.541	0.61
169_G	195_R	0.540	0.61
275_I	310_M	0.538	0.61
14_S	316_A	0.538	0.61
16_S	20_L	0.538	0.61
133_L	136_D	0.537	0.60
170_I	203_I	0.536	0.60
275_I	413_L	0.536	0.60
90_L	153_K	0.536	0.60
84_L	152_L	0.535	0.60
371_L	469_V	0.534	0.60
111_L	121_I	0.534	0.60
194_I	219_P	0.533	0.60
394_P	398_I	0.532	0.60
36_S	65_L	0.532	0.60
371_L	452_V	0.531	0.60
47_I	51_R	0.530	0.59
44_G	47_I	0.530	0.59
280_M	306_T	0.530	0.59
241_M	280_M	0.530	0.59
15_E	18_E	0.529	0.59
39_D	76_T	0.529	0.59
189_I	213_Q	0.527	0.59
90_L	103_K	0.526	0.59
106_V	160_V	0.525	0.59
64_L	413_L	0.525	0.59
75_H	154_N	0.525	0.59
82_I	88_K	0.525	0.59
157_G	249_V	0.524	0.59
390_A	398_I	0.524	0.59
33_L	38_G	0.523	0.58
418_F	444_I	0.523	0.58
113_H	135_V	0.523	0.58
273_P	307_D	0.522	0.58
268_N	304_D	0.522	0.58
31_A	54_S	0.522	0.58
415_S	455_A	0.522	0.58
193_F	250_E	0.521	0.58
185_G	215_I	0.521	0.58
153_K	156_K	0.519	0.58
122_L	190_A	0.519	0.58
276_T	305_G	0.516	0.57
18_E	22_K	0.515	0.57
159_N	171_T	0.514	0.57
309_I	329_H	0.514	0.57
46_R	49_N	0.513	0.57
367_T	452_V	0.513	0.57
382_S	461_S	0.512	0.57
193_F	246_D	0.510	0.57
240_L	270_L	0.510	0.57
107_T	154_N	0.509	0.56
457_T	468_K	0.509	0.56
399_V	444_I	0.509	0.56
86_T	147_L	0.509	0.56
210_H	215_I	0.507	0.56
84_L	123_L	0.507	0.56
191_P	194_I	0.507	0.56
92_I	111_L	0.506	0.56
204_R	236_V	0.505	0.56
95_D	98_V	0.505	0.56
135_V	143_K	0.504	0.56
64_L	308_A	0.504	0.56
112_V	137_A	0.504	0.56
234_L	272_K	0.504	0.56
24_M	227_V	0.502	0.55
178_I	212_A	0.502	0.55
135_V	140_R	0.502	0.55
262_E	265_K	0.501	0.55
167_L	194_I	0.500	0.55
88_K	149_N	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2e28A	3	0.9966	100	0.166	Contact Map
3t05A	3	0.9897	100	0.169	Contact Map
3gr4A	4	0.8034	100	0.287	Contact Map
1e0tA	3	0.759	100	0.288	Contact Map
1a3wA	3	0.7983	100	0.29	Contact Map
3gg8A	3	0.8	100	0.293	Contact Map
3khdA	3	0.8034	100	0.295	Contact Map
4kctB	3	0.8034	100	0.305	Contact Map
4drsA	3	0.7897	100	0.322	Contact Map
3qtgA	3	0.759	100	0.327	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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