GREMLIN Database
TRXB - Thioredoxin reductase
UniProt: P80880 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (284)
Sequences: 61224 (43842)
Seq/√Len: 2601.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_V232_T4.0081.00
37_R83_D3.7181.00
147_E170_K3.4311.00
206_E218_T3.1991.00
208_H218_T3.0591.00
172_T199_L3.0381.00
170_K197_D2.8251.00
8_D106_R2.7041.00
218_T229_E2.5731.00
33_L80_A2.4861.00
263_N267_E2.4531.00
8_D31_S2.3861.00
205_K220_V2.3481.00
199_L228_S2.3441.00
94_K102_E2.3091.00
147_E233_D2.2711.00
221_D228_S2.2551.00
117_K242_L2.2541.00
9_V25_T2.2501.00
203_T220_V2.2291.00
122_P206_E2.2221.00
21_A109_I2.2031.00
149_V174_V2.1801.00
188_A192_D2.1791.00
149_V217_V2.1681.00
10_I35_I2.1461.00
6_I104_K2.1221.00
35_I103_Y2.1161.00
254_T261_E2.0931.00
7_Y33_L2.0511.00
147_E172_T2.0441.00
109_I301_V1.9951.00
205_K218_T1.9761.00
10_I103_Y1.8861.00
6_I106_R1.8561.00
202_K221_D1.8061.00
89_D270_V1.7741.00
208_H229_E1.7691.00
8_D33_L1.7581.00
107_A272_G1.6971.00
176_R203_T1.6891.00
115_E244_L1.6771.00
96_V102_E1.6721.00
10_I95_V1.6431.00
93_Y272_G1.6331.00
172_T197_D1.6331.00
147_E231_K1.6301.00
115_E242_L1.6111.00
126_E209_E1.6021.00
31_S78_E1.5971.00
146_K233_D1.5921.00
255_N259_Y1.5921.00
174_V230_F1.5921.00
105_A108_V1.5921.00
17_A276_A1.5851.00
10_I105_A1.5621.00
219_L230_F1.5521.00
220_V227_E1.5261.00
60_L63_E1.5261.00
93_Y97_K1.4981.00
134_Y137_V1.4961.00
202_K228_S1.4721.00
205_K227_E1.4711.00
207_I235_V1.4641.00
147_E169_S1.4631.00
115_E246_K1.4571.00
219_L228_S1.4561.00
199_L202_K1.4501.00
254_T269_K1.4471.00
86_E96_V1.4381.00
202_K219_L1.4231.00
274_F304_Y1.4111.00
69_F73_K1.4081.00
112_A279_I1.3901.00
218_T227_E1.3891.00
298_A302_Q1.3741.00
10_I33_L1.3631.00
210_E215_G1.3571.00
94_K104_K1.3551.00
83_D98_A1.3391.00
109_I276_A1.3361.00
221_D227_E1.3361.00
107_A301_V1.3331.00
80_A101_K1.3331.00
178_D201_N1.3281.00
22_A34_M1.3271.00
267_E271_E1.3041.00
107_A274_F1.2981.00
172_T232_T1.2951.00
11_I18_G1.2791.00
148_L164_L1.2731.00
11_I22_A1.2601.00
209_E215_G1.2571.00
274_F300_S1.2551.00
297_A301_V1.2511.00
294_G298_A1.2421.00
14_A36_E1.2311.00
70_E74_K1.2301.00
88_I94_K1.2181.00
97_K103_Y1.2061.00
24_Y299_Q1.1881.00
9_V109_I1.1741.00
120_G124_E1.1571.00
9_V30_L1.1561.00
24_Y27_R1.1541.00
88_I92_E1.1521.00
33_L103_Y1.1481.00
190_A193_N1.1461.00
70_E73_K1.1401.00
89_D273_I1.1361.00
262_T280_R1.1241.00
66_N70_E1.1171.00
133_S137_V1.1161.00
71_H75_F1.1161.00
219_L227_E1.1151.00
270_V273_I1.1001.00
97_K100_S1.0991.00
174_V219_L1.0971.00
210_E213_K1.0961.00
12_I84_I1.0821.00
26_S77_A1.0811.00
38_G82_G1.0811.00
296_I300_S1.0791.00
85_K98_A1.0781.00
153_G175_H1.0771.00
165_T196_V1.0771.00
175_H200_W1.0731.00
148_L234_G1.0701.00
260_I275_A1.0691.00
144_K169_S1.0651.00
107_A304_Y1.0611.00
7_Y10_I1.0581.00
158_V173_I1.0571.00
17_A290_A1.0541.00
7_Y78_E1.0541.00
190_A194_E1.0471.00
111_A276_A1.0461.00
145_G169_S1.0441.00
85_K96_V1.0431.00
12_I110_I1.0391.00
86_E250_N1.0391.00
80_A103_Y1.0391.00
28_A302_Q1.0371.00
215_G231_K1.0351.00
35_I80_A1.0281.00
39_I69_F1.0271.00
247_P250_N1.0231.00
260_I279_I1.0181.00
97_K101_K1.0111.00
137_V140_G1.0091.00
165_T170_K0.9991.00
148_L169_S0.9801.00
172_T230_F0.9791.00
204_V217_V0.9761.00
33_L78_E0.9691.00
87_V108_V0.9661.00
276_A297_A0.9611.00
149_V230_F0.9551.00
210_E231_K0.9541.00
151_V235_V0.9521.00
88_I96_V0.9501.00
25_T298_A0.9451.00
68_M71_H0.9451.00
214_V235_V0.9451.00
28_A299_Q0.9441.00
24_Y28_A0.9431.00
267_E304_Y0.9401.00
7_Y31_S0.9371.00
9_V107_A0.9321.00
161_G173_I0.9301.00
208_H215_G0.9231.00
6_I31_S0.9061.00
123_G126_E0.9041.00
202_K220_V0.8951.00
42_G45_A0.8941.00
166_R194_E0.8911.00
266_M280_R0.8901.00
255_N261_E0.8891.00
185_I188_A0.8891.00
168_A171_V0.8881.00
82_G99_G0.8831.00
197_D228_S0.8821.00
275_A279_I0.8811.00
246_K249_E0.8811.00
189_R192_D0.8781.00
41_G44_M0.8691.00
21_A276_A0.8691.00
188_A200_W0.8611.00
262_T275_A0.8611.00
25_T30_L0.8551.00
150_V161_G0.8541.00
41_G45_A0.8531.00
35_I84_I0.8531.00
33_L105_A0.8511.00
8_D30_L0.8471.00
7_Y107_A0.8451.00
86_E89_D0.8431.00
21_A294_G0.8411.00
290_A294_G0.8331.00
23_V27_R0.8301.00
51_E55_G0.8301.00
12_I112_A0.8301.00
266_M297_A0.8281.00
59_I63_E0.8281.00
266_M296_I0.8261.00
8_D104_K0.8231.00
215_G229_E0.8221.00
21_A297_A0.8171.00
274_F301_V0.8161.00
24_Y295_S0.8161.00
93_Y98_A0.8131.00
11_I21_A0.8071.00
123_G206_E0.8051.00
149_V235_V0.8021.00
280_R293_D0.8011.00
265_R300_S0.8001.00
209_E213_K0.7961.00
207_I217_V0.7931.00
25_T301_V0.7931.00
63_E66_N0.7931.00
267_E272_G0.7921.00
9_V301_V0.7881.00
189_R193_N0.7871.00
98_A101_K0.7851.00
84_I95_V0.7841.00
208_H211_N0.7791.00
188_A198_F0.7791.00
72_A75_F0.7781.00
256_E261_E0.7761.00
30_L302_Q0.7711.00
133_S141_A0.7691.00
108_V273_I0.7691.00
129_G134_Y0.7681.00
157_A175_H0.7671.00
130_R133_S0.7671.00
199_L230_F0.7641.00
109_I297_A0.7631.00
255_N281_E0.7601.00
22_A77_A0.7571.00
110_I279_I0.7531.00
180_L200_W0.7521.00
62_P66_N0.7491.00
26_S32_T0.7481.00
14_A34_M0.7481.00
151_V239_I0.7461.00
289_T293_D0.7431.00
262_T266_M0.7421.00
82_G98_A0.7411.00
151_V237_I0.7401.00
138_C141_A0.7381.00
135_C138_C0.7381.00
136_A139_D0.7361.00
278_D290_A0.7331.00
18_G111_A0.7321.00
68_M72_A0.7321.00
174_V202_K0.7301.00
153_G180_L0.7301.00
211_N229_E0.7221.00
232_T235_V0.7191.00
272_G304_Y0.7171.00
22_A32_T0.7141.00
18_G22_A0.7141.00
114_A241_M0.7141.00
67_K70_E0.7121.00
275_A280_R0.7111.00
60_L67_K0.7111.00
129_G135_C0.7111.00
147_E232_T0.7101.00
65_S69_F0.7101.00
133_S136_A0.7081.00
151_V204_V0.7071.00
297_A300_S0.7071.00
136_A140_G0.7041.00
199_L219_L0.7031.00
25_T32_T0.7011.00
213_K231_K0.6991.00
40_P81_Y0.6961.00
124_E237_I0.6941.00
165_T194_E0.6921.00
135_C139_D0.6851.00
261_E269_K0.6821.00
130_R134_Y0.6811.00
94_K97_K0.6801.00
161_G196_V0.6751.00
131_G134_Y0.6711.00
8_D103_Y0.6701.00
131_G237_I0.6691.00
121_V124_E0.6671.00
276_A301_V0.6671.00
7_Y106_R0.6641.00
207_I214_V0.6631.00
266_M300_S0.6631.00
35_I97_K0.6621.00
90_G94_K0.6621.00
118_K237_I0.6601.00
20_T24_Y0.6601.00
267_E300_S0.6591.00
267_E274_F0.6591.00
118_K125_K0.6591.00
14_A40_P0.6571.00
146_K169_S0.6561.00
295_S299_Q0.6561.00
186_L189_R0.6511.00
174_V199_L0.6491.00
20_T294_G0.6481.00
165_T195_K0.6461.00
119_I237_I0.6451.00
274_F297_A0.6441.00
40_P79_Y0.6431.00
209_E214_V0.6421.00
133_S234_G0.6411.00
293_D297_A0.6401.00
191_F198_F0.6401.00
138_C164_L0.6401.00
133_S138_C0.6391.00
72_A77_A0.6371.00
186_L190_A0.6341.00
268_T275_A0.6341.00
179_K188_A0.6321.00
89_D92_E0.6321.00
162_V166_R0.6321.00
246_K250_N0.6311.00
35_I105_A0.6311.00
110_I247_P0.6281.00
36_E81_Y0.6231.00
63_E67_K0.6221.00
267_E270_V0.6221.00
248_F251_L0.6211.00
26_S76_G0.6211.00
192_D197_D0.6211.00
20_T23_V0.6181.00
10_I93_Y0.6161.00
215_G218_T0.6151.00
141_A234_G0.6141.00
175_H182_A0.6101.00
26_S78_E0.6071.00
276_A294_G0.6071.00
85_K88_I0.6071.00
17_A111_A0.6061.00
21_A298_A0.6061.00
11_I111_A0.6051.00
143_F146_K0.6031.00
71_H74_K0.6021.00
30_L106_R0.6021.00
66_N69_F0.6021.00
23_V75_F0.6011.00
26_S31_S0.5991.00
11_I32_T0.5981.00
64_L67_K0.5961.00
134_Y138_C0.5951.00
292_G295_S0.5941.00
175_H178_D0.5931.00
8_D105_A0.5931.00
61_G65_S0.5921.00
146_K234_G0.5921.00
161_G171_V0.5851.00
247_P251_L0.5841.00
292_G296_I0.5821.00
62_P65_S0.5801.00
146_K170_K0.5781.00
154_G240_G0.5761.00
281_E293_D0.5731.00
129_G138_C0.5731.00
173_I198_F0.5721.00
59_I67_K0.5721.00
286_Q289_T0.5711.00
261_E264_D0.5711.00
299_Q303_H0.5701.00
160_E163_Y0.5701.00
69_F81_Y0.5691.00
129_G133_S0.5681.00
30_L301_V0.5651.00
67_K71_H0.5651.00
20_T291_T0.5641.00
52_N55_G0.5591.00
36_E79_Y0.5581.00
120_G125_K0.5571.00
50_V55_G0.5561.00
40_P69_F0.5541.00
119_I124_E0.5521.00
89_D93_Y0.5511.00
118_K124_E0.5511.00
175_H180_L0.5511.00
61_G64_L0.5501.00
112_A247_P0.5491.00
121_V207_I0.5481.00
160_E236_F0.5471.00
160_E238_Y0.5451.00
34_M79_Y0.5411.00
56_F59_I0.5411.00
84_I87_V0.5391.00
150_V157_A0.5381.00
92_E272_G0.5361.00
157_A238_Y0.5351.00
50_V53_Y0.5331.00
175_H179_K0.5321.00
93_Y270_V0.5321.00
11_I34_M0.5291.00
249_E252_G0.5291.00
133_S139_D0.5291.00
192_D195_K0.5291.00
117_K239_I0.5281.00
185_I189_R0.5251.00
130_R136_A0.5251.00
201_N221_D0.5241.00
84_I97_K0.5221.00
143_F234_G0.5211.00
34_M77_A0.5191.00
51_E54_P0.5181.00
134_Y139_D0.5171.00
187_Q191_F0.5161.00
174_V232_T0.5161.00
130_R137_V0.5151.00
175_H198_F0.5141.00
57_E60_L0.5141.00
32_T78_E0.5121.00
149_V172_T0.5091.00
288_V291_T0.5081.00
158_V198_F0.5061.00
291_T295_S0.5051.00
137_V141_A0.5041.00
142_F145_G0.5031.00
21_A301_V0.5031.00
181_R184_S0.5011.00
147_E230_F0.5011.00
129_G137_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q7vA 2 0.9652 100 0.244 Contact Map
3f8dA 2 0.962 100 0.252 Contact Map
2q0lA 2 0.9557 100 0.253 Contact Map
2a87A 2 0.9778 100 0.259 Contact Map
3ctyA 2 0.9589 100 0.26 Contact Map
4up3A 2 0.9557 100 0.261 Contact Map
1fl2A 2 0.962 100 0.261 Contact Map
3r9uA 2 0.9589 100 0.261 Contact Map
1hyuA 2 0.9778 100 0.273 Contact Map
4jnqA 2 0.9715 100 0.274 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0111 seconds.