GREMLIN Database
G20U - General stress protein 20U
UniProt: P80879 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (139)
Sequences: 2857 (1635)
Seq/√Len: 138.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_T91_Q3.2261.00
6_I65_G2.6461.00
124_D128_A2.6261.00
115_D123_G2.5401.00
22_K99_D2.4671.00
26_Y95_S2.3381.00
72_K76_E2.2511.00
15_N79_S2.2401.00
124_D127_L2.1751.00
36_F40_E2.1641.00
23_L49_T2.0731.00
26_Y83_A2.0031.00
68_I77_T1.9971.00
111_M127_L1.9041.00
43_E47_N1.8601.00
114_A123_G1.7451.00
123_G127_L1.7141.00
121_T130_H1.6731.00
21_V71_M1.6491.00
38_L42_F1.6451.00
48_E136_H1.6311.00
17_T74_S1.6301.00
115_D120_E1.6041.00
101_T141_K1.5961.00
97_Y137_N1.5931.00
8_A110_G1.5741.00
26_Y92_M1.5601.00
101_T105_E1.5331.00
59_R119_D1.4911.00
10_N68_I1.4851.00
94_Q98_D1.4701.00
108_K134_E1.4551.00
120_E123_G1.4291.00
104_A137_N1.4021.00
41_K44_E1.3911.00
16_W56_L1.3881.00
83_A95_S1.3801.00
41_K45_L1.3681.00
112_D118_G1.3681.00
48_E132_N1.3621.00
137_N141_K1.3611.00
112_D116_E1.3611.00
48_E52_Y1.3521.00
59_R122_T1.3441.00
104_A134_E1.3371.00
25_N69_A1.3171.00
43_E46_Y1.2831.00
15_N106_E1.2761.00
105_E109_N1.2711.00
55_D125_M1.2531.00
110_G126_L1.2331.00
45_L100_F1.2261.00
16_W49_T1.1971.00
18_V75_L1.1931.00
101_T137_N1.1911.00
52_Y132_N1.1881.00
14_A77_T1.1690.99
23_L45_L1.1660.99
52_Y129_I1.1650.99
72_K82_E1.1630.99
119_D122_T1.1520.99
91_Q94_Q1.1520.99
90_E94_Q1.1150.99
18_V78_A1.1140.99
5_L117_V1.0880.99
36_F44_E1.0720.99
59_R134_E1.0720.99
111_M123_G1.0630.99
97_Y141_K1.0520.99
36_F41_K1.0510.99
8_A113_L1.0340.99
132_N135_K1.0330.99
108_K130_H1.0310.99
24_H53_I1.0300.99
79_S102_V1.0270.99
104_A130_H1.0250.99
100_F136_H1.0230.99
17_T53_I1.0180.99
11_K106_E1.0140.99
20_Y50_A1.0020.98
12_Q110_G1.0010.98
93_V140_L0.9950.98
64_N141_K0.9790.98
42_F92_M0.9760.98
83_A92_M0.9750.98
114_A122_T0.9530.98
18_V82_E0.9500.98
111_M130_H0.9470.98
79_S106_E0.9470.98
121_T131_Q0.9380.98
10_N60_L0.9180.97
12_Q107_L0.9170.97
120_E127_L0.9090.97
50_A53_I0.8980.97
18_V71_M0.8890.97
97_Y101_T0.8820.96
47_N51_T0.8740.96
63_L122_T0.8730.96
39_H58_E0.8700.96
98_D101_T0.8560.96
13_V56_L0.8490.96
11_K79_S0.8480.96
91_Q95_S0.8450.95
22_K82_E0.8430.95
111_M120_E0.8400.95
36_F143_Y0.8320.95
5_L114_A0.8270.95
37_T143_Y0.8250.95
112_D120_E0.8140.94
40_E44_E0.8060.94
15_N78_A0.8030.94
73_E76_E0.8010.94
100_F133_I0.7940.94
51_T55_D0.7910.94
34_D89_A0.7860.93
8_A109_N0.7690.93
132_N136_H0.7500.92
60_L65_G0.7480.92
30_V92_M0.7450.91
73_E77_T0.7360.91
104_A133_I0.7240.90
104_A108_K0.7230.90
12_Q106_E0.7230.90
21_V69_A0.7210.90
109_N113_L0.7210.90
35_F58_E0.7200.90
135_K138_W0.7190.90
90_E93_V0.7160.90
81_K98_D0.7150.90
15_N102_V0.7150.90
106_E109_N0.7080.89
75_L82_E0.7050.89
21_V74_S0.7010.89
41_K139_M0.6990.89
44_E47_N0.6970.88
34_D90_E0.6940.88
55_D128_A0.6940.88
33_K90_E0.6930.88
62_A135_K0.6920.88
128_A131_Q0.6870.88
8_A11_K0.6840.87
37_T40_E0.6820.87
109_N112_D0.6820.87
93_V143_Y0.6800.87
29_Y67_P0.6770.87
10_N14_A0.6760.87
59_R63_L0.6740.87
121_T134_E0.6740.87
42_F93_V0.6690.86
27_H58_E0.6580.85
107_L129_I0.6580.85
6_I60_L0.6540.85
96_V100_F0.6480.84
27_H39_H0.6450.84
31_K142_A0.6430.84
13_V16_W0.6410.84
107_L133_I0.6400.84
24_H46_Y0.6390.84
16_W52_Y0.6390.84
56_L129_I0.6380.84
45_L140_L0.6380.84
80_V99_D0.6370.83
8_A114_A0.6330.83
107_L126_L0.6290.83
7_Q11_K0.6240.82
24_H43_E0.6210.82
10_N67_P0.6190.82
114_A126_L0.6190.82
34_D143_Y0.6190.82
71_M75_L0.6090.81
72_K84_A0.6040.80
124_D131_Q0.6040.80
43_E50_A0.5980.79
66_K87_E0.5880.78
31_K61_L0.5870.78
20_Y56_L0.5790.77
46_Y139_M0.5790.77
35_F39_H0.5770.77
80_V106_E0.5770.77
24_H139_M0.5760.77
68_I73_E0.5760.77
13_V53_I0.5750.77
20_Y53_I0.5720.76
104_A121_T0.5700.76
70_T73_E0.5670.76
29_Y69_A0.5590.75
119_D134_E0.5560.74
122_T134_E0.5550.74
12_Q15_N0.5550.74
12_Q126_L0.5480.73
61_L142_A0.5470.73
95_S99_D0.5420.73
100_F140_L0.5390.72
8_A106_E0.5330.71
41_K93_V0.5320.71
81_K102_V0.5310.71
38_L93_V0.5290.71
55_D131_Q0.5270.70
98_D102_V0.5260.70
92_M96_V0.5260.70
22_K80_V0.5220.70
111_M114_A0.5190.69
51_T117_V0.5140.69
46_Y57_A0.5130.68
19_M23_L0.5130.68
113_L116_E0.5090.68
121_T127_L0.5010.67
42_F89_A0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zs3A 6 0.9793 100 0.211 Contact Map
1zujA 6 0.9793 100 0.214 Contact Map
2c2jA 6 0.9931 100 0.279 Contact Map
2cf7A 6 1 100 0.287 Contact Map
2xgwA 6 1 100 0.29 Contact Map
2c2uA 6 1 100 0.291 Contact Map
3ak8A 6 0.9793 100 0.294 Contact Map
2wluA 6 1 100 0.299 Contact Map
4m32A 6 0.9931 100 0.303 Contact Map
2pybA 6 1 100 0.303 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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