GREMLIN Database
MCAT - Probable manganese catalase
UniProt: P80878 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (260)
Sequences: 596 (238)
Seq/√Len: 14.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_L77_I6.2001.00
39_A67_L5.8271.00
10_H170_D4.7781.00
121_S125_V3.9831.00
32_Q131_Y3.8571.00
2_F43_L3.4560.99
62_T185_Q3.1830.98
28_I156_V2.9890.98
58_L218_L2.9840.98
23_K123_T2.8860.97
217_Q244_E2.8270.97
157_A176_L2.4870.93
28_I36_I2.4510.93
15_D166_K2.4430.93
43_L63_A2.3560.91
76_M171_M2.3020.90
113_S118_M2.2940.90
58_L87_D2.1360.86
230_Q235_E2.0090.83
23_K106_N2.0060.82
49_T62_T1.9720.81
126_P130_G1.9560.81
48_N116_G1.9440.80
27_E127_W1.9180.79
50_R82_E1.9060.79
191_K201_V1.8780.78
125_V130_G1.8770.78
68_G74_A1.8540.77
58_L62_T1.7760.74
23_K161_E1.7330.72
139_L190_I1.7250.72
29_L73_I1.7160.71
152_G179_D1.6990.70
255_K260_P1.6880.70
179_D186_W1.6620.69
4_H41_Q1.6580.68
98_I104_G1.6560.68
170_D210_E1.6470.68
38_V186_W1.6460.68
231_N234_N1.6040.66
144_A147_N1.5810.65
62_T142_F1.5720.64
56_K227_S1.5600.63
43_L67_L1.5290.62
11_P129_G1.5180.61
156_V176_L1.5000.60
80_L168_V1.4950.60
62_T70_V1.4900.60
235_E238_P1.4880.60
61_D220_N1.4760.59
245_Y249_A1.4500.58
38_V148_A1.4370.57
76_M80_L1.4270.56
98_I102_L1.4080.55
216_H239_D1.3760.54
234_N237_A1.3680.53
231_N237_A1.3620.53
184_N238_P1.3550.52
163_T171_M1.3430.52
55_Y192_E1.3410.52
47_W60_M1.3360.51
38_V179_D1.3360.51
133_V147_N1.3260.51
143_R146_L1.3250.51
212_Q215_S1.3180.50
88_Q92_A1.3100.50
74_A99_G1.3090.50
2_F121_S1.2970.49
230_Q233_L1.2960.49
164_D169_K1.2890.49
29_L156_V1.2760.48
108_H121_S1.2750.48
113_S116_G1.2690.48
61_D143_R1.2670.48
54_K192_E1.2590.47
220_N249_A1.2540.47
112_V155_Q1.2430.46
219_I244_E1.2400.46
89_Q223_E1.2360.46
41_Q144_A1.2340.46
39_A175_L1.2340.46
82_E146_L1.2340.46
44_F134_A1.2230.45
29_L169_K1.2010.44
134_A141_D1.1970.44
96_P103_G1.1910.43
24_K107_P1.1840.43
55_Y138_L1.1790.43
211_K215_S1.1720.42
6_K220_N1.1630.42
14_P76_M1.1630.42
74_A83_D1.1500.41
131_Y147_N1.1470.41
113_S134_A1.1470.41
3_K223_E1.1420.41
52_N64_T1.1410.41
28_I68_G1.1350.40
6_K61_D1.1330.40
27_E189_A1.1250.40
120_E130_G1.1230.40
106_N109_H1.1210.40
167_G170_D1.1090.39
121_S184_N1.1080.39
63_A117_A1.1050.39
129_G262_P1.0930.38
250_K254_E1.0910.38
43_L70_V1.0900.38
43_L48_N1.0890.38
40_M206_P1.0870.38
125_V216_H1.0760.37
17_P81_L1.0720.37
1_M8_L1.0700.37
189_A221_F1.0690.37
46_G60_M1.0660.37
9_Q184_N1.0630.36
108_H112_V1.0580.36
39_A49_T1.0570.36
181_M216_H1.0550.36
101_I174_F1.0430.35
145_N158_R1.0280.35
253_G258_L1.0260.35
147_N161_E1.0250.35
92_A99_G1.0240.35
140_A183_Q1.0240.35
128_S131_Y1.0020.33
67_L70_V0.9990.33
37_S41_Q0.9950.33
129_G204_T0.9940.33
60_M134_A0.9930.33
25_M73_I0.9890.33
122_S232_W0.9860.33
29_L36_I0.9840.33
163_T172_L0.9810.32
146_L187_L0.9750.32
106_N110_A0.9690.32
84_A261_A0.9650.32
4_H144_A0.9600.31
79_R169_K0.9590.31
78_A237_A0.9590.31
97_V105_M0.9510.31
60_M83_D0.9510.31
216_H241_E0.9500.31
20_L105_M0.9450.31
48_N63_A0.9360.30
32_Q147_N0.9340.30
97_V213_E0.9260.30
52_N70_V0.9250.30
143_R150_S0.9240.30
146_L150_S0.9190.29
247_K250_K0.9180.29
60_M107_P0.9080.29
20_L23_K0.9060.29
100_S104_G0.9050.29
53_E196_Q0.9020.29
72_M250_K0.9000.29
46_G142_F0.8980.28
77_I211_K0.8970.28
2_F64_T0.8940.28
213_E250_K0.8920.28
122_S151_Q0.8900.28
76_M165_D0.8820.28
14_P111_I0.8790.28
48_N113_S0.8790.28
52_N63_A0.8780.28
91_K94_E0.8710.27
80_L127_W0.8710.27
187_L191_K0.8680.27
17_P82_E0.8670.27
27_E80_L0.8670.27
181_M218_L0.8660.27
41_Q179_D0.8620.27
63_A68_G0.8540.27
37_S151_Q0.8540.27
216_H236_K0.8530.26
15_D122_S0.8530.26
128_S212_Q0.8490.26
201_V205_F0.8470.26
5_T75_T0.8470.26
28_I73_I0.8400.26
150_S183_Q0.8350.26
93_A97_V0.8330.26
119_P129_G0.8310.26
29_L70_V0.8300.25
82_E227_S0.8270.25
224_G230_Q0.8260.25
42_Y141_D0.8230.25
230_Q242_A0.8210.25
48_N117_A0.8170.25
217_Q246_V0.8170.25
108_H150_S0.8130.25
125_V128_S0.8100.25
6_K101_I0.8080.25
46_G195_A0.8050.24
68_G174_F0.8050.24
229_E232_W0.8050.24
135_S205_F0.8030.24
23_K109_H0.8010.24
146_L227_S0.8010.24
3_K237_A0.8000.24
129_G161_E0.7990.24
14_P221_F0.7940.24
258_L261_A0.7940.24
147_N190_I0.7910.24
104_G111_I0.7900.24
37_S176_L0.7880.24
81_L221_F0.7840.24
62_T181_M0.7830.24
76_M168_V0.7830.24
19_P51_G0.7780.23
93_A99_G0.7690.23
215_S239_D0.7650.23
31_G35_E0.7640.23
30_G35_E0.7640.23
163_T205_F0.7630.23
99_G260_P0.7620.23
127_W189_A0.7610.23
244_E247_K0.7590.23
154_L206_P0.7570.23
113_S121_S0.7550.22
146_L190_I0.7510.22
33_F135_S0.7460.22
104_G235_E0.7420.22
215_S236_K0.7400.22
40_M63_A0.7400.22
21_F24_K0.7350.22
248_E257_E0.7340.22
25_M172_L0.7340.22
108_H137_N0.7330.22
135_S140_A0.7310.22
117_A249_A0.7300.21
29_L98_I0.7290.21
133_V140_A0.7290.21
231_N238_P0.7270.21
1_M4_H0.7270.21
27_E33_F0.7260.21
14_P80_L0.7240.21
98_I101_I0.7230.21
12_A245_Y0.7200.21
222_S226_V0.7200.21
132_I261_A0.7200.21
230_Q234_N0.7200.21
153_R176_L0.7190.21
36_I68_G0.7180.21
19_P104_G0.7170.21
86_L96_P0.7070.21
92_A249_A0.7060.21
143_R200_V0.7060.21
60_M101_I0.7050.21
95_D100_S0.7040.21
21_F188_A0.7040.21
29_L152_G0.7020.20
78_A85_P0.7010.20
121_S124_G0.6950.20
23_K121_S0.6940.20
15_D175_L0.6930.20
190_I214_F0.6890.20
158_R183_Q0.6890.20
3_K121_S0.6880.20
80_L193_L0.6850.20
77_I202_P0.6790.20
80_L165_D0.6750.19
257_E260_P0.6750.19
51_G99_G0.6720.19
245_Y248_E0.6710.19
7_M79_R0.6700.19
2_F67_L0.6680.19
103_G192_E0.6660.19
160_F209_L0.6650.19
216_H219_I0.6620.19
9_Q183_Q0.6620.19
8_L258_L0.6620.19
247_K251_T0.6620.19
38_V177_A0.6590.19
241_E262_P0.6590.19
174_F198_G0.6560.19
156_V175_L0.6560.19
40_M134_A0.6550.19
61_D157_A0.6530.19
204_T262_P0.6510.19
13_K79_R0.6510.19
14_P201_V0.6480.19
135_S153_R0.6450.18
129_G138_L0.6400.18
108_H224_G0.6390.18
148_A186_W0.6360.18
159_L188_A0.6340.18
165_D210_E0.6300.18
52_N200_V0.6300.18
9_Q84_A0.6280.18
28_I122_S0.6270.18
91_K162_M0.6270.18
130_G133_V0.6260.18
23_K95_D0.6250.18
54_K138_L0.6250.18
37_S127_W0.6240.18
44_F152_G0.6230.18
43_L128_S0.6210.18
132_I142_F0.6200.18
225_E247_K0.6180.18
120_E260_P0.6170.18
112_V146_L0.6140.17
86_L99_G0.6140.17
18_D21_F0.6120.17
19_P84_A0.6120.17
81_L172_L0.6110.17
216_H242_A0.6080.17
16_R150_S0.6080.17
76_M112_V0.6060.17
19_P229_E0.6060.17
49_T138_L0.6060.17
27_E155_Q0.6040.17
61_D70_V0.6040.17
77_I142_F0.6010.17
143_R194_E0.6000.17
58_L223_E0.5990.17
37_S194_E0.5980.17
194_E200_V0.5980.17
106_N119_P0.5940.17
23_K105_M0.5880.17
3_K7_M0.5850.17
80_L224_G0.5830.16
62_T127_W0.5830.16
62_T233_L0.5820.16
49_T52_N0.5820.16
68_G221_F0.5810.16
68_G254_E0.5790.16
144_A184_N0.5750.16
43_L68_G0.5740.16
164_D223_E0.5730.16
7_M106_N0.5710.16
259_K262_P0.5680.16
28_I37_S0.5670.16
43_L75_T0.5670.16
224_G260_P0.5610.16
97_V103_G0.5590.16
231_N235_E0.5580.16
46_G49_T0.5580.16
19_P261_A0.5580.16
58_L100_S0.5580.16
127_W155_Q0.5560.16
46_G130_G0.5550.16
21_F41_Q0.5550.16
64_T122_S0.5540.16
33_F70_V0.5530.16
139_L151_Q0.5520.16
119_P179_D0.5520.16
21_F161_E0.5510.16
51_G109_H0.5510.16
79_R258_L0.5490.15
81_L134_A0.5490.15
236_K239_D0.5460.15
62_T122_S0.5450.15
246_V261_A0.5450.15
59_L192_E0.5440.15
101_I132_I0.5400.15
85_P90_E0.5390.15
33_F191_K0.5380.15
79_R256_P0.5350.15
7_M158_R0.5330.15
99_G103_G0.5320.15
39_A97_V0.5310.15
87_D169_K0.5300.15
82_E261_A0.5300.15
27_E168_V0.5270.15
229_E235_E0.5250.15
5_T249_A0.5240.15
30_G34_G0.5230.15
31_G34_G0.5230.15
15_D251_T0.5230.15
56_K176_L0.5220.15
87_D120_E0.5220.15
205_F209_L0.5210.15
27_E37_S0.5190.15
87_D225_E0.5170.15
170_D216_H0.5150.15
103_G107_P0.5150.15
205_F232_W0.5140.14
55_Y183_Q0.5130.14
160_F169_K0.5100.14
164_D232_W0.5070.14
114_G253_G0.5070.14
16_R131_Y0.5060.14
135_S158_R0.5060.14
47_W74_A0.5050.14
112_V116_G0.5040.14
118_M132_I0.5040.14
175_L252_F0.5030.14
148_A167_G0.5030.14
254_E257_E0.5010.14
97_V156_V0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o9iA 6 0.9744 100 0.351 Contact Map
2v8tA 5 0.9963 100 0.377 Contact Map
4di0A 2 0.4908 98.3 0.919 Contact Map
2fzfA 2 0.5751 98.3 0.919 Contact Map
4tofA 6 0.5568 98.2 0.922 Contact Map
4cvrA 2 0.5531 98.1 0.923 Contact Map
3fvbA 6 0.5604 98 0.925 Contact Map
2qqyA 6 0.4908 98 0.925 Contact Map
3uoiA 7 0.5641 97.9 0.927 Contact Map
1j30A 5 0.4945 97.9 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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