METE - BACSU - GREMLIN Contacts

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METE - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

UniProt:	P80877	Sequences: MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDELFLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGIKDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGPYTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRGAKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTHGFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKHPDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGANSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQKWRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFTKYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWSFPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTWAAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLKNHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEETVAALKNMVEAAKQARAQQTQLV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	762 (745)
Sequences:	1678 (1024)
Seq/√Len:	37.5

ECOLI - METE
BACSU - METE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
473_I	552_V	6.515	1.00
399_E	587_K	5.033	1.00
75_A	163_F	4.844	1.00
332_A	352_E	4.763	1.00
470_K	474_D	4.761	1.00
297_A	302_R	4.685	1.00
125_Y	167_A	4.594	1.00
572_I	577_I	4.205	1.00
457_S	460_Q	3.914	1.00
62_V	153_T	3.854	1.00
71_V	158_V	3.820	1.00
712_I	726_V	3.815	1.00
709_Y	753_Q	3.764	1.00
713_V	757_Q	3.756	1.00
602_V	633_T	3.666	1.00
27_Y	93_D	3.571	1.00
462_Q	539_K	3.559	1.00
33_D	36_T	3.514	1.00
505_F	562_I	3.490	1.00
424_S	598_Q	3.386	1.00
300_E	379_K	3.308	1.00
412_I	638_N	3.304	1.00
501_K	536_M	3.271	1.00
136_N	140_E	3.236	1.00
738_E	742_A	3.094	1.00
137_K	141_D	3.064	1.00
451_W	458_D	3.022	1.00
142_Y	198_V	3.001	1.00
450_K	455_E	2.998	1.00
143_R	196_E	2.977	1.00
45_F	144_R	2.921	1.00
8_N	322_P	2.898	1.00
66_T	73_D	2.823	1.00
244_V	250_L	2.773	1.00
142_Y	152_E	2.722	1.00
190_L	201_V	2.706	1.00
41_I	67_Q	2.645	1.00
338_H	509_K	2.639	1.00
180_K	221_E	2.613	1.00
343_L	506_A	2.608	1.00
470_K	547_L	2.602	1.00
158_V	162_T	2.595	1.00
425_L	599_I	2.542	1.00
363_G	371_I	2.464	1.00
289_I	297_A	2.422	1.00
70_H	158_V	2.393	1.00
458_D	462_Q	2.367	1.00
615_T	618_W	2.348	1.00
701_R	707_E	2.311	1.00
480_E	752_K	2.276	0.99
152_E	199_K	2.267	0.99
578_A	628_A	2.240	0.99
652_E	680_Y	2.236	0.99
446_S	450_K	2.226	0.99
78_F	185_L	2.226	0.99
44_L	48_A	2.214	0.99
199_K	234_N	2.184	0.99
139_L	189_L	2.171	0.99
530_V	581_I	2.153	0.99
475_I	741_V	2.147	0.99
422_N	689_G	2.146	0.99
619_D	623_T	2.144	0.99
705_T	749_E	2.143	0.99
414_F	418_L	2.135	0.99
78_F	182_L	2.114	0.99
24_L	518_S	2.106	0.99
393_N	503_A	2.101	0.99
34_K	93_D	2.096	0.99
322_P	357_L	2.072	0.99
705_T	746_N	2.064	0.99
393_N	531_E	2.045	0.99
98_I	108_S	2.045	0.99
11_F	351_K	2.043	0.99
346_G	385_L	2.019	0.99
541_T	597_I	2.016	0.99
63_S	137_K	2.008	0.99
468_E	471_R	2.008	0.99
108_S	121_I	1.995	0.99
288_V	306_V	1.983	0.99
139_L	196_E	1.979	0.99
27_Y	34_K	1.976	0.98
142_Y	153_T	1.972	0.98
499_G	507_F	1.970	0.98
211_A	614_K	1.964	0.98
109_E	168_K	1.935	0.98
605_P	661_L	1.926	0.98
115_N	264_H	1.919	0.98
447_A	456_W	1.916	0.98
157_I	189_L	1.912	0.98
296_K	378_A	1.899	0.98
59_V	154_K	1.897	0.98
447_A	465_I	1.895	0.98
404_T	407_D	1.895	0.98
480_E	550_K	1.893	0.98
392_A	397_K	1.887	0.98
51_T	351_K	1.886	0.98
156_V	204_D	1.877	0.98
298_D	301_E	1.872	0.98
716_L	721_T	1.869	0.98
741_V	745_K	1.859	0.98
585_L	605_P	1.857	0.98
418_L	689_G	1.856	0.98
320_I	357_L	1.855	0.98
623_T	627_E	1.850	0.98
483_V	599_I	1.838	0.98
38_L	67_Q	1.807	0.97
340_E	390_T	1.804	0.97
383_Q	387_Q	1.802	0.97
463_N	467_A	1.792	0.97
80_W	163_F	1.759	0.97
736_Q	740_T	1.756	0.97
568_P	577_I	1.756	0.97
618_W	653_D	1.746	0.97
200_W	236_L	1.744	0.97
11_F	51_T	1.736	0.97
262_F	286_A	1.727	0.96
50_K	54_D	1.721	0.96
462_Q	466_N	1.717	0.96
425_L	598_Q	1.713	0.96
75_A	108_S	1.709	0.96
538_V	595_A	1.705	0.96
579_F	627_E	1.694	0.96
496_E	522_R	1.692	0.96
475_I	479_L	1.690	0.96
466_N	539_K	1.679	0.96
46_L	149_Y	1.677	0.96
78_F	189_L	1.669	0.96
416_E	638_N	1.661	0.96
303_L	360_L	1.656	0.95
286_A	309_I	1.656	0.95
430_L	754_A	1.655	0.95
34_K	38_L	1.654	0.95
505_F	530_V	1.652	0.95
201_V	233_L	1.650	0.95
8_N	61_P	1.635	0.95
212_S	216_V	1.632	0.95
659_N	688_K	1.626	0.95
187_V	226_I	1.626	0.95
449_Q	453_K	1.614	0.95
279_P	282_K	1.612	0.95
335_P	510_Y	1.610	0.95
593_E	636_V	1.608	0.95
85_F	105_A	1.605	0.95
174_E	177_A	1.603	0.95
474_D	478_E	1.601	0.95
564_N	605_P	1.595	0.94
543_Y	547_L	1.589	0.94
238_Q	259_G	1.586	0.94
334_H	351_K	1.585	0.94
81_I	98_I	1.571	0.94
58_D	361_K	1.566	0.94
720_P	723_R	1.563	0.94
447_A	464_F	1.555	0.94
736_Q	742_A	1.554	0.94
139_L	192_E	1.543	0.93
590_K	635_S	1.529	0.93
586_R	635_S	1.528	0.93
378_A	382_I	1.521	0.93
290_D	570_N	1.503	0.92
39_K	43_E	1.496	0.92
6_T	357_L	1.495	0.92
265_D	269_N	1.480	0.92
705_T	753_Q	1.478	0.92
702_V	736_Q	1.467	0.91
97_A	102_I	1.466	0.91
472_W	489_F	1.462	0.91
168_K	676_G	1.456	0.91
22_K	26_A	1.455	0.91
135_R	139_L	1.455	0.91
310_L	318_L	1.452	0.91
181_R	184_P	1.442	0.91
675_G	711_I	1.435	0.91
209_V	239_T	1.433	0.90
416_E	419_A	1.433	0.90
444_V	489_F	1.433	0.90
216_V	219_A	1.425	0.90
568_P	573_S	1.421	0.90
212_S	219_A	1.421	0.90
136_N	192_E	1.420	0.90
367_G	371_I	1.414	0.90
532_F	591_A	1.412	0.90
6_T	320_I	1.399	0.89
394_S	398_K	1.393	0.89
607_L	649_S	1.392	0.89
274_K	309_I	1.383	0.89
333_K	344_L	1.383	0.89
403_L	407_D	1.383	0.89
207_A	210_T	1.382	0.89
162_T	207_A	1.381	0.89
307_L	368_K	1.377	0.89
74_T	78_F	1.377	0.89
16_L	47_S	1.374	0.88
66_T	95_Y	1.373	0.88
220_K	224_E	1.372	0.88
42_D	148_E	1.370	0.88
460_Q	463_N	1.365	0.88
170_Y	674_H	1.364	0.88
74_T	77_S	1.361	0.88
470_K	543_Y	1.353	0.88
408_F	627_E	1.353	0.88
578_A	624_W	1.352	0.88
408_F	631_L	1.352	0.88
719_C	724_F	1.345	0.87
572_I	576_E	1.339	0.87
237_L	250_L	1.338	0.87
589_V	602_V	1.337	0.87
242_D	614_K	1.334	0.87
17_N	510_Y	1.327	0.87
8_N	354_L	1.324	0.87
43_E	47_S	1.320	0.86
220_K	252_S	1.314	0.86
50_K	53_I	1.307	0.86
187_V	225_S	1.306	0.86
184_P	225_S	1.306	0.86
257_G	283_V	1.303	0.86
81_I	134_T	1.300	0.86
306_V	320_I	1.295	0.85
590_K	636_V	1.294	0.85
246_A	250_L	1.293	0.85
543_Y	546_S	1.285	0.85
471_R	475_I	1.280	0.85
57_I	354_L	1.280	0.85
77_S	138_Q	1.279	0.85
306_V	364_L	1.278	0.85
133_L	185_L	1.275	0.84
605_P	632_T	1.274	0.84
332_A	335_P	1.270	0.84
80_W	131_F	1.267	0.84
46_L	50_K	1.263	0.84
130_E	181_R	1.261	0.84
478_E	745_K	1.252	0.83
503_A	531_E	1.252	0.83
179_Q	222_L	1.252	0.83
180_K	225_S	1.251	0.83
339_L	508_T	1.249	0.83
574_R	610_G	1.246	0.83
178_I	181_R	1.244	0.83
473_I	547_L	1.243	0.83
125_Y	178_I	1.241	0.83
359_A	375_I	1.235	0.82
400_L	403_L	1.234	0.82
273_L	309_I	1.234	0.82
706_E	710_N	1.229	0.82
61_P	156_V	1.228	0.82
469_T	489_F	1.228	0.82
562_I	581_I	1.226	0.82
478_E	741_V	1.225	0.82
408_F	579_F	1.224	0.82
23_A	40_Q	1.224	0.82
452_R	496_E	1.222	0.82
749_E	753_Q	1.222	0.82
274_K	308_D	1.220	0.82
262_F	269_N	1.217	0.81
278_F	282_K	1.217	0.81
254_P	282_K	1.216	0.81
49_V	149_Y	1.216	0.81
60_V	151_V	1.211	0.81
17_N	335_P	1.207	0.81
579_F	631_L	1.206	0.81
6_T	361_K	1.205	0.81
620_E	623_T	1.205	0.81
84_R	124_E	1.205	0.81
143_R	146_K	1.201	0.81
104_D	701_R	1.197	0.80
593_E	640_T	1.196	0.80
568_P	572_I	1.196	0.80
8_N	57_I	1.193	0.80
26_A	32_T	1.191	0.80
7_S	154_K	1.191	0.80
236_L	257_G	1.185	0.80
456_W	460_Q	1.185	0.80
560_V	578_A	1.183	0.80
211_A	616_R	1.183	0.80
419_A	423_E	1.182	0.80
42_D	144_R	1.179	0.79
79_N	86_R	1.176	0.79
63_S	153_T	1.174	0.79
711_I	715_A	1.171	0.79
479_L	745_K	1.171	0.79
403_L	408_F	1.171	0.79
358_T	362_E	1.171	0.79
409_K	630_R	1.169	0.79
6_T	57_I	1.168	0.79
345_N	381_D	1.168	0.79
77_S	139_L	1.168	0.79
283_V	319_W	1.165	0.79
715_A	724_F	1.163	0.78
227_T	256_Q	1.160	0.78
306_V	360_L	1.159	0.78
266_K	269_N	1.158	0.78
378_A	381_D	1.151	0.78
430_L	751_A	1.150	0.78
142_Y	196_E	1.147	0.77
535_P	591_A	1.141	0.77
242_D	617_D	1.139	0.77
466_N	543_Y	1.138	0.77
627_E	631_L	1.137	0.77
705_T	709_Y	1.132	0.77
398_K	402_Q	1.131	0.76
79_N	132_R	1.127	0.76
294_I	525_V	1.125	0.76
303_L	363_G	1.125	0.76
61_P	155_P	1.124	0.76
315_V	318_L	1.123	0.76
299_L	359_A	1.120	0.76
250_L	258_I	1.117	0.76
602_V	632_T	1.114	0.75
357_L	361_K	1.112	0.75
169_G	175_A	1.112	0.75
11_F	350_A	1.111	0.75
32_T	36_T	1.108	0.75
702_V	738_E	1.107	0.75
463_N	466_N	1.103	0.75
289_I	302_R	1.103	0.75
414_F	689_G	1.099	0.74
97_A	103_K	1.092	0.74
73_D	95_Y	1.090	0.74
551_H	598_Q	1.090	0.74
413_P	416_E	1.086	0.73
467_A	470_K	1.086	0.73
71_V	162_T	1.084	0.73
749_E	752_K	1.070	0.72
650_N	676_G	1.069	0.72
605_P	649_S	1.067	0.72
452_R	522_R	1.067	0.72
675_G	715_A	1.064	0.72
111_T	676_G	1.064	0.72
288_V	302_R	1.063	0.72
97_A	701_R	1.057	0.71
712_I	754_A	1.057	0.71
62_V	142_Y	1.055	0.71
190_L	203_I	1.054	0.71
213_S	216_V	1.052	0.71
418_L	723_R	1.049	0.71
80_W	125_Y	1.046	0.71
465_I	469_T	1.046	0.71
363_G	367_G	1.045	0.71
589_V	632_T	1.045	0.71
259_G	285_A	1.045	0.71
424_S	639_E	1.045	0.71
131_F	182_L	1.045	0.71
372_S	376_Q	1.038	0.70
430_L	721_T	1.037	0.70
241_F	324_S	1.036	0.70
76_V	95_Y	1.032	0.70
359_A	371_I	1.029	0.69
35_D	39_K	1.029	0.69
702_V	742_A	1.027	0.69
194_E	232_S	1.024	0.69
708_M	751_A	1.024	0.69
659_N	687_L	1.023	0.69
154_K	319_W	1.019	0.69
212_S	217_R	1.019	0.69
194_E	233_L	1.018	0.68
289_I	357_L	1.018	0.68
23_A	37_F	1.018	0.68
126_D	129_I	1.017	0.68
63_S	138_Q	1.016	0.68
656_D	660_D	1.014	0.68
165_T	207_A	1.010	0.68
501_K	534_E	1.009	0.68
61_P	151_V	1.007	0.68
29_K	736_Q	1.006	0.68
299_L	360_L	1.005	0.67
547_L	551_H	1.002	0.67
451_W	456_W	1.002	0.67
161_Y	222_L	1.002	0.67
46_L	144_R	1.001	0.67
89_T	94_T	0.999	0.67
42_D	45_F	0.996	0.67
185_L	188_Q	0.995	0.67
79_N	134_T	0.992	0.66
751_A	755_R	0.991	0.66
127_E	171_E	0.990	0.66
539_K	542_V	0.987	0.66
505_F	581_I	0.987	0.66
618_W	654_I	0.987	0.66
702_V	740_T	0.985	0.66
342_D	390_T	0.984	0.66
264_H	290_D	0.976	0.65
40_Q	43_E	0.976	0.65
563_L	578_A	0.974	0.65
247_Y	273_L	0.974	0.65
183_V	222_L	0.973	0.65
108_S	163_F	0.969	0.65
529_D	580_Q	0.967	0.64
709_Y	713_V	0.966	0.64
268_R	271_E	0.962	0.64
444_V	464_F	0.962	0.64
299_L	363_G	0.962	0.64
342_D	384_A	0.962	0.64
430_L	716_L	0.956	0.64
241_F	325_S	0.953	0.63
13_R	70_H	0.952	0.63
564_N	610_G	0.952	0.63
653_D	743_A	0.952	0.63
534_E	539_K	0.950	0.63
583_L	631_L	0.949	0.63
247_Y	251_I	0.947	0.63
467_A	471_R	0.947	0.63
162_T	165_T	0.945	0.63
477_E	484_L	0.944	0.63
102_I	701_R	0.941	0.62
13_R	514_Q	0.941	0.62
481_L	550_K	0.939	0.62
63_S	141_D	0.939	0.62
138_Q	142_Y	0.936	0.62
53_I	151_V	0.932	0.62
564_N	574_R	0.929	0.61
342_D	388_F	0.929	0.61
208_L	237_L	0.927	0.61
34_K	92_T	0.925	0.61
32_T	40_Q	0.924	0.61
521_V	524_P	0.922	0.61
73_D	137_K	0.919	0.60
212_S	215_D	0.916	0.60
503_A	533_I	0.916	0.60
142_Y	193_L	0.914	0.60
200_W	257_G	0.913	0.60
335_P	352_E	0.913	0.60
239_T	244_V	0.913	0.60
244_V	260_L	0.907	0.59
85_F	98_I	0.906	0.59
23_A	32_T	0.906	0.59
289_I	360_L	0.904	0.59
376_Q	380_A	0.903	0.59
135_R	185_L	0.903	0.59
247_Y	278_F	0.903	0.59
109_E	676_G	0.901	0.59
299_L	378_A	0.897	0.59
418_L	422_N	0.897	0.59
71_V	163_F	0.894	0.58
362_E	371_I	0.890	0.58
532_F	587_K	0.890	0.58
200_W	234_N	0.888	0.58
260_L	273_L	0.886	0.58
180_K	184_P	0.885	0.58
497_Y	540_D	0.884	0.57
420_L	423_E	0.883	0.57
61_P	153_T	0.883	0.57
540_D	678_L	0.881	0.57
575_K	579_F	0.881	0.57
165_T	210_T	0.880	0.57
75_A	80_W	0.879	0.57
362_E	366_S	0.879	0.57
444_V	465_I	0.878	0.57
708_M	747_M	0.877	0.57
371_I	375_I	0.876	0.57
75_A	167_A	0.874	0.57
14_I	520_C	0.874	0.57
146_K	152_E	0.873	0.56
598_Q	639_E	0.872	0.56
355_A	358_T	0.870	0.56
37_F	41_I	0.868	0.56
593_E	637_K	0.868	0.56
169_G	173_S	0.867	0.56
188_Q	192_E	0.867	0.56
695_Y	743_A	0.865	0.56
659_N	684_H	0.863	0.56
198_V	201_V	0.862	0.56
192_E	196_E	0.862	0.56
618_W	671_S	0.861	0.55
611_L	622_L	0.859	0.55
385_L	570_N	0.858	0.55
411_P	638_N	0.854	0.55
265_D	268_R	0.853	0.55
345_N	384_A	0.851	0.55
541_T	585_L	0.849	0.54
508_T	525_V	0.848	0.54
373_E	377_Q	0.847	0.54
618_W	689_G	0.846	0.54
260_L	286_A	0.846	0.54
133_L	189_L	0.846	0.54
9_L	238_Q	0.846	0.54
83_K	126_D	0.845	0.54
154_K	496_E	0.842	0.54
94_T	134_T	0.842	0.54
692_L	724_F	0.840	0.54
215_D	218_G	0.839	0.53
11_F	48_A	0.837	0.53
475_I	478_E	0.837	0.53
590_K	593_E	0.833	0.53
396_Q	529_D	0.833	0.53
579_F	628_A	0.833	0.53
81_I	94_T	0.831	0.53
236_L	259_G	0.829	0.53
11_F	148_E	0.828	0.53
57_I	61_P	0.826	0.52
407_D	631_L	0.826	0.52
307_L	311_S	0.826	0.52
469_T	541_T	0.826	0.52
194_E	231_S	0.826	0.52
57_I	60_V	0.825	0.52
77_S	135_R	0.823	0.52
285_A	319_W	0.822	0.52
260_L	277_G	0.822	0.52
135_R	140_E	0.821	0.52
541_T	552_V	0.820	0.52
285_A	321_Q	0.819	0.52
403_L	631_L	0.819	0.52
388_F	392_A	0.818	0.52
414_F	723_R	0.817	0.52
165_T	216_V	0.814	0.51
111_T	715_A	0.814	0.51
354_L	564_N	0.813	0.51
71_V	74_T	0.812	0.51
632_T	661_L	0.812	0.51
125_Y	163_F	0.812	0.51
400_L	579_F	0.810	0.51
134_T	139_L	0.809	0.51
269_N	272_Q	0.808	0.51
510_Y	520_C	0.807	0.51
161_Y	207_A	0.807	0.51
361_K	365_V	0.806	0.51
310_L	315_V	0.806	0.51
405_D	409_K	0.805	0.50
395_E	531_E	0.805	0.50
139_L	143_R	0.803	0.50
85_F	97_A	0.803	0.50
77_S	133_L	0.801	0.50
706_E	753_Q	0.801	0.50
66_T	137_K	0.800	0.50
155_P	198_V	0.800	0.50
78_F	163_F	0.792	0.49
154_K	667_T	0.791	0.49
471_R	737_Q	0.789	0.49
649_S	668_I	0.787	0.49
442_A	736_Q	0.786	0.49
251_I	277_G	0.784	0.49
8_N	321_Q	0.782	0.48
111_T	168_K	0.781	0.48
371_I	374_E	0.781	0.48
74_T	163_F	0.781	0.48
302_R	320_I	0.779	0.48
412_I	416_E	0.778	0.48
296_K	333_K	0.777	0.48
81_I	207_A	0.777	0.48
575_K	620_E	0.777	0.48
20_W	41_I	0.775	0.48
526_I	581_I	0.774	0.48
346_G	388_F	0.772	0.48
347_L	573_S	0.771	0.47
748_V	751_A	0.771	0.47
527_Y	568_P	0.771	0.47
41_I	96_F	0.770	0.47
131_F	185_L	0.769	0.47
396_Q	583_L	0.767	0.47
359_A	363_G	0.766	0.47
40_Q	44_L	0.764	0.47
164_V	179_Q	0.763	0.47
157_I	203_I	0.761	0.47
303_L	367_G	0.761	0.47
77_S	137_K	0.760	0.46
562_I	585_L	0.758	0.46
667_T	723_R	0.758	0.46
340_E	345_N	0.757	0.46
16_L	331_V	0.757	0.46
677_F	690_L	0.755	0.46
646_M	666_I	0.755	0.46
227_T	254_P	0.754	0.46
190_L	233_L	0.753	0.46
133_L	188_Q	0.753	0.46
167_A	170_Y	0.752	0.46
474_D	550_K	0.750	0.46
160_P	179_Q	0.749	0.46
26_A	31_S	0.748	0.45
345_N	390_T	0.748	0.45
406_K	409_K	0.746	0.45
501_K	540_D	0.744	0.45
607_L	661_L	0.744	0.45
259_G	321_Q	0.743	0.45
248_E	277_G	0.743	0.45
190_L	194_E	0.742	0.45
16_L	332_A	0.740	0.45
164_V	176_K	0.739	0.45
746_N	749_E	0.736	0.44
381_D	384_A	0.736	0.44
367_G	374_E	0.735	0.44
391_G	397_K	0.734	0.44
303_L	364_L	0.734	0.44
161_Y	219_A	0.734	0.44
667_T	716_L	0.734	0.44
192_E	195_E	0.733	0.44
193_L	196_E	0.733	0.44
102_I	105_A	0.732	0.44
135_R	189_L	0.730	0.44
305_A	308_D	0.730	0.44
681_L	684_H	0.729	0.44
427_L	431_P	0.728	0.44
258_I	284_L	0.726	0.43
26_A	29_K	0.726	0.43
709_Y	757_Q	0.726	0.43
134_T	192_E	0.726	0.43
140_E	192_E	0.725	0.43
499_G	555_M	0.725	0.43
78_F	133_L	0.724	0.43
346_G	391_G	0.724	0.43
94_T	98_I	0.722	0.43
347_L	525_V	0.722	0.43
259_G	286_A	0.721	0.43
429_L	705_T	0.721	0.43
7_S	319_W	0.720	0.43
670_H	675_G	0.720	0.43
443_E	468_E	0.720	0.43
472_W	475_I	0.718	0.43
61_P	327_L	0.717	0.43
418_L	722_D	0.716	0.43
307_L	310_L	0.716	0.43
247_Y	277_G	0.715	0.43
183_V	332_A	0.715	0.43
475_I	737_Q	0.715	0.43
142_Y	146_K	0.714	0.42
380_A	383_Q	0.712	0.42
373_E	376_Q	0.712	0.42
234_N	256_Q	0.712	0.42
450_K	453_K	0.711	0.42
154_K	522_R	0.710	0.42
204_D	327_L	0.708	0.42
610_G	686_Y	0.708	0.42
322_P	354_L	0.706	0.42
605_P	718_V	0.705	0.42
44_L	47_S	0.704	0.42
347_L	527_Y	0.704	0.42
589_V	636_V	0.704	0.42
276_H	282_K	0.704	0.42
208_L	250_L	0.703	0.41
139_L	193_L	0.703	0.41
183_V	187_V	0.703	0.41
415_E	420_L	0.702	0.41
80_W	108_S	0.702	0.41
212_S	218_G	0.701	0.41
694_V	708_M	0.701	0.41
420_L	639_E	0.699	0.41
81_I	85_F	0.699	0.41
300_E	378_A	0.698	0.41
62_V	152_E	0.698	0.41
339_L	506_A	0.698	0.41
51_T	55_Q	0.694	0.41
45_F	141_D	0.693	0.41
667_T	678_L	0.692	0.41
164_V	178_I	0.691	0.40
397_K	576_E	0.691	0.40
91_A	94_T	0.690	0.40
241_F	521_V	0.690	0.40
650_N	653_D	0.690	0.40
67_Q	260_L	0.689	0.40
289_I	705_T	0.689	0.40
111_T	672_R	0.689	0.40
667_T	674_H	0.688	0.40
472_W	737_Q	0.688	0.40
127_E	173_S	0.688	0.40
531_E	552_V	0.687	0.40
183_V	225_S	0.685	0.40
686_Y	690_L	0.684	0.40
74_T	189_L	0.683	0.40
246_A	614_K	0.683	0.40
246_A	259_G	0.683	0.40
589_V	671_S	0.683	0.40
183_V	352_E	0.682	0.40
274_K	286_A	0.681	0.40
52_Q	64_D	0.680	0.40
9_L	259_G	0.680	0.40
670_H	677_F	0.680	0.40
165_T	667_T	0.680	0.40
14_I	649_S	0.679	0.39
337_E	509_K	0.679	0.39
423_E	426_G	0.679	0.39
602_V	642_I	0.675	0.39
168_K	673_S	0.675	0.39
430_L	712_I	0.673	0.39
294_I	507_F	0.673	0.39
109_E	673_S	0.673	0.39
60_V	153_T	0.673	0.39
388_F	391_G	0.672	0.39
88_L	94_T	0.670	0.39
736_Q	739_E	0.669	0.39
414_F	687_L	0.669	0.39
203_I	237_L	0.668	0.39
738_E	741_V	0.668	0.39
347_L	568_P	0.667	0.38
80_W	182_L	0.667	0.38
159_G	205_E	0.667	0.38
403_L	583_L	0.667	0.38
39_K	594_D	0.667	0.38
541_T	605_P	0.665	0.38
8_N	52_Q	0.665	0.38
16_L	335_P	0.665	0.38
105_A	108_S	0.665	0.38
548_T	552_V	0.663	0.38
240_Y	324_S	0.662	0.38
615_T	619_D	0.662	0.38
111_T	122_V	0.661	0.38
111_T	675_G	0.661	0.38
142_Y	199_K	0.660	0.38
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719_C	723_R	0.659	0.38
135_R	192_E	0.657	0.38
573_S	577_I	0.657	0.38
157_I	184_P	0.654	0.37
257_G	319_W	0.653	0.37
590_K	632_T	0.653	0.37
113_W	241_F	0.651	0.37
499_G	526_I	0.651	0.37
349_Y	525_V	0.650	0.37
143_R	192_E	0.650	0.37
465_I	489_F	0.650	0.37
560_V	624_W	0.649	0.37
667_T	726_V	0.648	0.37
346_G	390_T	0.648	0.37
61_P	322_P	0.647	0.37
106_V	701_R	0.647	0.37
682_K	718_V	0.647	0.37
248_E	276_H	0.645	0.37
610_G	681_L	0.645	0.37
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33_D	39_K	0.644	0.37
63_S	661_L	0.644	0.37
243_S	614_K	0.644	0.37
590_K	594_D	0.643	0.36
209_V	242_D	0.642	0.36
474_D	547_L	0.642	0.36
608_R	622_L	0.641	0.36
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429_L	722_D	0.641	0.36
191_K	194_E	0.640	0.36
87_H	90_D	0.640	0.36
11_F	47_S	0.640	0.36
296_K	381_D	0.638	0.36
62_V	154_K	0.638	0.36
251_I	281_D	0.637	0.36
38_L	137_K	0.636	0.36
135_R	141_D	0.636	0.36
42_D	46_L	0.634	0.36
411_P	594_D	0.634	0.36
710_N	717_A	0.632	0.36
93_D	337_E	0.632	0.36
535_P	538_V	0.631	0.35
343_L	527_Y	0.631	0.35
178_I	646_M	0.630	0.35
668_I	681_L	0.630	0.35
585_L	661_L	0.630	0.35
189_L	472_W	0.629	0.35
681_L	686_Y	0.629	0.35
85_F	94_T	0.629	0.35
712_I	750_A	0.629	0.35
716_L	724_F	0.628	0.35
291_G	324_S	0.627	0.35
232_S	256_Q	0.627	0.35
682_K	717_A	0.627	0.35
402_Q	405_D	0.625	0.35
95_Y	99_A	0.624	0.35
52_Q	354_L	0.624	0.35
710_N	722_D	0.623	0.35
237_L	255_V	0.623	0.35
176_K	179_Q	0.621	0.35
238_Q	321_Q	0.620	0.35
276_H	312_I	0.620	0.35
158_V	238_Q	0.620	0.35
327_L	521_V	0.620	0.35
214_E	224_E	0.620	0.35
16_L	48_A	0.619	0.34
499_G	524_P	0.618	0.34
80_W	98_I	0.618	0.34
383_Q	386_K	0.618	0.34
444_V	469_T	0.617	0.34
510_Y	525_V	0.617	0.34
533_I	591_A	0.617	0.34
98_I	121_I	0.617	0.34
238_Q	263_V	0.617	0.34
174_E	215_D	0.616	0.34
84_R	154_K	0.614	0.34
668_I	678_L	0.612	0.34
570_N	577_I	0.612	0.34
526_I	577_I	0.610	0.34
422_N	722_D	0.610	0.34
160_P	203_I	0.609	0.34
224_E	281_D	0.608	0.34
678_L	692_L	0.608	0.34
396_Q	400_L	0.607	0.34
377_Q	380_A	0.606	0.33
74_T	203_I	0.606	0.33
709_Y	754_A	0.605	0.33
203_I	290_D	0.605	0.33
679_D	683_N	0.604	0.33
59_V	319_W	0.604	0.33
541_T	599_I	0.603	0.33
652_E	684_H	0.603	0.33
600_I	640_T	0.603	0.33
63_S	66_T	0.603	0.33
451_W	720_P	0.602	0.33
165_T	213_S	0.602	0.33
203_I	223_F	0.602	0.33
460_Q	464_F	0.602	0.33
38_L	92_T	0.602	0.33
367_G	726_V	0.601	0.33
277_G	281_D	0.601	0.33
98_I	536_M	0.601	0.33
37_F	92_T	0.599	0.33
388_F	397_K	0.598	0.33
508_T	585_L	0.598	0.33
38_L	702_V	0.597	0.33
587_K	591_A	0.595	0.33
426_G	756_A	0.594	0.33
179_Q	219_A	0.594	0.33
706_E	709_Y	0.594	0.33
598_Q	637_K	0.594	0.33
91_A	135_R	0.593	0.32
67_Q	95_Y	0.592	0.32
304_D	368_K	0.592	0.32
388_F	570_N	0.592	0.32
400_L	631_L	0.592	0.32
138_Q	143_R	0.591	0.32
252_S	738_E	0.591	0.32
146_K	153_T	0.591	0.32
104_D	707_E	0.590	0.32
655_V	682_K	0.590	0.32
244_V	247_Y	0.588	0.32
324_S	536_M	0.588	0.32
380_A	384_A	0.588	0.32
24_L	667_T	0.587	0.32
216_V	246_A	0.587	0.32
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458_D	582_G	0.585	0.32
50_K	151_V	0.585	0.32
359_A	374_E	0.585	0.32
674_H	707_E	0.585	0.32
34_K	91_A	0.584	0.32
41_I	63_S	0.583	0.32
289_I	618_W	0.583	0.32
383_Q	712_I	0.583	0.32
332_A	351_K	0.583	0.32
673_S	676_G	0.582	0.32
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250_L	282_K	0.581	0.32
507_F	661_L	0.581	0.32
704_S	746_N	0.581	0.32
115_N	292_R	0.581	0.32
52_Q	322_P	0.581	0.32
35_D	307_L	0.581	0.32
158_V	203_I	0.580	0.31
76_V	98_I	0.580	0.31
633_T	636_V	0.580	0.31
133_L	139_L	0.580	0.31
458_D	539_K	0.580	0.31
511_A	585_L	0.579	0.31
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7_S	59_V	0.577	0.31
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302_R	305_A	0.576	0.31
288_V	300_E	0.576	0.31
83_K	726_V	0.575	0.31
131_F	178_I	0.575	0.31
62_V	155_P	0.575	0.31
94_T	105_A	0.574	0.31
70_H	202_Q	0.574	0.31
138_Q	153_T	0.573	0.31
307_L	367_G	0.573	0.31
63_S	151_V	0.573	0.31
251_I	279_P	0.573	0.31
7_S	321_Q	0.573	0.31
278_F	284_L	0.573	0.31
346_G	570_N	0.573	0.31
29_K	453_K	0.572	0.31
190_L	226_I	0.572	0.31
57_I	358_T	0.572	0.31
483_V	725_W	0.572	0.31
136_N	139_L	0.571	0.31
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88_L	599_I	0.570	0.31
681_L	690_L	0.570	0.31
195_E	409_K	0.570	0.31
692_L	711_I	0.569	0.31
170_Y	173_S	0.569	0.31
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167_A	430_L	0.568	0.31
473_I	541_T	0.567	0.30
97_A	105_A	0.567	0.30
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236_L	285_A	0.565	0.30
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589_V	633_T	0.564	0.30
14_I	331_V	0.564	0.30
585_L	597_I	0.564	0.30
194_E	201_V	0.564	0.30
125_Y	169_G	0.564	0.30
362_E	374_E	0.563	0.30
286_A	306_V	0.563	0.30
57_I	78_F	0.562	0.30
671_S	714_D	0.562	0.30
709_Y	750_A	0.562	0.30
152_E	198_V	0.562	0.30
442_A	446_S	0.562	0.30
48_A	522_R	0.562	0.30
456_W	465_I	0.562	0.30
269_N	274_K	0.561	0.30
269_N	309_I	0.560	0.30
224_E	227_T	0.560	0.30
481_L	564_N	0.560	0.30
297_A	363_G	0.560	0.30
138_Q	198_V	0.560	0.30
125_Y	129_I	0.559	0.30
259_G	737_Q	0.557	0.30
262_F	309_I	0.557	0.30
472_W	541_T	0.557	0.30
676_G	715_A	0.557	0.30
153_T	198_V	0.557	0.30
608_R	611_L	0.556	0.30
362_E	474_D	0.556	0.30
726_V	754_A	0.556	0.30
274_K	312_I	0.555	0.30
77_S	189_L	0.555	0.30
66_T	605_P	0.555	0.30
60_V	149_Y	0.555	0.30
209_V	243_S	0.554	0.29
131_F	176_K	0.553	0.29
655_V	680_Y	0.553	0.29
506_A	526_I	0.553	0.29
74_T	716_L	0.553	0.29
108_S	701_R	0.552	0.29
667_T	719_C	0.551	0.29
368_K	371_I	0.551	0.29
192_E	530_V	0.551	0.29
260_L	354_L	0.551	0.29
349_Y	508_T	0.551	0.29
334_H	344_L	0.551	0.29
375_I	379_K	0.550	0.29
382_I	385_L	0.549	0.29
36_T	39_K	0.549	0.29
341_K	394_S	0.549	0.29
143_R	198_V	0.549	0.29
244_V	273_L	0.549	0.29
52_Q	154_K	0.548	0.29
749_E	757_Q	0.548	0.29
74_T	158_V	0.547	0.29
135_R	138_Q	0.547	0.29
409_K	634_S	0.547	0.29
363_G	375_I	0.547	0.29
654_I	666_I	0.547	0.29
424_S	551_H	0.547	0.29
386_K	416_E	0.546	0.29
116_T	324_S	0.545	0.29
187_V	228_S	0.545	0.29
48_A	64_D	0.545	0.29
33_D	376_Q	0.545	0.29
156_V	202_Q	0.545	0.29
44_L	198_V	0.545	0.29
636_V	642_I	0.545	0.29
213_S	373_E	0.545	0.29
14_I	318_L	0.544	0.29
95_Y	575_K	0.543	0.29
9_L	321_Q	0.543	0.29
334_H	352_E	0.543	0.29
243_S	268_R	0.543	0.29
529_D	569_R	0.543	0.29
97_A	108_S	0.542	0.29
247_Y	276_H	0.542	0.29
456_W	511_A	0.542	0.29
97_A	104_D	0.542	0.29
697_I	701_R	0.541	0.29
114_F	162_T	0.541	0.29
20_W	532_F	0.541	0.29
77_S	141_D	0.540	0.28
351_K	740_T	0.540	0.28
46_L	419_A	0.540	0.28
76_V	94_T	0.540	0.28
407_D	578_A	0.540	0.28
366_S	374_E	0.539	0.28
677_F	686_Y	0.539	0.28
444_V	740_T	0.539	0.28
5_K	59_V	0.539	0.28
163_F	167_A	0.539	0.28
409_K	627_E	0.538	0.28
83_K	377_Q	0.537	0.28
81_I	252_S	0.537	0.28
244_V	251_I	0.537	0.28
129_I	181_R	0.536	0.28
80_W	129_I	0.536	0.28
300_E	348_S	0.536	0.28
283_V	317_E	0.535	0.28
542_V	595_A	0.535	0.28
505_F	508_T	0.534	0.28
85_F	511_A	0.534	0.28
375_I	581_I	0.534	0.28
298_D	382_I	0.533	0.28
552_V	756_A	0.533	0.28
320_I	481_L	0.533	0.28
26_A	46_L	0.533	0.28
593_E	630_R	0.532	0.28
464_F	468_E	0.531	0.28
503_A	525_V	0.531	0.28
563_L	624_W	0.531	0.28
7_S	165_T	0.530	0.28
574_R	581_I	0.530	0.28
9_L	156_V	0.530	0.28
541_T	548_T	0.530	0.28
374_E	378_A	0.530	0.28
426_G	752_K	0.530	0.28
702_V	741_V	0.529	0.28
139_L	142_Y	0.529	0.28
373_E	380_A	0.529	0.28
679_D	718_V	0.529	0.28
95_Y	695_Y	0.528	0.28
239_T	243_S	0.528	0.28
530_V	542_V	0.528	0.28
225_S	228_S	0.528	0.28
713_V	754_A	0.528	0.28
646_M	681_L	0.528	0.28
285_A	737_Q	0.528	0.28
496_E	666_I	0.527	0.28
451_W	465_I	0.527	0.28
543_Y	560_V	0.526	0.27
74_T	581_I	0.526	0.27
337_E	510_Y	0.526	0.27
296_K	300_E	0.526	0.27
564_N	577_I	0.526	0.27
499_G	564_N	0.526	0.27
605_P	679_D	0.525	0.27
26_A	44_L	0.525	0.27
320_I	474_D	0.525	0.27
242_D	269_N	0.525	0.27
320_I	361_K	0.525	0.27
67_Q	73_D	0.525	0.27
175_A	179_Q	0.524	0.27
281_D	317_E	0.523	0.27
42_D	630_R	0.523	0.27
653_D	670_H	0.523	0.27
751_A	754_A	0.523	0.27
8_N	712_I	0.523	0.27
678_L	714_D	0.522	0.27
54_D	552_V	0.521	0.27
385_L	391_G	0.521	0.27
462_Q	465_I	0.521	0.27
656_D	683_N	0.521	0.27
442_A	481_L	0.521	0.27
284_L	342_D	0.521	0.27
564_N	649_S	0.521	0.27
26_A	188_Q	0.520	0.27
220_K	284_L	0.520	0.27
675_G	692_L	0.520	0.27
630_R	634_S	0.519	0.27
405_D	627_E	0.519	0.27
444_V	667_T	0.519	0.27
46_L	49_V	0.519	0.27
246_A	273_L	0.519	0.27
48_A	52_Q	0.518	0.27
177_A	628_A	0.518	0.27
444_V	471_R	0.518	0.27
165_T	444_V	0.518	0.27
296_K	751_A	0.518	0.27
423_E	442_A	0.517	0.27
63_S	524_P	0.517	0.27
246_A	249_E	0.517	0.27
179_Q	183_V	0.516	0.27
243_S	265_D	0.516	0.27
530_V	707_E	0.515	0.27
677_F	719_C	0.515	0.27
602_V	684_H	0.515	0.27
131_F	577_I	0.514	0.27
220_K	717_A	0.514	0.27
499_G	541_T	0.514	0.27
647_C	730_C	0.514	0.27
411_P	602_V	0.514	0.27
627_E	660_D	0.513	0.27
128_S	228_S	0.513	0.27
327_L	514_Q	0.513	0.27
562_I	577_I	0.513	0.27
236_L	324_S	0.512	0.26
653_D	667_T	0.512	0.26
652_E	677_F	0.512	0.26
131_F	184_P	0.512	0.26
669_E	696_D	0.511	0.26
608_R	613_L	0.511	0.26
290_D	388_F	0.510	0.26
276_H	419_A	0.510	0.26
110_M	705_T	0.509	0.26
347_L	572_I	0.509	0.26
568_P	575_K	0.509	0.26
420_L	638_N	0.509	0.26
668_I	690_L	0.508	0.26
646_M	651_F	0.508	0.26
67_Q	92_T	0.508	0.26
381_D	385_L	0.508	0.26
60_V	521_V	0.508	0.26
161_Y	288_V	0.507	0.26
447_A	460_Q	0.507	0.26
602_V	685_P	0.507	0.26
189_L	193_L	0.507	0.26
681_L	714_D	0.507	0.26
257_G	538_V	0.506	0.26
447_A	468_E	0.506	0.26
303_L	371_I	0.506	0.26
138_Q	163_F	0.506	0.26
41_I	139_L	0.506	0.26
337_E	712_I	0.506	0.26
63_S	521_V	0.505	0.26
475_I	602_V	0.505	0.26
564_N	632_T	0.505	0.26
590_K	633_T	0.505	0.26
195_E	534_E	0.505	0.26
132_R	188_Q	0.505	0.26
66_T	242_D	0.505	0.26
146_K	752_K	0.505	0.26
398_K	704_S	0.505	0.26
7_S	97_A	0.504	0.26
463_N	470_K	0.504	0.26
348_S	631_L	0.503	0.26
20_W	66_T	0.503	0.26
304_D	398_K	0.503	0.26
30_G	749_E	0.502	0.26
270_L	274_K	0.502	0.26
80_W	269_N	0.501	0.26
394_S	413_P	0.501	0.26
57_I	357_L	0.501	0.26
125_Y	162_T	0.501	0.26
319_W	496_E	0.501	0.26
102_I	108_S	0.500	0.26
745_K	749_E	0.500	0.26
638_N	659_N	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l6hA	1	0.9724	100	0.326	Contact Map
1t7lA	1	0.9567	100	0.328	Contact Map
1u1jA	1	0.9646	100	0.337	Contact Map
2nq5A	1	0.9239	100	0.357	Contact Map
3rpdA	1	0.4252	100	0.753	Contact Map
1ypxA	1	0.3871	100	0.756	Contact Map
2infA	2	0.4108	99.9	0.936	Contact Map
2ejaA	2	0.4003	99.9	0.937	Contact Map
1j93A	2	0.4081	99.9	0.939	Contact Map
4zr8A	2	0.4147	99.9	0.942	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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