GREMLIN Database
METE - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
UniProt: P80877 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 762 (745)
Sequences: 1678 (1024)
Seq/√Len: 37.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
473_I552_V6.5151.00
399_E587_K5.0331.00
75_A163_F4.8441.00
332_A352_E4.7631.00
470_K474_D4.7611.00
297_A302_R4.6851.00
125_Y167_A4.5941.00
572_I577_I4.2051.00
457_S460_Q3.9141.00
62_V153_T3.8541.00
71_V158_V3.8201.00
712_I726_V3.8151.00
709_Y753_Q3.7641.00
713_V757_Q3.7561.00
602_V633_T3.6661.00
27_Y93_D3.5711.00
462_Q539_K3.5591.00
33_D36_T3.5141.00
505_F562_I3.4901.00
424_S598_Q3.3861.00
300_E379_K3.3081.00
412_I638_N3.3041.00
501_K536_M3.2711.00
136_N140_E3.2361.00
738_E742_A3.0941.00
137_K141_D3.0641.00
451_W458_D3.0221.00
142_Y198_V3.0011.00
450_K455_E2.9981.00
143_R196_E2.9771.00
45_F144_R2.9211.00
8_N322_P2.8981.00
66_T73_D2.8231.00
244_V250_L2.7731.00
142_Y152_E2.7221.00
190_L201_V2.7061.00
41_I67_Q2.6451.00
338_H509_K2.6391.00
180_K221_E2.6131.00
343_L506_A2.6081.00
470_K547_L2.6021.00
158_V162_T2.5951.00
425_L599_I2.5421.00
363_G371_I2.4641.00
289_I297_A2.4221.00
70_H158_V2.3931.00
458_D462_Q2.3671.00
615_T618_W2.3481.00
701_R707_E2.3111.00
480_E752_K2.2760.99
152_E199_K2.2670.99
578_A628_A2.2400.99
652_E680_Y2.2360.99
446_S450_K2.2260.99
78_F185_L2.2260.99
44_L48_A2.2140.99
199_K234_N2.1840.99
139_L189_L2.1710.99
530_V581_I2.1530.99
475_I741_V2.1470.99
422_N689_G2.1460.99
619_D623_T2.1440.99
705_T749_E2.1430.99
414_F418_L2.1350.99
78_F182_L2.1140.99
24_L518_S2.1060.99
393_N503_A2.1010.99
34_K93_D2.0960.99
322_P357_L2.0720.99
705_T746_N2.0640.99
393_N531_E2.0450.99
98_I108_S2.0450.99
11_F351_K2.0430.99
346_G385_L2.0190.99
541_T597_I2.0160.99
63_S137_K2.0080.99
468_E471_R2.0080.99
108_S121_I1.9950.99
288_V306_V1.9830.99
139_L196_E1.9790.99
27_Y34_K1.9760.98
142_Y153_T1.9720.98
499_G507_F1.9700.98
211_A614_K1.9640.98
109_E168_K1.9350.98
605_P661_L1.9260.98
115_N264_H1.9190.98
447_A456_W1.9160.98
157_I189_L1.9120.98
296_K378_A1.8990.98
59_V154_K1.8970.98
447_A465_I1.8950.98
404_T407_D1.8950.98
480_E550_K1.8930.98
392_A397_K1.8870.98
51_T351_K1.8860.98
156_V204_D1.8770.98
298_D301_E1.8720.98
716_L721_T1.8690.98
741_V745_K1.8590.98
585_L605_P1.8570.98
418_L689_G1.8560.98
320_I357_L1.8550.98
623_T627_E1.8500.98
483_V599_I1.8380.98
38_L67_Q1.8070.97
340_E390_T1.8040.97
383_Q387_Q1.8020.97
463_N467_A1.7920.97
80_W163_F1.7590.97
736_Q740_T1.7560.97
568_P577_I1.7560.97
618_W653_D1.7460.97
200_W236_L1.7440.97
11_F51_T1.7360.97
262_F286_A1.7270.96
50_K54_D1.7210.96
462_Q466_N1.7170.96
425_L598_Q1.7130.96
75_A108_S1.7090.96
538_V595_A1.7050.96
579_F627_E1.6940.96
496_E522_R1.6920.96
475_I479_L1.6900.96
466_N539_K1.6790.96
46_L149_Y1.6770.96
78_F189_L1.6690.96
416_E638_N1.6610.96
303_L360_L1.6560.95
286_A309_I1.6560.95
430_L754_A1.6550.95
34_K38_L1.6540.95
505_F530_V1.6520.95
201_V233_L1.6500.95
8_N61_P1.6350.95
212_S216_V1.6320.95
659_N688_K1.6260.95
187_V226_I1.6260.95
449_Q453_K1.6140.95
279_P282_K1.6120.95
335_P510_Y1.6100.95
593_E636_V1.6080.95
85_F105_A1.6050.95
174_E177_A1.6030.95
474_D478_E1.6010.95
564_N605_P1.5950.94
543_Y547_L1.5890.94
238_Q259_G1.5860.94
334_H351_K1.5850.94
81_I98_I1.5710.94
58_D361_K1.5660.94
720_P723_R1.5630.94
447_A464_F1.5550.94
736_Q742_A1.5540.94
139_L192_E1.5430.93
590_K635_S1.5290.93
586_R635_S1.5280.93
378_A382_I1.5210.93
290_D570_N1.5030.92
39_K43_E1.4960.92
6_T357_L1.4950.92
265_D269_N1.4800.92
705_T753_Q1.4780.92
702_V736_Q1.4670.91
97_A102_I1.4660.91
472_W489_F1.4620.91
168_K676_G1.4560.91
22_K26_A1.4550.91
135_R139_L1.4550.91
310_L318_L1.4520.91
181_R184_P1.4420.91
675_G711_I1.4350.91
209_V239_T1.4330.90
416_E419_A1.4330.90
444_V489_F1.4330.90
216_V219_A1.4250.90
568_P573_S1.4210.90
212_S219_A1.4210.90
136_N192_E1.4200.90
367_G371_I1.4140.90
532_F591_A1.4120.90
6_T320_I1.3990.89
394_S398_K1.3930.89
607_L649_S1.3920.89
274_K309_I1.3830.89
333_K344_L1.3830.89
403_L407_D1.3830.89
207_A210_T1.3820.89
162_T207_A1.3810.89
307_L368_K1.3770.89
74_T78_F1.3770.89
16_L47_S1.3740.88
66_T95_Y1.3730.88
220_K224_E1.3720.88
42_D148_E1.3700.88
460_Q463_N1.3650.88
170_Y674_H1.3640.88
74_T77_S1.3610.88
470_K543_Y1.3530.88
408_F627_E1.3530.88
578_A624_W1.3520.88
408_F631_L1.3520.88
719_C724_F1.3450.87
572_I576_E1.3390.87
237_L250_L1.3380.87
589_V602_V1.3370.87
242_D614_K1.3340.87
17_N510_Y1.3270.87
8_N354_L1.3240.87
43_E47_S1.3200.86
220_K252_S1.3140.86
50_K53_I1.3070.86
187_V225_S1.3060.86
184_P225_S1.3060.86
257_G283_V1.3030.86
81_I134_T1.3000.86
306_V320_I1.2950.85
590_K636_V1.2940.85
246_A250_L1.2930.85
543_Y546_S1.2850.85
471_R475_I1.2800.85
57_I354_L1.2800.85
77_S138_Q1.2790.85
306_V364_L1.2780.85
133_L185_L1.2750.84
605_P632_T1.2740.84
332_A335_P1.2700.84
80_W131_F1.2670.84
46_L50_K1.2630.84
130_E181_R1.2610.84
478_E745_K1.2520.83
503_A531_E1.2520.83
179_Q222_L1.2520.83
180_K225_S1.2510.83
339_L508_T1.2490.83
574_R610_G1.2460.83
178_I181_R1.2440.83
473_I547_L1.2430.83
125_Y178_I1.2410.83
359_A375_I1.2350.82
400_L403_L1.2340.82
273_L309_I1.2340.82
706_E710_N1.2290.82
61_P156_V1.2280.82
469_T489_F1.2280.82
562_I581_I1.2260.82
478_E741_V1.2250.82
408_F579_F1.2240.82
23_A40_Q1.2240.82
452_R496_E1.2220.82
749_E753_Q1.2220.82
274_K308_D1.2200.82
262_F269_N1.2170.81
278_F282_K1.2170.81
254_P282_K1.2160.81
49_V149_Y1.2160.81
60_V151_V1.2110.81
17_N335_P1.2070.81
579_F631_L1.2060.81
6_T361_K1.2050.81
620_E623_T1.2050.81
84_R124_E1.2050.81
143_R146_K1.2010.81
104_D701_R1.1970.80
593_E640_T1.1960.80
568_P572_I1.1960.80
8_N57_I1.1930.80
26_A32_T1.1910.80
7_S154_K1.1910.80
236_L257_G1.1850.80
456_W460_Q1.1850.80
560_V578_A1.1830.80
211_A616_R1.1830.80
419_A423_E1.1820.80
42_D144_R1.1790.79
79_N86_R1.1760.79
63_S153_T1.1740.79
711_I715_A1.1710.79
479_L745_K1.1710.79
403_L408_F1.1710.79
358_T362_E1.1710.79
409_K630_R1.1690.79
6_T57_I1.1680.79
345_N381_D1.1680.79
77_S139_L1.1680.79
283_V319_W1.1650.79
715_A724_F1.1630.78
227_T256_Q1.1600.78
306_V360_L1.1590.78
266_K269_N1.1580.78
378_A381_D1.1510.78
430_L751_A1.1500.78
142_Y196_E1.1470.77
535_P591_A1.1410.77
242_D617_D1.1390.77
466_N543_Y1.1380.77
627_E631_L1.1370.77
705_T709_Y1.1320.77
398_K402_Q1.1310.76
79_N132_R1.1270.76
294_I525_V1.1250.76
303_L363_G1.1250.76
61_P155_P1.1240.76
315_V318_L1.1230.76
299_L359_A1.1200.76
250_L258_I1.1170.76
602_V632_T1.1140.75
357_L361_K1.1120.75
169_G175_A1.1120.75
11_F350_A1.1110.75
32_T36_T1.1080.75
702_V738_E1.1070.75
463_N466_N1.1030.75
289_I302_R1.1030.75
414_F689_G1.0990.74
97_A103_K1.0920.74
73_D95_Y1.0900.74
551_H598_Q1.0900.74
413_P416_E1.0860.73
467_A470_K1.0860.73
71_V162_T1.0840.73
749_E752_K1.0700.72
650_N676_G1.0690.72
605_P649_S1.0670.72
452_R522_R1.0670.72
675_G715_A1.0640.72
111_T676_G1.0640.72
288_V302_R1.0630.72
97_A701_R1.0570.71
712_I754_A1.0570.71
62_V142_Y1.0550.71
190_L203_I1.0540.71
213_S216_V1.0520.71
418_L723_R1.0490.71
80_W125_Y1.0460.71
465_I469_T1.0460.71
363_G367_G1.0450.71
589_V632_T1.0450.71
259_G285_A1.0450.71
424_S639_E1.0450.71
131_F182_L1.0450.71
372_S376_Q1.0380.70
430_L721_T1.0370.70
241_F324_S1.0360.70
76_V95_Y1.0320.70
359_A371_I1.0290.69
35_D39_K1.0290.69
702_V742_A1.0270.69
194_E232_S1.0240.69
708_M751_A1.0240.69
659_N687_L1.0230.69
154_K319_W1.0190.69
212_S217_R1.0190.69
194_E233_L1.0180.68
289_I357_L1.0180.68
23_A37_F1.0180.68
126_D129_I1.0170.68
63_S138_Q1.0160.68
656_D660_D1.0140.68
165_T207_A1.0100.68
501_K534_E1.0090.68
61_P151_V1.0070.68
29_K736_Q1.0060.68
299_L360_L1.0050.67
547_L551_H1.0020.67
451_W456_W1.0020.67
161_Y222_L1.0020.67
46_L144_R1.0010.67
89_T94_T0.9990.67
42_D45_F0.9960.67
185_L188_Q0.9950.67
79_N134_T0.9920.66
751_A755_R0.9910.66
127_E171_E0.9900.66
539_K542_V0.9870.66
505_F581_I0.9870.66
618_W654_I0.9870.66
702_V740_T0.9850.66
342_D390_T0.9840.66
264_H290_D0.9760.65
40_Q43_E0.9760.65
563_L578_A0.9740.65
247_Y273_L0.9740.65
183_V222_L0.9730.65
108_S163_F0.9690.65
529_D580_Q0.9670.64
709_Y713_V0.9660.64
268_R271_E0.9620.64
444_V464_F0.9620.64
299_L363_G0.9620.64
342_D384_A0.9620.64
430_L716_L0.9560.64
241_F325_S0.9530.63
13_R70_H0.9520.63
564_N610_G0.9520.63
653_D743_A0.9520.63
534_E539_K0.9500.63
583_L631_L0.9490.63
247_Y251_I0.9470.63
467_A471_R0.9470.63
162_T165_T0.9450.63
477_E484_L0.9440.63
102_I701_R0.9410.62
13_R514_Q0.9410.62
481_L550_K0.9390.62
63_S141_D0.9390.62
138_Q142_Y0.9360.62
53_I151_V0.9320.62
564_N574_R0.9290.61
342_D388_F0.9290.61
208_L237_L0.9270.61
34_K92_T0.9250.61
32_T40_Q0.9240.61
521_V524_P0.9220.61
73_D137_K0.9190.60
212_S215_D0.9160.60
503_A533_I0.9160.60
142_Y193_L0.9140.60
200_W257_G0.9130.60
335_P352_E0.9130.60
239_T244_V0.9130.60
244_V260_L0.9070.59
85_F98_I0.9060.59
23_A32_T0.9060.59
289_I360_L0.9040.59
376_Q380_A0.9030.59
135_R185_L0.9030.59
247_Y278_F0.9030.59
109_E676_G0.9010.59
299_L378_A0.8970.59
418_L422_N0.8970.59
71_V163_F0.8940.58
362_E371_I0.8900.58
532_F587_K0.8900.58
200_W234_N0.8880.58
260_L273_L0.8860.58
180_K184_P0.8850.58
497_Y540_D0.8840.57
420_L423_E0.8830.57
61_P153_T0.8830.57
540_D678_L0.8810.57
575_K579_F0.8810.57
165_T210_T0.8800.57
75_A80_W0.8790.57
362_E366_S0.8790.57
444_V465_I0.8780.57
708_M747_M0.8770.57
371_I375_I0.8760.57
75_A167_A0.8740.57
14_I520_C0.8740.57
146_K152_E0.8730.56
598_Q639_E0.8720.56
355_A358_T0.8700.56
37_F41_I0.8680.56
593_E637_K0.8680.56
169_G173_S0.8670.56
188_Q192_E0.8670.56
695_Y743_A0.8650.56
659_N684_H0.8630.56
198_V201_V0.8620.56
192_E196_E0.8620.56
618_W671_S0.8610.55
611_L622_L0.8590.55
385_L570_N0.8580.55
411_P638_N0.8540.55
265_D268_R0.8530.55
345_N384_A0.8510.55
541_T585_L0.8490.54
508_T525_V0.8480.54
373_E377_Q0.8470.54
618_W689_G0.8460.54
260_L286_A0.8460.54
133_L189_L0.8460.54
9_L238_Q0.8460.54
83_K126_D0.8450.54
154_K496_E0.8420.54
94_T134_T0.8420.54
692_L724_F0.8400.54
215_D218_G0.8390.53
11_F48_A0.8370.53
475_I478_E0.8370.53
590_K593_E0.8330.53
396_Q529_D0.8330.53
579_F628_A0.8330.53
81_I94_T0.8310.53
236_L259_G0.8290.53
11_F148_E0.8280.53
57_I61_P0.8260.52
407_D631_L0.8260.52
307_L311_S0.8260.52
469_T541_T0.8260.52
194_E231_S0.8260.52
57_I60_V0.8250.52
77_S135_R0.8230.52
285_A319_W0.8220.52
260_L277_G0.8220.52
135_R140_E0.8210.52
541_T552_V0.8200.52
285_A321_Q0.8190.52
403_L631_L0.8190.52
388_F392_A0.8180.52
414_F723_R0.8170.52
165_T216_V0.8140.51
111_T715_A0.8140.51
354_L564_N0.8130.51
71_V74_T0.8120.51
632_T661_L0.8120.51
125_Y163_F0.8120.51
400_L579_F0.8100.51
134_T139_L0.8090.51
269_N272_Q0.8080.51
510_Y520_C0.8070.51
161_Y207_A0.8070.51
361_K365_V0.8060.51
310_L315_V0.8060.51
405_D409_K0.8050.50
395_E531_E0.8050.50
139_L143_R0.8030.50
85_F97_A0.8030.50
77_S133_L0.8010.50
706_E753_Q0.8010.50
66_T137_K0.8000.50
155_P198_V0.8000.50
78_F163_F0.7920.49
154_K667_T0.7910.49
471_R737_Q0.7890.49
649_S668_I0.7870.49
442_A736_Q0.7860.49
251_I277_G0.7840.49
8_N321_Q0.7820.48
111_T168_K0.7810.48
371_I374_E0.7810.48
74_T163_F0.7810.48
302_R320_I0.7790.48
412_I416_E0.7780.48
296_K333_K0.7770.48
81_I207_A0.7770.48
575_K620_E0.7770.48
20_W41_I0.7750.48
526_I581_I0.7740.48
346_G388_F0.7720.48
347_L573_S0.7710.47
748_V751_A0.7710.47
527_Y568_P0.7710.47
41_I96_F0.7700.47
131_F185_L0.7690.47
396_Q583_L0.7670.47
359_A363_G0.7660.47
40_Q44_L0.7640.47
164_V179_Q0.7630.47
157_I203_I0.7610.47
303_L367_G0.7610.47
77_S137_K0.7600.46
562_I585_L0.7580.46
667_T723_R0.7580.46
340_E345_N0.7570.46
16_L331_V0.7570.46
677_F690_L0.7550.46
646_M666_I0.7550.46
227_T254_P0.7540.46
190_L233_L0.7530.46
133_L188_Q0.7530.46
167_A170_Y0.7520.46
474_D550_K0.7500.46
160_P179_Q0.7490.46
26_A31_S0.7480.45
345_N390_T0.7480.45
406_K409_K0.7460.45
501_K540_D0.7440.45
607_L661_L0.7440.45
259_G321_Q0.7430.45
248_E277_G0.7430.45
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135_R189_L0.7300.44
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681_L684_H0.7290.44
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397_K576_E0.6910.40
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650_N653_D0.6900.40
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414_F687_L0.6690.39
203_I237_L0.6680.39
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80_W182_L0.6670.38
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403_L583_L0.6670.38
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541_T605_P0.6650.38
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111_T122_V0.6610.38
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142_Y199_K0.6600.38
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719_C723_R0.6590.38
135_R192_E0.6570.38
573_S577_I0.6570.38
157_I184_P0.6540.37
257_G319_W0.6530.37
590_K632_T0.6530.37
113_W241_F0.6510.37
499_G526_I0.6510.37
349_Y525_V0.6500.37
143_R192_E0.6500.37
465_I489_F0.6500.37
560_V624_W0.6490.37
667_T726_V0.6480.37
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682_K718_V0.6470.37
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209_V242_D0.6420.36
474_D547_L0.6420.36
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133_L192_E0.6410.36
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191_K194_E0.6400.36
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251_I281_D0.6370.36
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42_D46_L0.6340.36
411_P594_D0.6340.36
710_N717_A0.6320.36
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343_L527_Y0.6310.35
178_I646_M0.6300.35
668_I681_L0.6300.35
585_L661_L0.6300.35
189_L472_W0.6290.35
681_L686_Y0.6290.35
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716_L724_F0.6280.35
291_G324_S0.6270.35
232_S256_Q0.6270.35
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237_L255_V0.6230.35
176_K179_Q0.6210.35
238_Q321_Q0.6200.35
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67_Q95_Y0.5920.32
304_D368_K0.5920.32
388_F570_N0.5920.32
400_L631_L0.5920.32
138_Q143_R0.5910.32
252_S738_E0.5910.32
146_K153_T0.5910.32
104_D707_E0.5900.32
655_V682_K0.5900.32
244_V247_Y0.5880.32
324_S536_M0.5880.32
380_A384_A0.5880.32
24_L667_T0.5870.32
216_V246_A0.5870.32
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50_K151_V0.5850.32
359_A374_E0.5850.32
674_H707_E0.5850.32
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289_I618_W0.5830.32
383_Q712_I0.5830.32
332_A351_K0.5830.32
673_S676_G0.5820.32
84_R674_H0.5810.32
250_L282_K0.5810.32
507_F661_L0.5810.32
704_S746_N0.5810.32
115_N292_R0.5810.32
52_Q322_P0.5810.32
35_D307_L0.5810.32
158_V203_I0.5800.31
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29_K453_K0.5720.31
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66_T605_P0.5550.30
60_V149_Y0.5550.30
209_V243_S0.5540.29
131_F176_K0.5530.29
655_V680_Y0.5530.29
506_A526_I0.5530.29
74_T716_L0.5530.29
108_S701_R0.5520.29
667_T719_C0.5510.29
368_K371_I0.5510.29
192_E530_V0.5510.29
260_L354_L0.5510.29
349_Y508_T0.5510.29
334_H344_L0.5510.29
375_I379_K0.5500.29
382_I385_L0.5490.29
36_T39_K0.5490.29
341_K394_S0.5490.29
143_R198_V0.5490.29
244_V273_L0.5490.29
52_Q154_K0.5480.29
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363_G375_I0.5470.29
654_I666_I0.5470.29
424_S551_H0.5470.29
386_K416_E0.5460.29
116_T324_S0.5450.29
187_V228_S0.5450.29
48_A64_D0.5450.29
33_D376_Q0.5450.29
156_V202_Q0.5450.29
44_L198_V0.5450.29
636_V642_I0.5450.29
213_S373_E0.5450.29
14_I318_L0.5440.29
95_Y575_K0.5430.29
9_L321_Q0.5430.29
334_H352_E0.5430.29
243_S268_R0.5430.29
529_D569_R0.5430.29
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247_Y276_H0.5420.29
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697_I701_R0.5410.29
114_F162_T0.5410.29
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77_S141_D0.5400.28
351_K740_T0.5400.28
46_L419_A0.5400.28
76_V94_T0.5400.28
407_D578_A0.5400.28
366_S374_E0.5390.28
677_F686_Y0.5390.28
444_V740_T0.5390.28
5_K59_V0.5390.28
163_F167_A0.5390.28
409_K627_E0.5380.28
83_K377_Q0.5370.28
81_I252_S0.5370.28
244_V251_I0.5370.28
129_I181_R0.5360.28
80_W129_I0.5360.28
300_E348_S0.5360.28
283_V317_E0.5350.28
542_V595_A0.5350.28
505_F508_T0.5340.28
85_F511_A0.5340.28
375_I581_I0.5340.28
298_D382_I0.5330.28
552_V756_A0.5330.28
320_I481_L0.5330.28
26_A46_L0.5330.28
593_E630_R0.5320.28
464_F468_E0.5310.28
503_A525_V0.5310.28
563_L624_W0.5310.28
7_S165_T0.5300.28
574_R581_I0.5300.28
9_L156_V0.5300.28
541_T548_T0.5300.28
374_E378_A0.5300.28
426_G752_K0.5300.28
702_V741_V0.5290.28
139_L142_Y0.5290.28
373_E380_A0.5290.28
679_D718_V0.5290.28
95_Y695_Y0.5280.28
239_T243_S0.5280.28
530_V542_V0.5280.28
225_S228_S0.5280.28
713_V754_A0.5280.28
646_M681_L0.5280.28
285_A737_Q0.5280.28
496_E666_I0.5270.28
451_W465_I0.5270.28
543_Y560_V0.5260.27
74_T581_I0.5260.27
337_E510_Y0.5260.27
296_K300_E0.5260.27
564_N577_I0.5260.27
499_G564_N0.5260.27
605_P679_D0.5250.27
26_A44_L0.5250.27
320_I474_D0.5250.27
242_D269_N0.5250.27
320_I361_K0.5250.27
67_Q73_D0.5250.27
175_A179_Q0.5240.27
281_D317_E0.5230.27
42_D630_R0.5230.27
653_D670_H0.5230.27
751_A754_A0.5230.27
8_N712_I0.5230.27
678_L714_D0.5220.27
54_D552_V0.5210.27
385_L391_G0.5210.27
462_Q465_I0.5210.27
656_D683_N0.5210.27
442_A481_L0.5210.27
284_L342_D0.5210.27
564_N649_S0.5210.27
26_A188_Q0.5200.27
220_K284_L0.5200.27
675_G692_L0.5200.27
630_R634_S0.5190.27
405_D627_E0.5190.27
444_V667_T0.5190.27
46_L49_V0.5190.27
246_A273_L0.5190.27
48_A52_Q0.5180.27
177_A628_A0.5180.27
444_V471_R0.5180.27
165_T444_V0.5180.27
296_K751_A0.5180.27
423_E442_A0.5170.27
63_S524_P0.5170.27
246_A249_E0.5170.27
179_Q183_V0.5160.27
243_S265_D0.5160.27
530_V707_E0.5150.27
677_F719_C0.5150.27
602_V684_H0.5150.27
131_F577_I0.5140.27
220_K717_A0.5140.27
499_G541_T0.5140.27
647_C730_C0.5140.27
411_P602_V0.5140.27
627_E660_D0.5130.27
128_S228_S0.5130.27
327_L514_Q0.5130.27
562_I577_I0.5130.27
236_L324_S0.5120.26
653_D667_T0.5120.26
652_E677_F0.5120.26
131_F184_P0.5120.26
669_E696_D0.5110.26
608_R613_L0.5110.26
290_D388_F0.5100.26
276_H419_A0.5100.26
110_M705_T0.5090.26
347_L572_I0.5090.26
568_P575_K0.5090.26
420_L638_N0.5090.26
668_I690_L0.5080.26
646_M651_F0.5080.26
67_Q92_T0.5080.26
381_D385_L0.5080.26
60_V521_V0.5080.26
161_Y288_V0.5070.26
447_A460_Q0.5070.26
602_V685_P0.5070.26
189_L193_L0.5070.26
681_L714_D0.5070.26
257_G538_V0.5060.26
447_A468_E0.5060.26
303_L371_I0.5060.26
138_Q163_F0.5060.26
41_I139_L0.5060.26
337_E712_I0.5060.26
63_S521_V0.5050.26
475_I602_V0.5050.26
564_N632_T0.5050.26
590_K633_T0.5050.26
195_E534_E0.5050.26
132_R188_Q0.5050.26
66_T242_D0.5050.26
146_K752_K0.5050.26
398_K704_S0.5050.26
7_S97_A0.5040.26
463_N470_K0.5040.26
348_S631_L0.5030.26
20_W66_T0.5030.26
304_D398_K0.5030.26
30_G749_E0.5020.26
270_L274_K0.5020.26
80_W269_N0.5010.26
394_S413_P0.5010.26
57_I357_L0.5010.26
125_Y162_T0.5010.26
319_W496_E0.5010.26
102_I108_S0.5000.26
745_K749_E0.5000.26
638_N659_N0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l6hA 1 0.9724 100 0.326 Contact Map
1t7lA 1 0.9567 100 0.328 Contact Map
1u1jA 1 0.9646 100 0.337 Contact Map
2nq5A 1 0.9239 100 0.357 Contact Map
3rpdA 1 0.4252 100 0.753 Contact Map
1ypxA 1 0.3871 100 0.756 Contact Map
2infA 2 0.4108 99.9 0.936 Contact Map
2ejaA 2 0.4003 99.9 0.937 Contact Map
1j93A 2 0.4081 99.9 0.939 Contact Map
4zr8A 2 0.4147 99.9 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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