GREMLIN Database
GS18 - General stress protein 18
UniProt: P80876 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (160)
Sequences: 14167 (9830)
Seq/√Len: 777.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_K31_E2.8941.00
165_E168_A2.7201.00
6_A66_F2.5851.00
119_R148_D2.5431.00
6_A35_I2.5131.00
33_T66_F2.4871.00
120_K139_V2.4381.00
116_L121_A2.2961.00
119_R147_Q2.2101.00
33_T56_A2.1421.00
4_K33_T2.1271.00
24_A167_L1.9751.00
128_R132_E1.9711.00
28_A167_L1.9361.00
120_K137_D1.9151.00
42_T53_T1.9121.00
22_A26_K1.8641.00
94_M149_Q1.8171.00
119_R150_L1.7411.00
117_D137_D1.7261.00
94_M100_V1.6171.00
93_F98_K1.6081.00
102_A152_T1.5981.00
120_K147_Q1.5881.00
37_K83_D1.5801.00
101_F166_S1.5451.00
59_D85_R1.5451.00
68_A99_P1.5291.00
15_D19_T1.5211.00
130_D134_A1.5181.00
57_S60_D1.5141.00
153_S158_D1.4901.00
120_K141_K1.4771.00
130_D133_N1.4751.00
88_Q92_A1.4411.00
7_V22_A1.4281.00
87_V91_K1.4091.00
5_I68_A1.4051.00
89_F93_F1.3931.00
44_K51_E1.3911.00
13_F45_G1.3621.00
102_A110_L1.3551.00
7_V70_L1.3471.00
84_D88_Q1.3421.00
9_L18_Y1.3401.00
88_Q91_K1.3401.00
9_L34_V1.3311.00
36_E39_K1.3171.00
94_M115_A1.3141.00
94_M150_L1.2921.00
45_G48_G1.2881.00
85_R88_Q1.2871.00
119_R149_Q1.2741.00
13_F18_Y1.2661.00
92_A96_D1.2541.00
101_F162_F1.2511.00
112_N134_A1.2501.00
42_T51_E1.2491.00
97_K149_Q1.2171.00
25_F163_N1.2011.00
151_V162_F1.1981.00
11_Y44_K1.1851.00
131_M136_A1.1821.00
56_A60_D1.1781.00
97_K100_V1.1681.00
16_S20_E1.1671.00
142_E161_A1.1661.00
20_E160_P1.1651.00
8_V86_F1.1641.00
82_A112_N1.1511.00
87_V113_A1.1371.00
51_E55_D1.1271.00
45_G49_T1.1241.00
70_L162_F1.1211.00
108_Q130_D1.1151.00
105_H127_I1.1131.00
67_D98_K1.1091.00
23_K27_E1.0921.00
121_A138_V1.0921.00
20_E23_K1.0861.00
18_Y34_V1.0851.00
94_M97_K1.0761.00
5_I30_H1.0621.00
22_A34_V1.0581.00
92_A95_T1.0451.00
114_K117_D1.0351.00
39_K57_S1.0331.00
91_K95_T1.0321.00
99_P149_Q1.0271.00
131_M140_D1.0261.00
20_E163_N1.0031.00
81_R112_N1.0021.00
117_D135_G0.9991.00
9_L13_F0.9951.00
35_I56_A0.9831.00
154_R158_D0.9831.00
7_V32_L0.9801.00
44_K48_G0.9801.00
71_I90_T0.9791.00
124_Y155_T0.9681.00
99_P151_V0.9611.00
129_V133_N0.9611.00
153_S162_F0.9611.00
145_V165_E0.9581.00
43_V48_G0.9581.00
30_H68_A0.9571.00
37_K85_R0.9521.00
24_A163_N0.9471.00
102_A107_P0.9431.00
128_R140_D0.9401.00
160_P164_R0.9401.00
30_H167_L0.9241.00
21_P70_L0.9181.00
151_V166_S0.9131.00
21_P159_I0.9091.00
68_A166_S0.8871.00
56_A61_V0.8791.00
93_F96_D0.8721.00
20_E159_I0.8711.00
35_I61_V0.8621.00
151_V165_E0.8541.00
87_V112_N0.8511.00
24_A164_R0.8451.00
71_I109_L0.8441.00
23_K26_K0.8411.00
18_Y22_A0.8381.00
107_P123_G0.8361.00
145_V151_V0.8361.00
22_A32_L0.8341.00
111_I138_V0.8181.00
99_P166_S0.8171.00
131_M135_G0.8141.00
121_A136_A0.8131.00
71_I86_F0.8081.00
64_S92_A0.8021.00
71_I106_G0.8021.00
112_N135_G0.8011.00
11_Y38_E0.7991.00
68_A101_F0.7901.00
70_L101_F0.7891.00
83_D86_F0.7881.00
13_F52_V0.7821.00
66_F93_F0.7811.00
36_E54_V0.7721.00
127_I130_D0.7701.00
89_F92_A0.7661.00
91_K113_A0.7611.00
103_I159_I0.7441.00
125_T138_V0.7361.00
25_F166_S0.7351.00
69_L93_F0.7351.00
129_V132_E0.7341.00
108_Q127_I0.7331.00
13_F72_P0.7251.00
94_M119_R0.7221.00
123_G138_V0.7091.00
15_D49_T0.7001.00
126_S129_V0.6981.00
15_D47_Q0.6941.00
161_A164_R0.6921.00
143_V165_E0.6821.00
25_F30_H0.6771.00
42_T54_V0.6751.00
39_K54_V0.6731.00
122_T138_V0.6731.00
87_V109_L0.6721.00
5_I25_F0.6701.00
87_V90_T0.6691.00
118_G137_D0.6681.00
24_A28_A0.6671.00
125_T155_T0.6661.00
6_A61_V0.6651.00
141_K144_V0.6651.00
90_T113_A0.6621.00
61_V66_F0.6611.00
84_D87_V0.6581.00
110_L113_A0.6511.00
37_K58_I0.6441.00
124_Y156_P0.6421.00
6_A89_F0.6351.00
43_V46_K0.6261.00
102_A106_G0.6251.00
164_R168_A0.6241.00
82_A87_V0.6201.00
17_E156_P0.6181.00
121_A131_M0.6131.00
43_V47_Q0.6111.00
20_E24_A0.6111.00
65_D96_D0.6111.00
7_V21_P0.6111.00
90_T109_L0.6091.00
43_V49_T0.6031.00
12_Y44_K0.5991.00
132_E140_D0.5991.00
15_D45_G0.5981.00
24_A27_E0.5961.00
159_I163_N0.5951.00
17_E73_G0.5951.00
26_K32_L0.5951.00
111_I116_L0.5931.00
100_V149_Q0.5931.00
8_V71_I0.5931.00
78_D82_A0.5911.00
44_K49_T0.5871.00
24_A160_P0.5861.00
101_F151_V0.5861.00
107_P131_M0.5851.00
21_P25_F0.5841.00
161_A165_E0.5831.00
111_I131_M0.5701.00
123_G127_I0.5691.00
8_V35_I0.5681.00
76_S80_L0.5631.00
46_K49_T0.5611.00
7_V18_Y0.5601.00
120_K144_V0.5591.00
8_V69_L0.5581.00
64_S96_D0.5561.00
4_K67_D0.5561.00
79_Q82_A0.5551.00
91_K115_A0.5541.00
14_E23_K0.5531.00
14_E46_K0.5531.00
100_V150_L0.5361.00
9_L54_V0.5311.00
30_H67_D0.5281.00
36_E55_D0.5261.00
80_L83_D0.5251.00
15_D52_V0.5241.00
108_Q123_G0.5221.00
108_Q131_M0.5171.00
66_F69_L0.5161.00
74_G109_L0.5151.00
111_I136_A0.5101.00
16_S159_I0.5081.00
33_T55_D0.5081.00
103_I162_F0.5041.00
135_G138_V0.5041.00
54_V57_S0.5001.00
132_E142_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oi4A 2 0.9884 100 0.133 Contact Map
3ewnA 2 0.9767 100 0.161 Contact Map
3fseA 2 0.9884 100 0.162 Contact Map
3noqA 2 0.9709 100 0.162 Contact Map
2rk3A 2 0.9826 100 0.168 Contact Map
3l18A 2 0.9709 100 0.172 Contact Map
4e08A 2 0.9884 100 0.173 Contact Map
2vrnA 2 0.9826 100 0.173 Contact Map
4oggA 3 0.9826 100 0.176 Contact Map
3mgkA 2 0.9651 100 0.176 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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