GS18 - BACSU - GREMLIN Contacts

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GS18 - General stress protein 18

UniProt:	P80876	Sequences: MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVKGKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFAICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIPAFNRESLALLEK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	172 (160)
Sequences:	14167 (9830)
Seq/√Len:	777.1

ECOLI - YHBO YAJL HCHA
BACSU - GS18 YRAA YOAZ YDEA
HALSA - Q9HMG4 Q9HRT2
SULSO - Q97Z65

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
4_K	31_E	2.894	1.00
165_E	168_A	2.720	1.00
6_A	66_F	2.585	1.00
119_R	148_D	2.543	1.00
6_A	35_I	2.513	1.00
33_T	66_F	2.487	1.00
120_K	139_V	2.438	1.00
116_L	121_A	2.296	1.00
119_R	147_Q	2.210	1.00
33_T	56_A	2.142	1.00
4_K	33_T	2.127	1.00
24_A	167_L	1.975	1.00
128_R	132_E	1.971	1.00
28_A	167_L	1.936	1.00
120_K	137_D	1.915	1.00
42_T	53_T	1.912	1.00
22_A	26_K	1.864	1.00
94_M	149_Q	1.817	1.00
119_R	150_L	1.741	1.00
117_D	137_D	1.726	1.00
94_M	100_V	1.617	1.00
93_F	98_K	1.608	1.00
102_A	152_T	1.598	1.00
120_K	147_Q	1.588	1.00
37_K	83_D	1.580	1.00
101_F	166_S	1.545	1.00
59_D	85_R	1.545	1.00
68_A	99_P	1.529	1.00
15_D	19_T	1.521	1.00
130_D	134_A	1.518	1.00
57_S	60_D	1.514	1.00
153_S	158_D	1.490	1.00
120_K	141_K	1.477	1.00
130_D	133_N	1.475	1.00
88_Q	92_A	1.441	1.00
7_V	22_A	1.428	1.00
87_V	91_K	1.409	1.00
5_I	68_A	1.405	1.00
89_F	93_F	1.393	1.00
44_K	51_E	1.391	1.00
13_F	45_G	1.362	1.00
102_A	110_L	1.355	1.00
7_V	70_L	1.347	1.00
84_D	88_Q	1.342	1.00
9_L	18_Y	1.340	1.00
88_Q	91_K	1.340	1.00
9_L	34_V	1.331	1.00
36_E	39_K	1.317	1.00
94_M	115_A	1.314	1.00
94_M	150_L	1.292	1.00
45_G	48_G	1.288	1.00
85_R	88_Q	1.287	1.00
119_R	149_Q	1.274	1.00
13_F	18_Y	1.266	1.00
92_A	96_D	1.254	1.00
101_F	162_F	1.251	1.00
112_N	134_A	1.250	1.00
42_T	51_E	1.249	1.00
97_K	149_Q	1.217	1.00
25_F	163_N	1.201	1.00
151_V	162_F	1.198	1.00
11_Y	44_K	1.185	1.00
131_M	136_A	1.182	1.00
56_A	60_D	1.178	1.00
97_K	100_V	1.168	1.00
16_S	20_E	1.167	1.00
142_E	161_A	1.166	1.00
20_E	160_P	1.165	1.00
8_V	86_F	1.164	1.00
82_A	112_N	1.151	1.00
87_V	113_A	1.137	1.00
51_E	55_D	1.127	1.00
45_G	49_T	1.124	1.00
70_L	162_F	1.121	1.00
108_Q	130_D	1.115	1.00
105_H	127_I	1.113	1.00
67_D	98_K	1.109	1.00
23_K	27_E	1.092	1.00
121_A	138_V	1.092	1.00
20_E	23_K	1.086	1.00
18_Y	34_V	1.085	1.00
94_M	97_K	1.076	1.00
5_I	30_H	1.062	1.00
22_A	34_V	1.058	1.00
92_A	95_T	1.045	1.00
114_K	117_D	1.035	1.00
39_K	57_S	1.033	1.00
91_K	95_T	1.032	1.00
99_P	149_Q	1.027	1.00
131_M	140_D	1.026	1.00
20_E	163_N	1.003	1.00
81_R	112_N	1.002	1.00
117_D	135_G	0.999	1.00
9_L	13_F	0.995	1.00
35_I	56_A	0.983	1.00
154_R	158_D	0.983	1.00
7_V	32_L	0.980	1.00
44_K	48_G	0.980	1.00
71_I	90_T	0.979	1.00
124_Y	155_T	0.968	1.00
99_P	151_V	0.961	1.00
129_V	133_N	0.961	1.00
153_S	162_F	0.961	1.00
145_V	165_E	0.958	1.00
43_V	48_G	0.958	1.00
30_H	68_A	0.957	1.00
37_K	85_R	0.952	1.00
24_A	163_N	0.947	1.00
102_A	107_P	0.943	1.00
128_R	140_D	0.940	1.00
160_P	164_R	0.940	1.00
30_H	167_L	0.924	1.00
21_P	70_L	0.918	1.00
151_V	166_S	0.913	1.00
21_P	159_I	0.909	1.00
68_A	166_S	0.887	1.00
56_A	61_V	0.879	1.00
93_F	96_D	0.872	1.00
20_E	159_I	0.871	1.00
35_I	61_V	0.862	1.00
151_V	165_E	0.854	1.00
87_V	112_N	0.851	1.00
24_A	164_R	0.845	1.00
71_I	109_L	0.844	1.00
23_K	26_K	0.841	1.00
18_Y	22_A	0.838	1.00
107_P	123_G	0.836	1.00
145_V	151_V	0.836	1.00
22_A	32_L	0.834	1.00
111_I	138_V	0.818	1.00
99_P	166_S	0.817	1.00
131_M	135_G	0.814	1.00
121_A	136_A	0.813	1.00
71_I	86_F	0.808	1.00
64_S	92_A	0.802	1.00
71_I	106_G	0.802	1.00
112_N	135_G	0.801	1.00
11_Y	38_E	0.799	1.00
68_A	101_F	0.790	1.00
70_L	101_F	0.789	1.00
83_D	86_F	0.788	1.00
13_F	52_V	0.782	1.00
66_F	93_F	0.781	1.00
36_E	54_V	0.772	1.00
127_I	130_D	0.770	1.00
89_F	92_A	0.766	1.00
91_K	113_A	0.761	1.00
103_I	159_I	0.744	1.00
125_T	138_V	0.736	1.00
25_F	166_S	0.735	1.00
69_L	93_F	0.735	1.00
129_V	132_E	0.734	1.00
108_Q	127_I	0.733	1.00
13_F	72_P	0.725	1.00
94_M	119_R	0.722	1.00
123_G	138_V	0.709	1.00
15_D	49_T	0.700	1.00
126_S	129_V	0.698	1.00
15_D	47_Q	0.694	1.00
161_A	164_R	0.692	1.00
143_V	165_E	0.682	1.00
25_F	30_H	0.677	1.00
42_T	54_V	0.675	1.00
39_K	54_V	0.673	1.00
122_T	138_V	0.673	1.00
87_V	109_L	0.672	1.00
5_I	25_F	0.670	1.00
87_V	90_T	0.669	1.00
118_G	137_D	0.668	1.00
24_A	28_A	0.667	1.00
125_T	155_T	0.666	1.00
6_A	61_V	0.665	1.00
141_K	144_V	0.665	1.00
90_T	113_A	0.662	1.00
61_V	66_F	0.661	1.00
84_D	87_V	0.658	1.00
110_L	113_A	0.651	1.00
37_K	58_I	0.644	1.00
124_Y	156_P	0.642	1.00
6_A	89_F	0.635	1.00
43_V	46_K	0.626	1.00
102_A	106_G	0.625	1.00
164_R	168_A	0.624	1.00
82_A	87_V	0.620	1.00
17_E	156_P	0.618	1.00
121_A	131_M	0.613	1.00
43_V	47_Q	0.611	1.00
20_E	24_A	0.611	1.00
65_D	96_D	0.611	1.00
7_V	21_P	0.611	1.00
90_T	109_L	0.609	1.00
43_V	49_T	0.603	1.00
12_Y	44_K	0.599	1.00
132_E	140_D	0.599	1.00
15_D	45_G	0.598	1.00
24_A	27_E	0.596	1.00
159_I	163_N	0.595	1.00
17_E	73_G	0.595	1.00
26_K	32_L	0.595	1.00
111_I	116_L	0.593	1.00
100_V	149_Q	0.593	1.00
8_V	71_I	0.593	1.00
78_D	82_A	0.591	1.00
44_K	49_T	0.587	1.00
24_A	160_P	0.586	1.00
101_F	151_V	0.586	1.00
107_P	131_M	0.585	1.00
21_P	25_F	0.584	1.00
161_A	165_E	0.583	1.00
111_I	131_M	0.570	1.00
123_G	127_I	0.569	1.00
8_V	35_I	0.568	1.00
76_S	80_L	0.563	1.00
46_K	49_T	0.561	1.00
7_V	18_Y	0.560	1.00
120_K	144_V	0.559	1.00
8_V	69_L	0.558	1.00
64_S	96_D	0.556	1.00
4_K	67_D	0.556	1.00
79_Q	82_A	0.555	1.00
91_K	115_A	0.554	1.00
14_E	23_K	0.553	1.00
14_E	46_K	0.553	1.00
100_V	150_L	0.536	1.00
9_L	54_V	0.531	1.00
30_H	67_D	0.528	1.00
36_E	55_D	0.526	1.00
80_L	83_D	0.525	1.00
15_D	52_V	0.524	1.00
108_Q	123_G	0.522	1.00
108_Q	131_M	0.517	1.00
66_F	69_L	0.516	1.00
74_G	109_L	0.515	1.00
111_I	136_A	0.510	1.00
16_S	159_I	0.508	1.00
33_T	55_D	0.508	1.00
103_I	162_F	0.504	1.00
135_G	138_V	0.504	1.00
54_V	57_S	0.500	1.00
132_E	142_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1oi4A	2	0.9884	100	0.133	Contact Map
3ewnA	2	0.9767	100	0.161	Contact Map
3fseA	2	0.9884	100	0.162	Contact Map
3noqA	2	0.9709	100	0.162	Contact Map
2rk3A	2	0.9826	100	0.168	Contact Map
3l18A	2	0.9709	100	0.172	Contact Map
4e08A	2	0.9884	100	0.173	Contact Map
2vrnA	2	0.9826	100	0.173	Contact Map
4oggA	3	0.9826	100	0.176	Contact Map
3mgkA	2	0.9651	100	0.176	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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