GREMLIN Database
G16U - General stress protein 16U
UniProt: P80875 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (176)
Sequences: 3028 (1613)
Seq/√Len: 121.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_V106_I4.8751.00
159_G170_F3.7271.00
56_A60_D3.3651.00
51_A104_D3.3631.00
95_N98_A3.3091.00
140_E143_R3.1911.00
179_G183_R3.0931.00
68_E75_V2.7751.00
10_K171_S2.6811.00
162_Y169_K2.6661.00
182_A186_T2.6461.00
48_L74_V2.6221.00
177_Y187_D2.6071.00
48_L103_I2.5081.00
28_G129_F2.4381.00
105_K160_E2.3771.00
60_D70_G2.1961.00
30_D127_N2.0961.00
77_S93_K2.0931.00
130_V159_G2.0351.00
22_K95_N1.9681.00
164_H169_K1.9471.00
134_N137_T1.9181.00
131_R140_E1.9131.00
21_S97_S1.9091.00
24_V91_N1.8981.00
99_V106_I1.7521.00
12_D15_K1.7501.00
3_I11_V1.7391.00
77_S91_N1.7351.00
71_N100_P1.7311.00
109_V184_I1.6611.00
10_K169_K1.6131.00
134_N139_E1.6081.00
46_V92_V1.5851.00
64_Y113_H1.5821.00
144_Y174_G1.5051.00
26_G88_D1.4871.00
49_L107_S1.4371.00
160_E171_S1.4131.00
107_S160_E1.3861.00
75_V93_K1.3821.00
94_V108_F1.3471.00
88_D131_R1.3381.00
94_V161_L1.3361.00
45_S109_V1.3271.00
6_A9_Q1.3241.00
46_V108_F1.3151.00
41_D90_E1.3041.00
48_L60_D1.2921.00
45_S111_T1.2911.00
62_I69_G1.2771.00
152_I178_Q1.2560.99
24_V135_E1.2490.99
48_L99_V1.2430.99
47_F55_C1.2400.99
56_A102_N1.2310.99
162_Y171_S1.2240.99
130_V170_F1.1910.99
69_G73_S1.1810.99
108_F161_L1.1780.99
22_K97_S1.1770.99
41_D79_D1.1730.99
20_L23_V1.1580.99
80_N89_D1.1480.99
73_S99_V1.1400.99
53_G105_K1.1170.99
25_V108_F1.1150.99
42_L125_V1.1120.99
155_A177_Y1.1090.99
129_F143_R1.0770.98
24_V133_V1.0740.98
26_G131_R1.0740.98
183_R186_T1.0450.98
57_S60_D1.0390.98
65_N113_H1.0360.98
79_D90_E1.0260.98
25_V132_I1.0120.98
24_V93_K1.0110.98
78_G90_E0.9930.97
183_R187_D0.9870.97
157_I184_I0.9840.97
56_A103_I0.9690.97
153_E177_Y0.9640.97
43_D64_Y0.9520.97
144_Y172_A0.9490.97
135_E138_N0.9490.97
22_K93_K0.9480.97
164_H167_E0.9380.96
157_I160_E0.9350.96
76_H90_E0.9310.96
181_L185_A0.9290.96
53_G104_D0.9260.96
10_K162_Y0.9220.96
93_K135_E0.9100.96
104_D166_G0.9060.95
161_L170_F0.9050.95
180_G183_R0.9020.95
99_V163_R0.9010.95
41_D76_H0.8930.95
45_S64_Y0.8930.95
80_N85_G0.8810.95
48_L56_A0.8800.95
79_D83_G0.8720.94
49_L105_K0.8710.94
99_V103_I0.8710.94
60_D69_G0.8700.94
32_N36_G0.8620.94
11_V142_I0.8620.94
133_V140_E0.8590.94
58_P61_F0.8550.94
60_D71_N0.8550.94
48_L106_I0.8480.94
14_T167_E0.8450.93
111_T177_Y0.8450.93
40_F125_V0.8430.93
29_W90_E0.8410.93
50_D104_D0.8380.93
79_D89_D0.8370.93
22_K135_E0.8290.93
110_I158_A0.8240.93
48_L69_G0.8080.92
31_T84_A0.8080.92
165_N169_K0.8060.92
83_G90_E0.8030.92
121_N124_Q0.8000.91
118_R122_F0.7950.91
160_E173_I0.7860.91
29_W41_D0.7800.90
9_Q152_I0.7780.90
47_F111_T0.7720.90
66_Q69_G0.7670.90
15_K20_L0.7510.89
122_F125_V0.7460.88
49_L160_E0.7420.88
27_L44_S0.7390.88
121_N152_I0.7380.88
90_E110_I0.7370.88
111_T183_R0.7330.87
47_F187_D0.7320.87
48_L73_S0.7260.87
81_L118_R0.7250.87
8_G169_K0.7200.87
12_D167_E0.7200.87
50_D103_I0.7180.86
23_V96_L0.7170.86
50_D56_A0.7170.86
104_D163_R0.7140.86
118_R123_G0.7110.86
28_G131_R0.7110.86
50_D102_N0.7090.86
23_V161_L0.7050.85
47_F58_P0.7040.85
21_S95_N0.6960.85
9_Q171_S0.6940.85
8_G176_G0.6920.84
41_D89_D0.6900.84
25_V170_F0.6880.84
155_A181_L0.6870.84
64_Y111_T0.6860.84
37_G64_Y0.6790.83
153_E175_S0.6790.83
155_A188_Y0.6770.83
163_R168_W0.6750.83
10_K164_H0.6710.82
82_T85_G0.6700.82
67_L76_H0.6680.82
88_D129_F0.6670.82
150_F156_I0.6570.81
55_C58_P0.6550.81
68_E98_A0.6540.81
30_D126_S0.6490.80
119_S122_F0.6490.80
66_Q113_H0.6470.80
55_C60_D0.6460.80
61_F66_Q0.6440.80
150_F153_E0.6350.79
47_F63_F0.6330.79
26_G89_D0.6320.79
55_C185_A0.6310.78
153_E176_G0.6300.78
58_P63_F0.6250.78
157_I177_Y0.6230.78
181_L188_Y0.6230.78
134_N141_L0.6220.77
105_K157_I0.6210.77
82_T86_E0.6200.77
120_Q124_Q0.6200.77
4_S11_V0.6190.77
44_S76_H0.6160.77
39_D81_L0.6140.77
107_S157_I0.6120.76
25_V94_V0.6110.76
31_T126_S0.6100.76
96_L163_R0.6080.76
28_G88_D0.6060.76
108_F130_V0.6030.75
45_S76_H0.6030.75
7_K15_K0.5930.74
146_L158_A0.5920.74
132_I159_G0.5910.74
13_L73_S0.5880.73
38_H124_Q0.5830.73
99_V168_W0.5800.72
118_R124_Q0.5800.72
109_V185_A0.5760.72
129_F133_V0.5750.72
132_I179_G0.5730.72
44_S110_I0.5730.72
30_D84_A0.5730.72
90_E112_I0.5720.71
43_D79_D0.5710.71
10_K175_S0.5670.71
58_P70_G0.5670.71
30_D82_T0.5660.71
183_R189_G0.5660.71
177_Y184_I0.5650.71
129_F145_D0.5650.71
5_L90_E0.5630.70
49_L54_K0.5630.70
4_S12_D0.5620.70
128_A146_L0.5610.70
48_L71_N0.5600.70
62_I74_V0.5590.70
107_S188_Y0.5550.69
3_I12_D0.5510.69
134_N138_N0.5490.68
83_G89_D0.5480.68
32_N40_F0.5460.68
32_N150_F0.5450.68
175_S178_Q0.5440.68
105_K162_Y0.5430.67
7_K144_Y0.5420.67
88_D140_E0.5400.67
31_T40_F0.5380.67
69_G132_I0.5380.67
3_I6_A0.5380.67
76_H92_V0.5370.67
25_V158_A0.5370.67
123_G152_I0.5350.66
8_G162_Y0.5350.66
153_E180_G0.5340.66
48_L70_G0.5330.66
71_N98_A0.5290.66
66_Q70_G0.5280.65
120_Q125_V0.5270.65
8_G172_A0.5270.65
41_D83_G0.5230.65
157_I187_D0.5220.64
32_N126_S0.5210.64
55_C61_F0.5190.64
122_F172_A0.5190.64
112_I120_Q0.5190.64
56_A70_G0.5150.63
61_F181_L0.5140.63
78_G85_G0.5140.63
26_G133_V0.5120.63
6_A135_E0.5110.63
171_S175_S0.5100.63
65_N111_T0.5100.63
47_F150_F0.5050.62
80_N83_G0.5030.62
20_L102_N0.5010.61
128_A151_S0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ibzA 1 0.9171 100 -0.007 Contact Map
2kxtA 1 0.9016 100 -0.002 Contact Map
2qngA 1 0.8653 100 0.076 Contact Map
2qz7A 1 0.8601 100 0.086 Contact Map
2rn7A 1 0.1865 6.9 0.954 Contact Map
2i0fA 3 0.4611 6.8 0.954 Contact Map
3fcsB 1 0.7409 6.2 0.955 Contact Map
2o2pA 5 0.4819 6 0.955 Contact Map
1e0tA 3 0.8549 4.6 0.957 Contact Map
2e28A 3 0.8653 3.9 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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