GREMLIN Database
GS69 - General stress protein 69
UniProt: P80874 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (274)
Sequences: 31408 (19681)
Seq/√Len: 1189.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_A288_E3.2191.00
108_E148_K3.0771.00
33_E68_K3.0381.00
71_K115_Q2.8481.00
256_Y302_D2.8071.00
107_V143_L2.6081.00
299_N302_D2.5141.00
104_V142_E2.4631.00
37_I72_E2.3971.00
104_V146_A2.3901.00
42_A46_Q2.3141.00
255_R305_D2.2781.00
141_K145_D2.0921.00
249_D253_K2.0371.00
270_D303_Q2.0371.00
37_I68_K2.0191.00
255_R302_D2.0101.00
118_Y150_R1.9761.00
300_S304_K1.9641.00
75_K78_Q1.9371.00
109_N113_R1.9321.00
142_E146_A1.9261.00
250_K305_D1.8951.00
123_Q173_T1.8811.00
192_Y196_N1.8811.00
193_A200_T1.8691.00
17_G50_L1.8641.00
61_Q64_E1.8491.00
284_P288_E1.8301.00
100_R142_E1.8101.00
81_L116_T1.8071.00
163_D167_A1.7891.00
83_T119_I1.7721.00
258_K296_W1.7661.00
266_R296_W1.7581.00
42_A284_P1.7551.00
142_E145_D1.7361.00
271_Q307_N1.7311.00
46_Q288_E1.7251.00
64_E113_R1.7051.00
43_A48_I1.6961.00
32_D35_T1.6951.00
100_R104_V1.6521.00
247_Q250_K1.6511.00
46_Q291_S1.6481.00
37_I69_A1.6381.00
85_T103_I1.6361.00
85_T122_Y1.6331.00
83_T110_S1.6281.00
82_A123_Q1.6221.00
304_K308_T1.6171.00
292_E295_G1.6131.00
107_V122_Y1.6111.00
259_S289_A1.6081.00
37_I41_R1.5981.00
188_S191_P1.5971.00
199_T276_I1.5911.00
163_D192_Y1.5851.00
139_V142_E1.5801.00
123_Q201_L1.5701.00
20_T51_I1.5691.00
42_A45_D1.5601.00
104_V108_E1.5581.00
41_R72_E1.5141.00
55_P106_E1.5001.00
11_I151_A1.4961.00
105_E109_N1.4731.00
119_I149_I1.4581.00
35_T38_E1.4541.00
33_E37_I1.4411.00
194_K272_P1.4331.00
40_I69_A1.4151.00
258_K262_H1.3981.00
44_L79_V1.3921.00
108_E112_K1.3831.00
158_S161_Q1.3741.00
11_I80_I1.3631.00
191_P195_D1.3531.00
104_V139_V1.3391.00
143_L149_I1.3381.00
166_R192_Y1.3361.00
149_I152_I1.3321.00
288_E292_E1.3301.00
100_R138_E1.3271.00
109_N112_K1.3091.00
41_R45_D1.3061.00
305_D308_T1.2921.00
176_P200_T1.2871.00
107_V119_I1.2841.00
258_K263_L1.2811.00
166_R196_N1.2811.00
100_R139_V1.2801.00
151_A172_H1.2801.00
266_R270_D1.2741.00
281_A286_Q1.2581.00
159_I192_Y1.2501.00
51_I66_V1.2411.00
247_Q305_D1.2411.00
67_G115_Q1.2411.00
163_D195_D1.2341.00
38_E42_A1.2321.00
76_R118_Y1.2261.00
80_I121_L1.2211.00
63_E110_S1.2201.00
114_L119_I1.2091.00
281_A287_L1.2081.00
76_R116_T1.2051.00
250_K255_R1.1961.00
134_E168_V1.1931.00
251_L263_L1.1841.00
180_L306_I1.1831.00
34_K38_E1.1801.00
259_S262_H1.1791.00
64_E68_K1.1791.00
121_L173_T1.1751.00
68_K115_Q1.1721.00
285_G288_E1.1591.00
127_P161_Q1.1511.00
41_R73_Y1.1321.00
50_L201_L1.1311.00
190_L194_K1.1281.00
9_T151_A1.1231.00
144_Y172_H1.1181.00
39_T287_L1.1161.00
101_A105_E1.0971.00
135_E138_E1.0941.00
246_N250_K1.0941.00
268_I277_A1.0931.00
178_Y271_Q1.0891.00
141_K144_Y1.0871.00
108_E146_A1.0861.00
177_P182_E1.0851.00
102_R105_E1.0821.00
124_V140_M1.0811.00
249_D260_V1.0791.00
50_L82_A1.0761.00
140_M152_I1.0741.00
246_N249_D1.0681.00
99_N102_R1.0611.00
49_T80_I1.0551.00
163_D196_N1.0501.00
194_K273_G1.0451.00
41_R69_A1.0431.00
180_L264_A1.0411.00
20_T66_V1.0371.00
262_H292_E1.0271.00
38_E284_P1.0271.00
250_K253_K1.0201.00
8_D172_H1.0191.00
98_A124_V1.0171.00
248_L260_V1.0131.00
154_V171_L1.0131.00
164_T168_V1.0121.00
88_D97_H1.0081.00
269_L293_I1.0081.00
14_S49_T1.0081.00
64_E112_K1.0041.00
183_R310_L1.0031.00
9_T172_H1.0011.00
134_E164_T0.9961.00
159_I163_D0.9961.00
14_S48_I0.9921.00
173_T201_L0.9891.00
143_L148_K0.9881.00
100_R135_E0.9811.00
70_I79_V0.9781.00
15_R269_L0.9731.00
185_M200_T0.9721.00
141_K169_A0.9711.00
138_E142_E0.9651.00
262_H289_A0.9551.00
287_L291_S0.9551.00
120_D150_R0.9521.00
152_I171_L0.9401.00
40_I51_I0.9381.00
68_K72_E0.9381.00
55_P102_R0.9371.00
201_L276_I0.9271.00
183_R186_E0.9271.00
104_V107_V0.9201.00
191_P194_K0.9191.00
143_L146_A0.9181.00
154_V162_M0.9181.00
194_K274_A0.9131.00
285_G289_A0.9031.00
63_E113_R0.9021.00
289_A292_E0.9011.00
255_R299_N0.8981.00
82_A201_L0.8941.00
301_E304_K0.8901.00
156_N203_Y0.8881.00
187_E191_P0.8861.00
265_V293_I0.8851.00
304_K307_N0.8811.00
251_L256_Y0.8801.00
9_T144_Y0.8801.00
138_E141_K0.8751.00
270_D297_T0.8751.00
301_E305_D0.8741.00
181_F245_V0.8691.00
44_L75_K0.8681.00
15_R294_T0.8671.00
271_Q303_Q0.8641.00
139_V143_L0.8621.00
38_E41_R0.8611.00
97_H102_R0.8531.00
105_E108_E0.8501.00
164_T167_A0.8481.00
174_I193_A0.8481.00
18_L43_A0.8451.00
283_K286_Q0.8411.00
162_M198_I0.8381.00
256_Y299_N0.8371.00
104_V143_L0.8371.00
20_T62_S0.8361.00
205_S279_W0.8221.00
111_L148_K0.8211.00
190_L200_T0.8161.00
33_E61_Q0.8131.00
82_A121_L0.8031.00
126_W156_N0.7941.00
270_D300_S0.7931.00
34_K37_I0.7781.00
141_K152_I0.7771.00
183_R307_N0.7751.00
18_L23_I0.7741.00
159_I189_V0.7731.00
46_Q292_E0.7731.00
137_A165_F0.7701.00
266_R293_I0.7701.00
17_G279_W0.7651.00
137_A171_L0.7651.00
33_E65_I0.7581.00
53_T66_V0.7501.00
248_L264_A0.7441.00
98_A136_T0.7431.00
202_L277_A0.7421.00
264_A268_I0.7401.00
216_T249_D0.7391.00
72_E75_K0.7381.00
55_P113_R0.7351.00
192_Y195_D0.7331.00
107_V148_K0.7321.00
137_A169_A0.7271.00
199_T275_D0.7261.00
159_I188_S0.7261.00
166_R170_P0.7241.00
111_L116_T0.7241.00
40_I44_L0.7231.00
178_Y190_L0.7221.00
77_D118_Y0.7181.00
39_T284_P0.7161.00
106_E109_N0.7161.00
189_V193_A0.7141.00
11_I150_R0.7131.00
42_A287_L0.7111.00
267_W307_N0.7101.00
36_S65_I0.7101.00
298_L303_Q0.7081.00
263_L296_W0.7081.00
103_I143_L0.7051.00
55_P109_N0.7041.00
137_A152_I0.7041.00
247_Q309_I0.7041.00
258_K292_E0.7041.00
83_T122_Y0.7031.00
154_V157_F0.7021.00
48_I291_S0.7011.00
154_V174_I0.7001.00
243_S246_N0.6981.00
258_K266_R0.6981.00
144_Y151_A0.6951.00
253_K257_G0.6941.00
286_Q289_A0.6921.00
44_L51_I0.6901.00
251_L302_D0.6891.00
256_Y263_L0.6881.00
202_L205_S0.6861.00
242_L246_N0.6861.00
41_R75_K0.6851.00
16_I269_L0.6841.00
140_M144_Y0.6801.00
282_R286_Q0.6801.00
21_W204_G0.6801.00
258_K295_G0.6791.00
193_A198_I0.6751.00
132_P135_E0.6731.00
133_I168_V0.6681.00
248_L306_I0.6631.00
99_N136_T0.6621.00
49_T78_Q0.6611.00
103_I136_T0.6601.00
22_A208_R0.6601.00
263_L298_L0.6581.00
23_I39_T0.6541.00
268_I275_D0.6531.00
252_A263_L0.6481.00
205_S268_I0.6481.00
136_T139_V0.6441.00
110_S122_Y0.6441.00
85_T98_A0.6431.00
190_L271_Q0.6411.00
261_I289_A0.6381.00
35_T284_P0.6371.00
46_Q287_L0.6321.00
13_A276_I0.6311.00
251_L305_D0.6311.00
69_A73_Y0.6311.00
217_E246_N0.6291.00
178_Y268_I0.6281.00
103_I139_V0.6251.00
123_Q153_G0.6251.00
133_I136_T0.6241.00
55_P97_H0.6231.00
213_G216_T0.6231.00
39_T281_A0.6231.00
44_L73_Y0.6221.00
161_Q164_T0.6181.00
243_S247_Q0.6181.00
111_L119_I0.6151.00
75_K79_V0.6151.00
210_L245_V0.6131.00
298_L302_D0.6131.00
107_V111_L0.6121.00
104_V148_K0.6091.00
251_L309_I0.6081.00
252_A260_V0.6081.00
144_Y149_I0.6071.00
23_I36_S0.6061.00
52_D175_Q0.6051.00
13_A50_L0.6031.00
163_D166_R0.6021.00
119_I122_Y0.6021.00
24_G62_S0.6001.00
17_G276_I0.6001.00
166_R169_A0.5951.00
61_Q65_I0.5881.00
154_V165_F0.5881.00
56_A86_A0.5881.00
40_I66_V0.5871.00
245_V249_D0.5871.00
216_T219_Y0.5851.00
8_D170_P0.5841.00
178_Y200_T0.5841.00
216_T246_N0.5841.00
302_D305_D0.5831.00
111_L118_Y0.5821.00
178_Y186_E0.5821.00
60_G113_R0.5791.00
85_T106_E0.5751.00
45_D284_P0.5751.00
6_I199_T0.5721.00
180_L310_L0.5721.00
263_L306_I0.5711.00
44_L49_T0.5681.00
181_F210_L0.5681.00
63_E83_T0.5671.00
204_G208_R0.5651.00
53_T62_S0.5641.00
242_L245_V0.5641.00
180_L267_W0.5631.00
166_R198_I0.5631.00
51_I70_I0.5621.00
107_V139_V0.5601.00
44_L78_Q0.5591.00
160_E163_D0.5591.00
263_L302_D0.5561.00
256_Y296_W0.5541.00
44_L69_A0.5541.00
185_M190_L0.5501.00
25_G65_I0.5471.00
183_R187_E0.5461.00
165_F171_L0.5461.00
266_R297_T0.5411.00
17_G278_L0.5411.00
122_Y149_I0.5381.00
127_P157_F0.5361.00
8_D197_K0.5361.00
50_L80_I0.5351.00
266_R294_T0.5321.00
84_K125_H0.5301.00
251_L255_R0.5281.00
124_V136_T0.5281.00
16_I294_T0.5271.00
202_L274_A0.5271.00
111_L117_D0.5261.00
122_Y140_M0.5241.00
269_L277_A0.5231.00
252_A256_Y0.5221.00
66_V69_A0.5211.00
18_L39_T0.5211.00
178_Y275_D0.5201.00
76_R120_D0.5191.00
100_R103_I0.5181.00
271_Q275_D0.5171.00
178_Y183_R0.5161.00
262_H296_W0.5161.00
176_P189_V0.5161.00
55_P86_A0.5161.00
162_M193_A0.5141.00
144_Y170_P0.5121.00
128_D131_V0.5111.00
64_E115_Q0.5101.00
133_I161_Q0.5091.00
68_K71_K0.5091.00
144_Y152_I0.5071.00
87_L126_W0.5071.00
121_L153_G0.5061.00
134_E138_E0.5061.00
43_A51_I0.5051.00
248_L252_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pz1A 1 0.997 100 0.103 Contact Map
1pyfA 1 0.9366 100 0.123 Contact Map
3n2tA 1 0.9668 100 0.127 Contact Map
3v0sA 1 0.8248 100 0.135 Contact Map
4xk2A 5 0.9154 100 0.151 Contact Map
3lutA 3 0.9335 100 0.156 Contact Map
3eauA 3 0.9366 100 0.162 Contact Map
1lqaA 2 0.9426 100 0.165 Contact Map
3erpA 6 0.8761 100 0.167 Contact Map
3n6qA 5 0.8882 100 0.169 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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