GREMLIN Database
G16O - General stress protein 16O
UniProt: P80872 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (156)
Sequences: 388 (321)
Seq/√Len: 25.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_Q155_I5.7201.00
92_T110_T5.3541.00
90_E108_R3.6831.00
56_D59_T3.3151.00
92_T113_A3.2091.00
12_Y82_K2.9011.00
11_L81_M2.7390.99
18_M70_L2.6010.99
150_S154_E2.5510.99
22_L74_V2.5100.99
19_Q23_S2.2830.98
4_T7_Q2.2770.98
110_T113_A2.2170.97
11_L98_Y2.1560.97
25_E67_D2.0110.95
125_A129_E1.9940.95
57_R60_D1.9670.95
23_S75_N1.9300.94
151_Q154_E1.9000.94
152_T156_L1.8330.93
88_V95_E1.8250.92
32_M36_V1.7750.91
55_T58_M1.6930.89
10_H102_E1.6610.88
79_Q83_D1.6460.88
157_D161_D1.4880.82
33_T43_V1.4820.82
8_T81_M1.4660.81
104_V107_A1.4630.81
138_D149_S1.4590.80
125_A128_Y1.4570.80
54_V62_T1.4440.80
153_Y161_D1.4380.79
70_L106_Y1.3690.76
18_M21_E1.3640.76
56_D60_D1.3580.75
147_Q153_Y1.3570.75
19_Q71_L1.3520.75
51_G55_T1.3190.73
59_T63_V1.2750.71
139_L144_T1.2720.70
94_Q112_E1.2710.70
3_L7_Q1.2680.70
109_M115_A1.2430.69
76_R80_K1.2370.68
80_K108_R1.2200.67
139_L149_S1.2150.67
33_T41_N1.2120.67
12_Y81_M1.2100.66
54_V58_M1.2090.66
152_T157_D1.2050.66
7_Q98_Y1.2020.66
130_R133_H1.1800.64
14_K18_M1.1650.63
155_I158_R1.1650.63
22_L25_E1.1570.63
149_S153_Y1.1500.62
35_E56_D1.1370.62
76_R108_R1.1340.61
19_Q75_N1.1320.61
56_D103_A1.1240.61
51_G58_M1.1140.60
91_K113_A1.1100.60
145_I150_S1.0980.59
148_K154_E1.0920.58
77_A80_K1.0880.58
155_I159_E1.0790.57
143_E146_D1.0420.55
147_Q159_E1.0410.55
76_R90_E1.0360.54
149_S154_E1.0290.54
114_Q117_V1.0050.52
62_T92_T0.9980.52
39_L44_D0.9950.51
6_E10_H0.9930.51
3_L37_G0.9930.51
138_D153_Y0.9840.50
39_L45_N0.9840.50
69_E73_E0.9830.50
136_V150_S0.9760.50
73_E108_R0.9740.50
53_L56_D0.9730.50
9_Q12_Y0.9510.48
145_I149_S0.9350.47
20_K82_K0.9300.47
89_C92_T0.9290.46
31_S109_M0.9170.46
47_M126_P0.9100.45
107_A153_Y0.9100.45
138_D147_Q0.9080.45
31_S111_V0.9020.44
41_N50_H0.9010.44
29_T113_A0.8880.43
71_L152_T0.8860.43
41_N81_M0.8820.43
126_P129_E0.8780.43
47_M128_Y0.8690.42
39_L47_M0.8630.42
40_S45_N0.8610.42
147_Q150_S0.8610.42
131_E146_D0.8600.41
145_I154_E0.8580.41
75_N95_E0.8490.41
149_S157_D0.8170.38
9_Q13_H0.8160.38
4_T98_Y0.8130.38
40_S46_H0.7990.37
80_K146_D0.7970.37
93_G107_A0.7860.36
140_S149_S0.7850.36
89_C110_T0.7850.36
41_N107_A0.7800.36
114_Q157_D0.7790.36
37_G57_R0.7730.35
12_Y34_E0.7730.35
148_K151_Q0.7700.35
8_T74_V0.7680.35
153_Y160_Q0.7670.35
13_H16_L0.7660.35
10_H14_K0.7630.35
107_A114_Q0.7610.35
50_H53_L0.7600.35
33_T50_H0.7600.35
59_T103_A0.7540.34
59_T154_E0.7420.33
114_Q118_E0.7400.33
31_S36_V0.7380.33
59_T62_T0.7380.33
39_L46_H0.7360.33
48_A51_G0.7320.33
12_Y16_L0.7300.33
48_A103_A0.7280.32
17_D21_E0.7260.32
131_E144_T0.7230.32
3_L57_R0.7230.32
90_E109_M0.7220.32
15_L38_E0.7140.32
47_M125_A0.7140.32
3_L98_Y0.7090.31
5_K83_D0.7070.31
44_D47_M0.7020.31
10_H83_D0.7000.31
14_K79_Q0.7000.31
156_L159_E0.6930.30
47_M52_T0.6910.30
136_V146_D0.6900.30
30_E34_E0.6900.30
20_K23_S0.6890.30
35_E93_G0.6880.30
65_E85_T0.6800.29
29_T114_Q0.6780.29
26_K29_T0.6750.29
139_L147_Q0.6750.29
131_E138_D0.6610.28
142_K157_D0.6580.28
113_A160_Q0.6540.28
136_V149_S0.6520.28
136_V140_S0.6510.28
3_L122_E0.6500.28
3_L18_M0.6430.27
111_V114_Q0.6400.27
35_E60_D0.6370.27
20_K143_E0.6310.27
97_P109_M0.6280.26
36_V50_H0.6270.26
140_S150_S0.6240.26
116_D143_E0.6220.26
92_T151_Q0.6210.26
54_V153_Y0.6210.26
107_A135_Q0.6200.26
18_M102_E0.6180.26
4_T13_H0.6160.26
51_G63_V0.6160.26
23_S74_V0.6120.25
111_V121_L0.6120.25
153_Y159_E0.6100.25
93_G101_L0.6090.25
66_I121_L0.6020.25
40_S44_D0.6020.25
138_D144_T0.6010.25
50_H155_I0.6010.25
9_Q127_S0.6000.25
145_I153_Y0.5970.25
152_T161_D0.5940.24
110_T151_Q0.5900.24
81_M95_E0.5900.24
103_A118_E0.5890.24
74_V156_L0.5860.24
9_Q111_V0.5860.24
100_R105_P0.5830.24
47_M129_E0.5830.24
113_A161_D0.5820.24
55_T149_S0.5810.24
16_L20_K0.5790.24
73_E161_D0.5760.24
125_A131_E0.5750.23
28_E85_T0.5740.23
43_V62_T0.5730.23
32_M67_D0.5710.23
62_T66_I0.5690.23
41_N66_I0.5670.23
140_S144_T0.5660.23
132_F150_S0.5620.23
108_R140_S0.5590.23
43_V51_G0.5580.23
132_F138_D0.5580.23
149_S152_T0.5560.22
31_S50_H0.5530.22
140_S145_I0.5520.22
22_L94_Q0.5500.22
27_K127_S0.5500.22
22_L71_L0.5460.22
41_N152_T0.5400.22
138_D155_I0.5390.22
44_D60_D0.5370.22
146_D149_S0.5370.22
24_G94_Q0.5350.21
6_E17_D0.5330.21
70_L102_E0.5310.21
73_E106_Y0.5300.21
95_E143_E0.5280.21
20_K24_G0.5270.21
43_V46_H0.5250.21
58_M63_V0.5240.21
38_E129_E0.5170.21
39_L126_P0.5170.21
36_V158_R0.5160.20
153_Y157_D0.5130.20
21_E67_D0.5100.20
59_T150_S0.5090.20
25_E29_T0.5070.20
96_I100_R0.5040.20
5_K17_D0.5030.20
13_H142_K0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ijjA 1 0.7239 100 0.513 Contact Map
1tjlA 2 0.7485 100 0.53 Contact Map
2kq9A 1 0.6626 99.9 0.579 Contact Map
2kgoA 1 0.5276 99.8 0.655 Contact Map
1lkoA 3 0.7301 52.8 0.937 Contact Map
2gviA 3 0.5644 49.3 0.938 Contact Map
3w0fA 1 0.681 48 0.939 Contact Map
3pwfA 4 0.6748 44.3 0.94 Contact Map
1k3xA 1 0.6442 41.8 0.941 Contact Map
2lo3A 1 0.2699 37.4 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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