GREMLIN Database
GS14 - General stress protein 14
UniProt: P80871 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 175 (166)
Sequences: 3733 (2663)
Seq/√Len: 206.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_T56_E3.7051.00
8_V74_L2.4591.00
77_K81_L2.4531.00
34_R53_L2.4331.00
2_K30_N2.3771.00
35_D38_K2.3701.00
51_Q87_W2.1811.00
32_T53_L2.1141.00
101_L135_S2.1071.00
66_L105_V2.0851.00
7_A18_N2.0271.00
59_R100_E2.0231.00
34_R39_E1.9681.00
52_Q56_E1.9601.00
100_E141_K1.9251.00
43_E77_K1.9091.00
48_A52_Q1.9061.00
3_I59_R1.8891.00
60_I140_M1.8601.00
22_A26_S1.8551.00
55_E87_W1.8021.00
52_Q55_E1.8011.00
156_A160_S1.7621.00
155_A158_D1.7561.00
76_K80_D1.7561.00
4_L53_L1.7461.00
19_K23_E1.7441.00
49_K53_L1.7301.00
2_K56_E1.6951.00
123_S126_E1.6671.00
73_P77_K1.6311.00
32_T57_Y1.6271.00
8_V37_Y1.6261.00
39_E53_L1.6191.00
24_E167_A1.5731.00
5_V22_A1.5711.00
50_E78_W1.5711.00
164_K167_A1.5491.00
23_E26_S1.5381.00
79_Q83_L1.4861.00
17_V106_S1.4631.00
51_Q88_A1.4341.00
104_A166_L1.4211.00
4_L57_Y1.4171.00
63_Q166_L1.4131.00
101_L140_M1.4081.00
160_S164_K1.3841.00
24_E27_K1.3651.00
23_E27_K1.3571.00
20_A24_E1.3511.00
97_H139_G1.3441.00
34_R50_E1.3321.00
154_A159_I1.3171.00
39_E49_K1.3161.00
94_N97_H1.3061.00
161_H165_R1.3041.00
162_S165_R1.3021.00
18_N33_V1.2941.00
49_K52_Q1.2871.00
124_I147_V1.2821.00
47_V51_Q1.2661.00
90_G93_G1.2581.00
66_L124_I1.2371.00
63_Q104_A1.2281.00
46_D49_K1.2251.00
3_I29_D1.2191.00
146_Y165_R1.2171.00
135_S140_M1.2151.00
166_L170_I1.1681.00
14_T106_S1.1551.00
8_V75_L1.1511.00
37_Y74_L1.1501.00
164_K168_E1.1471.00
148_F154_A1.1351.00
126_E129_K1.1331.00
39_E50_E1.1241.00
20_A167_A1.1231.00
111_A115_Q1.1141.00
104_A146_Y1.1141.00
158_D161_H1.1121.00
61_V102_M1.1111.00
57_Y60_I1.1101.00
111_A149_Y1.1091.00
14_T63_Q1.0961.00
90_G95_A1.0871.00
133_A136_N1.0721.00
71_S75_L1.0721.00
21_W25_L1.0651.00
20_A23_E1.0651.00
98_G141_K1.0561.00
24_E28_H1.0511.00
22_A33_V1.0421.00
96_L140_M1.0351.00
83_L138_I1.0291.00
53_L56_E1.0271.00
48_A51_Q1.0271.00
107_T149_Y1.0241.00
6_L34_R1.0041.00
64_F103_L0.9971.00
148_F162_S0.9961.00
58_D99_K0.9781.00
16_V156_A0.9751.00
41_P44_A0.9460.99
51_Q84_T0.9360.99
7_A15_S0.9350.99
30_N56_E0.9290.99
110_E113_K0.9270.99
159_I163_A0.9270.99
55_E95_A0.9240.99
8_V36_L0.9100.99
27_K167_A0.9030.99
15_S18_N0.9000.99
68_W80_D0.8930.99
85_Y89_F0.8750.99
10_P67_Y0.8710.99
41_P77_K0.8660.99
105_V128_L0.8580.99
16_V163_A0.8550.99
26_S30_N0.8540.99
127_L133_A0.8520.99
100_E143_L0.8460.99
41_P45_I0.8460.99
23_E167_A0.8410.99
107_T124_I0.8390.99
166_L169_Y0.8210.98
2_K58_D0.8200.98
105_V147_V0.8170.98
161_H164_K0.8150.98
59_R102_M0.8050.98
79_Q134_T0.8000.98
107_T147_V0.7970.98
69_Y137_L0.7920.98
34_R78_W0.7880.98
104_A148_F0.7840.98
129_K132_Q0.7820.98
64_F124_I0.7660.98
66_L127_L0.7640.98
16_V159_I0.7610.97
102_M146_Y0.7600.97
18_N63_Q0.7540.97
134_T138_I0.7520.97
54_C60_I0.7490.97
12_M38_K0.7470.97
85_Y91_S0.7440.97
66_L114_Y0.7430.97
73_P81_L0.7430.97
154_A158_D0.7320.97
62_F135_S0.7310.97
20_A160_S0.7200.96
144_P169_Y0.7200.96
102_M169_Y0.7190.96
109_S120_N0.7180.96
54_C78_W0.7170.96
21_W104_A0.7160.96
2_K35_D0.7140.96
135_S142_Y0.7110.96
5_V61_V0.7100.96
46_D50_E0.7080.96
43_E81_L0.6940.96
165_R168_E0.6930.96
101_L142_Y0.6930.96
93_G97_H0.6870.95
54_C62_F0.6870.95
64_F105_V0.6840.95
100_E139_G0.6780.95
159_I162_S0.6750.95
119_A137_L0.6700.95
17_V104_A0.6700.95
11_H14_T0.6660.95
25_L166_L0.6660.95
126_E132_Q0.6640.94
50_E53_L0.6620.94
68_W89_F0.6590.94
40_Y45_I0.6570.94
64_F128_L0.6540.94
109_S150_G0.6480.94
6_L78_W0.6450.94
21_W166_L0.6430.93
51_Q82_V0.6370.93
41_P81_L0.6360.93
20_A163_A0.6350.93
64_F75_L0.6200.92
8_V35_D0.6180.92
86_G90_G0.6150.92
21_W148_F0.6100.92
94_N139_G0.6070.91
6_L62_F0.6060.91
16_V20_A0.6060.91
44_A77_K0.6040.91
107_T114_Y0.6040.91
4_L34_R0.6040.91
5_V21_W0.6030.91
25_L170_I0.6030.91
151_V159_I0.6020.91
72_P80_D0.6020.91
43_E74_L0.6010.91
120_N133_A0.5990.91
71_S79_Q0.5990.91
21_W170_I0.5980.91
48_A161_H0.5980.91
157_E161_H0.5930.90
69_Y133_A0.5920.90
132_Q145_P0.5910.90
93_G96_L0.5910.90
51_Q85_Y0.5770.89
15_S19_K0.5760.89
146_Y166_L0.5740.89
64_F71_S0.5720.89
121_H133_A0.5690.89
5_V31_I0.5670.88
116_A126_E0.5660.88
125_S145_P0.5620.88
113_K119_A0.5610.88
163_A167_A0.5600.88
69_Y109_S0.5560.87
75_L79_Q0.5550.87
64_F72_P0.5450.86
48_A84_T0.5440.86
52_Q168_E0.5430.86
114_Y118_G0.5430.86
132_Q142_Y0.5400.86
74_L78_W0.5390.86
69_Y120_N0.5390.86
108_G152_N0.5340.85
11_H81_L0.5330.85
54_C83_L0.5320.85
7_A12_M0.5310.85
20_A164_K0.5310.85
25_L28_H0.5310.85
43_E73_P0.5290.85
7_A33_V0.5280.85
86_G91_S0.5270.84
81_L84_T0.5260.84
62_F128_L0.5250.84
61_V166_L0.5250.84
17_V162_S0.5240.84
118_G126_E0.5220.84
163_A166_L0.5200.84
71_S134_T0.5190.84
146_Y169_Y0.5180.83
88_A96_L0.5170.83
71_S128_L0.5130.83
100_E142_Y0.5100.83
103_L128_L0.5090.82
24_E170_I0.5080.82
64_F138_I0.5030.82
51_Q89_F0.5020.82
128_L145_P0.5010.81
44_A74_L0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d4aA 2 0.9943 100 0.358 Contact Map
4gi5A 2 0.9943 100 0.38 Contact Map
2amjA 2 0.9429 100 0.412 Contact Map
3l9wA 2 0.9886 100 0.424 Contact Map
4fglA 2 0.9943 100 0.425 Contact Map
3rpeA 2 0.96 100 0.441 Contact Map
3f2vA 2 0.9714 100 0.442 Contact Map
3ha2A 2 0.9429 100 0.445 Contact Map
3lcmA 2 0.9657 100 0.448 Contact Map
4r81A 4 0.9771 100 0.472 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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