GREMLIN Database
GS13 - General stress protein 13
UniProt: P80870 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 130 (109)
Sequences: 2528 (2225)
Seq/√Len: 213.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_T57_E4.2261.00
12_T59_Q3.9681.00
10_V61_K2.8571.00
14_K57_E2.6981.00
66_D69_K2.6591.00
6_E9_S2.5641.00
33_G74_L2.5201.00
53_S56_D2.4971.00
46_K50_E2.2231.00
13_G25_V2.0741.00
27_L74_L2.0571.00
39_E80_Q1.9631.00
40_V52_L1.9051.00
21_Y34_L1.8591.00
47_D50_E1.8531.00
10_V59_Q1.8451.00
63_L75_S1.6891.00
35_V76_I1.6481.00
40_V48_I1.6271.00
39_E78_A1.6221.00
23_A52_L1.6221.00
5_F62_V1.5141.00
21_Y36_H1.4941.00
84_E87_E1.4611.00
42_H79_T1.4531.00
64_A73_S1.4331.00
92_K95_A1.3891.00
5_F28_D1.3831.00
108_F111_L1.3491.00
109_N112_K1.3291.00
58_V76_I1.3141.00
105_P108_F1.2881.00
18_L52_L1.2761.00
99_S102_A1.2651.00
75_S80_Q1.2291.00
94_K97_Q1.2231.00
39_E64_A1.2031.00
97_Q100_E1.2011.00
26_A30_E1.1271.00
20_A49_N1.1261.00
105_P111_L1.1241.00
49_N54_V1.1241.00
40_V76_I1.0811.00
107_G110_T1.0801.00
107_G111_L1.0751.00
85_K88_S1.0731.00
98_V101_E1.0631.00
35_V60_V1.0591.00
18_L48_I1.0471.00
26_A29_E1.0291.00
24_F34_L1.0011.00
21_Y24_F0.9901.00
10_V79_T0.9821.00
13_G74_L0.9781.00
98_V103_S0.9641.00
25_V35_V0.9591.00
63_L73_S0.9561.00
91_R94_K0.9441.00
87_E92_K0.9210.99
11_Y60_V0.9200.99
88_S91_R0.9160.99
42_H83_P0.9020.99
39_E77_R0.9020.99
104_T107_G0.9000.99
22_G34_L0.8920.99
27_L72_I0.8910.99
8_G82_A0.8900.99
11_Y62_V0.8850.99
84_E88_S0.8760.99
92_K100_E0.8600.99
27_L46_K0.8580.99
105_P109_N0.8560.99
16_T26_A0.8510.99
15_V52_L0.8470.99
62_V65_V0.8450.99
90_P94_K0.8310.99
100_E104_T0.8310.99
106_Q111_L0.8190.99
103_S108_F0.8170.99
34_L38_S0.8100.98
95_A98_V0.8030.98
45_V51_H0.7930.98
43_G51_H0.7920.98
26_A32_Q0.7850.98
103_S107_G0.7840.98
86_K93_P0.7730.98
36_H73_S0.7650.98
31_T67_E0.7650.98
43_G50_E0.7570.98
86_K92_K0.7550.98
41_T45_V0.7480.97
108_F112_K0.7300.97
105_P110_T0.7290.97
60_V76_I0.7270.97
96_A99_S0.7230.97
103_S109_N0.7200.97
85_K93_P0.7150.97
23_A48_I0.7120.97
96_A104_T0.7020.96
5_F32_Q0.7010.96
18_L54_V0.7010.96
89_K102_A0.6960.96
104_T110_T0.6950.96
93_P102_A0.6890.96
100_E105_P0.6740.95
61_K78_A0.6730.95
86_K90_P0.6680.95
89_K93_P0.6660.95
92_K102_A0.6630.95
103_S111_L0.6580.95
102_A108_F0.6530.94
24_F36_H0.6470.94
23_A51_H0.6360.94
90_P93_P0.6320.93
48_I52_L0.6300.93
21_Y41_T0.6300.93
88_S105_P0.6270.93
101_E104_T0.6240.93
7_V64_A0.6240.93
94_K98_V0.6200.93
5_F11_Y0.6190.93
93_P97_Q0.6170.93
106_Q110_T0.6120.92
88_S92_K0.6110.92
86_K89_K0.6110.92
106_Q109_N0.6100.92
87_E90_P0.6090.92
29_E32_Q0.6060.92
93_P99_S0.6060.92
96_A100_E0.6020.92
77_R81_A0.6010.92
81_A84_E0.5990.91
104_T108_F0.5990.91
104_T112_K0.5960.91
16_T73_S0.5940.91
10_V78_A0.5890.91
37_I45_V0.5890.91
98_V106_Q0.5880.91
54_V57_E0.5860.91
16_T32_Q0.5850.91
85_K91_R0.5840.90
97_Q102_A0.5810.90
107_G112_K0.5810.90
14_K23_A0.5800.90
52_L76_I0.5770.90
93_P96_A0.5730.90
44_F47_D0.5730.90
40_V45_V0.5690.89
4_K28_D0.5610.89
103_S106_Q0.5610.89
70_G73_S0.5610.89
25_V58_V0.5600.89
87_E91_R0.5550.88
97_Q101_E0.5530.88
101_E107_G0.5510.88
41_T46_K0.5500.88
92_K96_A0.5440.87
96_A106_Q0.5420.87
34_L73_S0.5200.85
21_Y73_S0.5170.84
98_V104_T0.5070.83
43_G46_K0.5020.83
97_Q109_N0.5010.82
85_K89_K0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nbqA 3 0.5077 99.7 0.286 Contact Map
4aidA 3 0 99.7 0.287 Contact Map
3cdiA 3 0 99.7 0.289 Contact Map
3psfA 1 0.2385 99.7 0.292 Contact Map
1e3pA 3 0.3 99.7 0.31 Contact Map
3psiA 1 0.6308 99.7 0.313 Contact Map
2k4kA 1 0.9923 99.7 0.328 Contact Map
3bzcA 1 0.6385 99.7 0.339 Contact Map
2khjA 1 0.6538 99.7 0.34 Contact Map
2khiA 1 0.7 99.6 0.35 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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