GREMLIN Database
SUCD - Succinyl-CoA ligase [ADP-forming] subunit alpha
UniProt: P80865 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (275)
Sequences: 4829 (2843)
Seq/√Len: 171.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_H202_H5.1481.00
259_A273_V3.4341.00
56_T59_E3.2721.00
55_N59_E3.0251.00
118_R185_G2.9021.00
86_V115_K2.8361.00
63_T66_A2.7941.00
83_M111_F2.6311.00
58_A84_E2.5641.00
263_I273_V2.5601.00
149_G173_S2.4081.00
60_A66_A2.3741.00
93_V117_T2.3471.00
266_L271_I2.2931.00
83_M107_K2.2711.00
101_P105_M2.2531.00
47_E50_G2.2461.00
173_S201_T2.2451.00
262_K266_L2.2351.00
274_A283_T2.1481.00
82_I93_V2.1471.00
73_V81_A2.1411.00
58_A87_D2.0641.00
232_G266_L2.0251.00
186_T191_V1.9731.00
79_A107_K1.9341.00
19_S22_L1.9211.00
158_T175_A1.9161.00
204_V226_M1.9031.00
85_A90_L1.8961.00
205_I284_L1.8491.00
73_V77_F1.8331.00
163_H167_E1.8231.00
38_G62_Q1.8211.00
69_S85_A1.8131.00
198_D201_T1.8041.00
106_V110_R1.8031.00
149_G201_T1.7771.00
196_N227_T1.7731.00
42_G60_A1.7551.00
45_G53_V1.7511.00
176_V191_V1.7451.00
95_C108_V1.7381.00
205_I280_M1.7281.00
83_M87_D1.7151.00
80_D84_E1.7061.00
129_T132_E1.6981.00
86_V117_T1.6951.00
18_G45_G1.6801.00
112_M119_L1.6761.00
83_M114_G1.6511.00
148_V203_A1.6461.00
221_W271_I1.5991.00
232_G271_I1.5571.00
206_M232_G1.5461.00
110_R114_G1.5341.00
14_Q69_S1.5321.00
204_V224_A1.5241.00
57_V85_A1.4891.00
7_K132_E1.4811.00
192_L204_V1.4751.00
78_A100_I1.4491.00
203_A284_L1.4411.00
220_E224_A1.4381.00
168_A285_I1.4241.00
86_V111_F1.4191.00
69_S90_L1.4181.00
221_W230_V1.4111.00
67_N91_D1.4021.00
71_I81_A1.3971.00
63_T88_A1.3831.00
124_C177_G1.3791.00
41_P51_V1.3501.00
78_A95_C1.3431.00
149_G195_F1.3391.00
237_K275_E1.3381.00
146_G171_G1.3351.00
26_K30_E1.3351.00
109_K113_E1.3141.00
258_T261_E1.3101.00
40_T54_F1.3021.00
80_D83_M1.2851.00
16_I25_T1.2731.00
213_T216_E1.2691.00
188_F208_G1.2621.00
265_T269_C1.2611.00
12_I37_G1.2571.00
68_A135_I1.2341.00
213_T217_E1.2341.00
13_V35_I1.2321.00
25_T49_E1.2251.00
196_N224_A1.2161.00
44_G55_N1.2081.00
216_E257_G1.2071.00
150_V172_Q1.2051.00
27_Q96_I1.2041.00
120_I127_V1.2021.00
13_V28_M1.2021.00
148_V284_L1.1951.00
118_R186_T1.1931.00
95_C119_L1.1911.00
82_I111_F1.1911.00
120_I191_V1.1801.00
151_V191_V1.1801.00
11_V134_K1.1791.00
48_A53_V1.1641.00
174_T195_F1.1611.00
231_V274_A1.1601.00
193_K197_E1.1581.00
54_F61_V1.1471.00
22_L25_T1.1451.00
29_L32_G1.1421.00
157_L277_P1.1361.00
210_I250_A1.1291.00
231_V287_V1.1281.00
109_K112_M1.1191.00
176_V195_F1.1181.00
46_T55_N1.1181.00
196_N226_M1.1151.00
109_K182_P1.1001.00
82_I108_V1.1001.00
264_K268_A1.0981.00
57_V88_A1.0811.00
259_A263_I1.0761.00
25_T29_L1.0751.00
111_F115_K1.0691.00
16_I48_A1.0551.00
240_P243_K1.0470.99
28_M51_V1.0400.99
193_K223_K1.0400.99
94_I127_V1.0320.99
107_K110_R1.0260.99
129_T174_T1.0240.99
75_A97_T1.0190.99
217_E221_W1.0140.99
174_T201_T1.0100.99
56_T84_E1.0070.99
189_I220_E1.0070.99
60_A63_T1.0010.99
74_P77_F1.0000.99
196_N223_K0.9990.99
260_D264_K0.9970.99
82_I117_T0.9950.99
181_D212_G0.9930.99
209_E247_H0.9900.99
40_T62_Q0.9890.99
275_E279_V0.9870.99
263_I267_N0.9820.99
218_A265_T0.9810.99
193_K216_E0.9740.99
145_K200_D0.9740.99
61_V66_A0.9600.99
130_P173_S0.9530.99
131_E200_D0.9510.99
276_T279_V0.9500.99
151_V178_I0.9490.99
42_G55_N0.9480.99
14_Q57_V0.9440.99
211_G262_K0.9410.99
131_E145_K0.9390.99
272_E283_T0.9340.99
40_T60_A0.9260.99
79_A108_V0.9250.99
10_R38_G0.9250.99
68_A94_I0.9240.99
81_A84_E0.9150.99
230_V271_I0.9130.99
162_V175_A0.9090.99
11_V33_T0.9070.98
197_E223_K0.9060.98
208_G232_G0.9030.98
95_C112_M0.9020.98
181_D188_F0.9000.98
101_P104_D0.9000.98
12_I66_A0.8990.98
110_R113_E0.8930.98
18_G49_E0.8890.98
279_V282_E0.8870.98
152_S158_T0.8860.98
100_I104_D0.8840.98
46_T53_V0.8830.98
125_P159_Y0.8810.98
58_A88_A0.8790.98
22_L48_A0.8770.98
83_M86_V0.8750.98
40_T44_G0.8740.98
92_L118_R0.8730.98
99_H102_V0.8730.98
151_V195_F0.8680.98
240_P247_H0.8680.98
18_G47_E0.8670.98
234_I259_A0.8650.98
27_Q30_E0.8640.98
165_L172_Q0.8630.98
61_V88_A0.8600.98
31_Y39_V0.8590.98
192_L196_N0.8560.98
150_V165_L0.8470.98
105_M180_G0.8470.98
231_V283_T0.8380.97
41_P54_F0.8370.97
16_I22_L0.8370.97
93_V112_M0.8290.97
205_I231_V0.8290.97
190_D216_E0.8260.97
23_F138_M0.8230.97
83_M115_K0.8210.97
10_R67_N0.8210.97
29_L49_E0.8140.97
5_I92_L0.8140.97
172_Q175_A0.8120.97
77_F81_A0.8070.97
120_I186_T0.8060.97
192_L206_M0.8040.97
222_V271_I0.8040.97
112_M116_K0.8020.97
237_K259_A0.8020.97
264_K267_N0.8020.97
151_V206_M0.8010.97
71_I78_A0.7910.96
187_N190_D0.7900.96
125_P156_T0.7890.96
92_L120_I0.7870.96
47_E51_V0.7830.96
60_A88_A0.7830.96
6_N176_V0.7820.96
246_G251_I0.7810.96
188_F206_M0.7790.96
86_V112_M0.7770.96
14_Q81_A0.7740.96
86_V108_V0.7710.96
37_G51_V0.7660.96
267_N275_E0.7640.96
79_A86_V0.7630.96
6_N132_E0.7610.96
11_V31_Y0.7600.96
246_G250_A0.7540.95
62_Q88_A0.7540.95
89_E115_K0.7530.95
28_M70_V0.7520.95
149_G174_T0.7510.95
237_K263_I0.7510.95
241_P244_R0.7500.95
86_V93_V0.7480.95
107_K111_F0.7470.95
27_Q70_V0.7430.95
196_N220_E0.7380.95
19_S25_T0.7360.95
144_K166_S0.7360.95
28_M41_P0.7350.95
89_E117_T0.7350.95
87_D115_K0.7300.94
79_A111_F0.7290.94
39_V51_V0.7220.94
14_Q85_A0.7200.94
18_G48_A0.7190.94
41_P53_V0.7170.94
244_R248_A0.7120.94
143_H162_V0.7110.94
174_T194_A0.7090.94
247_H250_A0.7090.94
152_S207_I0.7080.93
274_A280_M0.7050.93
100_I180_G0.7040.93
41_P52_P0.7040.93
191_V195_F0.7030.93
84_E87_D0.7020.93
164_Q281_G0.6990.93
215_E219_A0.6980.93
244_R247_H0.6980.93
186_T194_A0.6940.93
12_I41_P0.6920.93
47_E52_P0.6920.93
68_A136_G0.6920.93
68_A92_L0.6920.93
86_V89_E0.6910.93
35_I38_G0.6860.92
98_E248_A0.6850.92
165_L281_G0.6850.92
75_A79_A0.6820.92
16_I24_H0.6760.92
261_E265_T0.6760.92
168_A282_E0.6760.92
79_A83_M0.6760.92
272_E287_V0.6760.92
105_M109_K0.6720.92
192_L220_E0.6650.91
108_V112_M0.6650.91
244_R250_A0.6630.91
203_A231_V0.6620.91
48_A51_V0.6600.91
203_A287_V0.6600.91
62_Q66_A0.6590.91
91_D117_T0.6590.91
123_N180_G0.6580.91
72_Y96_I0.6570.91
189_I216_E0.6540.90
130_P133_C0.6520.90
243_K247_H0.6480.90
11_V35_I0.6480.90
178_I181_D0.6460.90
13_V41_P0.6450.90
9_T68_A0.6410.90
16_I51_V0.6390.89
105_M182_P0.6380.89
13_V25_T0.6380.89
58_A62_Q0.6370.89
102_V180_G0.6340.89
150_V162_V0.6320.89
187_N213_T0.6280.89
86_V114_G0.6280.89
219_A222_V0.6250.88
66_A90_L0.6250.88
28_M39_V0.6210.88
234_I273_V0.6200.88
178_I191_V0.6150.88
40_T55_N0.6070.87
75_A100_I0.6060.87
193_K220_E0.6040.87
239_A242_G0.6030.87
220_E223_K0.6020.87
16_I41_P0.6020.87
121_G179_G0.6010.86
7_K131_E0.5960.86
283_T286_K0.5940.86
97_T124_C0.5930.86
75_A99_H0.5930.86
112_M115_K0.5920.86
77_F80_D0.5910.85
193_K196_N0.5900.85
84_E88_A0.5870.85
46_T52_P0.5850.85
40_T61_V0.5830.85
57_V69_S0.5820.85
111_F114_G0.5810.85
28_M35_I0.5800.84
210_I249_G0.5790.84
7_K129_T0.5770.84
206_M230_V0.5750.84
69_S93_V0.5730.84
150_V161_A0.5720.84
124_C152_S0.5700.83
98_E156_T0.5690.83
17_T24_H0.5680.83
214_A217_E0.5680.83
21_A26_K0.5670.83
100_I105_M0.5650.83
89_E116_K0.5650.83
155_G209_E0.5640.83
257_G265_T0.5620.83
216_E219_A0.5580.82
263_I275_E0.5580.82
195_F201_T0.5580.82
132_E145_K0.5570.82
280_M284_L0.5560.82
118_R194_A0.5560.82
244_R252_I0.5550.82
247_H251_I0.5540.82
74_P97_T0.5540.82
123_N247_H0.5530.82
44_G59_E0.5530.82
23_F72_Y0.5520.81
139_P159_Y0.5520.81
29_L51_V0.5510.81
166_S172_Q0.5510.81
11_V67_N0.5500.81
71_I93_V0.5470.81
231_V284_L0.5470.81
66_A89_E0.5440.80
195_F204_V0.5440.80
221_W226_M0.5430.80
223_K268_A0.5430.80
105_M108_V0.5420.80
247_H257_G0.5400.80
74_P155_G0.5380.80
211_G217_E0.5360.80
45_G49_E0.5360.80
12_I69_S0.5350.79
36_V133_C0.5330.79
149_G229_P0.5290.79
91_D118_R0.5270.78
133_C136_G0.5270.78
151_V188_F0.5270.78
79_A82_I0.5250.78
113_E116_K0.5250.78
243_K248_A0.5240.78
90_L117_T0.5240.78
240_P244_R0.5230.78
5_I120_I0.5220.78
177_G207_I0.5210.78
113_E185_G0.5210.78
223_K226_M0.5210.78
193_K226_M0.5180.77
102_V105_M0.5170.77
78_A97_T0.5160.77
60_A90_L0.5130.77
40_T66_A0.5130.77
155_G249_G0.5120.76
12_I42_G0.5110.76
181_D249_G0.5110.76
37_G54_F0.5090.76
10_R40_T0.5080.76
16_I49_E0.5070.76
143_H175_A0.5060.76
178_I188_F0.5060.76
220_E268_A0.5040.75
207_I235_G0.5040.75
136_G139_P0.5030.75
196_N221_W0.5020.75
28_M134_K0.5010.75
244_R249_G0.5010.75
201_T228_K0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2csuA 2 0.9133 100 0.227 Contact Map
3pffA 2 0.92 100 0.23 Contact Map
3mwdB 1 0.9333 100 0.272 Contact Map
2fp4A 1 0.9667 100 0.335 Contact Map
2yv1A 1 0.8767 100 0.348 Contact Map
2nu8A 1 0.9433 100 0.351 Contact Map
1oi7A 1 0.89 100 0.364 Contact Map
2yv2A 1 0.8767 100 0.372 Contact Map
3dmyA 2 0.7333 100 0.396 Contact Map
3ff4A 1 0.4 99.9 0.727 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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