GREMLIN Database
TPX - Probable thiol peroxidase
UniProt: P80864 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 167 (143)
Sequences: 12994 (7990)
Seq/√Len: 668.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_V136_E3.5211.00
28_T36_E3.0071.00
45_K78_N2.9101.00
68_N100_D2.6141.00
55_I90_Q2.6101.00
24_A117_F2.5701.00
31_T35_E2.4821.00
135_D141_V2.4001.00
28_T38_S2.3811.00
23_Q139_K2.2821.00
71_A75_G2.2221.00
70_E73_K2.0431.00
26_D40_A2.0091.00
19_K22_D1.9751.00
38_S41_D1.9091.00
135_D139_K1.9081.00
109_R112_S1.8621.00
112_S116_A1.8561.00
32_N94_C1.8491.00
30_L36_E1.8301.00
121_I128_A1.8231.00
26_D38_S1.7021.00
114_G127_L1.6941.00
37_K42_M1.6691.00
71_A100_D1.6541.00
29_V105_L1.6301.00
31_T37_K1.6261.00
84_A111_M1.6221.00
66_R70_E1.5971.00
142_Y161_A1.5771.00
84_A114_G1.5551.00
47_T138_G1.4951.00
48_I133_V1.4601.00
42_M80_Y1.4191.00
64_T99_I1.4141.00
24_A134_L1.4091.00
70_E155_Y1.4081.00
29_V113_F1.4001.00
56_D97_N1.3961.00
47_T78_N1.3711.00
31_T103_E1.3531.00
56_D92_R1.3391.00
42_M47_T1.3381.00
77_V162_A1.2961.00
46_V77_V1.2751.00
91_A95_G1.2681.00
84_A127_L1.2471.00
75_G78_N1.2351.00
68_N102_V1.2101.00
70_E156_E1.2071.00
156_E160_E1.2021.00
65_R69_E1.1761.00
43_K47_T1.1711.00
46_V141_V1.1601.00
134_L140_V1.1271.00
47_T80_Y1.1171.00
43_K138_G1.1171.00
144_E161_A1.1061.00
111_M120_Y1.1041.00
20_V142_Y1.0921.00
78_N103_E1.0861.00
72_A75_G1.0691.00
115_E120_Y1.0651.00
119_V130_S1.0611.00
111_M115_E1.0611.00
50_S64_T1.0571.00
157_K160_E1.0481.00
66_R69_E1.0311.00
62_A152_H1.0271.00
51_V82_I1.0241.00
81_T104_T0.9991.00
31_T105_L0.9921.00
73_K159_I0.9901.00
92_R95_G0.9781.00
115_E125_R0.9771.00
26_D39_L0.9741.00
61_D97_N0.9681.00
86_L89_A0.9621.00
160_E163_K0.9621.00
119_V132_F0.9501.00
133_V161_A0.9471.00
122_K125_R0.9411.00
56_D96_A0.9351.00
48_I131_V0.9251.00
113_F117_F0.9221.00
50_S102_V0.9171.00
76_D136_E0.9081.00
46_V162_A0.9051.00
65_R68_N0.9021.00
88_F92_R0.9021.00
33_S91_A0.9011.00
49_I134_L0.8991.00
47_T134_L0.8911.00
56_D89_A0.8881.00
24_A140_V0.8751.00
87_P106_S0.8691.00
73_K163_K0.8681.00
112_S115_E0.8671.00
40_A43_K0.8611.00
153_P156_E0.8611.00
132_F140_V0.8571.00
80_Y105_L0.8561.00
91_A94_C0.8541.00
39_L47_T0.8541.00
159_I163_K0.8501.00
18_V140_V0.8411.00
133_V142_Y0.8391.00
52_I81_T0.8331.00
145_Y148_E0.8311.00
27_F113_F0.8121.00
46_V76_D0.8041.00
62_A65_R0.8041.00
64_T81_T0.7991.00
48_I77_V0.7961.00
114_G120_Y0.7891.00
141_V148_E0.7831.00
27_F117_F0.7831.00
123_E126_L0.7741.00
20_V143_A0.7741.00
65_R97_N0.7671.00
32_N91_A0.7651.00
111_M114_G0.7481.00
120_Y125_R0.7471.00
19_K143_A0.7431.00
44_G136_E0.7411.00
90_Q93_W0.7411.00
39_L42_M0.7391.00
67_F79_V0.7361.00
51_V119_V0.7331.00
52_I55_I0.7311.00
18_V22_D0.7301.00
30_L108_H0.7281.00
108_H111_M0.7251.00
67_F158_P0.7201.00
63_Q131_V0.7131.00
142_Y157_K0.7121.00
72_A100_D0.7121.00
23_Q43_K0.7071.00
37_K80_Y0.6951.00
24_A39_L0.6911.00
144_E157_K0.6861.00
87_P91_A0.6861.00
89_A92_R0.6831.00
20_V140_V0.6761.00
82_I113_F0.6761.00
50_S63_Q0.6721.00
54_S85_D0.6661.00
107_D111_M0.6661.00
33_S94_C0.6651.00
128_A148_E0.6641.00
131_V158_P0.6591.00
68_N72_A0.6501.00
130_S143_A0.6481.00
27_F39_L0.6431.00
150_T153_P0.6431.00
134_L138_G0.6351.00
37_K105_L0.6341.00
42_M78_N0.6331.00
153_P157_K0.6321.00
84_A107_D0.6321.00
68_N71_A0.6301.00
144_E158_P0.6281.00
49_I117_F0.6261.00
121_I124_L0.6211.00
51_V113_F0.6211.00
24_A113_F0.6141.00
74_L77_V0.6111.00
133_V144_E0.6091.00
71_A78_N0.6081.00
48_I67_F0.6041.00
128_A145_Y0.5991.00
46_V133_V0.5981.00
63_Q67_F0.5981.00
57_T129_R0.5961.00
86_L108_H0.5931.00
31_T34_L0.5891.00
22_D143_A0.5891.00
93_W97_N0.5881.00
130_S145_Y0.5861.00
100_D103_E0.5821.00
81_T102_V0.5801.00
30_L87_P0.5791.00
88_F91_A0.5781.00
30_L34_L0.5721.00
59_V150_T0.5691.00
48_I162_A0.5681.00
50_S131_V0.5681.00
59_V151_N0.5681.00
66_R155_Y0.5631.00
54_S126_L0.5621.00
53_P57_T0.5601.00
152_H155_Y0.5541.00
144_E154_N0.5461.00
70_E74_L0.5401.00
62_A66_R0.5391.00
34_L87_P0.5391.00
108_H125_R0.5391.00
52_I90_Q0.5381.00
132_F143_A0.5371.00
61_D93_W0.5311.00
32_N103_E0.5291.00
48_I158_P0.5291.00
154_N157_K0.5281.00
67_F155_Y0.5260.99
25_P116_A0.5230.99
50_S67_F0.5180.99
113_F116_A0.5120.99
114_G119_V0.5120.99
52_I93_W0.5080.99
94_C104_T0.5060.99
74_L159_I0.5060.99
26_D43_K0.5050.99
50_S81_T0.5020.99
51_V117_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v2gA 2 0.8802 100 0.301 Contact Map
1xiyA 1 0.8743 100 0.303 Contact Map
1xvwA 3 0.9281 100 0.304 Contact Map
3w6gA 6 0.8743 100 0.305 Contact Map
3zrdA 2 0.9641 100 0.307 Contact Map
3p7xA 3 0.9701 100 0.307 Contact Map
3a2vA 5 0.8982 100 0.308 Contact Map
1prxA 2 0.8922 100 0.31 Contact Map
1xccA 2 0.8802 100 0.313 Contact Map
1psqA 2 0.9641 100 0.319 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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