GREMLIN Database
SERC - Phosphoserine aminotransferase
UniProt: P80862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 359 (336)
Sequences: 23948 (16445)
Seq/√Len: 897.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_V345_E3.7631.00
148_S174_D3.5301.00
275_C348_A3.3171.00
56_L250_E3.1151.00
93_T118_I3.0951.00
171_M188_I3.0661.00
271_V341_L3.0421.00
247_L250_E2.7731.00
158_Q161_P2.7111.00
238_P241_A2.6301.00
59_E253_K2.6221.00
190_G203_V2.5721.00
181_D184_K2.5221.00
160_F184_K2.4951.00
68_D208_K2.4551.00
267_Q341_L2.4481.00
16_L20_Q2.4241.00
317_A353_K2.2511.00
62_G181_D2.2391.00
98_M121_T2.2171.00
56_L246_S2.1451.00
333_A347_L2.1441.00
93_T116_T2.1301.00
93_T138_V2.0251.00
56_L253_K2.0201.00
275_C278_E1.9911.00
262_E266_E1.9721.00
21_K247_L1.9461.00
22_A244_M1.9381.00
270_Q274_S1.9311.00
285_G300_T1.8841.00
271_V275_C1.8611.00
80_F103_S1.8271.00
92_K142_A1.7931.00
132_E135_L1.7701.00
283_Y300_T1.7511.00
298_T330_G1.7461.00
185_F188_I1.7381.00
93_T141_G1.7091.00
279_S352_K1.6961.00
19_L23_Q1.6921.00
118_I136_T1.6911.00
92_K140_D1.6811.00
129_Y132_E1.6701.00
272_L335_I1.6541.00
346_K350_F1.6501.00
52_K246_S1.6501.00
317_A350_F1.6491.00
134_D162_N1.6331.00
283_Y302_R1.6331.00
169_A185_F1.6251.00
17_E251_W1.6191.00
266_E270_Q1.6061.00
198_P244_M1.5931.00
73_Q78_L1.5921.00
149_N293_S1.5881.00
64_P183_S1.5741.00
275_C345_E1.5741.00
83_L187_V1.5541.00
6_N347_L1.5511.00
20_Q24_K1.5381.00
15_P251_W1.5321.00
55_S59_E1.5321.00
306_L309_T1.5311.00
20_Q23_Q1.5221.00
72_L79_Q1.5221.00
52_K56_L1.5211.00
76_A172_S1.5191.00
143_Y168_V1.5171.00
80_F168_V1.5061.00
179_K259_E1.4971.00
192_A245_L1.4891.00
52_K250_E1.4741.00
93_T140_D1.4611.00
156_Q178_R1.4601.00
187_V206_M1.4601.00
53_A246_S1.4501.00
246_S250_E1.4391.00
195_N245_L1.4321.00
121_T132_E1.4181.00
123_E127_Y1.4121.00
66_D208_K1.4031.00
144_L165_I1.4011.00
273_Y297_V1.3861.00
87_F166_P1.3841.00
269_A273_Y1.3691.00
131_P134_D1.3501.00
263_Q267_Q1.3411.00
275_C352_K1.3381.00
95_H141_G1.3371.00
277_D288_R1.3351.00
175_I190_G1.3271.00
313_K317_A1.3221.00
105_K108_A1.3201.00
321_G331_C1.3141.00
159_E169_A1.3121.00
182_V205_I1.3111.00
62_G183_S1.3031.00
131_P135_L1.3031.00
134_D163_S1.2931.00
260_A263_Q1.2921.00
24_K31_E1.2861.00
108_A111_K1.2781.00
149_N174_D1.2711.00
49_V243_Y1.2691.00
196_L336_Y1.2671.00
50_H242_I1.2621.00
64_P208_K1.2611.00
174_D188_I1.2531.00
299_F333_A1.2521.00
264_R268_K1.2511.00
274_S278_E1.2471.00
60_L175_I1.2471.00
341_L345_E1.2461.00
225_S229_K1.2451.00
312_Q316_D1.2451.00
91_E142_A1.2431.00
21_K24_K1.2421.00
148_S188_I1.2381.00
17_E254_E1.2221.00
192_A197_G1.2211.00
259_E263_Q1.2091.00
17_E247_L1.2071.00
130_I161_P1.1951.00
69_I205_I1.1931.00
116_T138_V1.1911.00
9_A296_N1.1811.00
145_H168_V1.1801.00
109_E112_L1.1761.00
186_D207_K1.1741.00
99_T157_W1.1711.00
346_K349_A1.1631.00
132_E136_T1.1541.00
281_G302_R1.1521.00
56_L59_E1.1521.00
278_E352_K1.1501.00
340_S343_D1.1421.00
79_Q189_Y1.1401.00
272_L344_C1.1401.00
319_M350_F1.1381.00
14_L19_L1.1301.00
225_S228_V1.1301.00
339_V343_D1.1241.00
313_K316_D1.1181.00
98_M119_T1.1161.00
96_F119_T1.1081.00
313_K354_F1.1051.00
319_M346_K1.1051.00
123_E129_Y1.1041.00
218_V225_S1.1001.00
8_N12_A1.0951.00
57_L249_L1.0931.00
146_I159_E1.0931.00
146_I167_L1.0861.00
105_K110_T1.0841.00
109_E113_F1.0721.00
348_A352_K1.0701.00
85_M224_Y1.0681.00
64_P68_D1.0561.00
168_V189_Y1.0551.00
61_M205_I1.0541.00
261_V264_R1.0511.00
342_E345_E1.0461.00
192_A201_V1.0441.00
179_K262_E1.0421.00
105_K109_E1.0401.00
63_I68_D1.0381.00
95_H136_T1.0351.00
106_A110_T1.0341.00
272_L297_V1.0281.00
48_A52_K1.0271.00
60_L249_L1.0271.00
130_I134_D1.0171.00
55_S58_I1.0171.00
187_V210_W1.0161.00
309_T313_K1.0151.00
120_A136_T1.0091.00
133_V144_L1.0071.00
350_F353_K1.0071.00
61_M182_V1.0031.00
166_P210_W1.0021.00
26_F240_F1.0001.00
311_V323_G0.9951.00
96_F107_L0.9951.00
257_G260_A0.9931.00
345_E349_A0.9911.00
110_T115_N0.9901.00
18_V248_V0.9871.00
89_T113_F0.9851.00
45_E48_A0.9801.00
319_M347_L0.9801.00
107_L110_T0.9791.00
85_M217_N0.9791.00
53_A56_L0.9781.00
289_K292_R0.9761.00
125_D288_R0.9761.00
8_N339_V0.9751.00
57_L203_V0.9711.00
285_G298_T0.9671.00
247_L251_W0.9651.00
264_R267_Q0.9631.00
272_L333_A0.9621.00
268_K344_C0.9541.00
31_E45_E0.9531.00
87_F187_V0.9521.00
276_I299_F0.9491.00
149_N294_R0.9481.00
250_E254_E0.9461.00
207_K210_W0.9451.00
195_N249_L0.9441.00
41_H315_K0.9441.00
288_R291_S0.9431.00
269_A297_V0.9371.00
308_K312_Q0.9341.00
138_V141_G0.9341.00
118_I141_G0.9301.00
261_V337_N0.9281.00
313_K350_F0.9251.00
88_L115_N0.9231.00
148_S169_A0.9231.00
166_P186_D0.9221.00
201_V242_I0.9211.00
175_I180_I0.9191.00
174_D178_R0.9171.00
335_I344_C0.9161.00
8_N338_A0.9151.00
166_P187_V0.9141.00
123_E126_N0.9131.00
47_E51_Q0.9131.00
148_S180_I0.9121.00
130_I133_V0.9081.00
97_V146_I0.9061.00
8_N336_Y0.9051.00
267_Q271_V0.9041.00
255_N261_V0.9001.00
282_F301_L0.8971.00
94_A107_L0.8971.00
41_H45_E0.8941.00
201_V241_A0.8911.00
137_D141_G0.8911.00
321_G333_A0.8891.00
9_A334_S0.8831.00
42_R320_I0.8771.00
310_F351_M0.8721.00
53_A242_I0.8681.00
312_Q315_K0.8671.00
80_F189_Y0.8661.00
171_M174_D0.8651.00
186_D209_S0.8641.00
275_C349_A0.8631.00
8_N13_A0.8591.00
347_L351_M0.8471.00
134_D138_V0.8471.00
168_V187_V0.8441.00
279_S282_F0.8401.00
19_L26_F0.8391.00
273_Y292_R0.8371.00
118_I138_V0.8371.00
273_Y277_D0.8351.00
342_E346_K0.8311.00
15_P18_V0.8311.00
147_T151_T0.8271.00
63_I205_I0.8271.00
349_A353_K0.8251.00
83_L204_V0.8241.00
255_N260_A0.8221.00
89_T92_K0.8221.00
49_V52_K0.8211.00
273_Y284_K0.8211.00
314_A321_G0.8201.00
260_A264_R0.8081.00
261_V265_N0.8011.00
274_S277_D0.7981.00
70_L82_M0.7981.00
148_S159_E0.7931.00
68_D183_S0.7901.00
180_I188_I0.7901.00
263_Q266_E0.7861.00
218_V224_Y0.7851.00
55_S66_D0.7791.00
104_E145_H0.7741.00
56_L249_L0.7721.00
285_G330_G0.7721.00
107_L111_K0.7671.00
175_I249_L0.7671.00
22_A26_F0.7661.00
172_S191_G0.7661.00
65_E208_K0.7641.00
182_V188_I0.7621.00
96_F145_H0.7611.00
259_E262_E0.7571.00
272_L347_L0.7571.00
106_A109_E0.7571.00
127_Y291_S0.7561.00
127_Y157_W0.7491.00
310_F354_F0.7481.00
63_I182_V0.7481.00
199_S239_T0.7451.00
225_S230_A0.7451.00
175_I195_N0.7431.00
277_D289_K0.7431.00
148_S156_Q0.7431.00
138_V163_S0.7361.00
60_L253_K0.7361.00
264_R341_L0.7341.00
18_V247_L0.7331.00
224_Y227_H0.7321.00
203_V245_L0.7291.00
59_E62_G0.7291.00
58_I63_I0.7261.00
137_D144_L0.7261.00
307_T323_G0.7251.00
55_S65_E0.7251.00
95_H118_I0.7241.00
56_L60_L0.7221.00
22_A240_F0.7211.00
147_T157_W0.7201.00
182_V185_F0.7181.00
78_L82_M0.7171.00
339_V344_C0.7161.00
309_T312_Q0.7151.00
58_I66_D0.7141.00
58_I65_E0.7131.00
107_L119_T0.7101.00
111_K119_T0.7091.00
133_V137_D0.7051.00
84_P106_A0.7051.00
17_E20_Q0.7051.00
194_K332_R0.7011.00
109_E224_Y0.6991.00
38_E43_S0.6981.00
57_L71_F0.6951.00
265_N295_M0.6951.00
227_H230_A0.6941.00
315_K320_I0.6891.00
6_N344_C0.6881.00
61_M175_I0.6881.00
76_A189_Y0.6871.00
25_E49_V0.6861.00
347_L350_F0.6841.00
279_S348_A0.6831.00
17_E255_N0.6831.00
196_L337_N0.6831.00
271_V344_C0.6821.00
271_V348_A0.6821.00
179_K258_V0.6821.00
311_V321_G0.6821.00
40_S43_S0.6791.00
266_E294_R0.6791.00
149_N156_Q0.6791.00
116_T140_D0.6781.00
108_A112_L0.6771.00
68_D207_K0.6751.00
273_Y293_S0.6731.00
349_A352_K0.6731.00
252_L258_V0.6731.00
15_P337_N0.6711.00
255_N264_R0.6671.00
146_I169_A0.6651.00
272_L276_I0.6621.00
301_L310_F0.6611.00
252_L261_V0.6591.00
268_K341_L0.6561.00
50_H239_T0.6531.00
267_Q270_Q0.6521.00
218_V228_V0.6511.00
208_K212_Q0.6501.00
81_S85_M0.6501.00
120_A133_V0.6501.00
16_L23_Q0.6491.00
11_P193_Q0.6481.00
201_V245_L0.6481.00
72_L82_M0.6471.00
145_H189_Y0.6471.00
271_V274_S0.6461.00
186_D210_W0.6441.00
245_L249_L0.6421.00
250_E253_K0.6401.00
79_Q204_V0.6401.00
297_V335_I0.6391.00
97_V100_G0.6391.00
275_C279_S0.6381.00
62_G179_K0.6381.00
85_M109_E0.6381.00
226_T229_K0.6361.00
227_H234_Y0.6351.00
148_S171_M0.6341.00
305_E310_F0.6341.00
16_L19_L0.6341.00
134_D161_P0.6291.00
83_L168_V0.6281.00
61_M190_G0.6271.00
159_E167_L0.6271.00
33_G36_V0.6231.00
177_S295_M0.6211.00
257_G261_V0.6201.00
301_L304_D0.6191.00
224_Y228_V0.6191.00
178_R294_R0.6161.00
87_F210_W0.6141.00
264_R337_N0.6141.00
54_K71_F0.6121.00
54_K58_I0.6111.00
35_S38_E0.6111.00
345_E348_A0.6101.00
50_H237_P0.6091.00
21_K243_Y0.6071.00
134_D137_D0.6051.00
246_S249_L0.6041.00
92_K115_N0.6031.00
110_T117_S0.6031.00
75_G202_T0.6021.00
266_E269_A0.6021.00
52_K55_S0.6011.00
272_L348_A0.6011.00
296_N334_S0.6001.00
14_L26_F0.6001.00
272_L275_C0.6001.00
25_E243_Y0.5991.00
18_V244_M0.5991.00
63_I69_I0.5981.00
258_V262_E0.5961.00
76_A80_F0.5931.00
121_T136_T0.5911.00
21_K25_E0.5911.00
51_Q55_S0.5901.00
24_K49_V0.5881.00
255_N337_N0.5811.00
152_I328_V0.5811.00
210_W213_N0.5811.00
11_P32_S0.5801.00
188_I205_I0.5791.00
37_M237_P0.5771.00
276_I351_M0.5771.00
167_L185_F0.5771.00
63_I183_S0.5771.00
127_Y155_T0.5741.00
251_W337_N0.5731.00
58_I69_I0.5731.00
177_S195_N0.5721.00
12_A196_L0.5701.00
310_F331_C0.5701.00
269_A292_R0.5701.00
159_E185_F0.5701.00
251_W255_N0.5691.00
148_S178_R0.5671.00
147_T150_N0.5641.00
77_S81_S0.5631.00
94_A110_T0.5621.00
344_C348_A0.5611.00
99_T122_S0.5551.00
187_V204_V0.5541.00
224_Y230_A0.5521.00
22_A241_A0.5511.00
139_K163_S0.5511.00
301_L351_M0.5491.00
314_A350_F0.5471.00
143_Y166_P0.5471.00
34_M38_E0.5461.00
251_W254_E0.5441.00
128_S157_W0.5431.00
84_P104_E0.5401.00
54_K233_L0.5391.00
162_N165_I0.5371.00
88_L92_K0.5361.00
25_E240_F0.5351.00
15_P255_N0.5341.00
95_H144_L0.5341.00
128_S133_V0.5341.00
32_S45_E0.5311.00
109_E114_G0.5311.00
292_R296_N0.5301.00
90_P114_G0.5301.00
137_D163_S0.5281.00
171_M175_I0.5271.00
92_K116_T0.5261.00
333_A351_M0.5251.00
57_L69_I0.5241.00
44_K48_A0.5231.00
276_I348_A0.5201.00
206_M211_L0.5201.00
54_K229_K0.5191.00
18_V22_A0.5191.00
195_N252_L0.5181.00
123_E132_E0.5161.00
133_V136_T0.5161.00
119_T122_S0.5151.00
144_L167_L0.5141.00
146_I157_W0.5141.00
166_P209_S0.5131.00
248_V252_L0.5121.00
196_L249_L0.5111.00
122_S129_Y0.5101.00
127_Y131_P0.5101.00
46_Y243_Y0.5081.00
268_K335_I0.5081.00
40_S320_I0.5051.00
122_S132_E0.5051.00
175_I245_L0.5041.00
49_V53_A0.5041.00
270_Q290_D0.5021.00
129_Y135_L0.5021.00
310_F314_A0.5011.00
49_V246_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e77A 2 0.9749 100 0.397 Contact Map
3qm2A 2 0.9053 100 0.406 Contact Map
2c0rA 2 0.9833 100 0.409 Contact Map
1w23A 2 0.9805 100 0.414 Contact Map
3m5uA 2 0.9666 100 0.417 Contact Map
3e9kA 2 0.961 100 0.419 Contact Map
3ffrA 2 0.9526 100 0.42 Contact Map
4xk1A 2 0.9694 100 0.421 Contact Map
3islA 2 0.9499 100 0.439 Contact Map
3zrpA 2 0.9331 100 0.441 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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