SERC - BACSU - GREMLIN Contacts

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SERC - Phosphoserine aminotransferase

UniProt:	P80862	Sequences: MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSKEYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAWSEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEFPNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANVPKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCIDESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRASIYNAVSLEDCEKLAAFMKKFQQENE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	359 (336)
Sequences:	23948 (16445)
Seq/√Len:	897.1

ECOLI - SERC ISCS CSDA SUFS DCEB DCEA
BACSU - SERC ISCS1 ISCS PUCG ISCS2 YCBU SUFS
HALSA - CSD Q9HR11 Q9HMR6 MFNA
SULSO - Q97VM5 Q97ZK0 Q97WK1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
271_V	345_E	3.763	1.00
148_S	174_D	3.530	1.00
275_C	348_A	3.317	1.00
56_L	250_E	3.115	1.00
93_T	118_I	3.095	1.00
171_M	188_I	3.066	1.00
271_V	341_L	3.042	1.00
247_L	250_E	2.773	1.00
158_Q	161_P	2.711	1.00
238_P	241_A	2.630	1.00
59_E	253_K	2.622	1.00
190_G	203_V	2.572	1.00
181_D	184_K	2.522	1.00
160_F	184_K	2.495	1.00
68_D	208_K	2.455	1.00
267_Q	341_L	2.448	1.00
16_L	20_Q	2.424	1.00
317_A	353_K	2.251	1.00
62_G	181_D	2.239	1.00
98_M	121_T	2.217	1.00
56_L	246_S	2.145	1.00
333_A	347_L	2.144	1.00
93_T	116_T	2.130	1.00
93_T	138_V	2.025	1.00
56_L	253_K	2.020	1.00
275_C	278_E	1.991	1.00
262_E	266_E	1.972	1.00
21_K	247_L	1.946	1.00
22_A	244_M	1.938	1.00
270_Q	274_S	1.931	1.00
285_G	300_T	1.884	1.00
271_V	275_C	1.861	1.00
80_F	103_S	1.827	1.00
92_K	142_A	1.793	1.00
132_E	135_L	1.770	1.00
283_Y	300_T	1.751	1.00
298_T	330_G	1.746	1.00
185_F	188_I	1.738	1.00
93_T	141_G	1.709	1.00
279_S	352_K	1.696	1.00
19_L	23_Q	1.692	1.00
118_I	136_T	1.691	1.00
92_K	140_D	1.681	1.00
129_Y	132_E	1.670	1.00
272_L	335_I	1.654	1.00
346_K	350_F	1.650	1.00
52_K	246_S	1.650	1.00
317_A	350_F	1.649	1.00
134_D	162_N	1.633	1.00
283_Y	302_R	1.633	1.00
169_A	185_F	1.625	1.00
17_E	251_W	1.619	1.00
266_E	270_Q	1.606	1.00
198_P	244_M	1.593	1.00
73_Q	78_L	1.592	1.00
149_N	293_S	1.588	1.00
64_P	183_S	1.574	1.00
275_C	345_E	1.574	1.00
83_L	187_V	1.554	1.00
6_N	347_L	1.551	1.00
20_Q	24_K	1.538	1.00
15_P	251_W	1.532	1.00
55_S	59_E	1.532	1.00
306_L	309_T	1.531	1.00
20_Q	23_Q	1.522	1.00
72_L	79_Q	1.522	1.00
52_K	56_L	1.521	1.00
76_A	172_S	1.519	1.00
143_Y	168_V	1.517	1.00
80_F	168_V	1.506	1.00
179_K	259_E	1.497	1.00
192_A	245_L	1.489	1.00
52_K	250_E	1.474	1.00
93_T	140_D	1.461	1.00
156_Q	178_R	1.460	1.00
187_V	206_M	1.460	1.00
53_A	246_S	1.450	1.00
246_S	250_E	1.439	1.00
195_N	245_L	1.432	1.00
121_T	132_E	1.418	1.00
123_E	127_Y	1.412	1.00
66_D	208_K	1.403	1.00
144_L	165_I	1.401	1.00
273_Y	297_V	1.386	1.00
87_F	166_P	1.384	1.00
269_A	273_Y	1.369	1.00
131_P	134_D	1.350	1.00
263_Q	267_Q	1.341	1.00
275_C	352_K	1.338	1.00
95_H	141_G	1.337	1.00
277_D	288_R	1.335	1.00
175_I	190_G	1.327	1.00
313_K	317_A	1.322	1.00
105_K	108_A	1.320	1.00
321_G	331_C	1.314	1.00
159_E	169_A	1.312	1.00
182_V	205_I	1.311	1.00
62_G	183_S	1.303	1.00
131_P	135_L	1.303	1.00
134_D	163_S	1.293	1.00
260_A	263_Q	1.292	1.00
24_K	31_E	1.286	1.00
108_A	111_K	1.278	1.00
149_N	174_D	1.271	1.00
49_V	243_Y	1.269	1.00
196_L	336_Y	1.267	1.00
50_H	242_I	1.262	1.00
64_P	208_K	1.261	1.00
174_D	188_I	1.253	1.00
299_F	333_A	1.252	1.00
264_R	268_K	1.251	1.00
274_S	278_E	1.247	1.00
60_L	175_I	1.247	1.00
341_L	345_E	1.246	1.00
225_S	229_K	1.245	1.00
312_Q	316_D	1.245	1.00
91_E	142_A	1.243	1.00
21_K	24_K	1.242	1.00
148_S	188_I	1.238	1.00
17_E	254_E	1.222	1.00
192_A	197_G	1.221	1.00
259_E	263_Q	1.209	1.00
17_E	247_L	1.207	1.00
130_I	161_P	1.195	1.00
69_I	205_I	1.193	1.00
116_T	138_V	1.191	1.00
9_A	296_N	1.181	1.00
145_H	168_V	1.180	1.00
109_E	112_L	1.176	1.00
186_D	207_K	1.174	1.00
99_T	157_W	1.171	1.00
346_K	349_A	1.163	1.00
132_E	136_T	1.154	1.00
281_G	302_R	1.152	1.00
56_L	59_E	1.152	1.00
278_E	352_K	1.150	1.00
340_S	343_D	1.142	1.00
79_Q	189_Y	1.140	1.00
272_L	344_C	1.140	1.00
319_M	350_F	1.138	1.00
14_L	19_L	1.130	1.00
225_S	228_V	1.130	1.00
339_V	343_D	1.124	1.00
313_K	316_D	1.118	1.00
98_M	119_T	1.116	1.00
96_F	119_T	1.108	1.00
313_K	354_F	1.105	1.00
319_M	346_K	1.105	1.00
123_E	129_Y	1.104	1.00
218_V	225_S	1.100	1.00
8_N	12_A	1.095	1.00
57_L	249_L	1.093	1.00
146_I	159_E	1.093	1.00
146_I	167_L	1.086	1.00
105_K	110_T	1.084	1.00
109_E	113_F	1.072	1.00
348_A	352_K	1.070	1.00
85_M	224_Y	1.068	1.00
64_P	68_D	1.056	1.00
168_V	189_Y	1.055	1.00
61_M	205_I	1.054	1.00
261_V	264_R	1.051	1.00
342_E	345_E	1.046	1.00
192_A	201_V	1.044	1.00
179_K	262_E	1.042	1.00
105_K	109_E	1.040	1.00
63_I	68_D	1.038	1.00
95_H	136_T	1.035	1.00
106_A	110_T	1.034	1.00
272_L	297_V	1.028	1.00
48_A	52_K	1.027	1.00
60_L	249_L	1.027	1.00
130_I	134_D	1.017	1.00
55_S	58_I	1.017	1.00
187_V	210_W	1.016	1.00
309_T	313_K	1.015	1.00
120_A	136_T	1.009	1.00
133_V	144_L	1.007	1.00
350_F	353_K	1.007	1.00
61_M	182_V	1.003	1.00
166_P	210_W	1.002	1.00
26_F	240_F	1.000	1.00
311_V	323_G	0.995	1.00
96_F	107_L	0.995	1.00
257_G	260_A	0.993	1.00
345_E	349_A	0.991	1.00
110_T	115_N	0.990	1.00
18_V	248_V	0.987	1.00
89_T	113_F	0.985	1.00
45_E	48_A	0.980	1.00
319_M	347_L	0.980	1.00
107_L	110_T	0.979	1.00
85_M	217_N	0.979	1.00
53_A	56_L	0.978	1.00
289_K	292_R	0.976	1.00
125_D	288_R	0.976	1.00
8_N	339_V	0.975	1.00
57_L	203_V	0.971	1.00
285_G	298_T	0.967	1.00
247_L	251_W	0.965	1.00
264_R	267_Q	0.963	1.00
272_L	333_A	0.962	1.00
268_K	344_C	0.954	1.00
31_E	45_E	0.953	1.00
87_F	187_V	0.952	1.00
276_I	299_F	0.949	1.00
149_N	294_R	0.948	1.00
250_E	254_E	0.946	1.00
207_K	210_W	0.945	1.00
195_N	249_L	0.944	1.00
41_H	315_K	0.944	1.00
288_R	291_S	0.943	1.00
269_A	297_V	0.937	1.00
308_K	312_Q	0.934	1.00
138_V	141_G	0.934	1.00
118_I	141_G	0.930	1.00
261_V	337_N	0.928	1.00
313_K	350_F	0.925	1.00
88_L	115_N	0.923	1.00
148_S	169_A	0.923	1.00
166_P	186_D	0.922	1.00
201_V	242_I	0.921	1.00
175_I	180_I	0.919	1.00
174_D	178_R	0.917	1.00
335_I	344_C	0.916	1.00
8_N	338_A	0.915	1.00
166_P	187_V	0.914	1.00
123_E	126_N	0.913	1.00
47_E	51_Q	0.913	1.00
148_S	180_I	0.912	1.00
130_I	133_V	0.908	1.00
97_V	146_I	0.906	1.00
8_N	336_Y	0.905	1.00
267_Q	271_V	0.904	1.00
255_N	261_V	0.900	1.00
282_F	301_L	0.897	1.00
94_A	107_L	0.897	1.00
41_H	45_E	0.894	1.00
201_V	241_A	0.891	1.00
137_D	141_G	0.891	1.00
321_G	333_A	0.889	1.00
9_A	334_S	0.883	1.00
42_R	320_I	0.877	1.00
310_F	351_M	0.872	1.00
53_A	242_I	0.868	1.00
312_Q	315_K	0.867	1.00
80_F	189_Y	0.866	1.00
171_M	174_D	0.865	1.00
186_D	209_S	0.864	1.00
275_C	349_A	0.863	1.00
8_N	13_A	0.859	1.00
347_L	351_M	0.847	1.00
134_D	138_V	0.847	1.00
168_V	187_V	0.844	1.00
279_S	282_F	0.840	1.00
19_L	26_F	0.839	1.00
273_Y	292_R	0.837	1.00
118_I	138_V	0.837	1.00
273_Y	277_D	0.835	1.00
342_E	346_K	0.831	1.00
15_P	18_V	0.831	1.00
147_T	151_T	0.827	1.00
63_I	205_I	0.827	1.00
349_A	353_K	0.825	1.00
83_L	204_V	0.824	1.00
255_N	260_A	0.822	1.00
89_T	92_K	0.822	1.00
49_V	52_K	0.821	1.00
273_Y	284_K	0.821	1.00
314_A	321_G	0.820	1.00
260_A	264_R	0.808	1.00
261_V	265_N	0.801	1.00
274_S	277_D	0.798	1.00
70_L	82_M	0.798	1.00
148_S	159_E	0.793	1.00
68_D	183_S	0.790	1.00
180_I	188_I	0.790	1.00
263_Q	266_E	0.786	1.00
218_V	224_Y	0.785	1.00
55_S	66_D	0.779	1.00
104_E	145_H	0.774	1.00
56_L	249_L	0.772	1.00
285_G	330_G	0.772	1.00
107_L	111_K	0.767	1.00
175_I	249_L	0.767	1.00
22_A	26_F	0.766	1.00
172_S	191_G	0.766	1.00
65_E	208_K	0.764	1.00
182_V	188_I	0.762	1.00
96_F	145_H	0.761	1.00
259_E	262_E	0.757	1.00
272_L	347_L	0.757	1.00
106_A	109_E	0.757	1.00
127_Y	291_S	0.756	1.00
127_Y	157_W	0.749	1.00
310_F	354_F	0.748	1.00
63_I	182_V	0.748	1.00
199_S	239_T	0.745	1.00
225_S	230_A	0.745	1.00
175_I	195_N	0.743	1.00
277_D	289_K	0.743	1.00
148_S	156_Q	0.743	1.00
138_V	163_S	0.736	1.00
60_L	253_K	0.736	1.00
264_R	341_L	0.734	1.00
18_V	247_L	0.733	1.00
224_Y	227_H	0.732	1.00
203_V	245_L	0.729	1.00
59_E	62_G	0.729	1.00
58_I	63_I	0.726	1.00
137_D	144_L	0.726	1.00
307_T	323_G	0.725	1.00
55_S	65_E	0.725	1.00
95_H	118_I	0.724	1.00
56_L	60_L	0.722	1.00
22_A	240_F	0.721	1.00
147_T	157_W	0.720	1.00
182_V	185_F	0.718	1.00
78_L	82_M	0.717	1.00
339_V	344_C	0.716	1.00
309_T	312_Q	0.715	1.00
58_I	66_D	0.714	1.00
58_I	65_E	0.713	1.00
107_L	119_T	0.710	1.00
111_K	119_T	0.709	1.00
133_V	137_D	0.705	1.00
84_P	106_A	0.705	1.00
17_E	20_Q	0.705	1.00
194_K	332_R	0.701	1.00
109_E	224_Y	0.699	1.00
38_E	43_S	0.698	1.00
57_L	71_F	0.695	1.00
265_N	295_M	0.695	1.00
227_H	230_A	0.694	1.00
315_K	320_I	0.689	1.00
6_N	344_C	0.688	1.00
61_M	175_I	0.688	1.00
76_A	189_Y	0.687	1.00
25_E	49_V	0.686	1.00
347_L	350_F	0.684	1.00
279_S	348_A	0.683	1.00
17_E	255_N	0.683	1.00
196_L	337_N	0.683	1.00
271_V	344_C	0.682	1.00
271_V	348_A	0.682	1.00
179_K	258_V	0.682	1.00
311_V	321_G	0.682	1.00
40_S	43_S	0.679	1.00
266_E	294_R	0.679	1.00
149_N	156_Q	0.679	1.00
116_T	140_D	0.678	1.00
108_A	112_L	0.677	1.00
68_D	207_K	0.675	1.00
273_Y	293_S	0.673	1.00
349_A	352_K	0.673	1.00
252_L	258_V	0.673	1.00
15_P	337_N	0.671	1.00
255_N	264_R	0.667	1.00
146_I	169_A	0.665	1.00
272_L	276_I	0.662	1.00
301_L	310_F	0.661	1.00
252_L	261_V	0.659	1.00
268_K	341_L	0.656	1.00
50_H	239_T	0.653	1.00
267_Q	270_Q	0.652	1.00
218_V	228_V	0.651	1.00
208_K	212_Q	0.650	1.00
81_S	85_M	0.650	1.00
120_A	133_V	0.650	1.00
16_L	23_Q	0.649	1.00
11_P	193_Q	0.648	1.00
201_V	245_L	0.648	1.00
72_L	82_M	0.647	1.00
145_H	189_Y	0.647	1.00
271_V	274_S	0.646	1.00
186_D	210_W	0.644	1.00
245_L	249_L	0.642	1.00
250_E	253_K	0.640	1.00
79_Q	204_V	0.640	1.00
297_V	335_I	0.639	1.00
97_V	100_G	0.639	1.00
275_C	279_S	0.638	1.00
62_G	179_K	0.638	1.00
85_M	109_E	0.638	1.00
226_T	229_K	0.636	1.00
227_H	234_Y	0.635	1.00
148_S	171_M	0.634	1.00
305_E	310_F	0.634	1.00
16_L	19_L	0.634	1.00
134_D	161_P	0.629	1.00
83_L	168_V	0.628	1.00
61_M	190_G	0.627	1.00
159_E	167_L	0.627	1.00
33_G	36_V	0.623	1.00
177_S	295_M	0.621	1.00
257_G	261_V	0.620	1.00
301_L	304_D	0.619	1.00
224_Y	228_V	0.619	1.00
178_R	294_R	0.616	1.00
87_F	210_W	0.614	1.00
264_R	337_N	0.614	1.00
54_K	71_F	0.612	1.00
54_K	58_I	0.611	1.00
35_S	38_E	0.611	1.00
345_E	348_A	0.610	1.00
50_H	237_P	0.609	1.00
21_K	243_Y	0.607	1.00
134_D	137_D	0.605	1.00
246_S	249_L	0.604	1.00
92_K	115_N	0.603	1.00
110_T	117_S	0.603	1.00
75_G	202_T	0.602	1.00
266_E	269_A	0.602	1.00
52_K	55_S	0.601	1.00
272_L	348_A	0.601	1.00
296_N	334_S	0.600	1.00
14_L	26_F	0.600	1.00
272_L	275_C	0.600	1.00
25_E	243_Y	0.599	1.00
18_V	244_M	0.599	1.00
63_I	69_I	0.598	1.00
258_V	262_E	0.596	1.00
76_A	80_F	0.593	1.00
121_T	136_T	0.591	1.00
21_K	25_E	0.591	1.00
51_Q	55_S	0.590	1.00
24_K	49_V	0.588	1.00
255_N	337_N	0.581	1.00
152_I	328_V	0.581	1.00
210_W	213_N	0.581	1.00
11_P	32_S	0.580	1.00
188_I	205_I	0.579	1.00
37_M	237_P	0.577	1.00
276_I	351_M	0.577	1.00
167_L	185_F	0.577	1.00
63_I	183_S	0.577	1.00
127_Y	155_T	0.574	1.00
251_W	337_N	0.573	1.00
58_I	69_I	0.573	1.00
177_S	195_N	0.572	1.00
12_A	196_L	0.570	1.00
310_F	331_C	0.570	1.00
269_A	292_R	0.570	1.00
159_E	185_F	0.570	1.00
251_W	255_N	0.569	1.00
148_S	178_R	0.567	1.00
147_T	150_N	0.564	1.00
77_S	81_S	0.563	1.00
94_A	110_T	0.562	1.00
344_C	348_A	0.561	1.00
99_T	122_S	0.555	1.00
187_V	204_V	0.554	1.00
224_Y	230_A	0.552	1.00
22_A	241_A	0.551	1.00
139_K	163_S	0.551	1.00
301_L	351_M	0.549	1.00
314_A	350_F	0.547	1.00
143_Y	166_P	0.547	1.00
34_M	38_E	0.546	1.00
251_W	254_E	0.544	1.00
128_S	157_W	0.543	1.00
84_P	104_E	0.540	1.00
54_K	233_L	0.539	1.00
162_N	165_I	0.537	1.00
88_L	92_K	0.536	1.00
25_E	240_F	0.535	1.00
15_P	255_N	0.534	1.00
95_H	144_L	0.534	1.00
128_S	133_V	0.534	1.00
32_S	45_E	0.531	1.00
109_E	114_G	0.531	1.00
292_R	296_N	0.530	1.00
90_P	114_G	0.530	1.00
137_D	163_S	0.528	1.00
171_M	175_I	0.527	1.00
92_K	116_T	0.526	1.00
333_A	351_M	0.525	1.00
57_L	69_I	0.524	1.00
44_K	48_A	0.523	1.00
276_I	348_A	0.520	1.00
206_M	211_L	0.520	1.00
54_K	229_K	0.519	1.00
18_V	22_A	0.519	1.00
195_N	252_L	0.518	1.00
123_E	132_E	0.516	1.00
133_V	136_T	0.516	1.00
119_T	122_S	0.515	1.00
144_L	167_L	0.514	1.00
146_I	157_W	0.514	1.00
166_P	209_S	0.513	1.00
248_V	252_L	0.512	1.00
196_L	249_L	0.511	1.00
122_S	129_Y	0.510	1.00
127_Y	131_P	0.510	1.00
46_Y	243_Y	0.508	1.00
268_K	335_I	0.508	1.00
40_S	320_I	0.505	1.00
122_S	132_E	0.505	1.00
175_I	245_L	0.504	1.00
49_V	53_A	0.504	1.00
270_Q	290_D	0.502	1.00
129_Y	135_L	0.502	1.00
310_F	314_A	0.501	1.00
49_V	246_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3e77A	2	0.9749	100	0.397	Contact Map
3qm2A	2	0.9053	100	0.406	Contact Map
2c0rA	2	0.9833	100	0.409	Contact Map
1w23A	2	0.9805	100	0.414	Contact Map
3m5uA	2	0.9666	100	0.417	Contact Map
3e9kA	2	0.961	100	0.419	Contact Map
3ffrA	2	0.9526	100	0.42	Contact Map
4xk1A	2	0.9694	100	0.421	Contact Map
3islA	2	0.9499	100	0.439	Contact Map
3zrpA	2	0.9331	100	0.441	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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