GREMLIN Database
G6PI - Glucose-6-phosphate isomerase
UniProt: P80860 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 450 (421)
Sequences: 3545 (1920)
Seq/√Len: 93.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_K227_D5.1151.00
408_G415_P4.5901.00
7_D10_K4.2171.00
235_D391_Y4.1301.00
160_K164_E4.0871.00
333_K387_E4.0661.00
75_V114_I3.2041.00
210_V229_M3.1081.00
271_I314_G3.0071.00
228_D391_Y2.8911.00
140_N178_T2.8691.00
330_N349_G2.8051.00
185_A188_T2.8001.00
74_D136_D2.6341.00
245_L251_Y2.6331.00
142_I214_V2.6261.00
261_Y322_R2.5901.00
287_L404_C2.5451.00
9_S12_L2.5351.00
362_N368_G2.5101.00
65_S198_F2.5031.00
20_L26_F2.5001.00
125_M157_I2.4771.00
329_L385_I2.4601.00
75_V112_Q2.3901.00
359_D362_N2.2601.00
11_A14_F2.1801.00
9_S245_L2.1511.00
238_K242_T2.1221.00
77_L132_L2.1031.00
192_E195_F2.0481.00
186_L197_S2.0201.00
77_L139_I1.9671.00
21_T29_T1.9521.00
253_Y399_F1.9451.00
75_V136_D1.9151.00
229_M393_F1.8891.00
270_L284_W1.8651.00
52_E237_S1.8591.00
93_E278_Q1.8541.00
265_K323_D1.8511.00
357_T360_F1.8511.00
279_Y282_E1.8401.00
393_F397_V1.8391.00
32_H43_D1.8301.00
91_A229_M1.8251.00
40_A56_K1.8181.00
13_T241_A1.8101.00
13_T17_E1.8051.00
66_A220_A1.7941.00
271_I326_E1.7901.00
358_V371_L1.7851.00
67_E70_K1.7831.00
48_V53_H1.7721.00
73_S138_S1.7671.00
16_N241_A1.7621.00
37_K56_K1.7581.00
37_K234_L1.7371.00
14_F19_E1.7211.00
331_V385_I1.7161.00
8_Y12_L1.7111.00
359_D363_K1.7081.00
332_E386_P1.6941.00
352_Y382_I1.6901.00
332_E384_N1.6821.00
66_A70_K1.6791.00
304_A313_L1.6721.00
211_L233_A1.6631.00
137_F161_L1.6571.00
134_D161_L1.6551.00
431_L434_K1.6461.00
36_E51_P1.6431.00
128_V132_L1.6421.00
279_Y304_A1.6211.00
210_V218_P1.6071.00
91_A218_P1.5941.00
330_N352_Y1.5891.00
219_I224_V1.5791.00
127_D276_A1.5761.00
358_V362_N1.5721.00
11_A409_Y1.5531.00
356_K364_K1.5531.00
162_L166_Y1.5461.00
236_A399_F1.5261.00
142_I178_T1.5251.00
266_T322_R1.5231.00
309_D314_G1.5181.00
66_A224_V1.4981.00
63_K224_V1.4941.00
92_I115_F1.4911.00
355_G360_F1.4851.00
225_N228_D1.4831.00
292_E415_P1.4771.00
356_K360_F1.4731.00
231_K391_Y1.4701.00
116_I125_M1.4691.00
228_D231_K1.4641.00
91_A397_V1.4601.00
355_G362_N1.4601.00
257_R288_F1.4571.00
231_K235_D1.4531.00
355_G359_D1.4511.00
43_D52_E1.4481.00
170_E173_A1.4481.00
244_E247_D1.4441.00
330_N384_N1.4320.99
179_T186_L1.4290.99
49_D52_E1.4190.99
66_A219_I1.4150.99
266_T321_R1.4100.99
140_N176_Y1.4080.99
278_Q305_N1.4070.99
57_E61_R1.4030.99
258_N410_L1.3960.99
29_T415_P1.3880.99
229_M397_V1.3860.99
76_L140_N1.3770.99
234_L238_K1.3760.99
85_Y89_R1.3760.99
391_Y395_Y1.3700.99
238_K241_A1.3690.99
39_G60_A1.3610.99
262_N411_L1.3610.99
236_A395_Y1.3590.99
153_I347_L1.3510.99
61_R196_E1.3360.99
181_K185_A1.3340.99
267_I302_S1.3320.99
79_V158_F1.3280.99
149_T432_L1.3190.99
32_H36_E1.3130.99
182_E194_G1.3100.99
89_R279_Y1.3070.99
187_K194_G1.2980.99
288_F298_G1.2950.99
333_K386_P1.2920.99
251_Y406_M1.2900.99
182_E197_S1.2900.99
97_H335_K1.2850.99
249_P399_F1.2760.99
41_G238_K1.2650.99
249_P252_Q1.2520.99
116_I158_F1.2520.99
255_V410_L1.2400.99
389_N392_T1.2360.98
91_A393_F1.2290.98
72_D176_Y1.2290.98
271_I309_D1.2270.98
42_S49_D1.2250.98
224_V390_A1.2250.98
68_K196_E1.2180.98
365_A374_T1.2180.98
31_H35_H1.2150.98
239_D395_Y1.2140.98
340_I347_L1.2080.98
386_P392_T1.2060.98
65_S176_Y1.1970.98
280_F396_L1.1850.98
370_M374_T1.1850.98
107_K221_V1.1830.98
162_L175_I1.1820.98
227_D231_K1.1780.98
39_G42_S1.1770.98
257_R403_A1.1770.98
317_V324_L1.1710.98
259_V263_K1.1660.98
231_K234_L1.1660.98
60_A64_K1.1650.98
114_I131_L1.1570.98
8_Y254_A1.1440.97
50_L204_V1.1390.97
316_Y321_R1.1340.97
268_E288_F1.1320.97
93_E279_Y1.1310.97
36_E39_G1.1260.97
257_R407_S1.1240.97
228_D390_A1.1160.97
240_F250_A1.1100.97
273_Y328_V1.1030.97
200_I213_A1.1010.97
139_I158_F1.0940.97
74_D114_I1.0910.97
182_E187_K1.0850.97
15_F21_T1.0840.97
59_F227_D1.0770.96
125_M129_M1.0720.96
353_L384_N1.0710.96
134_D165_K1.0670.96
67_E71_S1.0650.96
327_T381_L1.0580.96
35_H402_K1.0570.96
302_S313_L1.0480.96
29_T408_G1.0410.96
20_L46_G1.0380.96
120_I307_S1.0350.95
289_G313_L1.0310.95
75_V133_E1.0290.95
24_R28_K1.0230.95
15_F29_T1.0230.95
10_K14_F1.0220.95
126_R336_H1.0210.95
163_E167_G1.0200.95
349_G353_L1.0200.95
75_V132_L1.0190.95
91_A94_A1.0180.95
335_K387_E1.0170.95
356_K359_D1.0170.95
12_L245_L1.0150.95
194_G197_S1.0140.95
42_S51_P1.0130.95
123_S336_H1.0130.95
39_G56_K1.0130.95
271_I306_Y1.0110.95
70_K110_N1.0100.95
157_I341_E1.0090.95
43_D51_P1.0070.95
114_I128_V1.0050.95
182_E186_L1.0040.95
69_I138_S1.0040.95
167_G171_A1.0030.95
94_A388_L1.0030.95
236_A249_P1.0010.95
439_E442_A1.0010.95
94_A393_F0.9960.94
266_T323_D0.9900.94
36_E234_L0.9880.94
129_M161_L0.9870.94
51_P56_K0.9780.94
128_V131_L0.9730.94
123_S274_E0.9710.94
124_Y275_P0.9710.94
258_N262_N0.9710.94
163_E171_A0.9640.93
8_Y251_Y0.9630.93
316_Y324_L0.9620.93
257_R268_E0.9610.93
10_K13_T0.9570.93
120_I153_I0.9520.93
141_V155_F0.9510.93
347_L432_L0.9500.93
56_K234_L0.9460.93
280_F397_V0.9430.93
235_D395_Y0.9380.92
274_E331_V0.9380.92
89_R278_Q0.9370.92
59_F230_M0.9370.92
49_D237_S0.9360.92
228_D389_N0.9320.92
275_P278_Q0.9320.92
328_V380_N0.9310.92
179_T197_S0.9240.92
56_K227_D0.9240.92
163_E166_Y0.9230.92
159_R163_E0.9150.91
334_P337_E0.9120.91
180_D200_I0.9090.91
129_M132_L0.9080.91
78_V142_I0.9080.91
74_D112_Q0.9070.91
272_N305_N0.9050.91
268_E327_T0.9050.91
254_A258_N0.9040.91
23_L414_N0.9010.91
181_K184_G0.9000.91
243_S247_D0.8980.91
284_W287_L0.8950.91
387_E392_T0.8940.90
355_G361_V0.8920.90
351_N354_A0.8910.90
256_V260_L0.8880.90
58_E61_R0.8880.90
18_H22_Y0.8870.90
281_A303_S0.8870.90
12_L240_F0.8870.90
92_I113_V0.8860.90
130_D336_H0.8850.90
282_E304_A0.8850.90
331_V388_L0.8770.90
314_G326_E0.8700.89
267_I323_D0.8650.89
166_Y170_E0.8610.89
62_I220_A0.8560.88
91_A210_V0.8550.88
8_Y11_A0.8530.88
60_A227_D0.8520.88
361_V364_K0.8500.88
426_V429_F0.8490.88
326_E380_N0.8470.88
36_E41_G0.8450.88
178_T214_V0.8440.88
31_H251_Y0.8440.88
218_P229_M0.8410.88
123_S276_A0.8380.87
242_T247_D0.8360.87
277_L329_L0.8360.87
49_D53_H0.8350.87
267_I300_Y0.8320.87
349_G384_N0.8310.87
37_K231_K0.8290.87
219_I229_M0.8290.87
46_G203_D0.8280.87
119_N307_S0.8280.87
254_A406_M0.8230.86
37_K51_P0.8220.86
64_K68_K0.8210.86
163_E168_K0.8200.86
364_K367_Q0.8170.86
108_R111_P0.8170.86
180_D186_L0.8120.86
160_K341_E0.8110.86
8_Y245_L0.8070.85
361_V371_L0.8050.85
373_H419_P0.8040.85
253_Y381_L0.7970.85
430_A434_K0.7970.85
269_M304_A0.7960.85
295_D412_G0.7960.85
85_Y115_F0.7950.85
63_K67_E0.7940.84
24_R373_H0.7930.84
58_E199_V0.7910.84
39_G51_P0.7900.84
355_G364_K0.7900.84
187_K191_N0.7900.84
440_K443_E0.7890.84
298_G316_Y0.7840.84
132_L161_L0.7830.84
113_V221_V0.7820.84
355_G370_M0.7800.83
92_I221_V0.7780.83
93_E96_N0.7770.83
37_K42_S0.7740.83
78_V85_Y0.7740.83
7_D11_A0.7710.83
187_K197_S0.7710.83
45_L49_D0.7710.83
94_A277_L0.7690.83
138_S176_Y0.7690.83
68_K72_D0.7680.82
397_V401_E0.7670.82
277_L280_F0.7650.82
116_I128_V0.7650.82
149_T429_F0.7640.82
112_Q131_L0.7640.82
94_A397_V0.7610.82
70_K109_G0.7610.82
300_Y322_R0.7590.82
236_A383_V0.7580.82
57_E199_V0.7580.82
152_A156_R0.7550.81
75_V131_L0.7540.81
15_F32_H0.7530.81
270_L287_L0.7520.81
310_L424_Y0.7510.81
137_F162_L0.7460.81
125_M158_F0.7460.81
18_H21_T0.7440.80
273_Y306_Y0.7410.80
346_D436_G0.7410.80
327_T403_A0.7390.80
157_I338_L0.7370.80
229_M233_A0.7350.80
288_F403_A0.7350.80
70_K220_A0.7290.79
201_P213_A0.7290.79
9_S13_T0.7290.79
36_E43_D0.7280.79
367_Q371_L0.7270.79
301_P403_A0.7230.78
36_E42_S0.7230.78
147_T429_F0.7230.78
123_S127_D0.7230.78
268_E407_S0.7220.78
360_F363_K0.7220.78
362_N371_L0.7200.78
330_N363_K0.7200.78
95_L390_A0.7180.78
272_N281_A0.7170.78
329_L388_L0.7170.78
276_A335_K0.7140.78
218_P222_S0.7130.78
36_E56_K0.7100.77
139_I175_I0.7090.77
127_D336_H0.7090.77
184_G187_K0.7080.77
47_W50_L0.7060.77
240_F406_M0.7060.77
356_K362_N0.7060.77
145_S200_I0.7040.77
253_Y403_A0.7040.77
288_F301_P0.7020.76
235_D238_K0.6990.76
367_Q372_A0.6970.76
92_I218_P0.6950.76
60_A63_K0.6930.75
7_D14_F0.6930.75
37_K49_D0.6930.75
149_T347_L0.6920.75
149_T153_I0.6880.75
270_L400_F0.6870.75
28_K32_H0.6860.75
369_T372_A0.6850.75
306_Y317_V0.6820.74
405_A409_Y0.6820.74
386_P395_Y0.6820.74
184_G188_T0.6810.74
37_K227_D0.6810.74
409_Y415_P0.6810.74
70_K111_P0.6800.74
65_S69_I0.6760.74
64_K67_E0.6760.74
276_A336_H0.6750.74
20_L23_L0.6710.73
232_G394_G0.6680.73
346_D349_G0.6680.73
16_N32_H0.6670.73
37_K40_A0.6660.73
208_Y404_C0.6630.72
288_F407_S0.6630.72
385_I392_T0.6630.72
127_D335_K0.6610.72
278_Q304_A0.6610.72
148_T206_G0.6600.72
162_L171_A0.6570.72
52_E234_L0.6570.72
363_K366_F0.6570.72
361_V365_A0.6550.71
142_I217_L0.6530.71
76_L113_V0.6520.71
122_S274_E0.6470.70
144_K148_T0.6470.70
257_R299_I0.6470.70
69_I220_A0.6450.70
27_V251_Y0.6430.70
405_A416_F0.6430.70
373_H414_N0.6430.70
31_H402_K0.6420.70
58_E198_F0.6410.70
240_F249_P0.6400.70
13_T19_E0.6390.69
20_L28_K0.6370.69
27_V31_H0.6370.69
392_T395_Y0.6370.69
63_K225_N0.6370.69
388_L393_F0.6360.69
224_V227_D0.6350.69
340_I436_G0.6350.69
220_A226_I0.6340.69
114_I136_D0.6340.69
89_R93_E0.6340.69
318_Q420_G0.6330.69
418_Q421_V0.6330.69
362_N365_A0.6330.69
258_N407_S0.6330.69
43_D50_L0.6300.68
127_D130_D0.6290.68
121_S274_E0.6290.68
22_Y25_D0.6260.68
56_K60_A0.6240.68
288_F299_I0.6200.67
26_F29_T0.6200.67
239_D250_A0.6190.67
283_W287_L0.6190.67
10_K17_E0.6190.67
78_V90_A0.6180.67
92_I219_I0.6170.67
268_E403_A0.6170.67
17_E20_L0.6170.67
79_V151_P0.6160.67
56_K59_F0.6120.66
23_L26_F0.6100.66
261_Y266_T0.6100.66
214_V217_L0.6080.66
9_S17_E0.6080.66
11_A414_N0.6060.65
43_D46_G0.6050.65
89_R124_Y0.6050.65
256_V268_E0.6040.65
427_N431_L0.6040.65
43_D47_W0.6040.65
356_K361_V0.6040.65
438_E442_A0.6030.65
74_D137_F0.6030.65
42_S56_K0.6030.65
85_Y117_G0.6020.65
184_G438_E0.6020.65
313_L317_V0.6000.65
52_E238_K0.5990.65
139_I162_L0.5990.65
76_L111_P0.5980.64
306_Y310_L0.5970.64
192_E197_S0.5960.64
340_I361_V0.5960.64
432_L436_G0.5960.64
37_K41_G0.5940.64
253_Y383_V0.5940.64
80_G83_G0.5920.64
403_A407_S0.5920.64
48_V52_E0.5920.64
58_E213_A0.5920.64
179_T187_K0.5920.64
288_F404_C0.5910.63
357_T361_V0.5900.63
25_D29_T0.5890.63
371_L430_A0.5880.63
109_G130_D0.5880.63
260_L265_K0.5870.63
333_K389_N0.5830.62
289_G302_S0.5820.62
11_A23_L0.5820.62
357_T362_N0.5820.62
360_F364_K0.5820.62
40_A43_D0.5810.62
156_R160_K0.5810.62
53_H199_V0.5800.62
292_E407_S0.5790.62
61_R199_V0.5780.62
418_Q425_K0.5770.62
98_A127_D0.5770.62
406_M410_L0.5760.62
370_M382_I0.5750.61
125_M338_L0.5750.61
366_F370_M0.5720.61
84_S311_H0.5710.61
147_T152_A0.5700.61
291_S311_H0.5700.61
122_S157_I0.5690.61
328_V352_Y0.5680.60
9_S246_E0.5660.60
206_G286_Q0.5640.60
69_I72_D0.5640.60
111_P221_V0.5640.60
407_S411_L0.5640.60
236_A239_D0.5620.60
90_A393_F0.5610.59
216_L226_I0.5590.59
426_V431_L0.5580.59
385_I388_L0.5580.59
81_I312_S0.5560.59
124_Y308_T0.5560.59
62_I219_I0.5560.59
166_Y174_R0.5550.59
249_P253_Y0.5550.59
148_T311_H0.5550.59
97_H108_R0.5530.58
21_T28_K0.5520.58
258_N411_L0.5520.58
236_A253_Y0.5520.58
67_E130_D0.5520.58
77_L129_M0.5520.58
12_L241_A0.5510.58
76_L221_V0.5480.58
366_F371_L0.5470.58
153_I307_S0.5470.58
45_L50_L0.5460.57
268_E414_N0.5460.57
414_N417_D0.5450.57
83_G206_G0.5420.57
374_T380_N0.5420.57
160_K163_E0.5420.57
180_D197_S0.5410.57
73_S174_R0.5380.56
272_N304_A0.5380.56
355_G371_L0.5330.56
48_V51_P0.5320.56
301_P312_S0.5310.55
89_R117_G0.5300.55
79_V141_V0.5290.55
332_E352_Y0.5290.55
437_F440_K0.5290.55
260_L323_D0.5280.55
365_A372_A0.5280.55
62_I226_I0.5280.55
57_E60_A0.5270.55
8_Y15_F0.5260.55
13_T409_Y0.5260.55
236_A240_F0.5260.55
176_Y196_E0.5260.55
76_L178_T0.5250.55
297_K412_G0.5250.55
144_K205_G0.5240.54
190_S197_S0.5240.54
434_K442_A0.5240.54
286_Q290_E0.5230.54
269_M324_L0.5230.54
265_K322_R0.5230.54
81_I307_S0.5230.54
233_A394_G0.5230.54
59_F63_K0.5220.54
42_S45_L0.5220.54
204_V401_E0.5210.54
55_D213_A0.5210.54
96_N222_S0.5210.54
69_I73_S0.5210.54
10_K44_F0.5210.54
96_N127_D0.5200.54
265_K325_F0.5200.54
349_G352_Y0.5200.54
355_G365_A0.5200.54
271_I328_V0.5180.54
424_Y428_M0.5180.54
85_Y308_T0.5180.54
236_A250_A0.5180.54
319_E417_D0.5170.53
365_A369_T0.5170.53
280_F400_F0.5170.53
178_T200_I0.5160.53
337_E357_T0.5160.53
74_D133_E0.5150.53
267_I324_L0.5140.53
212_T396_L0.5130.53
206_G311_H0.5130.53
355_G374_T0.5120.53
68_K173_A0.5120.53
319_E420_G0.5100.52
12_L16_N0.5100.52
253_Y268_E0.5080.52
44_F49_D0.5080.52
286_Q418_Q0.5070.52
91_A222_S0.5070.52
254_A403_A0.5060.52
429_F433_G0.5060.52
261_Y411_L0.5050.52
122_S341_E0.5050.52
156_R159_R0.5040.52
288_F381_L0.5040.52
62_I213_A0.5040.52
72_D173_A0.5040.52
326_E378_V0.5040.52
76_L176_Y0.5020.51
309_D312_S0.5000.51
439_E443_E0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qkiA 2 0.9889 100 0.123 Contact Map
2wu8A 2 0.9711 100 0.123 Contact Map
2o2cA 2 0.9644 100 0.123 Contact Map
1t10A 2 0.9644 100 0.123 Contact Map
3ljkA 2 0.9644 100 0.124 Contact Map
3hjbA 4 0.9622 100 0.126 Contact Map
2cxnA 2 0.9689 100 0.127 Contact Map
3ujhA 2 0.9822 100 0.134 Contact Map
3ff1A 4 0.9844 100 0.141 Contact Map
1b0zA 4 0.9822 100 0.16 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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