GREMLIN Database
6PGD - 6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating
UniProt: P80859 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (463)
Sequences: 1779 (909)
Seq/√Len: 42.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
321_A407_Q4.6511.00
454_Y465_T4.1821.00
85_Q114_E3.6571.00
225_E323_R3.5991.00
109_Q175_D3.5221.00
5_Q65_E3.3541.00
24_S135_L3.3021.00
211_A248_P3.1551.00
57_I90_H3.0981.00
381_R391_D3.0161.00
213_E315_K2.9111.00
352_L357_I2.8901.00
30_S63_S2.8851.00
203_L322_V2.8661.00
210_S213_E2.8521.00
320_E323_R2.8481.00
215_H239_T2.7891.00
412_A419_V2.7591.00
201_F205_Q2.7221.00
43_L53_G2.6861.00
216_E239_T2.6651.00
303_L429_Y2.6261.00
341_M352_L2.5751.00
353_K356_E2.5331.00
153_K157_E2.5001.00
219_A239_T2.4941.00
4_Q30_S2.4301.00
7_G60_F2.4211.00
209_L217_V2.4191.00
163_V363_G2.4021.00
214_L238_F2.4021.00
61_V90_H2.3971.00
96_I151_L2.3911.00
236_D448_Y2.3831.00
249_L253_I2.3721.00
125_T140_I2.3591.00
123_I152_V2.3211.00
289_I431_S2.2861.00
203_L209_L2.2761.00
66_T92_E2.2511.00
295_E432_Y2.2321.00
40_E55_Y2.2221.00
78_T82_A2.2081.00
409_I413_V2.2041.00
174_P345_S2.1821.00
56_S59_E2.1661.00
245_T252_V2.1450.99
27_F158_A2.1420.99
40_E44_Q2.1330.99
324_K404_A2.1260.99
84_I97_L2.0490.99
410_S414_A2.0490.99
212_D241_K2.0340.99
211_A251_D2.0250.99
105_Y348_Y2.0170.99
12_A75_K2.0090.99
58_E62_Q1.9890.99
237_I444_A1.9860.99
328_M405_L1.9840.99
197_S442_I1.9690.99
293_K297_V1.9280.99
409_I423_S1.9220.99
69_K151_L1.8840.99
209_L319_I1.8590.98
374_K377_E1.8550.98
204_K211_A1.8410.98
170_T356_E1.8260.98
314_N317_E1.8200.98
191_G333_S1.8170.98
376_K380_D1.8120.98
23_E49_K1.7700.98
88_L118_S1.7570.98
329_S422_F1.7550.98
19_A31_V1.7480.98
396_N400_S1.7440.98
220_E223_K1.7410.98
298_K386_D1.7410.98
11_L42_F1.7370.98
202_I318_L1.7210.97
423_S427_A1.6950.97
146_K150_E1.6900.97
320_E324_K1.6690.97
84_I115_L1.6670.97
80_T103_T1.6650.97
203_L214_L1.6550.97
88_L120_I1.6500.97
192_D330_K1.6390.97
411_L414_A1.6320.97
6_I22_I1.6290.96
305_G402_Q1.6180.96
407_Q414_A1.5880.96
202_I322_V1.5750.96
166_E359_M1.5700.96
232_E368_R1.5690.96
389_L398_V1.5670.96
247_K252_V1.5580.95
406_R430_D1.5500.95
217_V319_I1.5480.95
199_S322_V1.5310.95
16_K45_E1.5290.95
180_Y269_S1.5250.95
324_K400_S1.5240.95
70_I97_L1.5150.95
270_A285_F1.5120.95
301_G435_A1.5050.94
150_E153_K1.4870.94
132_E136_K1.4810.94
203_L207_L1.4810.94
9_I32_Y1.4790.94
306_P402_Q1.4770.94
31_V42_F1.4750.94
206_V415_Q1.4660.94
321_A404_A1.4630.94
54_T59_E1.4610.94
114_E117_E1.4560.93
25_R158_A1.4400.93
455_E460_E1.4370.93
455_E462_I1.4370.93
112_N116_A1.4230.93
225_E320_E1.4210.93
22_I71_L1.4190.93
220_E323_R1.4130.92
385_L391_D1.4060.92
329_S405_L1.4050.92
36_S40_E1.4030.92
22_I155_I1.3940.92
220_E316_E1.3840.92
300_S435_A1.3700.91
98_I152_V1.3700.91
24_S136_K1.3690.91
278_P332_C1.3660.91
381_R392_S1.3650.91
264_K272_D1.3580.91
339_A428_Y1.3540.91
22_I29_V1.3520.91
30_S54_T1.3520.91
249_L252_V1.3450.90
224_G323_R1.3450.90
355_G376_K1.3350.90
88_L114_E1.3340.90
410_S413_V1.3330.90
207_L322_V1.3320.90
305_G433_R1.3240.90
83_T86_S1.3160.89
215_H238_F1.3150.89
170_T360_I1.3090.89
345_S354_Y1.2920.88
124_G143_G1.2920.88
436_V457_T1.2860.88
11_L31_V1.2860.88
116_A145_Q1.2820.88
355_G380_D1.2800.88
54_T60_F1.2790.88
70_I91_L1.2740.88
328_M401_Y1.2500.87
256_K455_E1.2420.86
344_A348_Y1.2380.86
113_K117_E1.2380.86
54_T63_S1.2370.86
322_V422_F1.2350.86
103_T107_D1.2320.86
241_K248_P1.2260.86
214_L322_V1.2240.86
455_E461_G1.2220.86
8_V71_L1.2190.85
199_S422_F1.2170.85
110_R114_E1.2130.85
281_T285_F1.2080.85
39_T55_Y1.1900.84
73_M159_I1.1860.84
345_S351_D1.1830.84
37_S41_E1.1770.83
46_A51_V1.1750.83
12_A33_N1.1690.83
318_L411_L1.1510.82
4_Q52_V1.1360.81
416_G433_R1.1350.81
34_R75_K1.1310.81
36_S55_Y1.1290.81
219_A223_K1.1290.81
343_A346_E1.1210.80
418_P434_T1.1200.80
184_V340_Q1.1180.80
172_I360_I1.1140.80
184_V266_T1.1140.80
73_M140_I1.1070.79
203_L217_V1.1020.79
23_E135_L1.0990.79
202_I412_A1.0980.79
342_K346_E1.0980.79
20_L135_L1.0950.79
298_K301_G1.0910.78
104_Y268_Q1.0910.78
75_K79_A1.0890.78
303_L433_R1.0870.78
139_S361_F1.0850.78
359_M376_K1.0850.78
227_D370_A1.0810.78
237_I445_Q1.0780.77
33_N39_T1.0760.77
206_V417_V1.0760.77
6_I98_I1.0710.77
158_A162_K1.0620.76
419_V423_S1.0590.76
79_A82_A1.0590.76
273_L348_Y1.0550.76
204_K251_D1.0550.76
121_H145_Q1.0520.76
109_Q348_Y1.0390.75
28_S50_N1.0370.75
18_L159_I1.0360.75
71_L98_I1.0340.74
395_K399_E1.0310.74
16_K135_L1.0300.74
267_S281_T1.0290.74
108_T124_G1.0280.74
413_V419_V1.0240.74
39_T53_G1.0210.73
140_I160_S1.0150.73
35_S38_K1.0120.73
30_S60_F1.0090.73
12_A34_R1.0080.72
172_I357_I1.0060.72
248_P251_D1.0040.72
174_P351_D1.0000.72
8_V29_V0.9980.72
295_E387_N0.9900.71
259_Q264_K0.9870.71
254_L293_K0.9840.71
254_L456_R0.9830.71
109_Q113_K0.9800.70
303_L306_P0.9780.70
70_I89_P0.9760.70
305_G429_Y0.9720.70
438_P441_L0.9700.70
402_Q433_R0.9650.69
273_L347_E0.9640.69
250_V441_L0.9570.69
100_G140_I0.9560.68
60_F63_S0.9560.68
243_E465_T0.9550.68
191_G279_I0.9520.68
38_K41_E0.9500.68
279_I332_C0.9500.68
72_L97_L0.9490.68
123_I171_Y0.9480.68
327_F397_I0.9480.68
201_F438_P0.9450.68
172_I177_A0.9430.67
324_K401_Y0.9430.67
23_E50_N0.9430.67
299_A432_Y0.9370.67
196_I326_L0.9360.67
149_H153_K0.9350.67
149_H170_T0.9290.66
215_H219_A0.9270.66
8_V31_V0.9260.66
434_T437_L0.9250.66
240_K465_T0.9240.66
205_Q434_T0.9210.66
163_V166_E0.9180.65
271_L284_V0.9160.65
335_A387_N0.9150.65
427_A430_D0.9120.65
75_K78_T0.9100.65
413_V427_A0.9100.65
149_H171_Y0.9090.64
28_S52_V0.9090.64
113_K116_A0.9090.64
373_Q377_E0.9040.64
125_T156_L0.9020.64
108_T122_F0.9010.64
220_E224_G0.8960.63
196_I231_I0.8950.63
106_K272_D0.8880.63
112_N145_Q0.8860.62
146_K171_Y0.8800.62
279_I425_A0.8800.62
6_I71_L0.8800.62
16_K23_E0.8760.62
36_S39_T0.8700.61
299_A390_L0.8690.61
146_K351_D0.8680.61
234_T445_Q0.8660.61
203_L319_I0.8620.60
430_D433_R0.8600.60
100_G127_V0.8580.60
166_E362_R0.8580.60
304_S399_E0.8570.60
402_Q429_Y0.8540.60
127_V140_I0.8530.60
96_I123_I0.8510.59
201_F204_K0.8510.59
25_R162_K0.8500.59
240_K249_L0.8490.59
121_H147_E0.8470.59
211_A250_V0.8460.59
125_T152_V0.8460.59
295_E339_A0.8450.59
282_E421_S0.8450.59
317_E321_A0.8410.58
371_F393_Y0.8390.58
303_L399_E0.8380.58
399_E429_Y0.8370.58
143_G177_A0.8360.58
154_P160_S0.8360.58
282_E285_F0.8350.58
343_A347_E0.8340.58
222_N232_E0.8340.58
316_E320_E0.8340.58
207_L318_L0.8310.57
259_Q268_Q0.8190.56
259_Q288_F0.8190.56
418_P437_L0.8190.56
382_E391_D0.8180.56
8_V11_L0.8180.56
115_L120_I0.8180.56
371_F394_F0.8150.56
195_L421_S0.8130.56
413_V426_L0.8130.56
175_D348_Y0.8080.55
327_F393_Y0.8030.55
213_E216_E0.7980.54
270_A277_L0.7960.54
283_S421_S0.7910.54
71_L100_G0.7900.54
61_V91_L0.7900.54
19_A22_I0.7890.54
209_L315_K0.7890.54
281_T350_W0.7840.53
202_I419_V0.7830.53
217_V238_F0.7810.53
439_A442_I0.7810.53
74_V80_T0.7810.53
5_Q28_S0.7770.52
176_G350_W0.7760.52
403_G407_Q0.7740.52
70_I92_E0.7740.52
55_Y59_E0.7730.52
275_V343_A0.7690.52
82_A86_S0.7680.52
104_Y269_S0.7670.52
19_A51_V0.7660.51
327_F371_F0.7650.51
139_S360_I0.7640.51
7_G10_G0.7610.51
140_I169_T0.7610.51
119_G152_V0.7580.51
140_I152_V0.7560.50
148_A152_V0.7560.50
4_Q28_S0.7550.50
116_A147_E0.7540.50
8_V73_M0.7540.50
150_E154_P0.7530.50
19_A30_S0.7520.50
140_I347_E0.7510.50
175_D349_N0.7500.50
206_V411_L0.7500.50
302_L395_K0.7490.50
73_M229_Y0.7480.50
79_A83_T0.7460.50
298_K390_L0.7460.50
356_E359_M0.7460.50
23_E51_V0.7460.50
297_V435_A0.7430.49
341_M361_F0.7400.49
341_M357_I0.7390.49
46_A49_K0.7370.49
58_E89_P0.7370.49
20_L46_A0.7370.49
44_Q47_K0.7360.49
74_V79_A0.7360.49
459_K462_I0.7330.48
33_N75_K0.7320.48
358_A375_I0.7310.48
406_R416_G0.7280.48
273_L343_A0.7280.48
35_S42_F0.7270.48
223_K247_K0.7250.48
294_E297_V0.7250.48
456_R463_F0.7230.47
150_E171_Y0.7220.47
292_M295_E0.7190.47
282_E424_S0.7190.47
211_A247_K0.7180.47
24_S45_E0.7160.47
24_S49_K0.7160.47
249_L457_T0.7160.47
303_L402_Q0.7150.47
65_E69_K0.7130.46
169_T259_Q0.7120.46
109_Q350_W0.7120.46
459_K463_F0.7090.46
269_S272_D0.7070.46
51_V135_L0.7040.46
416_G430_D0.7030.46
20_L24_S0.7020.45
120_I145_Q0.7020.45
377_E393_Y0.7010.45
204_K379_Y0.7000.45
41_E44_Q0.7000.45
232_E235_A0.7000.45
315_K319_I0.6980.45
234_T441_L0.6970.45
273_L344_A0.6970.45
34_R38_K0.6960.45
332_C369_A0.6960.45
344_A442_I0.6930.45
121_H152_V0.6930.45
323_R401_Y0.6900.44
115_L425_A0.6880.44
4_Q63_S0.6870.44
225_E401_Y0.6870.44
62_Q65_E0.6870.44
229_Y448_Y0.6870.44
224_G362_R0.6870.44
242_D245_T0.6850.44
71_L156_L0.6840.44
338_F442_I0.6840.44
243_E246_G0.6840.44
154_P158_A0.6790.43
200_Y204_K0.6790.43
328_M398_V0.6770.43
332_C405_L0.6760.43
209_L213_E0.6750.43
72_L83_T0.6750.43
142_P170_T0.6750.43
245_T248_P0.6740.43
369_A428_Y0.6740.43
374_K393_Y0.6720.43
93_K147_E0.6700.42
429_Y433_R0.6700.42
302_L392_S0.6700.42
33_N73_M0.6690.42
445_Q448_Y0.6690.42
38_K74_V0.6690.42
406_R427_A0.6680.42
256_K442_I0.6680.42
45_E135_L0.6660.42
121_H151_L0.6640.42
299_A433_R0.6620.42
70_I90_H0.6600.42
25_R136_K0.6600.42
56_S60_F0.6580.41
374_K397_I0.6570.41
351_D354_Y0.6570.41
142_P172_I0.6560.41
125_T169_T0.6550.41
338_F354_Y0.6550.41
332_C335_A0.6540.41
338_F350_W0.6500.41
108_T175_D0.6490.41
192_D196_I0.6490.41
109_Q112_N0.6470.40
225_E327_F0.6470.40
229_Y233_I0.6470.40
392_S395_K0.6460.40
201_F434_T0.6460.40
82_A85_Q0.6440.40
330_K371_F0.6440.40
80_T340_Q0.6440.40
85_Q88_L0.6430.40
193_M445_Q0.6420.40
219_A235_A0.6420.40
93_K118_S0.6420.40
220_E225_E0.6410.40
266_T277_L0.6410.40
33_N38_K0.6400.40
195_L326_L0.6390.40
115_L122_F0.6390.40
376_K398_V0.6390.40
318_L408_V0.6370.39
216_E220_E0.6360.39
355_G371_F0.6360.39
254_L458_D0.6340.39
31_V35_S0.6340.39
176_G192_D0.6340.39
285_F350_W0.6340.39
231_I234_T0.6340.39
448_Y468_M0.6340.39
31_V54_T0.6330.39
57_I86_S0.6290.39
323_R404_A0.6290.39
112_N175_D0.6280.39
100_G156_L0.6280.39
438_P442_I0.6260.38
375_I378_A0.6260.38
127_V445_Q0.6250.38
74_V83_T0.6230.38
411_L415_Q0.6220.38
288_F291_A0.6220.38
269_S340_Q0.6210.38
419_V427_A0.6200.38
58_E90_H0.6200.38
163_V376_K0.6200.38
321_A324_K0.6200.38
73_M135_L0.6200.38
116_A421_S0.6190.38
142_P169_T0.6180.38
133_G141_M0.6180.38
282_E431_S0.6170.38
21_N190_Y0.6170.38
75_K127_V0.6160.38
317_E407_Q0.6160.38
88_L115_L0.6160.38
378_A391_D0.6160.38
196_I330_K0.6150.37
328_M429_Y0.6140.37
268_Q278_P0.6120.37
160_S169_T0.6110.37
338_F393_Y0.6110.37
139_S325_A0.6090.37
277_L332_C0.6080.37
201_F206_V0.6070.37
225_E324_K0.6070.37
37_S40_E0.6070.37
156_L169_T0.6060.37
133_G190_Y0.6060.37
135_L269_S0.6040.37
275_V339_A0.6040.37
324_K328_M0.6000.36
397_I400_S0.6000.36
32_Y57_I0.5980.36
25_R85_Q0.5970.36
149_H157_E0.5960.36
255_D296_R0.5960.36
258_G291_A0.5950.36
113_K309_K0.5950.36
16_K42_F0.5950.36
345_S356_E0.5920.35
8_V19_A0.5910.35
103_T122_F0.5910.35
16_K24_S0.5900.35
453_T465_T0.5890.35
211_A238_F0.5890.35
61_V87_L0.5890.35
180_Y344_A0.5890.35
93_K223_K0.5890.35
258_G268_Q0.5890.35
73_M286_A0.5880.35
282_E286_A0.5880.35
398_V405_L0.5870.35
242_D456_R0.5860.35
146_K174_P0.5860.35
404_A407_Q0.5860.35
91_L97_L0.5860.35
306_P433_R0.5850.35
386_D396_N0.5850.35
229_Y358_A0.5830.35
204_K214_L0.5830.35
410_S418_P0.5820.35
295_E323_R0.5810.35
157_E170_T0.5800.34
207_L319_I0.5790.34
42_F46_A0.5780.34
242_D248_P0.5780.34
9_I57_I0.5770.34
42_F51_V0.5760.34
192_D350_W0.5760.34
249_L466_E0.5760.34
39_T56_S0.5750.34
195_L279_I0.5750.34
212_D248_P0.5740.34
170_T177_A0.5740.34
330_K350_W0.5740.34
78_T417_V0.5740.34
27_F155_I0.5730.34
12_A17_N0.5730.34
279_I421_S0.5720.34
313_E415_Q0.5710.34
242_D252_V0.5710.34
155_I158_A0.5700.34
108_T115_L0.5700.34
153_K170_T0.5700.34
320_E404_A0.5690.34
59_E62_Q0.5690.34
258_G445_Q0.5690.34
199_S202_I0.5680.33
57_I87_L0.5680.33
179_H259_Q0.5660.33
89_P93_K0.5650.33
207_L314_N0.5640.33
31_V166_E0.5630.33
39_T223_K0.5620.33
205_Q417_V0.5620.33
22_I98_I0.5620.33
18_L71_L0.5610.33
268_Q272_D0.5610.33
27_F154_P0.5600.33
271_L281_T0.5600.33
174_P357_I0.5590.33
64_L70_I0.5580.33
271_L285_F0.5580.33
174_P349_N0.5570.33
278_P369_A0.5570.33
114_E118_S0.5560.32
196_I226_L0.5560.32
157_E360_I0.5550.32
374_K391_D0.5550.32
11_L33_N0.5540.32
116_A349_N0.5530.32
213_E314_N0.5510.32
208_G436_V0.5500.32
12_A79_A0.5480.32
299_A406_R0.5470.32
264_K293_K0.5470.32
334_Y394_F0.5470.32
12_A35_S0.5460.32
39_T46_A0.5450.32
277_L281_T0.5440.31
201_F418_P0.5430.31
431_S437_L0.5420.31
223_K384_E0.5420.31
338_F358_A0.5420.31
235_A256_K0.5410.31
94_D119_G0.5410.31
69_K155_I0.5400.31
162_K363_G0.5400.31
45_E49_K0.5400.31
27_F162_K0.5390.31
97_L159_I0.5370.31
203_L318_L0.5370.31
188_I337_G0.5360.31
443_Q446_R0.5350.31
214_L441_L0.5350.31
202_I225_E0.5340.31
72_L148_A0.5330.31
104_Y273_L0.5330.31
378_A394_F0.5330.31
105_Y269_S0.5320.30
115_L118_S0.5320.30
214_L231_I0.5320.30
37_S329_S0.5320.30
269_S275_V0.5310.30
406_R433_R0.5310.30
314_N318_L0.5290.30
160_S166_E0.5280.30
297_V301_G0.5270.30
96_I148_A0.5260.30
219_A308_V0.5260.30
264_K444_A0.5260.30
49_K135_L0.5260.30
277_L340_Q0.5260.30
31_V51_V0.5240.30
454_Y463_F0.5240.30
21_N446_R0.5230.30
195_L327_F0.5230.30
210_S315_K0.5220.30
375_I394_F0.5220.30
286_A431_S0.5220.30
131_E451_A0.5190.29
70_I88_L0.5180.29
200_Y440_N0.5170.29
387_N432_Y0.5170.29
23_E428_Y0.5140.29
169_T350_W0.5140.29
177_A210_S0.5140.29
169_T360_I0.5130.29
293_K435_A0.5130.29
20_L191_G0.5130.29
212_D223_K0.5130.29
359_M363_G0.5130.29
79_A103_T0.5120.29
31_V60_F0.5120.29
458_D463_F0.5110.29
54_T277_L0.5110.29
190_Y263_G0.5110.29
135_L428_Y0.5110.29
274_G288_F0.5090.29
180_Y340_Q0.5090.29
31_V53_G0.5080.29
375_I388_L0.5080.29
396_N399_E0.5070.29
20_L51_V0.5070.29
245_T249_L0.5070.29
382_E385_L0.5060.28
79_A267_S0.5050.28
24_S428_Y0.5050.28
327_F394_F0.5050.28
267_S271_L0.5050.28
464_H467_W0.5050.28
65_E92_E0.5040.28
17_N38_K0.5030.28
331_I389_L0.5020.28
61_V68_R0.5020.28
183_M453_T0.5020.28
169_T431_S0.5010.28
226_L375_I0.5010.28
216_E316_E0.5010.28
51_V112_N0.5000.28
284_V288_F0.5000.28
192_D334_Y0.5000.28
12_A83_T0.5000.28
44_Q197_S0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zydA 2 0.9915 100 0.347 Contact Map
2p4qA 2 0.9915 100 0.353 Contact Map
4gwgA 2 0.9893 100 0.361 Contact Map
1pgjA 2 0.9851 100 0.361 Contact Map
2iz1A 2 0.9957 100 0.365 Contact Map
4e21A 4 0.6375 100 0.785 Contact Map
3dojA 3 0.6077 100 0.851 Contact Map
3pduA 4 0.5991 100 0.853 Contact Map
3pefA 5 0.6034 100 0.854 Contact Map
3ckyA 4 0.6183 100 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0123 seconds.