LEUC - BACSU - GREMLIN Contacts

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LEUC - 3-isopropylmalate dehydratase large subunit

UniProt:	P80858	Sequences: MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEGLRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHSVDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQQRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMTVCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKSIVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKIEDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLDQIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMAAMAAIHGHFVDVRKFYQEKTVV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	472 (419)
Sequences:	6626 (2273)
Seq/√Len:	111.0

ECOLI - LEUC YBHJ ACON1 ACON2
BACSU - LEUC ACON
HALSA - Q9HMF1
SULSO - LEUC Q97Z42

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
169_R	278_V	5.053	1.00
285_S	301_D	4.896	1.00
280_D	283_K	4.092	1.00
356_R	389_E	4.078	1.00
456_H	460_V	3.931	1.00
237_E	241_E	3.542	1.00
167_E	204_T	3.431	1.00
4_R	12_D	3.302	1.00
171_D	278_V	3.241	1.00
46_R	92_E	3.030	1.00
342_V	450_A	2.990	1.00
352_M	385_Q	2.763	1.00
180_A	215_E	2.761	1.00
373_A	400_F	2.709	1.00
425_A	445_V	2.664	1.00
167_E	276_S	2.598	1.00
189_G	297_V	2.589	1.00
238_V	241_E	2.575	1.00
171_D	206_E	2.570	1.00
169_R	276_S	2.540	1.00
355_L	386_A	2.471	1.00
393_Q	397_E	2.435	1.00
204_T	276_S	2.426	1.00
336_D	458_H	2.418	1.00
207_V	281_G	2.415	1.00
186_A	190_K	2.368	1.00
190_K	279_L	2.267	1.00
344_I	373_A	2.213	1.00
186_A	287_M	2.212	1.00
449_M	453_A	2.206	1.00
427_T	450_A	2.182	1.00
173_T	210_N	2.118	1.00
28_I	123_T	2.094	1.00
7_I	163_P	2.087	1.00
285_S	299_P	2.082	1.00
363_K	394_I	2.066	1.00
174_L	183_V	2.036	1.00
170_V	281_G	2.033	1.00
360_D	363_K	2.011	1.00
261_E	264_A	2.004	1.00
344_I	358_A	1.998	1.00
392_D	396_L	1.967	1.00
170_V	187_V	1.952	1.00
199_Y	275_K	1.948	1.00
357_Q	448_A	1.924	1.00
391_L	395_F	1.922	1.00
184_I	219_V	1.895	1.00
203_Y	223_S	1.890	1.00
342_V	425_A	1.890	1.00
169_R	204_T	1.868	1.00
173_T	206_E	1.856	1.00
175_Q	178_V	1.835	1.00
8_E	165_T	1.831	1.00
168_V	187_V	1.831	1.00
352_M	389_E	1.818	1.00
352_M	356_R	1.785	1.00
164_K	274_D	1.767	1.00
299_P	302_S	1.753	1.00
287_M	297_V	1.732	1.00
365_K	455_I	1.731	1.00
212_T	353_T	1.712	1.00
170_V	183_V	1.695	1.00
219_V	233_I	1.690	1.00
186_A	189_G	1.671	1.00
339_V	453_A	1.663	1.00
200_V	230_A	1.660	1.00
355_L	375_V	1.657	1.00
80_K	84_T	1.641	1.00
356_R	391_L	1.640	1.00
186_A	284_I	1.629	1.00
209_R	237_E	1.615	1.00
392_D	402_W	1.609	1.00
183_V	211_M	1.597	1.00
186_A	279_L	1.574	1.00
254_E	257_K	1.573	1.00
235_P	260_E	1.572	1.00
385_Q	389_E	1.558	1.00
166_L	275_K	1.555	1.00
338_K	458_H	1.555	1.00
376_V	408_S	1.549	1.00
168_V	201_I	1.547	1.00
201_I	226_A	1.538	1.00
341_H	422_E	1.530	1.00
52_V	95_V	1.528	1.00
255_F	259_V	1.513	1.00
179_T	357_Q	1.510	1.00
383_K	387_E	1.509	1.00
46_R	93_F	1.506	1.00
10_I	232_L	1.505	1.00
445_V	459_F	1.492	1.00
179_T	448_A	1.490	1.00
362_I	373_A	1.487	1.00
164_K	199_Y	1.481	1.00
194_K	275_K	1.480	1.00
213_M	238_V	1.477	1.00
418_V	424_C	1.473	1.00
387_E	392_D	1.459	1.00
215_E	353_T	1.452	1.00
27_Y	157_T	1.448	1.00
367_V	373_A	1.445	1.00
140_L	230_A	1.434	1.00
235_P	240_F	1.432	1.00
420_E	440_A	1.428	1.00
180_A	211_M	1.428	1.00
184_I	222_M	1.420	1.00
338_K	370_S	1.414	1.00
58_T	153_L	1.413	1.00
137_F	213_M	1.406	1.00
339_V	371_V	1.405	1.00
257_K	261_E	1.391	1.00
339_V	342_V	1.378	1.00
383_K	405_S	1.372	1.00
170_V	208_F	1.365	1.00
223_S	231_G	1.358	1.00
376_V	403_R	1.348	1.00
304_V	336_D	1.348	1.00
412_S	417_V	1.339	1.00
445_V	450_A	1.339	1.00
358_A	395_F	1.330	1.00
183_V	207_V	1.327	1.00
394_I	397_E	1.323	1.00
290_W	298_L	1.322	1.00
138_G	235_P	1.317	1.00
300_V	449_M	1.313	0.99
9_K	268_D	1.312	0.99
110_V	378_G	1.311	0.99
59_F	117_L	1.310	0.99
88_R	92_E	1.308	0.99
7_I	165_T	1.304	0.99
84_T	88_R	1.296	0.99
119_L	122_K	1.290	0.99
175_Q	285_S	1.289	0.99
144_I	149_V	1.287	0.99
110_V	379_S	1.278	0.99
190_K	277_I	1.275	0.99
175_Q	284_I	1.271	0.99
125_V	144_I	1.264	0.99
237_E	263_K	1.252	0.99
17_K	22_K	1.240	0.99
220_C	233_I	1.239	0.99
287_M	299_P	1.239	0.99
7_I	200_V	1.233	0.99
110_V	350_S	1.231	0.99
81_R	85_A	1.228	0.99
244_K	250_P	1.227	0.99
384_L	397_E	1.221	0.99
174_L	178_V	1.217	0.99
213_M	239_T	1.210	0.99
7_I	230_A	1.204	0.99
288_V	303_E	1.192	0.99
59_F	99_D	1.188	0.99
289_T	297_V	1.181	0.99
208_F	219_V	1.177	0.99
37_T	411_L	1.172	0.99
187_V	201_I	1.169	0.99
170_V	207_V	1.167	0.99
393_Q	396_L	1.166	0.99
241_E	244_K	1.160	0.99
418_V	440_A	1.155	0.99
32_L	108_V	1.149	0.99
343_F	428_S	1.147	0.99
137_F	217_M	1.141	0.99
388_K	393_Q	1.132	0.98
44_G	150_E	1.129	0.98
363_K	397_E	1.121	0.98
281_G	284_I	1.120	0.98
101_H	104_D	1.119	0.98
136_A	213_M	1.115	0.98
113_P	217_M	1.111	0.98
174_L	210_N	1.107	0.98
191_Y	195_F	1.107	0.98
30_L	117_L	1.106	0.98
190_K	283_K	1.106	0.98
37_T	127_G	1.106	0.98
208_F	211_M	1.097	0.98
384_L	388_K	1.093	0.98
288_V	445_V	1.092	0.98
372_R	401_E	1.088	0.98
267_T	273_Y	1.085	0.98
340_E	422_E	1.083	0.98
118_T	137_F	1.080	0.98
445_V	449_M	1.078	0.98
396_L	401_E	1.077	0.98
453_A	460_V	1.076	0.98
166_L	199_Y	1.067	0.98
446_S	449_M	1.067	0.98
355_L	395_F	1.062	0.98
8_E	162_R	1.057	0.98
361_M	451_A	1.055	0.98
5_T	165_T	1.055	0.98
342_V	454_A	1.052	0.98
132_S	223_S	1.046	0.97
337_I	458_H	1.045	0.97
207_V	211_M	1.045	0.97
125_V	152_V	1.042	0.97
87_E	99_D	1.036	0.97
60_A	86_L	1.029	0.97
190_K	275_K	1.022	0.97
234_A	266_R	1.022	0.97
199_Y	274_D	1.021	0.97
214_D	353_T	1.021	0.97
357_Q	360_D	1.020	0.97
293_N	296_M	1.019	0.97
267_T	270_G	1.018	0.97
302_S	305_P	1.018	0.97
421_G	439_G	1.014	0.97
240_F	259_V	1.008	0.97
33_I	108_V	1.007	0.97
343_F	408_S	1.005	0.97
341_H	372_R	1.004	0.97
212_T	238_V	1.003	0.97
60_A	90_C	1.000	0.97
134_H	141_A	1.000	0.97
118_T	134_H	1.000	0.97
240_F	263_K	0.996	0.97
384_L	387_E	0.995	0.97
208_F	233_I	0.992	0.96
28_I	152_V	0.990	0.96
174_L	281_G	0.990	0.96
240_F	244_K	0.988	0.96
140_L	200_V	0.987	0.96
342_V	427_T	0.980	0.96
212_T	215_E	0.975	0.96
206_E	209_R	0.972	0.96
118_T	124_I	0.970	0.96
304_V	337_I	0.966	0.96
191_Y	226_A	0.965	0.96
420_E	438_K	0.965	0.96
256_D	259_V	0.962	0.96
425_A	450_A	0.959	0.96
206_E	210_N	0.953	0.96
348_T	429_N	0.952	0.96
191_Y	201_I	0.949	0.95
19_G	22_K	0.948	0.95
244_K	249_T	0.945	0.95
356_R	385_Q	0.945	0.95
298_L	302_S	0.941	0.95
425_A	453_A	0.939	0.95
171_D	280_D	0.935	0.95
228_A	231_G	0.934	0.95
30_L	122_K	0.928	0.95
241_E	245_N	0.927	0.95
175_Q	282_N	0.927	0.95
36_V	39_P	0.926	0.95
362_I	455_I	0.924	0.95
259_V	263_K	0.921	0.95
183_V	284_I	0.918	0.95
118_T	255_F	0.915	0.94
52_V	153_L	0.913	0.94
7_I	232_L	0.912	0.94
364_G	397_E	0.908	0.94
246_R	381_S	0.907	0.94
356_R	360_D	0.906	0.94
34_H	108_V	0.905	0.94
385_Q	388_K	0.905	0.94
423_R	443_H	0.904	0.94
339_V	425_A	0.904	0.94
183_V	219_V	0.901	0.94
8_E	12_D	0.898	0.94
203_Y	231_G	0.898	0.94
372_R	422_E	0.898	0.94
104_D	247_K	0.897	0.94
173_T	282_N	0.897	0.94
425_A	459_F	0.892	0.94
171_D	281_G	0.892	0.94
6_I	10_I	0.892	0.94
290_W	303_E	0.888	0.94
422_E	439_G	0.886	0.93
223_S	228_A	0.886	0.93
387_E	396_L	0.881	0.93
169_R	206_E	0.879	0.93
403_R	408_S	0.876	0.93
31_H	149_V	0.874	0.93
15_I	24_D	0.873	0.93
244_K	255_F	0.872	0.93
391_L	394_I	0.871	0.93
337_I	459_F	0.870	0.93
168_V	277_I	0.870	0.93
144_I	152_V	0.867	0.93
54_R	57_N	0.867	0.93
33_I	38_S	0.865	0.93
13_Q	263_K	0.863	0.93
454_A	457_G	0.861	0.93
55_P	94_G	0.859	0.92
189_G	287_M	0.858	0.92
33_I	58_T	0.854	0.92
216_R	236_D	0.851	0.92
362_I	400_F	0.851	0.92
210_N	238_V	0.850	0.92
252_G	256_D	0.849	0.92
418_V	422_E	0.848	0.92
115_L	381_S	0.845	0.92
51_K	92_E	0.845	0.92
183_V	208_F	0.845	0.92
233_I	281_G	0.843	0.92
13_Q	261_E	0.841	0.92
166_L	274_D	0.840	0.92
352_M	391_L	0.839	0.92
52_V	58_T	0.837	0.91
5_T	271_A	0.837	0.91
132_S	224_I	0.834	0.91
119_L	247_K	0.831	0.91
247_K	381_S	0.830	0.91
69_V	415_N	0.828	0.91
125_V	158_L	0.827	0.91
188_I	226_A	0.826	0.91
136_A	217_M	0.823	0.91
252_G	255_F	0.818	0.90
44_G	47_Q	0.817	0.90
183_V	281_G	0.816	0.90
346_S	428_S	0.811	0.90
358_A	375_V	0.811	0.90
11_W	24_D	0.809	0.90
355_L	391_L	0.807	0.90
341_H	440_A	0.807	0.90
71_R	418_V	0.803	0.90
300_V	459_F	0.803	0.90
26_L	160_Q	0.802	0.90
28_I	31_H	0.802	0.90
43_E	47_Q	0.801	0.90
267_T	271_A	0.799	0.89
30_L	59_F	0.798	0.89
336_D	459_F	0.797	0.89
25_L	159_W	0.795	0.89
31_H	152_V	0.794	0.89
285_S	302_S	0.793	0.89
383_K	392_D	0.788	0.89
376_V	409_M	0.788	0.89
358_A	448_A	0.786	0.89
290_W	443_H	0.783	0.88
107_I	350_S	0.780	0.88
18_H	24_D	0.777	0.88
12_D	15_I	0.776	0.88
268_D	271_A	0.773	0.88
426_S	439_G	0.772	0.88
209_R	269_P	0.771	0.88
339_V	423_R	0.770	0.88
375_V	400_F	0.766	0.87
366_K	397_E	0.765	0.87
240_F	243_C	0.762	0.87
65_N	79_A	0.762	0.87
6_I	232_L	0.761	0.87
367_V	454_A	0.757	0.87
452_M	456_H	0.755	0.87
6_I	265_L	0.753	0.86
198_G	229_R	0.751	0.86
252_G	257_K	0.749	0.86
103_V	384_L	0.748	0.86
176_K	360_D	0.745	0.86
206_E	281_G	0.744	0.86
209_R	238_V	0.743	0.86
419_P	422_E	0.740	0.85
33_I	127_G	0.740	0.85
38_S	86_L	0.737	0.85
384_L	393_Q	0.735	0.85
254_E	258_A	0.735	0.85
85_A	88_R	0.732	0.85
28_I	158_L	0.731	0.85
55_P	58_T	0.726	0.84
112_G	118_T	0.724	0.84
208_F	267_T	0.724	0.84
88_R	91_E	0.723	0.84
104_D	381_S	0.721	0.84
148_E	160_Q	0.720	0.84
356_R	386_A	0.716	0.84
362_I	398_A	0.715	0.83
341_H	419_P	0.715	0.83
99_D	103_V	0.715	0.83
99_D	104_D	0.712	0.83
164_K	275_K	0.712	0.83
340_E	440_A	0.711	0.83
10_I	200_V	0.708	0.83
15_I	18_H	0.707	0.83
209_R	266_R	0.707	0.83
186_A	283_K	0.705	0.83
102_S	115_L	0.705	0.83
66_I	105_Q	0.705	0.83
105_Q	380_Q	0.702	0.82
352_M	386_A	0.700	0.82
421_G	440_A	0.700	0.82
207_V	215_E	0.700	0.82
396_L	402_W	0.700	0.82
71_R	101_H	0.699	0.82
115_L	247_K	0.699	0.82
166_L	201_I	0.698	0.82
204_T	273_Y	0.697	0.82
445_V	453_A	0.695	0.82
12_D	19_G	0.695	0.82
362_I	365_K	0.695	0.82
31_H	58_T	0.692	0.81
367_V	370_S	0.692	0.81
107_I	378_G	0.689	0.81
61_T	108_V	0.685	0.81
453_A	459_F	0.683	0.81
87_E	91_E	0.683	0.81
449_M	460_V	0.681	0.80
30_L	119_L	0.679	0.80
387_E	402_W	0.678	0.80
453_A	458_H	0.677	0.80
99_D	102_S	0.676	0.80
189_G	193_V	0.672	0.80
184_I	187_V	0.672	0.80
168_V	279_L	0.670	0.79
79_A	411_L	0.669	0.79
269_P	272_V	0.668	0.79
163_P	200_V	0.668	0.79
174_L	215_E	0.666	0.79
133_T	217_M	0.665	0.79
118_T	139_A	0.664	0.79
243_C	249_T	0.662	0.79
220_C	230_A	0.662	0.79
337_I	423_R	0.662	0.79
380_Q	405_S	0.661	0.78
53_R	58_T	0.661	0.78
385_Q	391_L	0.660	0.78
113_P	137_F	0.659	0.78
33_I	153_L	0.659	0.78
191_Y	196_G	0.657	0.78
359_A	394_I	0.656	0.78
341_H	424_C	0.656	0.78
425_A	449_M	0.656	0.78
30_L	112_G	0.656	0.78
342_V	371_V	0.653	0.78
244_K	259_V	0.653	0.78
35_E	40_Q	0.651	0.77
341_H	374_I	0.650	0.77
175_Q	283_K	0.650	0.77
183_V	206_E	0.647	0.77
35_E	38_S	0.647	0.77
382_V	385_Q	0.647	0.77
27_Y	54_R	0.646	0.77
181_K	348_T	0.646	0.77
279_L	283_K	0.645	0.77
104_D	115_L	0.644	0.77
168_V	190_K	0.644	0.77
133_T	221_N	0.643	0.76
117_L	248_Y	0.642	0.76
343_F	409_M	0.642	0.76
34_H	37_T	0.642	0.76
403_R	406_G	0.640	0.76
249_T	252_G	0.639	0.76
170_V	174_L	0.638	0.76
300_V	303_E	0.638	0.76
138_G	265_L	0.638	0.76
367_V	371_V	0.638	0.76
178_V	286_P	0.635	0.76
193_V	295_G	0.634	0.75
45_L	154_S	0.633	0.75
11_W	15_I	0.633	0.75
214_D	382_V	0.633	0.75
11_W	162_R	0.630	0.75
383_K	402_W	0.629	0.75
165_T	273_Y	0.628	0.75
222_M	348_T	0.628	0.75
36_V	82_Q	0.627	0.75
443_H	459_F	0.626	0.75
31_H	125_V	0.624	0.74
62_M	83_V	0.622	0.74
187_V	279_L	0.621	0.74
16_V	27_Y	0.621	0.74
90_C	95_V	0.621	0.74
136_A	220_C	0.620	0.74
372_R	419_P	0.620	0.74
359_A	391_L	0.618	0.74
422_E	440_A	0.618	0.74
58_T	95_V	0.615	0.73
113_P	134_H	0.614	0.73
110_V	382_V	0.614	0.73
234_A	267_T	0.614	0.73
124_I	139_A	0.613	0.73
419_P	440_A	0.612	0.73
207_V	282_N	0.611	0.73
196_G	228_A	0.610	0.73
132_S	141_A	0.610	0.73
350_S	355_L	0.608	0.72
144_I	158_L	0.608	0.72
362_I	395_F	0.608	0.72
258_A	262_W	0.607	0.72
260_E	266_R	0.607	0.72
15_I	26_L	0.607	0.72
226_A	231_G	0.605	0.72
59_F	248_Y	0.605	0.72
342_V	453_A	0.605	0.72
125_V	160_Q	0.604	0.72
165_T	200_V	0.604	0.72
170_V	206_E	0.604	0.72
81_R	420_E	0.604	0.72
257_K	260_E	0.603	0.72
152_V	158_L	0.603	0.72
303_E	453_A	0.603	0.72
36_V	411_L	0.602	0.72
241_E	269_P	0.601	0.72
303_E	336_D	0.600	0.71
338_K	368_A	0.598	0.71
191_Y	277_I	0.597	0.71
352_M	382_V	0.595	0.71
14_H	29_D	0.594	0.71
166_L	277_I	0.593	0.71
38_S	60_A	0.592	0.70
23_P	159_W	0.592	0.70
451_A	457_G	0.589	0.70
252_G	258_A	0.588	0.70
251_K	255_F	0.584	0.69
208_F	234_A	0.583	0.69
180_A	219_V	0.582	0.69
150_E	433_E	0.581	0.69
38_S	41_A	0.580	0.69
284_I	287_M	0.578	0.69
447_P	457_G	0.578	0.69
218_T	447_P	0.577	0.69
26_L	123_T	0.577	0.69
210_N	244_K	0.576	0.68
43_E	46_R	0.575	0.68
162_R	165_T	0.574	0.68
173_T	207_V	0.571	0.68
213_M	217_M	0.571	0.68
207_V	278_V	0.569	0.67
371_V	453_A	0.568	0.67
166_L	191_Y	0.568	0.67
211_M	215_E	0.566	0.67
124_I	134_H	0.565	0.67
429_N	447_P	0.563	0.67
211_M	219_V	0.558	0.66
220_C	232_L	0.558	0.66
367_V	398_A	0.558	0.66
171_D	174_L	0.557	0.66
167_E	273_Y	0.557	0.66
362_I	375_V	0.557	0.66
172_G	282_N	0.556	0.66
175_Q	301_D	0.555	0.66
25_L	157_T	0.554	0.65
69_V	372_R	0.554	0.65
266_R	269_P	0.554	0.65
62_M	99_D	0.552	0.65
187_V	277_I	0.551	0.65
44_G	146_T	0.550	0.65
209_R	281_G	0.549	0.65
61_T	111_V	0.547	0.64
407_C	410_C	0.545	0.64
192_G	295_G	0.545	0.64
133_T	348_T	0.544	0.64
111_V	379_S	0.543	0.64
209_R	234_A	0.542	0.64
251_K	254_E	0.542	0.64
52_V	93_F	0.541	0.64
240_F	264_A	0.541	0.64
87_E	102_S	0.541	0.64
337_I	443_H	0.541	0.64
171_D	209_R	0.541	0.64
403_R	409_M	0.541	0.64
237_E	240_F	0.540	0.63
292_I	433_E	0.540	0.63
65_N	82_Q	0.539	0.63
194_K	197_T	0.539	0.63
117_L	122_K	0.539	0.63
452_M	460_V	0.537	0.63
68_T	374_I	0.537	0.63
51_K	93_F	0.536	0.63
129_S	145_G	0.536	0.63
379_S	382_V	0.535	0.63
232_L	235_P	0.534	0.63
387_E	393_Q	0.533	0.62
135_G	220_C	0.533	0.62
304_V	460_V	0.532	0.62
37_T	146_T	0.531	0.62
37_T	41_A	0.531	0.62
18_H	21_G	0.530	0.62
85_A	89_N	0.529	0.62
174_L	207_V	0.526	0.61
122_K	139_A	0.526	0.61
7_I	123_T	0.526	0.61
131_T	141_A	0.526	0.61
171_D	282_N	0.524	0.61
14_H	27_Y	0.523	0.61
180_A	218_T	0.523	0.61
286_P	300_V	0.523	0.61
375_V	395_F	0.522	0.61
373_A	451_A	0.522	0.61
144_I	148_E	0.521	0.61
344_I	350_S	0.521	0.61
123_T	230_A	0.520	0.61
221_N	429_N	0.520	0.61
383_K	404_E	0.519	0.60
250_P	258_A	0.519	0.60
237_E	244_K	0.518	0.60
450_A	457_G	0.517	0.60
41_A	45_L	0.516	0.60
218_T	348_T	0.516	0.60
207_V	219_V	0.516	0.60
166_L	194_K	0.515	0.60
196_G	226_A	0.515	0.60
129_S	430_R	0.514	0.60
4_R	8_E	0.513	0.60
65_N	411_L	0.513	0.60
171_D	279_L	0.513	0.60
17_K	164_K	0.512	0.59
13_Q	265_L	0.512	0.59
376_V	395_F	0.512	0.59
5_T	8_E	0.511	0.59
303_E	459_F	0.511	0.59
167_E	267_T	0.511	0.59
250_P	254_E	0.511	0.59
21_G	162_R	0.510	0.59
174_L	211_M	0.510	0.59
208_F	238_V	0.510	0.59
207_V	210_N	0.510	0.59
21_G	161_Q	0.508	0.59
300_V	460_V	0.508	0.59
406_G	415_N	0.508	0.59
401_E	404_E	0.508	0.59
357_Q	361_M	0.508	0.59
168_V	186_A	0.507	0.59
400_F	454_A	0.506	0.58
189_G	299_P	0.506	0.58
187_V	191_Y	0.505	0.58
42_F	89_N	0.505	0.58
57_N	122_K	0.504	0.58
84_T	419_P	0.504	0.58
376_V	404_E	0.504	0.58
181_K	429_N	0.504	0.58
170_V	283_K	0.504	0.58
168_V	231_G	0.503	0.58
288_V	449_M	0.503	0.58
353_T	357_Q	0.503	0.58
37_T	40_Q	0.502	0.58
206_E	278_V	0.501	0.58
82_Q	411_L	0.500	0.58
386_A	392_D	0.500	0.58

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4kp1A	1	0.8771	100	0.12	Contact Map
4kp2A	2	0.8771	100	0.138	Contact Map
1c96A	1	0.9322	100	0.188	Contact Map
2b3yA	1	0.9852	100	0.213	Contact Map
1l5jA	1	0.8962	100	0.235	Contact Map
1p3y1	6	0.3305	78.4	0.973	Contact Map
1mvlA	3	0.3369	68.6	0.975	Contact Map
1qzuA	3	0.3072	50.7	0.978	Contact Map
3qjgA	5	0.322	20	0.982	Contact Map
4jelA	2	0.0699	12.4	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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