GREMLIN Database
LEUC - 3-isopropylmalate dehydratase large subunit
UniProt: P80858 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 472 (419)
Sequences: 6626 (2273)
Seq/√Len: 111.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_R278_V5.0531.00
285_S301_D4.8961.00
280_D283_K4.0921.00
356_R389_E4.0781.00
456_H460_V3.9311.00
237_E241_E3.5421.00
167_E204_T3.4311.00
4_R12_D3.3021.00
171_D278_V3.2411.00
46_R92_E3.0301.00
342_V450_A2.9901.00
352_M385_Q2.7631.00
180_A215_E2.7611.00
373_A400_F2.7091.00
425_A445_V2.6641.00
167_E276_S2.5981.00
189_G297_V2.5891.00
238_V241_E2.5751.00
171_D206_E2.5701.00
169_R276_S2.5401.00
355_L386_A2.4711.00
393_Q397_E2.4351.00
204_T276_S2.4261.00
336_D458_H2.4181.00
207_V281_G2.4151.00
186_A190_K2.3681.00
190_K279_L2.2671.00
344_I373_A2.2131.00
186_A287_M2.2121.00
449_M453_A2.2061.00
427_T450_A2.1821.00
173_T210_N2.1181.00
28_I123_T2.0941.00
7_I163_P2.0871.00
285_S299_P2.0821.00
363_K394_I2.0661.00
174_L183_V2.0361.00
170_V281_G2.0331.00
360_D363_K2.0111.00
261_E264_A2.0041.00
344_I358_A1.9981.00
392_D396_L1.9671.00
170_V187_V1.9521.00
199_Y275_K1.9481.00
357_Q448_A1.9241.00
391_L395_F1.9221.00
184_I219_V1.8951.00
203_Y223_S1.8901.00
342_V425_A1.8901.00
169_R204_T1.8681.00
173_T206_E1.8561.00
175_Q178_V1.8351.00
8_E165_T1.8311.00
168_V187_V1.8311.00
352_M389_E1.8181.00
352_M356_R1.7851.00
164_K274_D1.7671.00
299_P302_S1.7531.00
287_M297_V1.7321.00
365_K455_I1.7311.00
212_T353_T1.7121.00
170_V183_V1.6951.00
219_V233_I1.6901.00
186_A189_G1.6711.00
339_V453_A1.6631.00
200_V230_A1.6601.00
355_L375_V1.6571.00
80_K84_T1.6411.00
356_R391_L1.6401.00
186_A284_I1.6291.00
209_R237_E1.6151.00
392_D402_W1.6091.00
183_V211_M1.5971.00
186_A279_L1.5741.00
254_E257_K1.5731.00
235_P260_E1.5721.00
385_Q389_E1.5581.00
166_L275_K1.5551.00
338_K458_H1.5551.00
376_V408_S1.5491.00
168_V201_I1.5471.00
201_I226_A1.5381.00
341_H422_E1.5301.00
52_V95_V1.5281.00
255_F259_V1.5131.00
179_T357_Q1.5101.00
383_K387_E1.5091.00
46_R93_F1.5061.00
10_I232_L1.5051.00
445_V459_F1.4921.00
179_T448_A1.4901.00
362_I373_A1.4871.00
164_K199_Y1.4811.00
194_K275_K1.4801.00
213_M238_V1.4771.00
418_V424_C1.4731.00
387_E392_D1.4591.00
215_E353_T1.4521.00
27_Y157_T1.4481.00
367_V373_A1.4451.00
140_L230_A1.4341.00
235_P240_F1.4321.00
420_E440_A1.4281.00
180_A211_M1.4281.00
184_I222_M1.4201.00
338_K370_S1.4141.00
58_T153_L1.4131.00
137_F213_M1.4061.00
339_V371_V1.4051.00
257_K261_E1.3911.00
339_V342_V1.3781.00
383_K405_S1.3721.00
170_V208_F1.3651.00
223_S231_G1.3581.00
376_V403_R1.3481.00
304_V336_D1.3481.00
412_S417_V1.3391.00
445_V450_A1.3391.00
358_A395_F1.3301.00
183_V207_V1.3271.00
394_I397_E1.3231.00
290_W298_L1.3221.00
138_G235_P1.3171.00
300_V449_M1.3130.99
9_K268_D1.3120.99
110_V378_G1.3110.99
59_F117_L1.3100.99
88_R92_E1.3080.99
7_I165_T1.3040.99
84_T88_R1.2960.99
119_L122_K1.2900.99
175_Q285_S1.2890.99
144_I149_V1.2870.99
110_V379_S1.2780.99
190_K277_I1.2750.99
175_Q284_I1.2710.99
125_V144_I1.2640.99
237_E263_K1.2520.99
17_K22_K1.2400.99
220_C233_I1.2390.99
287_M299_P1.2390.99
7_I200_V1.2330.99
110_V350_S1.2310.99
81_R85_A1.2280.99
244_K250_P1.2270.99
384_L397_E1.2210.99
174_L178_V1.2170.99
213_M239_T1.2100.99
7_I230_A1.2040.99
288_V303_E1.1920.99
59_F99_D1.1880.99
289_T297_V1.1810.99
208_F219_V1.1770.99
37_T411_L1.1720.99
187_V201_I1.1690.99
170_V207_V1.1670.99
393_Q396_L1.1660.99
241_E244_K1.1600.99
418_V440_A1.1550.99
32_L108_V1.1490.99
343_F428_S1.1470.99
137_F217_M1.1410.99
388_K393_Q1.1320.98
44_G150_E1.1290.98
363_K397_E1.1210.98
281_G284_I1.1200.98
101_H104_D1.1190.98
136_A213_M1.1150.98
113_P217_M1.1110.98
174_L210_N1.1070.98
191_Y195_F1.1070.98
30_L117_L1.1060.98
190_K283_K1.1060.98
37_T127_G1.1060.98
208_F211_M1.0970.98
384_L388_K1.0930.98
288_V445_V1.0920.98
372_R401_E1.0880.98
267_T273_Y1.0850.98
340_E422_E1.0830.98
118_T137_F1.0800.98
445_V449_M1.0780.98
396_L401_E1.0770.98
453_A460_V1.0760.98
166_L199_Y1.0670.98
446_S449_M1.0670.98
355_L395_F1.0620.98
8_E162_R1.0570.98
361_M451_A1.0550.98
5_T165_T1.0550.98
342_V454_A1.0520.98
132_S223_S1.0460.97
337_I458_H1.0450.97
207_V211_M1.0450.97
125_V152_V1.0420.97
87_E99_D1.0360.97
60_A86_L1.0290.97
190_K275_K1.0220.97
234_A266_R1.0220.97
199_Y274_D1.0210.97
214_D353_T1.0210.97
357_Q360_D1.0200.97
293_N296_M1.0190.97
267_T270_G1.0180.97
302_S305_P1.0180.97
421_G439_G1.0140.97
240_F259_V1.0080.97
33_I108_V1.0070.97
343_F408_S1.0050.97
341_H372_R1.0040.97
212_T238_V1.0030.97
60_A90_C1.0000.97
134_H141_A1.0000.97
118_T134_H1.0000.97
240_F263_K0.9960.97
384_L387_E0.9950.97
208_F233_I0.9920.96
28_I152_V0.9900.96
174_L281_G0.9900.96
240_F244_K0.9880.96
140_L200_V0.9870.96
342_V427_T0.9800.96
212_T215_E0.9750.96
206_E209_R0.9720.96
118_T124_I0.9700.96
304_V337_I0.9660.96
191_Y226_A0.9650.96
420_E438_K0.9650.96
256_D259_V0.9620.96
425_A450_A0.9590.96
206_E210_N0.9530.96
348_T429_N0.9520.96
191_Y201_I0.9490.95
19_G22_K0.9480.95
244_K249_T0.9450.95
356_R385_Q0.9450.95
298_L302_S0.9410.95
425_A453_A0.9390.95
171_D280_D0.9350.95
228_A231_G0.9340.95
30_L122_K0.9280.95
241_E245_N0.9270.95
175_Q282_N0.9270.95
36_V39_P0.9260.95
362_I455_I0.9240.95
259_V263_K0.9210.95
183_V284_I0.9180.95
118_T255_F0.9150.94
52_V153_L0.9130.94
7_I232_L0.9120.94
364_G397_E0.9080.94
246_R381_S0.9070.94
356_R360_D0.9060.94
34_H108_V0.9050.94
385_Q388_K0.9050.94
423_R443_H0.9040.94
339_V425_A0.9040.94
183_V219_V0.9010.94
8_E12_D0.8980.94
203_Y231_G0.8980.94
372_R422_E0.8980.94
104_D247_K0.8970.94
173_T282_N0.8970.94
425_A459_F0.8920.94
171_D281_G0.8920.94
6_I10_I0.8920.94
290_W303_E0.8880.94
422_E439_G0.8860.93
223_S228_A0.8860.93
387_E396_L0.8810.93
169_R206_E0.8790.93
403_R408_S0.8760.93
31_H149_V0.8740.93
15_I24_D0.8730.93
244_K255_F0.8720.93
391_L394_I0.8710.93
337_I459_F0.8700.93
168_V277_I0.8700.93
144_I152_V0.8670.93
54_R57_N0.8670.93
33_I38_S0.8650.93
13_Q263_K0.8630.93
454_A457_G0.8610.93
55_P94_G0.8590.92
189_G287_M0.8580.92
33_I58_T0.8540.92
216_R236_D0.8510.92
362_I400_F0.8510.92
210_N238_V0.8500.92
252_G256_D0.8490.92
418_V422_E0.8480.92
115_L381_S0.8450.92
51_K92_E0.8450.92
183_V208_F0.8450.92
233_I281_G0.8430.92
13_Q261_E0.8410.92
166_L274_D0.8400.92
352_M391_L0.8390.92
52_V58_T0.8370.91
5_T271_A0.8370.91
132_S224_I0.8340.91
119_L247_K0.8310.91
247_K381_S0.8300.91
69_V415_N0.8280.91
125_V158_L0.8270.91
188_I226_A0.8260.91
136_A217_M0.8230.91
252_G255_F0.8180.90
44_G47_Q0.8170.90
183_V281_G0.8160.90
346_S428_S0.8110.90
358_A375_V0.8110.90
11_W24_D0.8090.90
355_L391_L0.8070.90
341_H440_A0.8070.90
71_R418_V0.8030.90
300_V459_F0.8030.90
26_L160_Q0.8020.90
28_I31_H0.8020.90
43_E47_Q0.8010.90
267_T271_A0.7990.89
30_L59_F0.7980.89
336_D459_F0.7970.89
25_L159_W0.7950.89
31_H152_V0.7940.89
285_S302_S0.7930.89
383_K392_D0.7880.89
376_V409_M0.7880.89
358_A448_A0.7860.89
290_W443_H0.7830.88
107_I350_S0.7800.88
18_H24_D0.7770.88
12_D15_I0.7760.88
268_D271_A0.7730.88
426_S439_G0.7720.88
209_R269_P0.7710.88
339_V423_R0.7700.88
375_V400_F0.7660.87
366_K397_E0.7650.87
240_F243_C0.7620.87
65_N79_A0.7620.87
6_I232_L0.7610.87
367_V454_A0.7570.87
452_M456_H0.7550.87
6_I265_L0.7530.86
198_G229_R0.7510.86
252_G257_K0.7490.86
103_V384_L0.7480.86
176_K360_D0.7450.86
206_E281_G0.7440.86
209_R238_V0.7430.86
419_P422_E0.7400.85
33_I127_G0.7400.85
38_S86_L0.7370.85
384_L393_Q0.7350.85
254_E258_A0.7350.85
85_A88_R0.7320.85
28_I158_L0.7310.85
55_P58_T0.7260.84
112_G118_T0.7240.84
208_F267_T0.7240.84
88_R91_E0.7230.84
104_D381_S0.7210.84
148_E160_Q0.7200.84
356_R386_A0.7160.84
362_I398_A0.7150.83
341_H419_P0.7150.83
99_D103_V0.7150.83
99_D104_D0.7120.83
164_K275_K0.7120.83
340_E440_A0.7110.83
10_I200_V0.7080.83
15_I18_H0.7070.83
209_R266_R0.7070.83
186_A283_K0.7050.83
102_S115_L0.7050.83
66_I105_Q0.7050.83
105_Q380_Q0.7020.82
352_M386_A0.7000.82
421_G440_A0.7000.82
207_V215_E0.7000.82
396_L402_W0.7000.82
71_R101_H0.6990.82
115_L247_K0.6990.82
166_L201_I0.6980.82
204_T273_Y0.6970.82
445_V453_A0.6950.82
12_D19_G0.6950.82
362_I365_K0.6950.82
31_H58_T0.6920.81
367_V370_S0.6920.81
107_I378_G0.6890.81
61_T108_V0.6850.81
453_A459_F0.6830.81
87_E91_E0.6830.81
449_M460_V0.6810.80
30_L119_L0.6790.80
387_E402_W0.6780.80
453_A458_H0.6770.80
99_D102_S0.6760.80
189_G193_V0.6720.80
184_I187_V0.6720.80
168_V279_L0.6700.79
79_A411_L0.6690.79
269_P272_V0.6680.79
163_P200_V0.6680.79
174_L215_E0.6660.79
133_T217_M0.6650.79
118_T139_A0.6640.79
243_C249_T0.6620.79
220_C230_A0.6620.79
337_I423_R0.6620.79
380_Q405_S0.6610.78
53_R58_T0.6610.78
385_Q391_L0.6600.78
113_P137_F0.6590.78
33_I153_L0.6590.78
191_Y196_G0.6570.78
359_A394_I0.6560.78
341_H424_C0.6560.78
425_A449_M0.6560.78
30_L112_G0.6560.78
342_V371_V0.6530.78
244_K259_V0.6530.78
35_E40_Q0.6510.77
341_H374_I0.6500.77
175_Q283_K0.6500.77
183_V206_E0.6470.77
35_E38_S0.6470.77
382_V385_Q0.6470.77
27_Y54_R0.6460.77
181_K348_T0.6460.77
279_L283_K0.6450.77
104_D115_L0.6440.77
168_V190_K0.6440.77
133_T221_N0.6430.76
117_L248_Y0.6420.76
343_F409_M0.6420.76
34_H37_T0.6420.76
403_R406_G0.6400.76
249_T252_G0.6390.76
170_V174_L0.6380.76
300_V303_E0.6380.76
138_G265_L0.6380.76
367_V371_V0.6380.76
178_V286_P0.6350.76
193_V295_G0.6340.75
45_L154_S0.6330.75
11_W15_I0.6330.75
214_D382_V0.6330.75
11_W162_R0.6300.75
383_K402_W0.6290.75
165_T273_Y0.6280.75
222_M348_T0.6280.75
36_V82_Q0.6270.75
443_H459_F0.6260.75
31_H125_V0.6240.74
62_M83_V0.6220.74
187_V279_L0.6210.74
16_V27_Y0.6210.74
90_C95_V0.6210.74
136_A220_C0.6200.74
372_R419_P0.6200.74
359_A391_L0.6180.74
422_E440_A0.6180.74
58_T95_V0.6150.73
113_P134_H0.6140.73
110_V382_V0.6140.73
234_A267_T0.6140.73
124_I139_A0.6130.73
419_P440_A0.6120.73
207_V282_N0.6110.73
196_G228_A0.6100.73
132_S141_A0.6100.73
350_S355_L0.6080.72
144_I158_L0.6080.72
362_I395_F0.6080.72
258_A262_W0.6070.72
260_E266_R0.6070.72
15_I26_L0.6070.72
226_A231_G0.6050.72
59_F248_Y0.6050.72
342_V453_A0.6050.72
125_V160_Q0.6040.72
165_T200_V0.6040.72
170_V206_E0.6040.72
81_R420_E0.6040.72
257_K260_E0.6030.72
152_V158_L0.6030.72
303_E453_A0.6030.72
36_V411_L0.6020.72
241_E269_P0.6010.72
303_E336_D0.6000.71
338_K368_A0.5980.71
191_Y277_I0.5970.71
352_M382_V0.5950.71
14_H29_D0.5940.71
166_L277_I0.5930.71
38_S60_A0.5920.70
23_P159_W0.5920.70
451_A457_G0.5890.70
252_G258_A0.5880.70
251_K255_F0.5840.69
208_F234_A0.5830.69
180_A219_V0.5820.69
150_E433_E0.5810.69
38_S41_A0.5800.69
284_I287_M0.5780.69
447_P457_G0.5780.69
218_T447_P0.5770.69
26_L123_T0.5770.69
210_N244_K0.5760.68
43_E46_R0.5750.68
162_R165_T0.5740.68
173_T207_V0.5710.68
213_M217_M0.5710.68
207_V278_V0.5690.67
371_V453_A0.5680.67
166_L191_Y0.5680.67
211_M215_E0.5660.67
124_I134_H0.5650.67
429_N447_P0.5630.67
211_M219_V0.5580.66
220_C232_L0.5580.66
367_V398_A0.5580.66
171_D174_L0.5570.66
167_E273_Y0.5570.66
362_I375_V0.5570.66
172_G282_N0.5560.66
175_Q301_D0.5550.66
25_L157_T0.5540.65
69_V372_R0.5540.65
266_R269_P0.5540.65
62_M99_D0.5520.65
187_V277_I0.5510.65
44_G146_T0.5500.65
209_R281_G0.5490.65
61_T111_V0.5470.64
407_C410_C0.5450.64
192_G295_G0.5450.64
133_T348_T0.5440.64
111_V379_S0.5430.64
209_R234_A0.5420.64
251_K254_E0.5420.64
52_V93_F0.5410.64
240_F264_A0.5410.64
87_E102_S0.5410.64
337_I443_H0.5410.64
171_D209_R0.5410.64
403_R409_M0.5410.64
237_E240_F0.5400.63
292_I433_E0.5400.63
65_N82_Q0.5390.63
194_K197_T0.5390.63
117_L122_K0.5390.63
452_M460_V0.5370.63
68_T374_I0.5370.63
51_K93_F0.5360.63
129_S145_G0.5360.63
379_S382_V0.5350.63
232_L235_P0.5340.63
387_E393_Q0.5330.62
135_G220_C0.5330.62
304_V460_V0.5320.62
37_T146_T0.5310.62
37_T41_A0.5310.62
18_H21_G0.5300.62
85_A89_N0.5290.62
174_L207_V0.5260.61
122_K139_A0.5260.61
7_I123_T0.5260.61
131_T141_A0.5260.61
171_D282_N0.5240.61
14_H27_Y0.5230.61
180_A218_T0.5230.61
286_P300_V0.5230.61
375_V395_F0.5220.61
373_A451_A0.5220.61
144_I148_E0.5210.61
344_I350_S0.5210.61
123_T230_A0.5200.61
221_N429_N0.5200.61
383_K404_E0.5190.60
250_P258_A0.5190.60
237_E244_K0.5180.60
450_A457_G0.5170.60
41_A45_L0.5160.60
218_T348_T0.5160.60
207_V219_V0.5160.60
166_L194_K0.5150.60
196_G226_A0.5150.60
129_S430_R0.5140.60
4_R8_E0.5130.60
65_N411_L0.5130.60
171_D279_L0.5130.60
17_K164_K0.5120.59
13_Q265_L0.5120.59
376_V395_F0.5120.59
5_T8_E0.5110.59
303_E459_F0.5110.59
167_E267_T0.5110.59
250_P254_E0.5110.59
21_G162_R0.5100.59
174_L211_M0.5100.59
208_F238_V0.5100.59
207_V210_N0.5100.59
21_G161_Q0.5080.59
300_V460_V0.5080.59
406_G415_N0.5080.59
401_E404_E0.5080.59
357_Q361_M0.5080.59
168_V186_A0.5070.59
400_F454_A0.5060.58
189_G299_P0.5060.58
187_V191_Y0.5050.58
42_F89_N0.5050.58
57_N122_K0.5040.58
84_T419_P0.5040.58
376_V404_E0.5040.58
181_K429_N0.5040.58
170_V283_K0.5040.58
168_V231_G0.5030.58
288_V449_M0.5030.58
353_T357_Q0.5030.58
37_T40_Q0.5020.58
206_E278_V0.5010.58
82_Q411_L0.5000.58
386_A392_D0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kp1A 1 0.8771 100 0.12 Contact Map
4kp2A 2 0.8771 100 0.138 Contact Map
1c96A 1 0.9322 100 0.188 Contact Map
2b3yA 1 0.9852 100 0.213 Contact Map
1l5jA 1 0.8962 100 0.235 Contact Map
1p3y1 6 0.3305 78.4 0.973 Contact Map
1mvlA 3 0.3369 68.6 0.975 Contact Map
1qzuA 3 0.3072 50.7 0.978 Contact Map
3qjgA 5 0.322 20 0.982 Contact Map
4jelA 2 0.0699 12.4 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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